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ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

Max. Marks: 300

ROSE PHARMACY GPAT Time: 3 hours
Model Test Paper – 1

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(We originate aroma)
Instructions
1. All questions are multiple choice objective, you have to select one correct answer.
2. There are 100 questions in question paper. Each question contains three marks.
3. There will be ⅓ (one third) negative marking for each wrong answer.

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Q.1 Emetine is biogenetically derived from one of the following
a) Phenylalanine b) Tyrosine c) Di hydroxy phenylalanine d) Tryptophan

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Q.2 Lignified Trichomes are microscopically identification of one of the following
a) Kurchi bark b) Nux Vomica seed c) Cinchona bark d) Physiostigma seed
Q.3 Dried juice obtained from the leaves of a plant belonging to Liliaceae family is
a) Sennoside b) Aloe-emodin c) Opium d) Rhubarb
Q.4 Killer Killiani test is used for the identification of

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a) Digitalis b) Picrotoxin c) Quinine d) Morphine
Q.5 the starting material for the synthesis of ISONIAZID is
CH3
CH3
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a) b) c) d)
N N CH3 CH3
N
Q.6 A Morphinan ring system is present in one of the following
a) Pentazocin b) Pethidine c) Levorphanol d) Codiene
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Q.7 Canrenone is active metabolite of

a) Aldosterone b) Betamethasone c) Triamicinolone d) Spironolactone
Q.8 the IUPAC name for KETOPROFEN is
a) [2-(3-phenoxy)phenyl)]-propionic acid b) [2-(3-benzoyl)phenyl)]-propionic acid
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c) [2-(6-ethoxy-2-naphthyl)]-propionic acid d) [2-(p-isobutyl)phenyl)]-propionic acid

Q.9 Vitamin which forms part of NAD and NADH and acts as co-enzyme is
a) Pyridoxine b) Riboflavin c) Thiamine d) Niacin
Q.10 A target material used in the production of X-rays is
a) potassium b) molybdenum c) aluminium d) sodium
Q.11 The method of expressing magnetic field strength
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a) Cycles/sec b) Pulses/sec c) Debye units d) Tesla

Q.12 The preferred titrant in the titration of acidic substances by non aqueous method is
a) Mercuric acetate b) Tetrabutyl ammonium hydroxide c) both a & b d) none
Q.13 Temperature programming is done in
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a) Gas Chromatography b) HPLC c) Liquid Chromatography d) none of these

Q.14 Commercial production of Gluconic acid is carried out by the microbial culture of
a) Fusarium moniliformi b) Rhizopus nigrican c) Aspergillus Niger d) Candida utilis
Q.15 The dengue fever virus is
a) arbo virus b) echo virus c) entero virus d) orthomyxo virus
Q.16 Facultative anaerobes

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 ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

a) Can tolerate oxygen and grow better in its presence b) Do not tolerate oxygen
and die in its presence c) Can grow in presence or absence of oxygen d) can grow in
Presence of atmospheric oxygen
Q.17 Enzyme linked immunosorbent assay detect
a) antigen b) antibody c) toxin d) toxiod
Q.18 Galactosemia is because of the lack of

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a) Acid phosphates b) Lactate dehydrogenase
c) Galactose-1-phosphate-uridyl transferase d) Amylase
Q.19 Which one is not a part of urea cycle in liver?
a) Ornithine b) Lysine c) Citruline d) Arginine

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+
Q.20 6-phosphogluconate + NADP  …….+ CO2 + NADP
a) ribulose-5-lactone b) Keto hexose c) 6-phosphogluconate d) None of these
Q.21 Penicillin solution has half life of 21 days. How long will it take for the potency to

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drop to 80 % of the initial potency. Penicillin undergoes first order kinetics.
a) 2.3 days b) 3.2 days c) 6.7 days d) 9.3 days
Q.22 Acid treatment gelatin type A exhibits an isoelectric point in the region of pH
a) 6 b) 7 c) 8 d) 9

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Q.23 Which of the following is not used as disintegrant
a) Starch b) Clays c) Cellulose d) Stearic acid
Q.24 According to D and C “Standard for Patent or Propreitary medicines” comes under
a) Schedule W b) Schedule T c) Schedule U d) Schedule V
Q.25 One of the followings is not an exofficio member of D.T.A.B.
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a) Director, CDL :- Kolkata b) Director, CRI – Kausoli
c) Director, NML - New Delhi d) Director, CDRI - Lucknow
Q.26 Methyldopa consist of one asymmetric carbon at α-position. Which form of this
compound is active
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a) d-form b) l-form c) a and b d) None of these

