Formula 3

Cynara dry extract 100 mg

Silymarin 50 mg
Mentha dry extract 25 mg
Heavy Mg Oxide 40 mg

Silymarin Cynara dry extract

Cynara scolymus
1- Different names Silbum marianum
Globe artichoke
of drug: Milk thistle
Alcachofra
2- Part used: Fruits Leaves
Flavonids 1- Caffeic acid derivative:
-Silybin (60-70%) -di-caffeoylquinic
-Taxifolin (Cynarin)
-Silychristin -Mono-caffeoyquinic

2- Flavonoids:
3- Active -Luteolin
constituent: -Rutin
-Apigenin

3- Sesquiterpene lactone:
(Cynaropicrin)

1- Support liver functions (used in liver cirrhosis

and hepatitis(liver inflammation)
2- Gall bladder disorder
4- Medicinal uses: 3- Antioxidant
4- Digestive disorder
5- Lowering cholesterol level
(mainly due to Cynara)

1
 1- Effect on 1- Increase liver
hepatocytes: regeneration
Increase protein 2- Antioxidant
synthesisà Stimulation 3- increase bile secretions
of liver regeneration and flow
(as silymarin)
2- Effect on
inflammatory cells: 4- increased hepatic
Stabilization of mast circulation
cells, inhibition of
neutrophils, PG, LT à
Anti-inflammatory effect

5- Mode of Action: 3- Effect on liver

detoxifying system:
Increase GSH and
SODà antioxidant
effect

4- Effect on bile:
Choleretic: promotes
bile secretions by
hepatocytes
Cholagogue: Stimulates
the flow of bile that has
already been formed

-Due to increased bile flow and secretions

1- Mild laxative effect (diarrhea)
6- Side Effects: 2- Upset stomach

3- Allergy 3- Contact dermatitis

Cynara and Silymarin should NOT taken in the

presence of gall stones or other bile duct occlusion
otherwise liver damage occurs
7- Precautions: (due to their bile stimulating effect)

The formula should not be taken during pregnancy

and lactation.

2
 Standardized to contain
70-80% silymarin used
Cynara leaf extract (5:1)
in dose of 140 mg in the
standardized to contain 13-
8- Information of form of capsules of
18% cynarin used in the
any standardized concentrated extract.
dose of 320 mg 1-3 times
extract:
daily in the form of capsule
NB: can't be taken as
or tablets.
tea because silymarin is
poorly soluble in water

9- Drug Taken cautiously with cholesterol lowering and statin

interactions: drugs.

3
 Mentha

1- Common name: Peppermint

2- Part used: Leaves

3- Constituents: Volatile oil

-menthol
-menthone
-menthofuran
Flavonoids

4- Commercial preparations:
-tea
-enteric coated capsule (to prevent heart burn)

5- Uses: (traditional herbal medicine)

-Digestive disorders (Volatile oil)
(Bloating, nausea, vomiting…etc)
-Gall stones (Volatile oil, Flavonoids)

NB: Therefore, we use it in this formula to relieve side effects of the other
two drugs.

6- Mode of action:
-Allow gases to leave stomach by releasing the esophageal sphincter
(carminative effect)

-Lower bile cholesterol level, so it decreases the incidence of gall stones.

4
Disease:

Liver Disorders

1- Definition:
A- Cirrhosis: scar of liver.
B- Hepatitis: inflammation of liver

2- Etiology:
-high stress levels
-excessive alcohol
-medications
-poor water quality
-processed fast food
-air pollution

3- Signs and Symptoms:

1- Extreme tiredness
2- Weight loss
3- Loss of appetite
4- Nausea and vomiting
5- Fever
6- Enlarged or tender liver
7- Jaundice

4- Complementary and alternative therapy:

A- Daily routine:
1- Avoiding exposure to environmental toxins.
B- Nutrition:
1- Healthy food (vegetables, fruits, whole grain cereal, low fats,
beans)
2- Drinking plenty of clean water
3- Avoiding alcohol consumption
C- Supplement:
1- Antioxidants (Vitamins A, C and E)
D- Herbs in combinations:
1- Dandelion
2- Turmeric
3- Chinese throughwax
4- Shizandra berry

5
Herbal products in Egyptian market:

Silymarin only:
Mepasil
Legalon
Hepamarin

Livit:
Silymarin + GSH + Vit. A, C, E

Livavit:
Silymarin + Artichoke + Dandelion + Vit. A, C, E

Normolive:
Silymarin + Dandelion + Turmeric