New coronavirus research（Fangruida2021）

The mechanism of mutual mutagenesis and mutation of new coronavirus pneumonia bacteria
(Fangruida)
2021 revision 2021v.1.5

Medical scientist virologist Fang Ruida new coronavirus research) Besque compiles 2020v3.1 online
version e-book
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Fang Ruida's major discovery in the research and prevention of new coronavirus pneumonia

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Abstract
The new coronavirus pneumonia has spread globally for more than a year, with more than 2 million
deaths and more than 20 million infections. In addition to the pathological source of the pandemic and
the development of vaccine drugs, the most critical issue is this virus. The concealment of the specific
spreading variability is particularly important. In addition to the omissions of various methods and
measures for prevention and control of human beings, it is the cause of the generation and spread of
such viruses, especially the biochemical derivative mechanism, the formation and spread of viruses, and
the mutual induction of mutagenesis and cross-infection of various viruses and bacteria. The virus is very
active, the infection spreads very large, the cycle is long, and the outbreak is repeated. Although the
vaccine can play a major role, the complete suppression of the virus still requires unremitting efforts,
prevention and control. Closure of cities and cities, masks and other prevention and treatment methods
have played a considerable role, but in some countries and regions, the virus is still rampant, and the
epidemic and mortality rate remain high. In addition to the season, climate, environment, region,
ethnicity, animals and plants, endemic diseases, infectious diseases, frequently-occurring common
diseases and other factors, the specific and insidious transmission of the mutation and mutation of the
new coronavirus pneumonia virus is very important Pathogenesis and transmission mechanism. Closing
the city, wearing masks, measuring body temperature, including nucleic acid testing, are not completely
effective for some special cases, such as concealed patients and asymptomatic infections. This is the
focus and difficulty of epidemic prevention. Obvious cases are easy to find, while for the latter it is very
difficult and easy to be misdiagnosed and missed. The three mechanisms of mutual mutagenesis and
mutation of the new coronavirus pneumonia virus, the major discovery of the medical scientist virologist
Fangruida medical science, is of special significance for the study of the prevention and treatment of new
coronavirus pneumonia. Pathogens, pathogens, pathology, vaccines, drugs, etc. are also significant