Q.27 A cardioselective beta blocker with bronchodilationg properties is
a) Pindolol b) Atenolol c) Bisoprolol d) Celiprolol
Q.28 cyclosporin decrease metabolism of …….. and causes ventricular arrhythmia.
a) Cisapride b) Aminoglycosides c) Phenytoin d) Rifampin
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Q.29 Which drug is used in myocardial infarction?

a) Morphine b) Pethidine c) Acetyl Salicylic acid d) Ibuprofen
Q.30 Amphotericin B is obtained from Streptomyces Nodosus and acts as
a) Antibacterial b) Antifungal c) Antiviral d) none of these
Q.31 Electrical driving of charged molecules into tissue is known as
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a) Phonophoresis b) Iontophoresis c) Electroporation d) none of these

Q.32 By first order kinetics in four half lives, the drug is excreted near about
a) 75 % b) 87.5 % c) 93.75 % d) 97%
Q.33 Any viscometer can be used for determining viscosity of …….systems.
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a) Newtonian b) Non-Newtonian c) both a and b d) none of these

Q.34 Picking process occurs in tablets due to
a) Entrapment of air b) Moisture content in tablet c) Defects of tablets d) none
Q.35 A hypolipidmic agent obtained from Commiphora mukul consisting of a mixture of
sterols including Z- pregna-(20)-diene-3,16-dione
a) Guggulipid b) Cardiac glycoside c) Ergosterol d) Cholesterol

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 ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

Q.36 Cinnamon is the………….of Cinnamon zeylanicum

a) Dried stem bark b) Dried inner bark of shoots of coppiced tree
c) Dried bark of the shoots of coppiced tree d) Dried bark of stem and roots
Q.37 What is biological source of turmeric?
a) Roots and rhizomes of Zinger officinales b) Roots and rhizomes of Curcuma longa
c) Dried fruits of Capsicum annum d) Dried fruits of Capsicum officinales

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Q.38 Drug which reacts with hydrochloric acid and potassium ferricyanide solution gives
yellow colour
a) Morphine b) Codeine c) Papaverine d) Meconic acid
Q.39 2,4-diamino-6-piperidino Pyrimidine-3-oxide is chemical name of

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a) Pyremethamine b) Minoxidil c) Trazadone d) Trimethoprim
Q.40 Mesoridazine active metabolite of thioridazine, the route of metabolism is
a) Desulfuration b) Nitro reduction c) Oxidative deamination d) Sulfoxidation

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H3CO Cl
Q.41 N
HN
N O A What is the name of A?
N
H3CO + O
NH2

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a) Terazosin b) Quinine c) Prazosin d) Quinidine
Q.42 For anti-Psychotropic action the 2- position of phenothiazine ring is substituted by
a) Chloro group b) Triflouromethyl c) Methylthio group d) All of these
Q.43 A drug has pKa of 5.5. If the pH of patient urine is 7.5, what would be the ratio of
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dissociated to undissociated drug concentration?
a) 1:25 b) 25:1 c) 1:100 d) 100:1
Q.44 N-acetyl glucosamine and N-acetyl muramic acid is major components of cell wall
a) Gram positive bacteria b) Gram negative bacteria c) Mycobacteria d) Spirochetes
Q.45 What is causative organism of Gas Gangrene?
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a) Cornibactrium diphtheriae b) Streptococcus pyogenes

c) Clostridium perfringens d) Staphylococcus aureus
Q.46 Which one of the following is hydroxyl group containing aliphatic amino acid?
a) Tyrosine b) Threonine c) Methionine d) Tryptophan
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Q.47 Pellagra disease is characterized by

a) Gastroenteritis b) Osteomalacia c) Exfloliative dermatitis d) none
Q.48 Which one of the following band originate from a compound containing a
conjugated system?
a) R-band b) B-band c) R-band d) K-band
Q.49 Isoniazid is titrated by
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a) Non aqueous titration b) Excess bromine treated with potassium iodide and N/10
sodium thiosulphate c) Using N/10 sulphuric acid d) Spectrophotometrically
Q.50 Which of the following is used as a cell container or prism material in IR radiation
a) NaCl b) KBr c) Both a & b d) None of these
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Q.51 Which method is suitable to determine initial distribution of drug into tissue?
a) Food material in stomach b) Plasma protein binding c) Stomach emptying time
d) Rate of blood supply to the tissue
Q.52 Which of the following dosage form gives rapid drug bioavailability?
a) Sustained release dosage form b) Compressed tablets c) Suspension d) Solution
Q.53 The potency of pharmacologic action of drug depends upon

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 ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

a) Concentration of drug at receptor site b) Biological half life

c) Concentration of drug in dosage form d) Route of administration
Q.54 Which drug is used in myasthenia gravis?
a) Physiostigmine b) Rivastigmine c) Neostigmine d) Pyridostigmine
Q.55 Which one of the following is selective α2-antagonist?
a) Yohambine b) Prazosin c) Indoramine d) Clonidine

