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Volume 4 Issue 5, July-August 2020 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470
@ IJTSRD | Unique Paper ID – IJTSRD31867 | Volume – 4 | Issue – 5 | July-August 2020 Page 472
International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470
PI cause impaired glucose metabolism that cause activation food, animal meat, refined carbohydrate, starchy staples
of serine/threonine kinases that leads to endothelial such as noodles. High Refined carbohydrates such as
dysfunction and increase risk of CVD. PI also responsible for polished white rice, corn starch, white wheat floor ,increase
conduit arterial stiffness and reduced endothelium risk of CVD disease and also cause type 2 diabetes, obesity
dependent dilation (flow mediated dilation) and endothelial etc. High glycemic food (such as refined carbohydrates,
cell activation and increase endothelial cell apoptosis. It also desserts, snacks, soft drink) which increases low density
cause oxidative stress which dysfunction endothelial, so the lipoprotein, increasing the risk of myocardial infraction,
uncoupling of endothelial nitric oxide synthase that reduce coronary heart disease (CHD) etc.
nitric oxide and increased production of superoxide. Both
these radicals exposed to one another and undergo diffusion Vegitables oil made of mono and polyunsaturated fat alpha
limited radical –radical reaction to form peroxynitrite anion _linolenic acid. These are cardioprotective substances.
that degrades nitrate and nitrite and the production of Recently vegetable oil has replaced by Hydrogenated fats
oxygen derived free radicals increased 4-fold in patients which is main source of trans fatty acids and bleached oils
with heart failure. After the long time of endothelial which increases risk of CVD.
dysfunction that affect the vascular compliance and then
finally give elevated loads on the left ventricle (LV) results to Non vegterian food like poultry food and meat contains high
LV stiffening, chamber modeling, and increases the risk of amount of protein, iron, zinc, vitamin B, high amount of
Heart Failure. cholesterol, saturated fatty acid that raise low density
lipoprotein, cholesterol and triglyceride. This type of food
PA balance calcium level by sarcoendoplasmic reticulum product (poultry food, meat) also contains heme iron which
calcium transport Atpase and increase expression of the increase formation of N-nitroso compound that leads
mRNA. It reduce the C-reactive protein which protect from oxidative stress. Processed meat consumption increase risk
inflammation myocardial fibrosis and dysfunction. All these of CHD. Eggs are source of dietary cholesterol (medium eggs
help to improve compliance, reduce stiffness, and afterload, has 225mg of cholesterol) that increase the risk of CVD.
finally reduce risk of future cardiac dysfunction. It improve
Cardiorespiratory fitness (Peak Vo2). PA reduce blood Fermented dairy products such as yogurt, cheese, thick
pressure, systemic inflammation and myocardial oxygen fermented milk that also increase of CVD.[3] In modern
demands, visceral adiposity, myocardial infarction and period or recent period, people are making distance from
improved heart rate variability, endothelial function, sleep, healthy foods like nuts, vegetables, whole grains, fruits
increase insulin sensitivity, capillary density, mitochondrial ,healthy oils, fish such as Mediterranean diet which have
density.[1] PA higher the aerobic capacity. PI produce anti-inflammatory properties and turning towards western
glucose intolerance and rapidly decrease CRF diet or unhealthy food or junk food fast food because these
(cardiorespiratory fitness) so decreases VO2max, loss of foods are very tasty and take very short time to consume it
insulin sensitivity so accumulation of lipid intermediate in but these contains high amount of salt, trans-fats (like baked
skeletal muscles, reduced lean mass, increase visceral goods, fried food) that cause lower level of HDL. Fast food,
adipose tissue. PI causes lower CRF which alters insulin red meat, high calorie foods have proinflammatory
sensitivity, blood lipid and lipoprotein profile, body properties, that leads to hypertension, CHD, stroke, heart
composition, systemic inflammation, blood pressure, attack. Over consumption of these food cause over weight,
autonomic nervous system. PI associated with morbidity and high blood pressure, and high cholesterol which play major
mortality. PI increases the risk of CVD and CHD upto 59% role in increasing the risk of CVD.
