MITOCHONDRIAL: THE ENERGY PATHWAY IN MOOD DISORDERS
Debree Septiawan*
Abstract
Mitochondrial dysfunctions are assuming an increasingly important role in hypotheses of mood
disorders. Neuronal energy supplies are completely dependent on mitochondrial oxidative phosphorylation, which makes them particularly vulnerable to mitochondrial dysfunction. Mitochondria pathway use microtubule networks to move around, including synapses and areas of neurite outgrowth. ATP produced by mitochondria is essential for loading neurotransmitters into synaptic vesicles and maintaining neuronal membrane potentials. Mitochondria are also involved in the regulation of intracellular calcium levels, which is crucial at synapses because calcium stimulates neurotransmitter release and facilitates many other processes (including gene transcription, the activation of second-messenger pathways, etc.). ________________________________________________________________________________
Keywords: Mitochondrial, energy, pathway, mood.
* Department of Psychiatry, Division of Biological Psychiatry, Sebelas Maret University,