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Clinical Radiology
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Radiologists have long relied upon the use of metaphoric imaging signs to attribute meaning to
Article history: disease or anatomy-specific imaging patterns encountered in clinical imaging. Teachers of
Received 9 July 2016 radiology often employ the use of such signs to help learners rapidly identify the typical
Received in revised form appearance of various pathologies. Head and neck (H&N) imaging is no exception, and as a
9 July 2016 specialty that deals with uncommon pathologies and complex anatomy, learners and prac-
Accepted 8 September 2016 tising radiologists alike may benefit from this simplistic, pattern-based approach. In this re-
view, we present a compendium of classic imaging signs of H&N lesions, including signs
related to traumatic, infectious, neoplastic, congenital, and inflammatory aetiologies found
throughout the spectrum of H&N sites (temporal bones, orbits, paranasal sinuses, larynx,
salivary glands, and neck soft tissues). Additionally, we identify potential pitfalls and detail
critical clinical ramifications related to the rapid and accurate diagnosis of these pathologies.
© 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
http://dx.doi.org/10.1016/j.crad.2016.09.006
0009-9260/© 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
Please cite this article in press as: Koontz NA, et al., Classic signs in head and neck imaging, Clinical Radiology (2016),
http://dx.doi.org/10.1016/ j.crad.2016.09.006
e2 N.A. Koontz et al. / Clinical Radiology xxx (2016) e1ee12
“Broken heart” and “Y” signs of incudomalleolar X-linked stapes gusher is a rare congenital aetiology for
disarticulation mixed conductive and profound sensorineural hearing loss
due to POU3F4 gene mutation.14 At temporal bone
Trauma, typically blunt injury, may result in disarticu- computed tomography (CT), these patients demonstrate a
lation of the incudomalleolar joint, which manifests as characteristic “corkscrew” configuration of the cochlea
subtle joint widening and lateral displacement of the (Fig 3) due to absence of the interscalar septum and mod-
incus.6,7 Patients present with conductive hearing loss on iolus, as well as a bulbous configuration of the lateral in-
the affected side. While this can be seen in the axial plane, ternal auditory canal with deficient lamina cribrosa.15 This
conspicuity of the finding is increased when viewed in allows communication between subarachnoid cerebrospi-
coronal reconstruction (Fig 1), which has previously nal fluid (CSF) and cochlear perilymph, which may result in
described as the “Y” sign in the earenoseethroat (ENT) a perilympheCSF gusher and perilymph fistula if stape-
literature8 and by the pithy moniker of the “broken heart” dectomy or cochleostomy is attempted.
sign by neuroradiologists.9 Incudomalleolar disarticulation
has been reported as the one of the most common ossicular
chain injuries,6,7 thus multiplanar imaging is advised to Orbits
scrutinise for subtle incudomalleolar disarticulation.
“Tram-track” sign of optic nerve sheath meningioma
“Ice-cream cone” sign of vestibular schwannoma
Optic nerve sheath meningiomas are the most common
Schwannomas are a commonly encountered nerve tumour of the optic nerve sheath, but only account for
sheath tumour, which grow eccentric to the nerve of around 2% of orbital tumours.16,17 At MRI, they character-
origin.10 On high-resolution magnetic resonance imaging istically demonstrate linear, often parallel enhancement
(MRI) of along the periphery of the nerve sheath due to spread of
Figure 1 “Broken Heart” and “Y” signs of incudomalleolar disarticulation. (a) Coronal non-contrast enhanced CT shows widening of the incu-
domalleolar joint (white solid arrow) with lateral displacement of the short process of the incus (white open arrow) relative to the head of the
malleus (white arrowhead). (b) This configuration of the ossicles observed on coronal CT has been likened to the appearance of a “broken heart”
or “Y”.
N.A. Koontz et al. / Clinical Radiology xxx (2016) e1ee12 e3
Figure 2 “Ice-cream cone” sign of vestibular schwannoma. (a) Axial T1 SPGR post-contrast image shows an avidly enhancing mass (white solid
arrow) extending from the CPA to the fundus of the IAC. (b) When large enough, vestibular schwannomas viewed in the axial plane resemble an
“ice-cream cone” with the bulbous extension of tumour in the CPA resembling the ice-cream sitting upon a cone of tumour in the IAC.
