Desflurane

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Desflurane

Systematic (IUPAC) name

2-(difluoromethoxy)-1,1,1,2-tetrafluoro-ethane

Clinical data Pregnancy cat. ? Legal status ? Pharmacokinetic data Metabolism Not metabolized Half-life Elimination dependent on minute ventilation Identifiers CAS number 57041-67-5 ATC code PubChem DrugBank N01AB07 CID 42113 APRD00907

ChemSpider 38403 UNII KEGG ChEMBL CRS35BZ94Q D00546 CHEMBL1200733 Chemical data

Formula Mol. mass SMILES

C3H2F6O 168.038 g/mol eMolecules & PubChem

InChI[show]
(what is this?) [1]

Desflurane (2,2,2-trifluoro-1-fluoroethyl-difluoromethyl ether) is a highly fluorinated methyl ethyl ether used for maintenance of general anesthesia. Like halothane, enflurane and isoflurane, it is a racemic mixture of (R) and (S) optical isomers (enantiomers). Together with sevoflurane, it is gradually replacing isoflurane for human use, except in the third world, where its high cost precludes its use. It has the most rapid onset and offset of the volatile anesthetic drugs used for general anesthesia due to its low solubility in blood. Some drawbacks of desflurane are its low potency, its pungency and its high cost. It may cause tachycardia and airway irritability when administered at concentrations greater than 10 vol%. Due to this airway irritability, desflurane is infrequently used to induce anesthesia via inhalation techniques. Additionally, desflurane is a greenhouse gas. Anesthesia gases used globally contribute the equivalent of 1 million cars to global warming.[1] Desflurane has a global warming potential of 3714. One tonne of desflurane emitted is equivalent to 3714 tonnes of carbon dioxide in the atmosphere, much higher than sevoflurane or isoflurane. Taking into account the different amounts typically used in 1 hour of anesthesia (1 minimal alveolar concentrationhour), desflurane causes 26.8 times the global warming of sevoflurane.[2] Though it vaporises very readily, it is a liquid at room temperature. Anaesthetic machines are fitted with a specialized anaesthetic vaporiser unit that heats liquid desflurane to a constant temperature. This enables the agent to be available at a constant vapor pressure, negating the effects fluctuating ambient temperatures would otherwise have on its concentration imparted into the fresh gas flow of the anesthesia machine. Desflurane, along with enflurane and to a lesser extent isoflurane, has been shown to react with the carbon dioxide absorbent in anesthesia circuits to produce detectable levels of carbon monoxide through degradation of the anesthetic agent. The CO2 absorbent, Baralyme, when dried, is most culpable for the production of carbon monoxide from desflurane degradation, although it is also seen with soda lime absorbent as well. Dry conditions in the carbon dioxide absorbent are conducive to this phenomenon, such as those resulting from high fresh gas flows.[3]

[edit] Physical properties

Boiling point : Density : 23.5 C (at 1 atm) 1.465 g/cm (at 20 C)

Molecular Weight : Vapor pressure: Blood:Gas partition coefficient : Oil:Gas partition coefficient : MAC :

168 88.5 kPa 672 mmHg (at 20 C) 107 kPa 804 mmHg (at 24 C) 0.42 19 6 vol %

[edit] References
1. ^ Sulbaek Andersen MP, Sander SP, Nielsen OJ, Wagner DS, Sanford Jr TJ, Wallington TJ (July 2010). "Inhalation anaesthetics and climate change". British Journal of Anaesthesia 105 (6): 760766. doi:10.1093/bja/aeq259. 2. ^ Ryan SM, Nielsen CJ (July 2010). "Global Warming Potential of Inhaled Anesthetics: Application to Clinical Use". Anesthesia and Analgesia 111 (1): 92 98. 3. ^ Fang, et al. (1995). "Carbon Monoxide Production from Degradation of Desflurane". Anesthesia and Analgesia.

[edit] Book references and Additional Reading

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Eger, Eisenkraft, Weiskopf. The Pharmacology of Inhaled Anesthetics. 2003. Rang, Dale, Ritter, Moore. Pharmacology 5th Edition. 2003. Martin Bellgardt: Evaluation der Sedierungstiefe und der Aufwachzeiten frisch operierter Patienten mit neurophysiologischem Monitoring im Rahmen der Studie: Desfluran versus Propofol zur Sedierung beatmeter Patienten. Bochum, Dissertation, 2005 (pdf) Susanne Lohmann: Vertrglichkeit, Nebenwirkungen und Hmodynamik der inhalativen Sedierung mit Desfluran im Rahmen der Studie: Desfluran versus Propofol zur Sedierung beatmeter Patienten. Bochum, Dissertation, 2006 (pdf) Patel SS, Goa KL. (1995) "Desflurane. A review of its pharmacodynamic and pharmacokinetic properties and its efficacy in general anaesthesia." Drugs Oct;50(4):742-67. PMID: 8536556.