1.

Graft survival can be enhanced without generalized immunosuppression by …

A. Matching for HLA antigens.
B. Anti-thymocyte globulin.
C. Cyclosporin A therapy.
D. Steroids or cytotoxic drugs.
E. Anti CD25 antibodies

2. Immunosuppression is not induced by …

A. Antihistamines.
B. Removal of lymphoid tissue.
C. Use of anti-lymphocyte antibodies.
D. Cytotoxic drugs.
E. Corticosteroids

3. Bone marrow engraftment is a unique type of organ transplantation because …

A. MHC differences are not recognized.
B. Minor histocompatibility differences are the only antigenic differences that can
lead to rejection.
C. Graft versus host disease may occur.
D. Immunosuppression is never required.
E. MHC class II allelic difference is always the target

4. Graft rejection …
A. Occurs between identical twins.
B. Rarely involves T lymphocytes.
C. Can be accelerated by a previous graft from the same donor.
D. Can be prevented by immunostimulation.
E. Is mainly prevented by matching at the HLA A, B or C loci.

5. The following statements are correct regarding Major histocompatibility antigens

except they are….
A. Linked with a number of autoimmune diseases.
B. Important for interactions between T and B cells during an immune response.
C. The only antigens which result in graft rejection.
D. Important for graft versus host reactions.
E. Of the Class II type are expressed by antigen presenting cells

6. Which of the following will be most important in reducing the effect of graft-versus-
host disease in a bone marrow recipient?
A. matching HLA-A, B, C and D antigens of donor and recipient.
B. administering alpha interferon.
C. removing mature T cells from the graft.
 D. removing T cells from the recipient.
E. items A and C.

7. Currently approved virus vaccines for tumours include...

A. HIV
B. HPV
C. Measles
D. HBV
E. B and D

8. Potential immunological mechanisms for protection against tumours include..

A. Antibody and complement
B. Antibody dependent cellular cytotoxicity (ADCC) mediated by macrophages,
PMNs and NK cells - through Fc receptors
C. Specific cytotoxic T cells - mainly CD8+ recognising tumour peptides associated
with MHC class I
D. Natural killer cells
E. All of the above

9. Immunosuppressive cytokines produced by tumours include..

A. IL-2
B. IL-5
C. IL-10
D. IL1
E. IL8

10. The following statements regarding the monoclonal antibody (Mab) treatment of
tumours are true except..
A. The do not always produce a HAMA response
B. Mabs cannot be used to target antigen released from the tumour cells
C. Mabs are not efficient in penetrating large tumour masses
D. Mabs can be used to target intracellular antigens
E. Mabs result in the selection of weak antigen positive cells
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