The common side effects of mRNA (messenger ribonucleic acid) vaccines (such as fever, nausea, etc.) may
be the cause of the death of these frail elderly people. The risk of the vaccine is very small. Only in a few
cases, especially for the elderly with poor health, the side effects may cause the elderly to get worse.
China’s health authorities have stepped up efforts to contain the resurgence of new crown cases, and
China is currently facing its worst rebound since the first outbreak at the beginning of last year. There has
been a serious rebound of the epidemic in urban and rural areas in some areas.
Some cities in northern provinces, such as Hebei, Heilongjiang, and Jilin, have established temporary
isolation facilities, imposed lockdown measures on millions of residents, and conducted rounds of full-
staff testing.
The epidemic situation in Europe, the United States and other countries is also very serious, and the
epidemic situation in China has rebounded severely. These data and statistical studies on a large number
of cases, as well as the genetic sequencing of various viruses, including studies on newly discovered
various mutant virus strains, show that; 1. Origin 2. Genetic variation of the virus 3. Virulence and spread
of the virus strain 4. The effectiveness and safety of the vaccine 5. The spread and occult nature of the
new coronavirus and various virus mutations 6. Under certain circumstances, the new coronavirus
progenitor Inducing mutagenesis with various germs, causing the epidemic to continue to spread. This is
the most important factor. Of course, it also includes errors in prevention and control, regions,
population, climate, animals and plants, epidemics and infectious diseases. The use of effective drugs, the
protection of susceptible people, etc. 7. A large number of cases proved that the specific transmission of
new coronavirus pneumonia and the new coronavirus, the specific invisibility and previous coronaviruses
have their particularities, the virus is not easy to inactivate, difficult to detect, even nucleic acid testing,
etc. Sometimes it is not easy to complete accurate verification For example, asymptomatic infections,
concealed patients are difficult to be completely discovered or misdiagnosed and missed, so the epidemic
has spread repeatedly, the number of patients has increased, and the number of deaths has been rising.
Although countries around the world have adopted stricter control measures, such as closing the city,
wearing masks, measuring body temperature, negative nucleic acid tests, taking drugs and injecting
various vaccines, etc., the virus is still very active, and epidemic prevention still faces serious challenges.
8. The new coronavirus pandemic, the virus continues, spreads widely, and the death toll is huge, which is
no different from the previous major plagues in the world. The changes in the natural universe, the
pollution of the air environment, the activity of microorganisms, the use of a large number of harmful
substances, the defects of human biological evolution, the loss of human gene cells and some non-
adaptive mutations or degradation, etc., will also make various viruses more Rampant (the specific
invisibility of the virus makes prevention, control and treatment more difficult). 9. The repetitive, occult,
asymptomatic transmission of the new coronavirus is difficult to detect asymptomatic (temperature
measurement, nucleic acid, etc. sometimes fail). The harm is very serious. This is the case in Europe,
America and other countries and China, and it is impossible to prevent it. Therefore, don't think that
wearing a mask to measure body temperature will close the city and close the city, and get a vaccine, etc.
It will be safe and reliable. This is also an illusion. Anti-epidemic prevention requires sustained and
unremitting efforts, which must not be taken lightly. The struggle between humans and various viruses
has been repeated for a long time. 10. The research and development of various new coronavirus drugs is
imperative. Only when vaccines and various drugs are mutually used can the disease be fundamentally
treated. This is also a very important aspect of epidemic prevention and fighting. For various drugs,
chemical modification and chemical modification can also develop various new crown drugs. The surface
of the virus has spike-like protrusions, and the spike protein is located on the top of these protrusions,
which looks like a crown, and the coronavirus gets its name. This spike protein contains certain types of
amino acids, which can use furin in the body to break down the cell wall, thereby allowing it to enter
human cells. Spike Glycoprotein (Spike, S): It is a type I transmembrane protein that is composed of a
stick-like protrusion on the surface of the virus particle. It can be broken down by S enzyme into two
functional units, S1 and S2. S1 is used to promote the binding of the virus to the host cell receptor, and
the host receptor interaction region (RBD region) to bind to the receptor. This area can bind to the ACE2
protein. If the binding is completed, the new coronavirus will infect human respiratory epithelial cells,
which will lead to pneumonia.
Hemagglutinin-esterase protein (hemagglutinin-esterase, HE): the structure of β-coronavirus (new
coronavirus), type I transmembrane protein
Membrane glycoprotein (M): It is embedded in the virus envelope through three transmembrane
domains
Envelope protein (envelope, E): transmembrane protein
Nucleocapsid (N): binds to the RNA genome in the form of beads to form a spirally symmetrical
nucleocapsid
Genome