Figure 3 “Corkscrew cochlea” sign of X-linked stapes gusher. (a) Axial non-contrast CT of the temporal bones demonstrates an abnormal
morphology of the cochlea (white solid arrow) with absent interscalar septum and modiolus, as well as a bulbous configuration of the lateral
internal auditory canal (white open arrow). (b) This abnormal cochlear configuration resembles a corkscrew and is typical of X-linked stapes
gusher.
Persistent hyperplastic primary vitreous (PHPV) is a Inverted papilloma is an uncommon benign epithelial
congenital developmental malformation of the eye due to tumour of the sinonasal tract.25 At MRI, they demonstrate a
characteristic gently lobulate morphology resembling the
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Figure 4 “Tram-track” sign of optic nerve sheath meningioma. (a) Axial post-contrast T1-weighted fat-saturated image shows parallel linear
enhancement along the orbital segment of the optic nerve sheath (white solid arrows), which resembles the parallel orientation of light rail or
train tracks (Powell/Hyde cable car line, San Francisco, California). This pattern of enhancement is sensitive, but not speci fic for optic nerve
sheath meningioma. (b) Non-contrast enhanced CT reveals “tram-track” calcification of the optic nerve sheath (white open arrows), which, in
comparison, is highly specific for meningioma.
Figure 5 “Martini glass” sign of PHPV. (a) Axial fat-saturated T2-weighted image demonstrates a small right globe with abnormal triangular-
shaped retrolenticular soft tissue (white open arrow) in a child with PHPV. (b) This configuration of the retrolenticular soft tissue resembles
the shape of a martini glass.
gyral and sulcal pattern of the brain (Fig 6). This Most
“convoluted cerebriform pattern” has a reported sensitivity
of 100% and specificity of 87% for diagnosing inverted
papilloma, and focal loss of this pattern within an inverted
papilloma may signal the presence of a coexistent
malignancy.25 Despite a benign histopathology, inverted
papilloma is locally aggressive with high rate of recurrence,
multicentricity, and can have coexistent squamous cell
carcinoma.26,27 Most commonly found at the lateral nasal
wall near the middle turbinate and maxillary ostium,
inverted papilloma can also be found within the paranasal
sinuses.25,28
Figure 6 “Convoluted cerebriform pattern” of inverted papilloma. (a) Axial T1 SPGR post-contrast image demonstrates a large, heterogeneously
enhancing mass (white solid arrow) centred in the right frontal sinus. (b) This lobular morphology with repetitive curvilinear striations re-
sembles the surface topography of the brain and is specific for inverted papilloma.
Figure 7 “Bow” sign of JNA. (a) Axial CT of the paranasal sinuses demonstrates a large soft-tissue mass (white solid arrow) expanding the right
pterygopalatine fossa and extending into the nasal cavity via a widened sphenopalatine foramen (white arrowhead). Note relatively benign
remodelling of the posterior wall of the maxillary sinus (white open arrow). (b) This pattern of anterior displacement of the antrum resembles
the shape of a bow and is suggestive of JNA or other slow-growing retroantral mass.
Figure 8 “Black turbinate” sign of invasive fungal sinusitis. (a) Axial fat-saturated contrast-enhanced T1-weighted image in a diabetic patient
with facial pain demonstrates loss of mucosal contrast enhancement of the left middle turbinate (white open arrow) and medial wall of the left
maxillary sinus, which corresponds with the black eschar of necrotic tissue (b) observed on nasal endoscopy (image courtesy of Richard H.
Wiggins, III, MD, University of Utah Health Sciences Center). Normally, the mucosa of the nasal cavity and paranasal sinuses should enhance
avidly (white solid arrows) and in neutropenic or functionally neutropenic patients, areas of loss of contrast enhancement are highly concerning
for invasive fungal sinusitis.