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Q.56 Bambuterol is prodrug of
a) Phenylephrine b) Terbutiline c) Salbutamol d) Esmolol
Q.57 Drug depressing electrophysiological properties of myocardial cells
a) Disopyramide b) Phenytoin c) Sotalol d) Verapamil

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Q.58 ACE inhibitors and Potasium sparing diuretics not used together because of
a) Hopkalemia b) Hyperkalemia c) Hyper natrimia d) none of these
Q.59 Lithium toxicity is produced by

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a) Neuroleptics b) Antidepressant c) Diuretics d) Antianxiety
Q.60 A condition in which intact red blood cells appear in the urine
a) Hemoglobinurea b) Hematurea c) Phenylketourea d) ketourea
Q.61 Advese reactions produced by Kanamycin is

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a) Deafness b) Nephrotoxicity c) Neuromuscular blockade d) all of these
Q.62 All amino glycosides are prepared by fermentation from various species of
Streptomyces except
a) Streptomycin b) Gentamicin c) Kanamycin d) Tobramycin
Q.63 All of the following drugs are thymidine inhibitors except
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a) Idoxuridine b) Cytarbine c) Vidarbine d) Triflouridine
Q.64 The Ex-officio members of pharmacy council of India includes
a) Director general of health services b) Director of central drug laboratory
c) Drug controller of India d) All of these
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Q.65 Schedule T refers to according to drugs and Cosmetic acts

a) Standards of cosmetics b) The hygienic conditions for Ayurvedic and Unani drugs
c) Standards of patent and proprietory medicines d) Life period of drugs
Q.66 Collenchymatous parenchyma containing in its outer part numerous ellipsoidal
schizolysogenous oil glands is microscopy of
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a) Cinnamon cassia b) Syzygium aromaticum c) Eleterra cardamom d) None

Q.67 Ideal property of radiopharmaceuticals is
a) Slow localization in target tissue b) Very long half-life to provide enough
exposure to get imaging information c) Rapid localization in target tissue and quick
clearance from non-target organs d) none of these
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Q.68Which microorganism is used in the I.P. assay of Streptomycin?

a) Bacillus cereus b) Staphylococcus epidermidis
c) Klebsiella peumoniae d) Micrococcus luteus
Q.69 Which Immunoglobulin (Ig) is Agglutinating and cytolytic?
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a) Ig G b) Ig A c) Ig M d) Ig E
n
Q.70 Calculate the amount of sodium chloride required to make 1.5% sol of pilocarpine
HCl isotonic with tear solution.Freezing point of 1% soln of pilocarpine HCl = -0.130C
Freezing point of 1% soln of NaCl = -.5760C
a) 0.65 % b) 0.585 % c) 0.9 % d) 0.564 %
Q.71 Which of the enzyme is not used in citric acid cycle

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 ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

a) Isocitrate dehydrogenase b) α-ketoglutarate dehydrogenase

c) Aconitase d) Carbonic anhydrase
Q.72 Woods of Acokanthera schimiperi belongs to the family Apocynaceae is source of
a) Scilarenin b) G-stropanthin c) Cannogenin d) Diosgenin
Q.73 Pyridine-Pyrrolidine heterocyclic ring system is present in one of the followings:
a) Coniine b) Nicotine c) Papaverine d) Anabasine

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Q.74 A typical auxin of plant, which is found in growing tissue is
a) Indole-3-acetic acid b) Gibberlin c) Abscisic acid d) None of these
Q.75 Atropine, hyoscyamine and hyoscine are distinguished from other alkaloids by
a) Mayer’s test b) Wagner’s test c) Hager’s test d) Vitali’s test

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Q.76 Avoid milk products and milk of magnesia half an hour before or after taking the
Medicine with which one of the followings drug
a) Isoniazid b) Rifampicin c) Doxycycline d) Cetrazine

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Q.77 Choose the correct key intermediate for the bio-synthesis of C6-C3 units, which
serves as a precursor for the biosynthesis of amino acid
a) Shikimic acid b) Pyruvic acid c) Dehydro qunic acid d) Mevalonic acid
Q.78 Thermistor which measures resistance (IR detector) is composed

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a) Oxides of Mn, Co and Ni b) Bi-Sb c) Xenon d) Triglycin sulphate
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a) 245 nm b) 259 nm
Q.79 Calculate λmax
c) 256 nm d) 269 nm
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Q.80 Which of the following factors influences chemical shift
a) Inductive effect and Vander waals deshielding b) Anisotropic effect
c) hydrogen bonding d) All of these
Q.81 The distance between band peaks divided by average bandwidth of two adjustant
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bands in chromatography is known as

a) Ghost peak b) Tailing effect c) Resolution d) Retention time
Q.82 Most widely used mobile phase in reverse phase chromatography is
a) n-heptane b) n-hexane c) cyclohexane d) Water and acetonitrile
Q.83 Potentiometer is used to measure
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a) Temperature b) Concentration c) pH d) EMF