Reference genome sequence

"Information quoted from the relevant website NCBI (quoted from ChinaGene library network
resources)"
Since December 14, 2020, at least seven mutated new coronaviruses have appeared in the world,
including two in the United Kingdom, one in South Africa, one in Nigeria, one in Japan and Brazil, and
three in the United States. According to statistics from the World Health Organization, at present, the
mutant new coronavirus discovered in the UK has appeared in 50 countries and regions around the
world, and the mutant new coronavirus discovered in South Africa has appeared in 20 countries and
regions. D614G, that is, the 614th position of the viral spike protein becomes glycine (G).
In this way, the wild strain before mutation is called D614 strain, and the after mutation is called G614
strain. In addition, there are other variations. Of course, the gene sequence shows that they should be
homologous and the mutation is A. B. C. D. E and so on, and even continue to undergo genetic mutations,
resulting in new mutations and specializations. This genetic variation includes the modalities of virus
original variation, variant variation, cross-conversion variation, mixed variation, compound variation,
evolutionary variation and so on. Therefore, the prevention, control and treatment of the new
coronavirus requires a large number of follow-up and durable medical drugs (chemical drugs, biological
drugs, plant drugs, Gene drugs and other existing drugs and newly developed various drugs, etc.) and
long-term vaccine responses. Based on the analysis and judgment of a large number of clinical cases,
death cases and cured cases, the effect of vaccine prevention and drug combination treatment is obvious,
including the comprehensive application of ventilator, artificial lung and other technologies. The curative
effect is 50%-84.7% higher than single treatment. In fact, most of the tens of millions of patients in the
world who can be treated and recovered are treated with comprehensive treatment, including the
current universal vaccination prevention. If this line of defense fails and the virus mutates and the virus
rages, the mortality rate will reach tens of millions or even billions of billions. This is not alarmist.
To sum up, in response to the new coronavirus, the comprehensive application of high-efficiency vaccines
and effective drugs has obvious effects, can treat a large number of patients, and can save hundreds of
thousands of lives, including high-risk groups. This is the only effective, safe, reliable and feasible way to
overcome the epidemic. s Choice. No matter whether it is Europe, America, India, Brazil, or other Asian
countries such as China, Japan, etc.
——————————————————————— ———————————————— The
mechanism of mutual mutagenesis and mutation of coronavirus and germs-Major milestones
in modern medicine and virology research include new coronavirus vaccines and new special drugs The
research and development of viruses and the treatment and protection of viruses, the three mechanisms
of mutual mutagenesis and mutation of coronaviruses and bacteria, (derivation, mutation and
transformation of viruses and bacteria, mutual induced mutation and transformation under certain
conditions, will produce various mutations and evolutions 1. One-way changes 2. Two-way changes 3.
Compound elimination of changes, short-term and long-term changes and mutations. The universality
and specificity of various viral pathogens) Virus mutation (Mutation) refers to the sequence of nucleic
acid bases in the genome The chemical change can be a single nucleotide change, or a deletion or
translocation of hundreds or thousands of nucleotides. The natural mutation rate in virus replication is
10-5 ～ 10-8, and various physical and chemical mutagens (Mutagens) can increase the mutation rate,
such as temperature, radiation, 5-bromouracil, nitrite, etc. Inducible mutations. When two related viruses
infect the same host cell, their genetic material exchanges, resulting in heritable offspring different from
the parent, which is called genetic recombination A. Phenotype mixing After the mixed infection of two
viruses, the genome of one virus is occasionally loaded into the capsid of the other virus, or into the
capsid composed of two virus components, and phenotype mixing occurs. This kind of mixing is unstable,
and its original characteristics can be restored after passage. B. Genotype mixing means that the nucleic
acids of two viruses are occasionally mixed and packed in the same virus capsid, or the nucleocapsid of
two viruses are occasionally packed in a capsule, but their nucleic acids are not recombined, so there is
no Hereditary. C. Complementation means that the protein products (such as enzymes, capsids or
envelopes) produced by two viruses are insufficiently complementary to each other, such as between
helper virus and defective virus, between two defective viruses, live virus and dead virus Both can
complement each other, and the offspring of the original virus will still be produced after
complementation. D. Enhancement means that when two viruses are mixed, one virus can promote the
enhancement of the production of the other virus, possibly because the former suppresses the
production of interferon. E. The derivation, mutation and transformation of viruses and bacteria, mutual
induction of mutagenesis and transformation under certain conditions, will produce various mutations
and evolutions. Isomorphic transformation, heterogeneous transformation, this important specificity of
the new coronavirus has not been recognized by humans. The pandemic of the new coronavirus has
caused more than 70 million patients and nearly 2 million deaths. Today, with the increasingly powerful
science and technology, human beings are still vulnerable to viruses and germs. In addition to the
misunderstanding of cognitive prevention and prevention, it is very important that the virus has a special
variability and concealed transmission. It is importantly related to the mutual interaction and
mutagenesis of viruses and bacteria. , Air, environment, climate, population, human pneumonia,
respiratory infections, influenza, endemic infectious diseases and other factors), this is the key to the
prevention and control of the new crown pandemic. Therefore, vaccine control should continue to