Figure 9 “Spinnaker sail” sign of vocal cord paralysis. (a) Axial contrast-enhanced CT of the neck in a young man with left vocal cord paralysis
due to an upper mediastinal mass demonstrates marked dilatation of the ipsilateral laryngeal ventricle (white solid arrow), which resembles the
appearance of a flying spinnaker sail (b). In this case, the spinnaker sails are the striped sails.
Figure 10 “Thumb” sign of epiglottitis. (a) Lateral radiograph of the soft tissues of the neck in a child with fever and sore throat demonstrates
thickening and enlargement of the epiglottis (white open arrow). (b) The appearance of the oedematous epiglottis resembles a thumb and
heralds an emergent finding.
Figure 11 “Steeple” and “wine bottle” signs of laryngotracheobronchitis. (a) Anteroposterior radiograph of the neck in a child with cough and
fever demonstrates narrowing of the lateral convexities of the subglottic larynx and upper trachea (white open arrow) due to subglottic oedema
from croup. (b) This appearance resembles the silhouette of a steeple or wine bottle.
e8 N.A. Koontz et al. / Clinical Radiology xxx (2016) e1ee12
Figure 12 “Panda” sign of sarcoidosis. (a) Gallium-67 scintigraphy demonstrates abnormal symmetric radiotracer uptake in the parotid (white
solid arrow) and lacrimal glands (black solid arrow), as well as avid physiological activity in the nasopharynx (white arrowhead). (b) This
pattern of radiotracer uptake resembles the facial markings of the giant panda and is most typically associated with sarcoidosis, although several
other less common aetiologies can demonstrate this pattern.
Figure 13 “Target” sign of neurofibroma. (a) Axial T2-weighted image demonstrates a heterogeneously hyperintense extradural mass extending
into the left C2eC3 neuroforamen, which shows concentric rings of signal intensity (white solid arrow). (b) This cross-sectional appearance
resembles a “target” and is a characteristic, but not pathognomonic finding of neurofibromas. (c) Coronal short tau inversion recovery (STIR) in a
child with NF1 demonstrates numerous “target” signs (white open arrows) in a plexiform neurofibroma of the right face.
Figure 14 “Salt and pepper” sign of paraganglioma. (a) Axial non-contrast enhanced T1-weighted image demonstrates a circumscribed mass
(white arrowhead) splaying the internal and external carotid arteries and demonstrating a speckled appearance with foci of intrinsic bright T1
signal (white open arrows). (b) Axial T2-weighted imaging shows the mass (white arrowhead) to have areas of peripheral dark T2 signal (white
solid arrows). (c) This pattern has been likened to the appearance of “salt and pepper” and is pathognomonic for paraganglioma.
Figure 15 “Lyre” sign of carotid body tumour. (a) Lateral digital subtraction angiography image demonstrates a hypervascular mass (white solid
arrow) located at the carotid bifurcation (black solid arrow). (b) Characteristic splaying of the internal carotid artery (white open arrow) and
external carotid artery (white arrowhead) by a paraganglioma of the carotid body resembles the lyre, a harp-like instrument of classic Greek
antiquity.
e10 N.A. Koontz et al. / Clinical Radiology xxx (2016) e1ee12
Figure 16 “Tiger stripe” sign of non-suppurative tonsillopharyngitis. (a) Coronal contrast-enhanced CT image demonstrates enlargement of the
palatine tonsils, which are hyperaemic and show a striated pattern of enhancement (white open arrows). (b) This pattern of enhancement
resembles the striped coat of a tiger and when present usually excludes the diagnosis of tonsillar abscess.
Figure 17 “Kissing carotids” sign of medialised course of the internal carotid arteries. (a) Axial contrast-enhanced CT image shows a markedly
medialised course of the internal carotid arteries, which nearly contact at midline (white open arrow). (b) The close proximity of the carotids has
been described as resembling the kissing embrace of lovers (Unconditional Surrender sculpture, San Diego, California). Although typically an
incidental finding, a medialised course of the internal carotid arteries may place them at increased risk of iatrogenic injury during surgery or
instrumentation.
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