R.T.

Romualdez Memorial Schools

Makati Medical Center

DRUG STUDY

Patient’s Name: Age: Newborn Medical Diagnosis:

Attending Physician/s: Dr. ALLERGIES: None Allergic Responses: None

DRUG NAME MECHANISM OF RATIONALE FOR THIS ADVERSE DRUG NURSING IMPLICATIONS
ACTION PATIENT EFFECT
GENERIC: Binds to negatively Short-term treatment of − Hypersensitivity − Monitor signs of toxicity
Amikacin charged sites on serious infections due to − Drowsness (tinnitus or vertigo)
bacteria’s outer cell susceptible gm-ve strains − Headache − Patient education
BRAND: membrane, disrupting cell including Pseudomonas − Nausea/vomiting o Daily laboratory
Amikin integrity. Alos binds to sp. May be of use in the − Apnea exam is is
bacterial riboomal treatment of known or necessary during
− Nephrotoxicity
DOSE AND subunits and inhibits suspected staphylococcal treatment
FREQUENCY: protein synthesis leading disease. − Muscle fatigue
− hyperkalemia o Instruct parent’s to
44 mg once daily to cell death. report hearing
changes,
TIME: headache, nausea
0800H and vomiting
ROUTE:
IV

Rx CLASSIFICATION:
Aminoglycoside
 DRUG NAME MECHANISM OF
ACTION
GENERIC: Cefuroxime, a
Cefuroxime semisynthetic, broad-
spectrum 2nd generation
BRAND: cephalosporin antibiotic,
Zengen exerts its bactericidal
activity by interfering with
DOSE AND the synthesis of the
FREQUENCY: bacterial cell wall. It binds
147 mg every 12 hrs to penicillin-binding protein
3, responsible for the
TIME: synthesis of peptidoglycan,
0500H, 1700H a heteropolymeric structure
that gives the cell wall its
ROUTE: mechanical stability.
IV Push
Rx CLASSIFICATION:
Antibiotics- Second
Generation Cephalosporin
RATIONALE FOR THIS
PATIENT
Treatment of infections due
to cefuroxime-sensitive
organisms like sepsis
ADVERSE DRUG NURSING
EFFECT IMPLICATIONS
− Thrombophlebitis − Reconstitute the
− Hypersensitivity medicine following the
− Pseudomembranous manufacturer’s
colitis instruction
− Chills, fever − Store reconstituted
− Headache parenteral drug for up to
96 hours in refrigerator
− Unusual bleeding
− Monitor IV site for
− superinfection
extravasation and
phlebitis
− Monitor signs of
allergic reaction to the
drug
− Health Education
o Instruct
patient to
immediately
report for severe
diarrhea or
evidence of blood
dyscrasia