develop, and drug control is also very important. The harm of the virus itself and the induced
mutagenesis of the bacteria also require vigorous protection and prevention. One-way infection
transmission, two-way infection transmission, and multi-directional infection transmission, so strict
vigilance is required. Even large-scale lockdowns and large-scale injections of various vaccines are not
absolutely safe. It is very wrong to think that everything will be fine, you can sit back and relax, and relax
all kinds of control, prevention, and personal protection. This is especially important in key susceptible
populations in epidemic areas during extraordinary times, and must not be paralyzed. As for whether the
virus will make a comeback, outbreak again on a large scale, and out of control again, there are of course
hidden dangers, but as long as prevention and control are in place, the application of vaccines and
various effective drugs can of course be avoided. However, small partial or sporadic cases are difficult to
avoid completely, and it is unrealistic to completely prevent them from happening. Therefore, strict
prevention and control cannot be relaxed. Virus self-ification and virus mutagenesis are important
reasons for the spread of the new coronavirus pneumonia pandemic. In addition to the limited human-
made prevention and control and mistakes, it is the blind spots and defects in the understanding and
prevention of the new coronavirus and the coronavirus. In particular, the mutation and evolution of the
new coronavirus pneumonia virus and various pathogens induced by mutagenesis. Therefore, the
development of the new crown vaccine must be continuously deepened and strengthened, otherwise,
there will be some omissions, and the fully effective effect will not be achieved, including drug
development. New coronavirus pneumonia and other coronaviruses are causing great harm to humans.
The 2019 new coronavirus has infected tens of millions and died of millions, all over the world. Medical
scientist, virologist, pharmacist, Professor Fang Ruida, devoted himself to research and found that the
mutual mutagenesis of the new coronavirus and the disease induces each other, causing the mutation
and evolution of the coronavirus. 1. One-way change of virus, one-way mutation 2. Two-way change of
virus, mutual induced mutagenesis, 3. Compound elimination of changes Some characteristics of the virus
are eliminated, and some recombination strengthens the alienation. Viruses are prone to mutation.
Except for virus-like viruses, viruses can be said to be the simplest members of life. Its genetic code or
genome is mainly concentrated on the nucleic acid chain, and any change in this nucleic acid chain will
affect the characteristics of their offspring. In fact, the genome of the virus is not static during its
propagation, but is automatically mutated all the time. The British Coronavirus Genome (COG-UK) expert
Roman said, "There are many mutations in the new coronavirus than we thought, and some of them are
worthy of attention." 　　 There are two main mutations, both of which appear in the spike protein of
the new coronavirus. Above, the spike protein is an important part of the virus used to unlock access to
human cells. 　 The virus is currently named VUI-202012/01 by the British Ministry of Health, and the
strain is named N501. Base-negative sequencing shows that there are some differences between the
isoforms and isoforms of the N501 virus and Coronavirus disease (COVID-19). The evolutionary mutation
and the natural source-related mutagenicity of the new coronavirus are firstly the physical changes and
chemical changes of the virus's body structure, and secondly the interaction of various pathogens,
including the invisible intervention of various factors such as the environment, climate, climate, and the
human body. Some minor or larger mutations and genetic recombination of the new coronavirus have
occurred. The new crown virus pneumonia lasted more than a year, with tens of millions of patients, up
to hundreds of millions of people infected and infected, and more than 1 million deaths were shocking.
The epidemic has not yet been fully controlled and subsided, and it is still severe in some regions and
countries. Although various countries in the world have developed various vaccines and have begun to
use them in large quantities, this is undoubtedly essential for epidemic prevention and fighting. However,
with the global pandemic of the new crown virus pneumonia, the harm and intensity of the virus
exceeded people's expectations. The mutation and evolution of the new coronavirus are also very
important reasons. Asymptomatic virus, invisible virus infection and transmission, and mutual induced
mutagenesis of the new coronavirus and various germs, the mutation and recombination of the new
coronavirus is also one of the important reasons, which cannot be underestimated. The evolution of
microbes, the evolution of the natural universe, the evolution of the earth and living things are also
closely related to this. This is also a new hot spot and new problem in medical science, epidemic
prevention and anti-epidemic. Vaccines are very important, and it is necessary to vigorously develop
various new drugs, such as antiviral drugs, anti-respiratory infectious disease drugs, immune drugs, etc.,
in order to completely defeat and prevent and control various viral bacteria. Efficient and safe vaccines
and drugs are the first choice.Bacteria are the pathogens of many diseases. They can spread diseases
among normal human bodies through various methods, such as contact, digestive tract, respiratory tract,
insect bites, etc. They are highly infectious and cause great harm to society. In plants, bacteria cause leaf
spot, fire blight, and wilting. The difference between viruses and bacteria is that viruses have no cell
structure and can be said to be the lowest organisms, but their tolerance is not small. Human diseases
are related to them from small colds to large cancers. Bacteria, like plants, have cell walls, while human
cells have no cell walls. As RNA viruses, influenza virus, AIDS virus and dengue fever virus have a high
frequency of gene mutation and recombination. Humans can develop vaccines against one of its
subtypes, but the virus may mutate and recombine more in the process. The subtype continues to infect
humans.

