Evan Luisa Marie P.

Ventilacion
2C
CASE 5

A 42-year-old woman who has had proteinuria for

approximately 5 years develops renal failure. She also has
developed hypertension and has had several bacterial and
vaginal yeast infections over the last 10 years. Her two
pregnancies were uncomplicated, although she required cesarean
deliveries for large babies of 9 lb and 9.5 lb. A kidney biopsy
reveals increased mesangial matrix and acellular periodic acid-
Schiff (PAS)-positive nodules.
What is the most likely diagnosis? Nephrotic Syndrome
resulting from diabetic glomerusclerosis
What is the underlying mechanism? Diabetic
microangiopathy causing injury to the glomerulus.
Discuss the pathogenesis of diabetic microangiopathy and
glomerulopathy
Diabetic microangiopathy: Hyperglycaemia has been shown to play a central role
in diabetic microangiopath.

Diabetic nephropathy: is likely to be as a result of metabolic and hemodynamic

abnormalities, as seen in diabetes, interacting with each other and with various
reactive oxygen species‐dependent pathways.

Describe other complications of DM