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Unit 12 - Week 9
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Certification exam Assignment 9
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Course As per our records you have not submitted this Due on 2019-04-03, 23:59 IST.
outline
assignment.
How to access 1) Lidocaine is a longer lasting local anaesthetic than procaine because 1 point
the portal procaine has an ester group which is susceptible to hydrolysis whereas
lidocaine has an amide group that is resistant to hydrolysis.
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Pune
Pre-Requisite
True
Assignment
False
Week 1
No, the answer is incorrect.
Week 2 Score: 0
Accepted Answers:
Week 3 True
2) Esters are frequently used as prodrugs because esters are more 1 point
Week 4
susceptible to hydrolysis if the alcohol moiety has an electron donating
Week 5 group.
Week 6 True
False
Week 7
No, the answer is incorrect.
Week 8 Score: 0
Accepted Answers:
Week 9 False
Quiz : 3) Structures (I) and (II) are prodrugs of the antibiotic chloramphenicol. 1 point
Assignment 9 Structure (II) is more water soluble than chloramphenicol and is used to
Optimizing achieve higher concentrations for injections. Structure (I) has lower water
Access to the solubility, as a result it reduces the bitter taste of the drug when given by
Target mouth.
Prodrugs
Prodrugs and
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True
A project of
Endogenous In association with
False
Compounds,
Peptidomimetics No, the answer is incorrect.
and
Score: 0 Funded by
Oligonucleotides
as Drugs
Accepted Answers:
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Optimizing
False
Access-
4) The term ‘prodrugs’ is used for some drugs containing an ester 1 point
Prodrugs
group that are inactive in vitro, but are active once the drug has been
Medicinal absorbed in vivo.
Chemistry :
Week 9
True
Feedback form
False
Week 10
No, the answer is incorrect.
Week 11 Score: 0
Accepted Answers:
Week 12 True
TRANSCRIPTS
Interaction True
Session
False
No, the answer is incorrect.
Score: 0
Accepted Answers:
True
6) In Parkinson's disease, there is a lack of the neurotransmitter 1 point
dopamine in the brain. Adding dopamine itself is not very effective because
dopamine cannot access the brain easily, rapidly metabolized and shows
poor selectivity between different types of dopaminergic receptors.
True
False
No, the answer is incorrect.
Score: 0
Accepted Answers:
True
7) Phosphate drugs are less polar in nature than their parent drugs. 1 point
True
False
No, the answer is incorrect.
Score: 0
Accepted Answers:
False
8) L791456 is an anti-arthritic drug with a shorter lifetime in the body 1 point
than L787257. The only difference in the structures is a methyl substituent on
one of the pyridine rings. Why does the presence of a methyl group decrease
the lifetime of the drug?
It acts as a steric shield and hinders the drug binding to its target
It increases the basicity of the pyridine ring causing it to bind to
plasma proteins
No, the answer is incorrect.
Score: 0
Accepted Answers:
It is metabolized by oxidative enzymes to an alcohol or carboxylic acid. The
resulting polar metabolites are rapidly excreted
9) Tioconazole is a non-polar antifungal agent which is used topically, 1 point
whereas fluconazole is a polar drug which is used systemically. Which of the
following statements is correct?
enzymes
12)Why does chlorpropamide have a longer antibiotic activity than 1 point
tolbutamide?
The parent drug can be administered orally, whereas the ester prodrug cannot
15)Carbachol is more stable than acetylcholine to hydrolysis. Which of 1 point
the following statements is not true?