Many hepatitis viruses and papilloma viruses can integrate into the genome of infected cells, causing mild
or no obvious symptoms, but they can continue to release virus particles to infect more cells and people.

Bird flu virus, swine flu virus, and the relatively rare cat scratch fever virus, etc. can lodge in animals, and
they may cross into the human body at any time.
Bacteria and viruses are living organisms and have the ability to inherit, mutate, and evolve.
Viruses are a type of non-cellular microorganisms that are tiny in individuals, simple in structure,
containing only a single nucleic acid (DNA/RNA), and must be parasitic in living cells and proliferate in a
replication manner. A virus is a very small life form with an extremely simple structure. The virus is highly
parasitic and completely relies on the energy and metabolic system of the host cell to obtain the
substances and energy required for life activities. It is just a big When chemical molecules stop their
activities, they can be made into protein crystals. It is a non-living body. When encountering host cells, it
will show the typical characteristics of living body by adsorbing, entering, replicating, assembling, and
releasing offspring viruses. A primitive life form of living things and non-living things.
Rabies virus and HIV have a long incubation period, and are contagious during the incubation period, and
have escaped human detection. Bacteria are larger germs, about one micron long, and ten thousand
bacteria line up one centimeter. Viruses are the smallest germs, colds, influenza, and measles are all
caused by viral infections.

