PATHOPHYSIOLOGY OF DIABETES MELLITUS TYPE 2 HYPONATREMIA SECONDARY TO DIABETIC NEPHROPATHY

Predisposing factors: AgeLate adultho od LifestyleSeldom Exercise s Diet- 2 cups Precipitating factors: DIABETES MELLITUS TYPE

Production of glucose by the liver

Altered pancreatic insulin

Impaired insulin production

Glucose can not enter target cells

Peripheral resistance to insulin

Glucose accumulation in the blood or HYPERGLYCE

Diminished intracellular reaction

NAU SEA VOM ITIN G FATI GUE

HYPONATREMIA

Dilution of SODIUM in ECF

Concentratio n of ECF

Blood glucose more than the Renal

Pressure of blood vessels in the urine

PROTEINURIA

Stressed Filtration System

Thickening in the glomerulus

DIABETIC NEPHROPATHY