Q.84 When estrone is by reacted with potassium acetylide results in
a) Ethinyl estradiol b) Diethyl stilbesterol c) Dienosterol d) Cortisol
Q.85 Which of the following antibiotics act on the ribosomes 30 S subunit?
a) Aminoglycosides b) Tetracycline c) Both a & b d) Penicillin
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Q.86 Which one of the followings is not nitrogen mustard derivative?

a) Mephalan b) Chlormbucil c) Mechlorethamine d) Cisplatin
Q.87 Optics neuritis is major side effect of one of the anti-T.B.
a) Pyrazinamide b) Isoniazid c) Ethambutol d) Rifampicin
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Q.88 Which of the following nucleus present in Hydralazine?

a) Pteridine b) Phthalazine c) Naphthalene d) Aziridine
Q.89 p-methoxy benzyl chloride + 2-aminopyridine + Cl-CH2-CH2-N(CH3)2  A?
a) Mepyramine b) Tripelennamine c) Doxylamine d) Triprolidine
Q.90 Filariasis is treate with Di ethyl carbamazine and caugative agent is
a) Teania saginata b) Schistosoma heamatobium c) Wucheria Bancroft d) Ascaris
Q.91 9-[(2-hydroxyethoxymethyl)guanine is known as

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 ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

a) Ganciclovir b) Acyclovir c) Penciclovir d) Adenovir

Q.92 Which one is starting material for xylocaine
CH3 CH3 H3C CH3 CH3

NH2 NH2 NH2 NH2

a) b) c) d)

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CH3 OH
Q.93 Electrodialysis Process is used for
a) Preparation b) Purification c) Seperation d) None of these
Q.94 In the assay of sulphamethoxazole IP. (C10H11N3O3S), 0.2 g of the sample was

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dissolve in 50ml of 2M HCl. To this was added 3.0 g of KBr and titration was carried
out. If the volume of 0.1M titrant consumed was 8.0 ml, calculate the % purity
a) 99.70 % b) 101.2 % c) 8.87 % d) 98.79 %

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Q.95 The pinene hydrochloride rearranged into bornyl terpenoid is called as
a) Wagner-Meerwein rearrangement b) Pinacol rearrangement
c) Fries rearrangement d) Beckmann rearrangement
Q.96 Boerhavia diffusa is biological source of
a) Gentian b) Liquorice c) Eucalyptus d) Punarnava

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Q.97 Anthraquinone glycosides are absent in
a) Dog senna b) Palthe senna c) Indian Senna d) Alxenderian senna
Q.98 Metabolic oxidation of carbon-nitrogen, carbon-oxygen and carbon-sulphur systems
Principally involves two basic type of bio-transformation processes.
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a) Hydroxylation of the α-carbon atom attached directly to the heteroatom
b) Hydroxylation or oxidation of the hetero-atom only c) both a & b d) none
Q.99 Calfactant is
a) a sterile non-pyrogenic lung surfactant intended for intratracheal instillation to
premature infants b) a synthetic surfactant popularly used to prepare total parenteral
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nutrition c) a potent chelating agent used to prevent metal induced oxidation process
d) none of these
Q.100 presence of anomocytic stomata on the epidermis of pericarp and mesocarp
containing lignified and reticulate parenchyma
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a) Cinnamon b) Fennel c) Cardamom d) Nutmegh

Answer Key (Model Test paper-1)

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1.c 2.b 3.b 4.a 5.b 6.c 7.d 8.b 9.d 10.b 11.d 12.b 13.a 14.c 15.a
16.c 17.b 18.c 19.b 20.a 21.c 22.d 23.d 24.d 25.c 26.b 27.d 28.a 29.c 30.b
31.b 32.c 33.a 34.b 35.a 36.b 37.b 38.c 39.b 40.d 41.c 42.d 43.d 44.a 45.c
46.b 47.c 48.d 49.b 50.c 51.d 52.d 53.a 54.c 55.a 56.b 57.a 58.b 59.c 60.b
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61.d 62.b 63.c 64.d 65.b 66.b 67.c 68.c 69.c 70.d 71.d 72.b 73.b 74.a 75.d 76.c
77.a 78.a 79.b 80.d 81.c 82.d 83.c 84.a 85.c 86.d 87.c 88.b 89.a 90.c 91.b
92.a 93.c 94.b 95.a 96.d 97.b 98.c 99.a 100.b

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