Rheumatology

Arthritis
1. Osteoarthritis is not an inflammatory arthritis.
2. HLA B5 is associated with Behcet.
3. Proximal interphalangeal, distal interphalangeal& 1st carpometacarpal joint involvement and sparing of wrist is
a feature of Osteoarthritis.
4. Least common site to be involved in osteoarthritis is Metacarpophalangeal joint.
5. Heberden's arthropathy affects Distal interphalangeal joints.
6. Arthroscopic washout is the best treatment of a patients of Osteo arthritis Aphrolan grade II .

Rheumatoid Arthritis
1. HLA most characteristically associated with Rheumatoid arthritis – HLA DR4.
2. TNF-alpha is involved in the pathogeneses of RA.
3. Synovium is the initial site of disease in RA.
4. DIP joint least likely involved in RA.
5. Erosion radiological feature would help differentiate rheumatoid arthritis with SLE.
6. Cervical spine is most commonly affected Vertebral Joint in Rheumatoid arthritis.
7. Ulnar deviation of fingers is Pathognomic of RA.
8. Hammer toe is seen in Rheumatoid arthritis.
9. Rheumatoid arthritis causes pleural effusion with low sugar.
10. Type of anemia seen in Rheumatoid arthritis is Normocytic normochromic anaemia.
11. Rh factor is a Antibody.
12. Rheumatoid factor is IgM.
13. Rheumatoid factor in rheumatoid arthritis is important because RA factor is associated with bad prognosis.
14. Anti CCP is the most specific antibody for rheumatoid arthritis.
15. Sclerosis is a X-ray finding in RA.
16. Leucocytosis is not a marker of active RA.
17. Hemophilia with Rheumatoid arthritis, analgesic of choice is Acetaminophen.
18. Anakinra is the IL-1 Receptor antagonist.
19. Flupirtine is Analgesic.

Systemic Lupus Erythematosus

1. Polyserositis is seen in SLE
2. Procainamide causes SLE.
3. In SLE, characteristic kidney lesion is Wire loop lesions.
4. Wire loop lesions are often characteristic diffuse proliferative glomerulonephritis (WHO class IV) class of lupus
nephritis.
5. Shrinking lung is a feature of SLE.
6. Autoimmune destruction of platelet is seen in SLE.
7. Carpet tack sign is seen in SLE.
8. In APLA, BT & PT are normal but PTT is increased.
9. Thrombocytosis is not associated with an Anti-phospholipid syndrome.
10. Anti beta 2 glycoprotein antibody is used for diagnosis of anti-phospholipid antibody syndrome.
11. ANA is the most sensitive test for SLE.
12. Anti ds DNA ab is specific test for SLE.
13. Anti – Ro (SS- A) antibody is associated with subacute cutaneous lupus.
14. Anti ribosomal P antibody is associated with psychosis or depression due to CNS SLE.
15. Best marker for drug induced lupus is Anti histone antibodies.
16. U1 RNP antibodies is most important in a diagnosis of Mixed Connective tissue disorder.
17. Sapporo criteria is used for Anti phospholipid syndrome.

Spondylo – Arthrosis
1. Ankylosing spondylitis in associated with HLA-B27.
2. Sacroiliitis is the earliest joint involved in ankylosing spondylitis.
3. The Schober test is done for Ankylosing Spondylitis.
4. Bamboo spine is seen in Ankylosing Spondylitis.
5. Treatment of choice in seronegative spondyl-arthritis is Indomethacin
6. Subcutaneous nodules are not seen in Reiter’s syndrome.
7. Chlamydia most commonly causes reactive arthritis.
8. Reiter’s disease can occur in epidemic form.
9. Circinate balanitis is seen in Reiter’s disease.
10. Sausage dactylitis is seen in Reiter’s disease.
11. Keratoderma blennorrhagica is seen in Reiter’s disease.
12. Patrick test is done for Sacroiliitis.

Systemic Sclerosis
1. Sudden renal failure occurs in PSS.
2. Anti centromere antibodies are most commonly associated with CREST syndrome.
3. Bosentan is used to treat Raynaud’s phenomena.
4. Hypothyroidism occurs in Scleroderma.

Sjögren syndrome
1. Commonest cause of secondary Sjögren’s syndrome is RA.
2. Alpha fodrin antibodies are present in Sjögren’s syndrome.
3. Focus score is use in the diagnosis of Sjögren’s syndrome.
4. Schirmer’s test is done to diagnose Sjögrensyndrome.

Behçet’s Syndrome
1. Recurrent Bilateral Hypopyon formation associated with thrombophlebitis is most consistent with Behçet’s
syndrome.
2. Pathergy test is done for Behçet’s syndrome.
3. Thalidomide is used to treat Behçet’s syndrome.

Crystals deposit disease

1. Gout is a disorder of Purine metabolism.
2. Allopurinol is not used in treatment of acute gout.
3. Most specific test for gout is Raised uric acid in synovial fluid of joint.
4. Martel’s or G’ sign is seen in Gout.
5. Benzbromarone is used in gout because it is Uricosuric.
6. Tienilic acid is the only diuretic that can be used in Gout.
7. Febuxostat is a Xanthine oxidase inhibitor and is used in the treatment of Gout .
8. Rasburicase is used in the treatment of Gout .
9. Small joints affected is not seen in pseudogout.
10. Hemochromatosis causes pseudogout.
11. Knee is the most common joint involved in pseudogout.

Vasculitis
1. ANCA is sensitive and specific for Idiopathic crescentic glomerulonephritis.
2. C-ANCA Positivity is specific for Wegener's granulomatosis.
3. c-ANCA positivity indicates, antibody formed against Proteinase 3.
4. p-ANCA is characteristic for Microscopic polyangiitis.
5. Headache is the most frequent presenting symptoms in patients with Giant cell arteritis.
6. The investigation of choice for diagnosis of Giant cell Arteritis is Temporal Artery biopsy.
7. Biopsy in PAN shows Necrotizing arteritis.
8. Kawasaki disease is common cause of Vasculitis in children.
9. Kawasaki disease is associated with coronary artery aneurysm.
10. The treatment of choice for Kawasaki disease is Immunoglobulins.
11. Intravenous immunoglobulin is given in a. Kawasaki disease, b. GB syndrome, c. Myasthenia gravis.
12. Cavitating lesion in lung is seen in Wegner's granulomatosis.
13. Churg Strauss diseases manifest as asthma.
14. A characteristic of Henoch - Schonlein Purpura Blood in stool.
15. Henoch - Schonlein purpura is characterized by the deposition IgAimmunoglobulin around the vessels.
16. Hypersensitive vasculitis involves Post capillary venules.

Marfan' s syndrome
1. Root of aorta is the site of Aortic aneurysm in Marfan syndrome.
2. Ghent criteria is used to diagnose Marfan syndrome.
3. Most important differential diagnosis of Marfan syndrome is Homocystinuria.

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