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Recap
A is dominant, a is recessive
Gene frequency for A is p, for a is q
Relative proportion of AA, Aa and aa genotypes are p^2 (p squared), 2pq and q^2 (q squared)
p^2 + 2pq + q^2 = 1
Fitness coefficient is s
A is completely dominant. Fitness for AA and Aa are 1+s, fitness for aa is 1
Instead of the relative proportion being p^2, 2pq, q^2, after selection, the relative proportions are p^2(1+s), 2pq(1+s), q^2
p(new) can be calculated by (2 x number of AA individuals + number of Aa individuals) / 2(total number of individuals) [2 x total, b/c each ind'l has 2 all.]
The new population after selection is now p^2(1+s) + 2pq(1+s) + q^2
So, p(new) = {2p^2(1+s) + 2pq(1+s)} / 2{p^2(1+s) + 2pq(1+s) + q^2}
This is surprisingly easy to calculate in excel
Now look at "How the sheet works" page, which explains how the spreadsheet works.
s= 0.1 <-- Here we define the selection coefficient. This is the advantage the dominant form has over the recessive form. If it's 0.1, then the advantage is 10%.
starting p = 0.01 <-- Here we define the starting gene frequency for the dominant allele A. 0.01 means it starts at 1% of the gene pool.
{p^2(1+s) + pq(1+s)} / T
pq is a calculated value
and blue shaded cells)
1-p
If it's 0.1, then the advantage is 10%.
This is the same sheet as "How the sheet works," except it shows the first 100 generations
The pertinent formula is p(new) = {2p^2(1+s) + 2pq(1+s)} / 2{p^2(1+s) + 2pq(1+s) + q^2}
2 cancels to give {p^2(1+s) + pq(1+s)} / (p^2(1+s) + 2pq(1+s) + q^2)
T = p^2(1+s) + 2pq(1+s) + q^2
s= 0.1 <-- Here we define the selection coefficient. This is the advantage the dominant form has over the recessive form. If it's 0.1, then the advantage is 10%.
starting p = 0.01 <-- Here we define the starting gene frequency for the dominant allele A. 0.01 means it starts at 1% of the gene pool.
The graph on the next sheet plots p vs generations
0.9
Column B Column K
0.8
0.7
0.6
0.5
p
0.4
0.3
0.2
0.1
0
0 20 40 60 80 100
Generations