virus
Viruses are between biological and non-biological, with a total length of less than 0.1 micron, and 1
million viruses are about 1 cm long. Germs are pervasive, and any place is a habitat for germs. Everyone’s
mouth and skin are affected by germs. If germs enter the blood, it can cause sepsis. Bacteria that can
make people or other organisms sick, such as typhi, anthracis, etc. Also called pathogenic bacteria or
pathogenic bacteria. For example, among animals and plants. Plant diseases can be divided into non-
infectious diseases and invasive diseases. Infectious diseases include fungal diseases, bacterial diseases,
and viral diseases. (1) Fungal diseases are the most common and most common plant diseases Kind.
Plants with fungal diseases generally produce white powder layer, black powder layer, downy mildew
layer, rust spore centipede, sclerotia, etc. If one of the above characteristics is seen on the diseased plant,
it can be preliminarily judged as a fungal disease. . (2) Bacterial diseases are the least common type of
plant diseases, but there are many bacterial diseases that have a serious impact on production, causing a
lot of production reduction or destruction of fields. Bacteria invade through the stomata, wounds, etc. of
plants, and the plants after the onset of disease generally show necrosis, decay or wilting. (3) Plant viral
diseases are also called mosaic diseases, which are second only to fungal diseases. Most plant diseases
caused by viruses are systemic diseases, that is, the whole plant exhibits yellowing, partial or whole plant
atrophy, small leaves, small fruits, dwarfing, arbuscular branches, fern-leaf abnormalities and other
pathological changes and symptom. (4) Physiological disease is a disease that affects plants due to
improper management measures. For example, the leaf color of the plant caused by lack of nitrogen is
light green, and the bottom leaves are gradually yellow and withered; the old leaves caused by potassium
deficiency are brown and green, and there are many small brown spots along the leaf margins. (5) Plant
diseases are also caused by mutual induced mutagenesis of bacteria.
In addition, the same is true in animals. 1. Spread through saliva. For example, cats and dogs suffering
from rabies, their saliva contains a large amount of rabies virus. When a cat or dog bites a person, the
virus enters the body with the saliva and causes rabies.
2. Spread by drowning. It is well known that the stool contains various germs. Pathogens such as
tuberculosis, brucellosis, and salmonellosis can all be spread by contaminating human food, drinking
water and supplies through feces. Most parasite eggs are in the feces. The cause of leptospirosis is
transmitted through urine.
3. Sick livestock and poultry often bring out viruses or germs when they have runny nose, sneezing and
coughing, and form infectious droplets in the air to spread diseases.
4. The whole body coat and skin scales of livestock and poultry often contain bacteria on the table and
bed, which may cause comorbidities from them. Human and livestock diseases include various diseases
caused by pathogens such as viruses, bacteria, chlamydia, rickettsiae, mycoplasma, spirochetes, fungi,
protozoa and worms. 5. Other transmissions 6. Most animal diseases are closely related to mutual
induced mutagenesis of viruses and bacteria, of course, there is a difference between primary and
secondary.
According to relevant literature records, there are more than 200 types of animal infectious diseases,
more than half of which can be transmitted to humans, and more than 100 types of parasitic diseases can
also infect humans. There are more than 250 kinds of infectious diseases and parasitic animal diseases
that have been confirmed by humans and animals in the world, for example, viral infectious diseases,
bacterial infectious diseases, animal biochemistry, animal infectious diseases, animal microbiology,
animal immunology and many more. As for anthropology, modern medicine, virology, bacteriology,
quantum biochemistry, etc., there are many more. From the appearance of the new coronavirus
pneumonia, there is not too much speciality, but through a large number of case pathological studies and
analysis, the production and spread of the new coronavirus and the mutual induced mutagenesis of
various viruses and bacteria are significantly related. Questionable, undisputed scientific proof. Animal
infectious diseases are also important evidence.
In the new crown pneumonia epidemic, the concealed transmission of "asymptomatic infections" has
been paid attention to for the first time. The virus hides in the population in this way, which greatly
hinders the detection and control of infected persons.
Global statistics (main countries)

The common side effects of mRNA (messenger ribonucleic acid) vaccines (such as fever, nausea, etc.) may
be the cause of the death of these frail elderly people. The risk of the vaccine is very small. Only in a few
cases, especially for the elderly with poor health, the side effects may cause the elderly to get worse.

