To play game, go inside The simpsons - Hit & Run folder, right click and run the
Simpsons.exe as administrator
If you experience any slow loading or stuck loading screen here's the fix:
Right click Simpsons.exe
-Go to the compatibility tab,
-Click Run in Windows XP SP3(you can play around with this if needed, this one works for me so far), -Click "Run this program as an administrator" > Apply and OK.