Drug Data Classification Mechanism of Action Indication Contraindications Adverse Reaction Nursing Responsibilities

Generic Name: Pharmacologi > Because of the low > inhalational Sevoflurane can cause CNS: Crying, Before
Sevoflurane c Class: solubility of anesthetic agent malignant hyperthermia. It Nervousness, > Assess patient’s GI condition before therapy.
Halogenated sevoflurane in blood for use in Confusion, > Assess patient for hypersensitivity to drug and
Trade Name: general (blood/gas partition induction and should not be used in patients Hypertonia, Dry history of cardiovascular disease
Ultane inhalation coefficient @ 37°C = maintenance of with known sensitivity to Mouth, Insomnia > Assess patient and family’s knowledge of drug
Minimum Dose: anesthetic 0.63-0.69), a minimal general Resp: Sputum therapy.
0.5 % oxygen drug amount of anesthesia sevoflurane or to other Increased, Apnea, > Assess the for pain prior to admission.
inhalation sevoflurane is halogenated agents nor in Hypoxia, > Explain therapy to patient and to patient’s
required to be Patient’s Actual patients with known or Wheezing, family.
Maximum Dose: dissolved in the blood Indication: Bronchospasm, > Assess laboratory studies.
3% oxygen before the alveolar suspected susceptibility to Hyperventilation, > Tell patient about adverse reactions and instruct
inhalation partial pressure is in malignant hyperthermia. Pharyngitis, to report symptoms that occur.
equilibrium with the Hiccup, >Review all other significant and life threatening
Contents: arterial partial Hypoventilation, adverse reactions
Liquid (10019- pressure. Therefore Dyspnea, Stridor During
651) sevoflurane there is a rapid rate of CV: Arrhythmia, > prepare rescusative equipments at easy access
250 milliliter in increase in the Ventricular > continuously monitor vital signs
250 milliliter alveolar (end-tidal) Extrasystoles, >monitor patients at risk for hyperlipidemia for
concentration (FA) Supraventricular increased tryglyceride level
Availability: toward the inspired Extrasystoles, > monitor urine output, in prolonged therapy,
Bottle: 250 ml concentration (FI) Complete AV urine may turn green
during induction. Block, Bigeminy, > Monitor hemodynamic status and assess for
Hemorrhage,
dose-related hypotension.
Metabolism: Inverted T Wave,
cytochrome P450 Atrial Fibrillation, >Take seizure precautions. Tonic-clonic seizures
2E1, to Atrial Arrhythmia, have occurred following general anesthesia
hexafluoroisopropanol Second Degree AV >Be alert to the potential for drug induced
(HFIP) with release of Block, Syncope, S-
inorganic fluoride and T Depressed excitation (e.g., twitching, tremor, hyperclonus)
CO2. GI: GI bleeding, and take appropriate safety measures.
Excretion: 3.5% of abnormal taste, After
the sevoflurane dose diarrhea, dry > monitor vital signs especially for respiratory
appears in the urine mouth, dyspepsia, depression
as inorganic fluoride GI pain, nausea, > assess for level of consciousness
GU: Urination > orient patient to person, place, time, and date
Impaired, Urine > initiate actions to prevent hypothermia
Abnormality,
Urinary Retention,
Source: Source: Source: Davis Oliguria
Davis Drug Guide Drug Guide Source: Davis
for Nurses for Nurses Drug Guide for Source: Davis Drug Guide for Source: Davis Drug Guide for Nurses
Nurses Nurses Source: Davis Drug
Guide for Nurses
Source: Davis Drug
Guide for Nurses