GIT Practical lab

orofacial herpetic infections

 Herpesvirus infection ,A: Herpesvirus blister in mucosa.
B, cells from blister in A, showing glassy intranuclear HSV inclusion
bodies.
 Pyogenic granuloma
Grossly it appear as polypoidal lesion that usually ulcerate
Histologically it composed of highly vascular proliferation of
organizing granulation tissue.
SCC
Mucocele
Pleomorphic Adenoma
Pleomorphic Adenoma
Mallory-Weiss tears
Esophageal Varices
Barrett’s Esophagitis
Acute gastritis due to use of NSAIDs. There is diffuse and
extensive erythema with focal erosions.
 Acute peptic ulcer There is diffuse hemorrhagic gastritis and focal
peptic ulceration which is extending nearly through the gastric wall.
Gastric ulcer. There is a characteristic sharp demarcation from the
surrounding mucosa, with radiating gastric folds. The base of the
ulcer is gray owing to fibrin deposition.
 Ulcer of the duodenum. Note that the ulcer is small (2 cm) with a
sharply punched-out appearance. Unlike cancerous ulcers, the
margins are not elevated. The ulcer base is clean (compare with the
ulcerated carcinoma).
PUD share similar histology of the four layers N= Necrotic area,
I = Inflammatory region, G = Granulation tissue and S = Scar
formation.
Gastric carcinoma (Malignant gastric ulcer)
 Gastric carcinoma.
A, Intestinal type demonstrating gland formation by malignant cells,
which are invading the muscular wall of the stomach
 Infiltrating gastric carcinoma (linitis plastica). Flattening of
rugae and gastric wall thickened by tumor and desmoplasia
Gastric adenocarcinoma, poorly differentiated that glands are not
visible. Instead, rows of infiltrating neoplastic cells with marked
pleomorphism are seen. Many of the neoplastic cells have clear
vacuoles of mucin.
IBD
Crohn’s Disease
Crohn’s enterocolitis: longitudinal ulcers and intervening
normal mucosa.
 Ulcerative Colitis
The most intense inflammation
begins at the lower right in the
sigmoid colon and extends
upward and around to the
ascending colon.
 Inflammatory polyps of the colon in ulcerative colitis.
Nodules of regenerative mucosa and inflammation surrounded by
denuded areas provide a diffuse polypoid appearance of the mucosa.
Toxic megacolon
Ulcerative Colitis:
Glandular distortion and
crypt abscess.
Hyperplastic Intestinal Polyp
Adenomatous Intestinal Polyps
Tubular adenoma
Villous Adenoma
Tubulo villous Adenoma
Familial Adenomatous Polyposis
ColoRectal Carcinoma
Carcinoma of the descending colon Infitrative
Napkin-ring type.
 Microscopy: Invasive adenocarcinoma of colon,
showing malignant glands infiltrating the muscle wall.
Chronic cholecystitis
Liver cirrhosis
Cavernous hemangiomas
Hepatocellular carcinoma
Metastatic Tumors
Thank you