China’s health authorities have stepped up efforts to contain the resurgence of new crown cases, and
China is currently facing its worst rebound since the first outbreak at the beginning of last year. There has
been a serious rebound of the epidemic in urban and rural areas in some areas.
Some cities in northern provinces, such as Hebei, Heilongjiang, and Jilin, have established temporary
isolation facilities, imposed lockdown measures on millions of residents, and conducted rounds of full-
staff testing.
The epidemic situation in Europe, the United States and other countries is also very serious, and the
epidemic situation in China has rebounded severely. These data and statistical studies on a large number
of cases, as well as the genetic sequencing of various viruses, including studies on newly discovered
various mutant virus strains, show that; 1. Origin 2. Genetic variation of the virus 3. Virulence and spread
of the virus strain 4. The effectiveness and safety of the vaccine 5. The spread and occult nature of the
new coronavirus and various virus mutations 6. Under certain circumstances, the new coronavirus
progenitor Inducing mutagenesis with various germs, causing the epidemic to continue to spread. This is
the most important factor. Of course, it also includes errors in prevention and control, regions,
population, climate, animals and plants, epidemics and infectious diseases. The use of effective drugs, the
protection of susceptible people, etc. 7. A large number of cases proved that the specific transmission of
new coronavirus pneumonia and the new coronavirus, the specific invisibility and previous coronaviruses
have their particularities, the virus is not easy to inactivate, difficult to detect, even nucleic acid testing,
etc. Sometimes it is not easy to complete accurate verification For example, asymptomatic infections,
concealed patients are difficult to be completely discovered or misdiagnosed and missed, so the epidemic
has spread repeatedly, the number of patients has increased, and the number of deaths has been rising.
Although countries around the world have adopted stricter control measures, such as closing the city,
wearing masks, measuring body temperature, negative nucleic acid tests, taking drugs and injecting
various vaccines, etc., the virus is still very active, and epidemic prevention still faces serious challenges.
8. The new coronavirus pandemic, the virus continues, spreads widely, and the death toll is huge, which is
no different from the previous major plagues in the world. The changes in the natural universe, the
pollution of the air environment, the activity of microorganisms, the use of a large number of harmful
substances, the defects of human biological evolution, the loss of human gene cells and some non-
adaptive mutations or degradation, etc., will also make various viruses more Rampant (the specific
invisibility of the virus makes prevention, control and treatment more difficult). 9. The repetitive, occult,
asymptomatic transmission of the new coronavirus is difficult to detect asymptomatic (temperature
measurement, nucleic acid, etc. sometimes fail). The harm is very serious. This is the case in Europe,
America and other countries and China, and it is impossible to prevent it. Therefore, don't think that
wearing a mask to measure body temperature will close the city and close the city, and get a vaccine, etc.
It will be safe and reliable. This is also an illusion. Anti-epidemic prevention requires sustained and
unremitting efforts, which must not be taken lightly. The struggle between humans and various viruses
has been repeated for a long time. 10. The research and development of various new coronavirus drugs is
imperative. Only when vaccines and various drugs are mutually used can the disease be fundamentally
treated. This is also a very important aspect of epidemic prevention and fighting. For various drugs,
chemical modification and chemical modification can also develop various new crown drugs. The surface
of the virus has spike-like protrusions, and the spike protein is located on the top of these protrusions,
which looks like a crown, and the coronavirus gets its name. This spike protein contains certain types of
amino acids, which can use furin in the body to break down the cell wall, thereby allowing it to enter
human cells. Spike Glycoprotein (Spike, S): It is a type I transmembrane protein that is composed of a
stick-like protrusion on the surface of the virus particle. It can be broken down by S enzyme into two
functional units, S1 and S2. S1 is used to promote the binding of the virus to the host cell receptor, and
the host receptor interaction region (RBD region) to bind to the receptor. This area can bind to the ACE2
protein. If the binding is completed, the new coronavirus will infect human respiratory epithelial cells,
which will lead to pneumonia.
Hemagglutinin-esterase protein (hemagglutinin-esterase, HE): the structure of β-coronavirus (new
coronavirus), type I transmembrane protein
Membrane glycoprotein (M): It is embedded in the virus envelope through three transmembrane
domains
Envelope protein (envelope, E): transmembrane protein
Nucleocapsid (N): binds to the RNA genome in the form of beads to form a spirally symmetrical
nucleocapsid
Genome

