KPJ HEALTHCARE UNIVERSITY

COLLEGE

BPH1073 DOSAGE FORM DESIGN

AND DISPENSING II

SUPPOSITORIES - CBL

S.POONGUZHALI

NAME : SITI AMIRAH HAKIMAH BINTI MOHD FAIRUZ

STUDENT ID : 2062191008
BACHELOR OF PHARMACY (HONS)
PROGRAMME :
COHORT 7
1. In order to produce 70 mL of a mixture containing 100 mg of DRUG Y in each
5mL dose, the pharmacist is required to add 50mL of water to the DRUG Y
powder mix. Calculate the displacement volume for a quantity of powder
equivalent to 100 mg of DRUG Y.

100 mg drug Y ÷ 5 mL solution = 20 mg of drug Y per mL

70 mL of solution contains
= 20 mg/mL × 70 mL
= 1400 mg drug Y in 70 mL solution

70 mL – 50 mL of water = 20 mL

1400 mg of drug Y displaced 20 mL of solvent

100 mg of drug Y displaced X of solvent
X = (20 x 100) ÷ 1400
= 1.4286 mL of solvent

∴ 100 mg of drug Y will displace 1.4286 mL of solvent , 100 mg/1.4286 mL

2. Diphenhydramine BP 5% suppository is to be made. Diphenhydramine

immiscible liquid is to be prepared for a 4-year-old child in a glycerogelatin
base suppository. Calculate the amount of glycerogelatin base needed for 15
suppositories. No extra is needed.

Weight of diphenhydramine BP required = 5%

= 0.05 gm x 15 suppositories
= 0.75 gm

The displacement value of diphenhydramine BP is 1.3.

X/1 = 0.75/1.3
X (amount of glycerogelatin base displaces by the drug) = 0.577 gm

Total amount of glycerogelatin base needed = (15 suppositories x 1.2 gm) –

0.577 gm
∴ = 17.423 gm

Rx
Diphenhydramine BP 0.75 gm
Glycerogelatin 17.423 gm
Total 18.173 gm
3. Calculate the amount of base for the following prescriptions for 20 adult
suppositories. No excess needed. Resorcinal 120 mg in Hard Fat BP per
suppository.

Weight of resorcinol required = 20 suppositories x (120 mg ÷ 1000)

= 2.4 gm

The displacement value of resorcinol is 1.5.

X/1 = 2.4/1.5
X (amount of hard fat base displaces by the drug) = 1.6 gm

Total amount of hard fat base needed = (20 suppositories x 2.0 gm) – 1.6 gm
∴ = 38.40 gm

Rx
Resorcinal 2.40 gm
Hard Fat BP 38.40 gm
Total 40.80 gm

4. Calculate the amount of base for the following prescriptions for 15 adult
suppositories. No excess needed. Sulphur BP 60 mg in Theobroma Oil per
suppository.

Weight of Sulphur BP required = 15 suppositories x (60 mg ÷ 1000)

= 0.9 gm

The displacement value of Sulphur BP is 1.6.

X/1 = 0.9/1.6
X (amount of Theobroma oil displaces by the drug) = 0.5625 gm

Total amount Theobroma oil needed = (15 suppositories x 2.0 gm) – 0.5625 gm
∴ = 29.44 gm

Rx
Sulphur BP 0.90 gm
Theobroma oil 29.44 gm
Total 30.34 gm
5. How would you calculate the quantities required to make 12 theobroma oil
suppositories of 1g mould each containing 300 mg of zinc oxide
(Displacement value=4.7)? No excess needed. (FOR THE DISPLACEMENT
VALUES OF THE DRUG , PLEASE CHECK THE MATERIALS).

Weight of Zinc Oxide required = 12 suppositories x (30 mg ÷ 1000)

= 3.6 gm

The displacement value of Zinc Oxide is 4.7.

X/1 = 3.6/4.7
X (amount of Theobroma oil displaces by the drug) = 0.766 gm

Total amount Theobroma oil needed = (12 suppositories x 1.0 gm) – 0.766 gm
∴ = 11.234 gm

Rx
Zinc Oxide 3.60 gm
Theobroma oil 11.234 gm
Total 14.834 gm