ALL Tdt Children Increased WBC, Anemia, infection, petechiae brusing

decreased granulocytes bleeding

Bone pain, lymphadenopathy,
hepatosplenmegly
T-CELL Cd2-8 Teenagers Mediastinal mass
B-CEll CD10, T(12;21)-Good/child Need extra prophylaxis
CD19, T(9;22)- bad/adults to scrotum and CSF
CD20
AML CD34, T(8;21)-RUNX1 MPO Fever, petechieal rash, bleed muscosa
CD33 Inv(16) CBFB AUER RODS Bone pain, anemia, thormbo
T(15;17) RAR+PML fusion Graunels- release
(bloc diff @promyleocytic procoag and fibroytic Infiltrate the skin and gingiva
level)
CML CD5 BCL2 Males and Trisomy 12, deletions in Helpatosplenomegly
SLL CD19 old 11,13,17 Lymphadenopathy
CD20 P: 4-10yrs Increase WBC Hypogammablobienia
Indolent DLBL with abdominal AHA, ITP
mass=Reiters
B-cell lymphomas- including SLL above
Follicular CD19, T(14;18) 90% Old No apoptoic Painless lympadenopaty
40% 20 BCLIgH indolent macrophages
BCL Ritiximab DLBL (40%)
6,10
Mantle CD5 T(11;14) Male Wide spread to spleen, W/F, generalized painless
4% CD19 Cylcin D II older BM, GI lymphadenopathy
CD20 increasespromotes
cells G1-S1
Burkits T(8;14) Children/y Fast growing human 1) African- jaw mass
MYC gene(TF reculator oung tumor 2) Sporatic 30% us children-
that promotes glycolysis adult Stary sky abdominal mass
and rapid cell growth Intensive chemo
DLBL CD19 T(14;18)-BCL Most Co infections with EBV TYPE:
50% CD20 MYC translcation common Extranodal almost Primary effusion (HIV) kshv/hv8
BCL6 BCL6 mutation in adults everywhere besides BM Immune defiecny- co infection EBV
15% child Medistainal LBCL- large mass youn
women
Extranodal t Indolent sjorgen/hashimotos Epithelial tissue: stomach, salivary glands
marginal Auto- H. pylori) Some localized to gi, lungs, orbit can be
immune completely excised or cured with
Chronic antibiotic
infections
Harry cell CD103 Mutation in Indolent Massive splenomegaly
CD11c ser/threonine kinease Male Pancytopenia
CD BRAF downstream from Old
19,20 RAS/MAPK cascade
T cell lymomas
Mycosis Tumor CD4 cells Cerebriform appearance
fungiodes Pautrier Microabcesses
Involves skinlymph
nodes visceral
Sezary Patient with erythroderma and
syndrome circulating malignant CD4 cells in
 peripheral blood
Adult tcell CD25 HTVL-1 retrovirus caused Japan, Hepatosplenomegly
leukemia/lym tumor CD4 cells carb, Lymphadenopathy
phoma W.africa. Hypercalcemia
SE usa Circulating tumor cll
Hodgkins EBV->NF-KBsurvival and proliferation fo lymphocytes and survial of germinal B cells that normally would go apop but
instead undergo mutation producing R/S cells
- Neutrophils and eosinophils increase
Nodular CD15 Young Lacunar cell (clear space Mass in cervical, supraclavicular and
CD30 adults around nucleus) medistrinal
Mixed PAX5 75% EBV Most
eosinophils common
in adults
Lymph rich EBV (40%)
Lymph poor EBV (90%) OLD
HIV
Lymph CD20 POPCORN CELLS
predom BCL6
Plasma cell disorders
Multiple IL-6 T(?;14) cyclin D1, cyclin Old Bence jones protiens Bone lesions (malignamt PC secrete IL-
myeloma IgG or D3 MYC p-4-5 yr secretes RANKLosteoclast
IgA BM lesion >10% PC
Renal failure myleoma kidney
Bone pain, anemia, fracture,
hypercalemia
Increased infection
Plasmacytom M Protein M in serum and Nasopharynx
as protein tumor cells. skeleton or Soft tissue
Neoplastic MC PC
Lymphoplas IgM Neoplast MC PC and Indolent Increase in blood viscosityvisual
macytic small lymphocytes impairment, neurosymptoms, increased
lymoma bleeding, cryglobuiemia
Heavy chain IgA N, MC, PC and Lesion Upper GI or resp
disease lymphocyte proliferation
Primary or AI PC-secrete free light Amyloid in kidney, heart,
amyloidosis chain BV
MGUS LESS THAN 3gm/dl of 3-5% >50 Asympomatic
monoclonal protein 1%
myleoma
Histocytic Proliferation of immature BIERBEC Letter-siwer- multifocal, multisystem <2yrs. Cutaneous
neoplasm- dendricic cells K- tennis infiltraes, lytic bone leasion, BM infiltration
langerhans racket Hand- Scheller-christen: triad: bone lesion, DI,
exopathomas
Neutropenia: Leukocytosis (increase neut) Neutrophilic leuko- acute bacteria inf (dhole
bodies and immature granulocytes
Suppression of HSC- aplastic anemia Increase pdt (inflame, hod, Myleo) Eosinophic leuk- allergic
Suppression of granulocyte pdt: alkylating agents Increase relase from BM- infection Basophilic- CML
Ineffective hemopoiesis: megablastic anemia Decreased migration-execerise MONOCYTOSIS- chronic infect(sle, endoc
Inc destruction, splenic sequestration (sle, drug, cirr) Decrease extravaseion-steroids Lymphocytosis: mon, viral infection