and 36% (respectively) more than normal. But PA reduce the
risk of CVD and CHD upto 41% and 64% respectively.[2] A/Q to Swedish study on 43396 women shows that
increasing protein intake by 10% (5g protein) while
Regular physical activity reduces myocardial infraction, decreasing carbohydrate intake by 10% (20g carbohydrate)
stable angina pectoris and increases functional capacity of increase risk of CVD. [4]
heart. People who lives in developed countries do most of
the work by machine which make their life comfortable but Insulin resistance lead to the development of dyslipidemia,
physical inactive. They always work with machine and high level of plasma triglycerides, low level of HDL (high
working most of time in setting position. In developed density lipoprotein) and LDL(low density lipoprotein) which
countries, technology makes people life sedentary that affect cause endothelium dysfunction that help in atherosclerotic
their health very badly which is the major cause of diseases plaque formation.
like diabetes, obesity, CVD etc.
Food Play a major role to live a healthy life. In these modern
In the past people are much more physically active than the era we play with our life because we are habituated of taking
recent so they are more healthy than today’s modern junk foods and we do not follow the proper diet that is one of
people.. But it is also very important to change with time and the big reason to develop various type of diseases like
it is technological time so we have to follow this routine but diabetes, obesity, CVD.
health is more important than everything so we must do
some physical activity. Alcohol consumption and Smoking
Excess alcohol consumption raise the level of fats
Food Habit (triglycerides) in body. A high triglyceride level combined
Poor diet contains high refined grains, added sugar, salt, with high LDL(bad) cholesterol and low HDL (good)
unhealthy fats and animal source foods and lower whole cholesterol has been associated with fatty buildup in the
grains, fruits, vegetables, legumes, fish, nuts. In recent people artery walls that increase the risk of heart attack, stroke.
take in their diets, more and more snack, fried and processed Excessive drinking lead to high blood pressure,
@ IJTSRD | Unique Paper ID – IJTSRD31867 | Volume – 4 | Issue – 5 | July-August 2020 Page 473
International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470
cardiomyopathy, cardiac arrhythmia and even death from Oxidant gases such as oxides of nitrogen and many free
alcohol poisoning. five or more drinking for men and four or radical from gas and tar phase of cigarette reduce the level of
more for women in 2 hours cause higher risk of atrial antioxidants, blood level of vitamin C, increase level of lipid
fibrillation, an irregular or quivering heart beat that can lead peroxidation products in plasma, which produce Acrolein
blood clots, stroke, heart failure. It also cause weakening of that cause atherosclerosis. Cigarette contain many metals
the heart muscles which lead to cardiomyopathy and sudden like aluminum, cadmium, copper, lead, mercury, nickel, zinc
heart failure. that catalyze the oxidation of cellular proteins which is
responsible for structural damage, endothelial dysfunction,
Alcoholic drinks contain calories and many mixture added to detachment of endothelial cells from the walls of the blood
alcoholic drinks like soda, juice, cream. Added sugar in the vessels. It influence the CVD factors such as glucose
form of simple syrup, liqueurs. A bear or glass of wine intolerance and low serum levels HDL cholesterol. It helps in
contains around 100 to 150 calories and cocktail has 100 to development of atherosclerotic plaque and ventricular
500 calories. dysfunction. Smoking also play a great role in the
development of the risk of CVD.[6]
Alcohol consumption decrease coagulation factors like
fibrinogen which play a proinflammatory role in the CONCLUSION
development of CVD including vascular wall disease and All these factor described above are very important which
atherosclerosis. Alterteration of platelets responses ( such as help in the development of the risk of the cardiovascular
increased platelet activation/ aggregation) which help in diseases. Today it is the big problem around the world and
blood clot formation in some condition of CVD and daily needs to overcome on it. We have to change our lifestyle,
alcohol consumption increases platelets aggregation and food habit, should avoid alcohol, smoking, fast food,
reactivity and also high level of oxidative stress which result unhealthy food, excess oil and fats etc and think more about
alcoholic cardiomyopathy. It also create sarcoplasmic health than other things so we live a healthy life.
reticulum dysfunction that lead to systolic dysfunction as
well as thickening of the heart muscle that make ventricles REFERENCE
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@ IJTSRD | Unique Paper ID – IJTSRD31867 | Volume – 4 | Issue – 5 | July-August 2020 Page 474