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or 15 anticoagulants,
mg/dose. PO sulfonamides, etc.
(XL) 5 mg/day Decrease:
with hypoglycemic
breakfast may effects – thiazide
increase to 10 diuretics,
mg/day max rifampin,
20 mg/day. cholestyrmine,
etc. Drug/herb
Geriatric: PO interaction:
2.5 mg/day; Increase anti-
may increase diabetic effect –
if needed. alfalfa, aloe,
basil, bay, etc.
Increase or
decrease:
hypoglycemic
effect –
chromium,
ginseng, etc.
Assess:
Hypo/Hyperglyce
mic reaction that
can occur soon
after meals, CBC
baseline and
throughout
treatment.
Func class: Adult: PO Increase:
hydrochlorothiazide Thiazide 12.5-100 hyperglycemia,
diuretic, anti- mg/day hyperuricemia,
hypertensive increased
(HCTZ, Esidrix, Geriatric: PO antihypertensives
Hydro-Chlor) Chem class: 12.5 mg/day, – diazoxide.
Sulfonamide initially Increase:
derivative hypokalemia –
glucocorticoids.
Increase: toxicity
– lithium, cardiac
glycosides.
Increase: renal
failure risk –
3
NSAIDs.
Increases:
effects – loop
diuretics.
Drug/Herb:
severe
photosensitivity:
St John’s Wart.
Drugs/Lab Test:
Increase: BSP
retention,
amylase,
parathyroid test.
Decrease: PBI,
PSP.
Assess: Weight,
I&O daily to
determine fluid
loss; effect of
product may be
decreased if used
daily. Rate, depth,
rhythm of
respiration,
effect of
exertion. BP lying,
standing; postural
hypotension may
occur.
Func class: non- Adult and Hypoprothrombin
acetaminophen opioid analgesic, child >12 yr: ema: warfarin.
anti-pyretic PO/RECT 325 Renal adverse
– 650 mg q4- reactions:
Chem class: 6hr prn, max NSAIDs,
Nonsalicylate, 4 g/day. salicylates.
paraaminophenol Decrease: effect,
derivative increase
hepatotoxicity –
barbiturates,
alcohol,
carbamazepine,
etc. Decrease:
4
absorption –
cholestyramine.
Drug/Herb-
Decrease:
acetaminophen
effect – St
John’s Wart.
Assess: Hepatic
studies: AST,
ALT, bilirubin,
creatinine prior
to therapy if
long-term
therapy is
anticipated; may
cause hepatic
toxicity at doses
>4 g/day with
chronic use. Renal
studies: BUN,
Urine creatinine,
occult blood,
albumin. I&O
ratio; decreasing
output may
indicate renal
failure.
Hepatotoxicity:
dark urine; clay-
colored stools;
yellowing of skin,
sclera; itching,
abdominal pain;
fever; diarrhea if
pt is on long-term
therapy.
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