NT&NM RELEASED FROM WHICH RECEPTORS TYPE ACTION/EFFECT

NEURONS OR PART OF
NS

Acetylcholine Terminals of the large Cholinergic receptors Excitatory in most of the cases
pyramidal cells from the like muscle to contract but
motor cortex, (nicotinic, muscarinic)
inhibitory

Neurons in the basal

ganglia,

Motor neurons that

innervate the skeletal
muscles,

Preganglionic neurons of
the autonomic nervous
system,

The postganglionic
neurons of the
parasympathetic nervous
system,

Some of the
postganglionic neurons
of the sympathetic
nervous system.

Norepinephrine Brain stem specifically Adrenergic receptor Excitatory, increases the level of
locus ceruleus in pons (α1, α 2) ,(β1, β 2, β 3) alertness and wakefulness.
,hypothalamus ,post Stimulate various process of body
ganglion neuron of SNS .

Histamine Neurons of H1 & H2 Excitatory, regulates wakefulness,

hypothalamus pain, sexual behaviour and blood
pressure.

GABA(gamma Nerve terminals in spinal GABA receptors Powerful inhibitory

aminobutyric acid) cords, cerebellum ,basal neurotransmitters of CNS.
ganglia and many areas
of the cortex
Glycine At synapses in spinal Glycine receptors Always inhibitory.
cord

Sertonin By nuclei that originate 5-HT1,5-HT2,5-HT3 Excitatory effect on motor system

in the median raphe of ,inhibitory effect on sensory
brainstem system ,regulate body
temperature ,perception of pain
 & emotions and sleep cycle

Glutamate By presynaptic terminals Glutamate receptors & Powerful inhibitory

in many of the sensory NMDA neurotransmitters of CNS
pathways entering
central nervous system

Dopamine Substancia nigra Dopamine receptors Usually inhibitory. inhibits

unnecessary movements, inhibits
the release of prolactin