Reference genome sequence

"Information quoted from the relevant website NCBI (quoted from ChinaGene library network
resources)"
Since December 14, 2020, at least seven mutated new coronaviruses have appeared in the world,
including two in the United Kingdom, one in South Africa, one in Nigeria, one in Japan and Brazil, and
three in the United States. According to statistics from the World Health Organization, at present, the
mutant new coronavirus discovered in the UK has appeared in 50 countries and regions around the
world, and the mutant new coronavirus discovered in South Africa has appeared in 20 countries and
regions. D614G, that is, the 614th position of the viral spike protein becomes glycine (G).
In this way, the wild strain before mutation is called D614 strain, and the after mutation is called G614
strain. In addition, there are other variations. Of course, the gene sequence shows that they should be
homologous and the mutation is A. B. C. D. E and so on, and even continue to undergo genetic mutations,
resulting in new mutations and specializations. This genetic variation includes the modalities of virus
original variation, variant variation, cross-conversion variation, mixed variation, compound variation,
evolutionary variation and so on. Therefore, the prevention, control and treatment of the new
coronavirus requires a large number of follow-up and durable medical drugs (chemical drugs, biological
drugs, plant drugs, Gene drugs and other existing drugs and newly developed various drugs, etc.) and
long-term vaccine responses. Based on the analysis and judgment of a large number of clinical cases,
death cases and cured cases, the effect of vaccine prevention and drug combination treatment is obvious,
including the comprehensive application of ventilator, artificial lung and other technologies. The curative
effect is 50%-84.7% higher than single treatment. In fact, most of the tens of millions of patients in the
world who can be treated and recovered are treated with comprehensive treatment, including the
current universal vaccination prevention. If this line of defense fails and the virus mutates and the virus
rages, the mortality rate will reach tens of millions or even billions of billions. This is not alarmist.
To sum up, in response to the new coronavirus, the comprehensive application of high-efficiency vaccines
and effective drugs has obvious effects, can treat a large number of patients, and can save hundreds of
thousands of lives, including high-risk groups. This is the only effective, safe, reliable and feasible way to
overcome the epidemic. s Choice. No matter whether it is Europe, America, India, Brazil, or other Asian
countries such as China, Japan, etc. Region Number of confirmed deaths
Global 97,446,548 2,088,069
United States 24,611,923 409,667
India 10,610,883 152,869
Brazil 8,697,368 214,147
Russia 3,616,680 66,810
United Kingdom 3,553,727 94,759
France 3,046,248 72,138
Spain 2,456,675 55,41
Italy 2,428,221 84,202
Turkey 2,412,505 24,640
Germany 2,108,895 50,381
Colombia 1,972,345 Vomiting 50,187
Global 97,446,548 2,088,069
United States 24,611,923 409,667
India 10,610,883 152,869
Brazil 8,697,368 214,147
Russia 3,616,680 66,810
United Kingdom 3,553,727 94,759
France 3,046,248 72,138
Spain 2,456,675 55,41
Italy 2,428,221 84,202
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Main reference materials, reference books, medical websites, etc.
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Journal of the American Medical Association-"JAMA"
Johns Hopkins Infectious Disease Database
A pneumonia outbreak associated with a new coronavirus of ...
pubmed.ncbi.nlm.nih.gov/32015507
Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia
pubs.rsna.org/doi/10.1148/radiol.2020200274
Pubmed overview
Differential diagnosis of coronavirus disease 2019 from ...
idpjournal.biomedcentral.com/articles
Coronavirus and Covid-19 research archive
www.tandfonline.com/page/covid19?sortBy=Earliest.
Home | NIH COVID-19 Research
covid19.nih.gov
The clinical characteristics of pneumonia patients coinfected ...
onlinelibrary.wiley.com
Coronavirus and Covid-19 research archive
www.tandfonline.com/page/covid19

ProQuest full text retrieval

ProQuest
Stanford Human Genome Center
"Journal of bioenergetics and biomembranes"
Coronavirus disease (COVID-19)-WHO
www.who.int/.../diseases/novel-coronavirus-2019
Vaccine Page
BMCD Biomacromolecule Crystallization Database
Dialog web database
"Journal of bioenergetics and biomembranes"
Gene therapy
Clinical Microbiology Review-"Clinical Microbiology Revie
cell
Lancet
Who
wikipedia
Encyclopedia