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Perindopril(coversyl) 2mg po
BID
Tablets is a pro-drug for
perindoprilat, which inhibits
ACE in human subjects and
animals. The mechanism
through which perindoprilat
lowers blood pressure is
believed to be primarily
inhibition of ACE activity. ACE
For the treatment of mild to
moderate essential
hypertension, mild to
moderate congestive heart
failure, and to reduce the
cardiovascular risk of
individuals with hypertension
or post-myocardial infarction
Patients known to be
hypersensitive to this product
or to any other ACE inhibitor.
Contraindicated in patients
with a history of angioedema
related to previous treatment
with an ACE inhibitor.
Hypertension
Gastrointestinal:
constipation, dry mouth, dry
mucous membrane, appetite
increased, gastroenteritis.
‘espiratory: posterior nasal
j tell your doctor and
pharmacist if you are
allergic to perindopril,
benazepril (Ñotensin),
captopril (Capoten),
enalapril (Vasotec),
fosinopril (Monopril),
lisinopril (Prinivil,
is a peptidyl dipeptidase that and stable coronary disease. j Children drip, bronchitis, rhinorrhea, Zestril), moexipril
catalyzes conversion of the j Pregnancy-Do not throat disorder, dyspnea, (Univasc), quinapril
inactive decapeptide, take perindopril if you sneezing, epistaxis, (Accupril), ramipril
angiotensin I, to the are pregnant. If you hoarseness, pulmonary (Altace), trandolapril
vasoconstrictor, angiotensin become pregnant fibrosis (<0.1%). (Mavik), or any other
II. Angiotensin II is a potent while taking medications.
peripheral vasoconstrictor, perindopril, call your Urogenital: vaginitis, kidney j tell your doctor and
which stimulates aldosterone doctor immediately. stone, flank pain, urinary pharmacist what
secretion by the adrenal Perindopril may harm frequency, urinary retention. prescription and
cortex, and provides negative the fetus. nonprescription
feedback on renin secretion. j Ñactation Cardiovascular: hypotension, medications,
Inhibition of ACE results in j ‘enal failure ventricular extrasystole, vitamins, nutritional
decreased plasma myocardial infarction, supplements, and
angiotensin II, leading to vasodilation, syncope, herbal products you
decreased vasoconstriction, abnormal conduction, heart are taking. Be sure to
increased plasma renin murmur, orthostatic mention any of the
activity and decreased hypotension. following:
aldosterone secretion. The cyclosporine (Neoral,
latter results in diuresis and Endocrine: gout. Sandimmune),
natriuresis and may be diuretics ('water
associated with a small Hematology: hematoma, pills'), heparin,
increase of serum potassium. ecchymosis. indomethacin
(Indocin), lithium
While the principal Musculoskeletal: arthralgia, (Eskalith, Ñithobid),
mechanism of perindopril in
blood pressure reduction is
believed to be through the
renin-angiotensin-
aldosterone system, ACE
inhibitors have some effect
even in apparent low-renin
hypertension. Perindopril has
been studied in relatively few
myalgia. and potassium
supplements (K-Dur,
CNS: migraine, amnesia, Klor-Con, others).
vertigo, cerebral vascular Your doctor may
accident (0.2%). need to change the
doses of your
Psychiatric: anxiety, medications or
psychosexual disorder. monitor you carefully
for side effects.
black patients, usually a low-
renin population, and the
average response of diastolic
blood pressure to perindopril
was about half the response
seen in nonblacks, a finding
consistent with previous
experience of other ACE
inhibitors.
Dermatology: sweating, skin
infection, tinea, pruritus, dry
skin, erythema, fever blisters,
purpura (0.1%).
Special Senses: conjunctivitis,
earache.
Ñaboratory: potassium
decrease, uric acid increase,
alkaline phosphatase
increase, cholesterol increase,
AST increase, creatinine
increase, hematuria, glucose
j tell your doctor if you
are on dialysis and if
have or have ever
had heart failure;
lupus (SÑE);
scleroderma;
diabetes; swelling of
the face, throat,
tongue, lips, eyes,
hands, feet, ankles,
and/or lower legs
(angioedema); or
kidney or liver
disease.
increase. j tell your doctor if you
plan to become
When Perindopril erbumine pregnant or are
tablets was given breast-feeding.
concomitantly with thiazide
diuretics, adverse events
were generally reported at
the same rate as those for
Perindopril erbumine tablets
alone, except for a higher
incidence of abnormal
j you should know that
diarrhea, vomiting,
not drinking enough
fluids, and sweating a
lot can cause a drop
in blood pressure,
which may cause
laboratory findings known to
be related to treatment with
thiazide diuretics alone (e.g.,
increases in serum uric acid,
triglycerides and cholesterol
and decreases in serum
potassium).
lightheadedness and
faintingK
low-salt or low-sodium diet,
follow these directions
carefully.
Take the missed dose as soon
as you remember it.
However, if it is almost time
for the next dose, skip the
missed dose and continue
your regular dosing schedule.
Do not take a double dose to
make up for a missed one.