Townsend Letter for Doctors

 -­‐  Quantum  Medicine  Update  Aug-­‐Sept  2010–  Paul  Yanick,  Jr.  Ph.D.  ©2010                            1  

Colonization Resistance of Barrier Microflora in Carcinogenesis

& Allergic Patients
Paul Yanick, Jr. Ph.D. - American Academy of Quantum Medicine www.aaqm.org
       The astounding degree of microbial diversity in the gut indicates a multitude of
ecological niches, which are generated through the development of complex food
webs (niche construction) whereby beneficial colonization leads to commensalism,
symbiosis and immunological competence.1-10
Over the past two decades, my research has focused on acquiring an understanding of gut
microflora composition, loops and processes such as intestinal adherence, colonization,
translocation, and immunological reciprocity and competence. Recently, an independent study by
a group of 24 scientists has scientifically validated my earlier work on commensal colonization
resistance. These researchers state, “It has been estimated that the microbes in our bodies
collectively make up to 100 trillion cells, tenfold the number of human cells, and suggested that
they encode 100-fold more unique genes than our own genome. The majority of microbes reside
in the gut, have a profound influence on human physiology and nutrition, and are crucial for
human life. Furthermore, the gut microbes contribute to energy harvest from food, and changes
of gut microbiome may be associated with bowel diseases or obesity.”1
Four decades of my clinical research on thousands of patients has taught me that colonization
resistance of commensal cell microflora causes digestive symptomatology, opportunistic
infections, and carcinogenesis. Human and commensal cell polarity deficits are the prime force
behind these ecosystem disruptions. Cell polarity involves signaling networks; transcription
factors, membrane-trafficking pathways, and quorum cell-to-cell communication, all of which
need to be restored in order to properly colonize the human ecosystem. 11,12
Viewing the gut as a complex ecosystem with a diverse assemblage of commensal cell
microflora possessing a rich genetic diversity can help us realize that these cells can produce all
sorts of anti-allergic, anti-cancer, anti-inflammatory and anti-viral compounds. Our consortium of
gut microbes (microbiome) possesses at least a hundred times more genes as the mere 20,000 in
the human genome. Since human rely on their microbiome for digestion, detoxification and a
wide spectrum of immunological functions, we can be thought of as a “superorganism” nourishing
and restoring the quorum language and teamwork of our commensal cell microbiotica.1,65
Scrutinizing popular health claims can provide a new window onto our clinical worlds and
enable us to make better decisions in detoxifying our patients of carcinogens. Since cells need to
have the proper polarity to clean house, the challenge in today’s toxic world is to find ways to
eliminate man-made chemicals with a positive ionic charge that disrupt colonization. This
aberrant cell physiology has it primary effect by depolarizing hepatocytes. When this happens,
hepatobiliary stagnation with diminished bile production, has the tendency to induce and promote
allergic, respiratory and inflammatory reactions that induce and promote carcinogenesis.11-14
Irwin M. Arias, MD of the Unit of Cell Polarity at Tufts University School of Medicine stated,
”Polarization of hepatocytes critical for hepatocyte production of bile. A lack of hepatocyte polarity
can impair biliary secretion resulting in cholestasis (i.e., bile secretory failure).” Dr. Arias and
other scientists have used live-cell fluorescent, biochemical, genetic, and molecular techniques to
study mechanisms responsible for trafficking of proteins selectively to the apical domain of
hepatocytes and other polarized cells to confirm my original hepatobiliary research.11-30
Cell polarity deficits cause liver detoxification deficits, which, in turn, cause prolonged
inflammation in the gastroduodenal excretion channel so allergens and carcinogenic toxins cannot
be safely excreted out of the body. Enhancing bile production has the potential to play an
important clinical role in providing relief in allergic patients and in restoring innate immunological
integrity in cancer patients. But, the war on microbes and the simplistic nuke-the-microbe
mindset has caused a rising incidence of human ecosystem disorders like multiple chemical
sensitivity (MCS), asthma, and all sorts of allergic disorders. For this reason, caution needs to be
exercised with the excessive clinical use of natural anti-infective herbs, colloidal silver and anti-
microbial compounds like allicin from garlic or oregano oil.
Commensals are immunological peacekeepers and the strong arm of immune defenses that
promote the proper digestion of food and the excretion of toxins. Indeed, two Nobel laureates
reported that commensal flora is a realistic therapeutic strategy for infectious, inflammatory and
Townsend Letter for Doctors  -­‐  Quantum  Medicine  Update  Aug-­‐Sept  2010–  Paul  Yanick,  Jr.  Ph.D.  ©2010                            2  

neoplastic disorders.30-33 Studies reveal that commensals are essential health assets that confer
protection against infections, prime mucosal immunity, produce a rich repository of nutrients and
metabolites, and have efficacy in acute enteric infections, post-antibiotic syndromes, colitis, and
irritable bowel syndrome. 31-43
Clinically, when we fail to address colonization resistance and barrier function, we may
inadvertently induce efferent-generated cytokine inflammation and carcinogenesis, which results
in an inability of the body to maintain stable ecological niches and quorum cell-to-cell
communication. The complex, dynamic and spatially diversified microbiotica and its microbiome of
collective genomes have been studied via culture-based assays, and a variety of molecular
methods that include fluorescent in situ hybridization, terminal restriction fragment length
polymorphisms, microarrays, and direct sequencing. These studies offer hope and help for
patients with allergic conditions or cancer as proper 8-strain commensal colonization can help
detoxify the body, fight inflammation, employ innate immunologic weaponry with greater force
and nourish afferent neurons that regenerate the body.48-61

In summary, we need to view commensal microbiotica as our close allies and consider
employing effective colonization techniques to restore this vast, complex, and dynamic
consortium of cells. A recent editorial in Medical Hypothesis says, “this symbiont provides us, the
host, with metabolic functions far beyond the scope of our own physiological
capabilities…imbalances of this intestinal microbial community structure have the potential to
cause many debilitating conditions such as Crohn’s disease, inflammatory bowel disease, allergy,
obesity, and even cancer.”65 Clearly, the body’s commensal weaponry can outperform any we
can do or prescribe for our patients. When we restore colonization lost by antibiotics or natural
anti-infective agents, we restore homeostasis and our “superorganism” potential.65
Finally, studies show that colonization patterns are influenced by physicochemical properties
and by the health of the gut mucosa and fulfilling a niche.60-64 In keeping up with the steady pace
of scientific change, clinicians need to understand how to overcome colonization resistance and
realize that the prospects for clinical success with current fragmented approaches are limited
because the body cannot detoxify and cleanse itself completely without the hundreds of
thousands of nanoscale, synbiotic nutrients produced by commensal cells.15-22, 58-61
To Learn More – www.quorumnutritionllc.com
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Townsend Letter for Doctors  -­‐  Quantum  Medicine  Update  Aug-­‐Sept  2010–  Paul  Yanick,  Jr.  Ph.D.  ©2010                            3  

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