Normal pancreas at Rt.

Abnormal pancreas at Lt.

Adenocarcinoma of Pancreas
Gross: Ill defined, pale, hard mass athead/body/tail/entire Cut surface: yellowish, Foci of necrosis and hemorrhage () Patho: Neoplastic cell arrange in glandular pattern and veriable Variable mucin production Pleomorphism neoplastic cells (Atypical, irregularity, bizarre) Hyperchromatic nuclei with mitosis Dense fibrous stroma Inflammatory cell infiltration

Tumor cells (large, hyperchromatic nuclei) spreading along nerve sheath (perineural invasion)

Mucinous Cystic Neoplasm

Gross: Encapsulated multiloculated cyst Thick mucin content Patho: Cyst line by single columnar epithelium Mucin producing (goblet cell) cytoplasm Hypercellular dense ovarian stroma

Serous Cystadenoma
Gross: Encapsulated mass Honeycomb appearance Small multiple cysts and clear or straw-color fluid Stellate scar and calcification Patho: Cyst line by cuboid epithelium without atypia Hypocellular stroma Honeycomb appearance

Pseudocyst
Gross: Large cystic mass Ill-defined cyst Patho: Lack of true epithelium Cyst lined by fibrin and granulation tissue

Acute pancreatitis
Gross: Pancreatic swelling Large area of hemorrhage Fat necrosis Saponification Patho: Interstitial space edema, Fat necrosis Acinar cell necrosis with hemorrhage Inflammatory cell infiltration

Chronic pancreatitis
Gross: Shrunken and fibrosis pancrease Dilated duct with numerous stone Patho: Atrophic lobule of acinar cell Dense fibrous stoma Lymphocytic infiltration Pancreatic duct dilatation

Fatty Liver
Gross: Liver slightly enlarged Pale yellow color liverparenchyma and homogenous Patho: Fat vacuoles in hepatocytic cytoplasm Small numerous fat vacuole in liver parenchyma

HCC

Gross: Macronudular cirrhotic liver single/multiple yellow-tan firm mass Multifoci of necrosis and hemorrhage Satellite nodules Patho: Disorganized appearance Irregular cords of hepatocytes and polygonal shape Enlarged nuclei and prominent nucleoli Nuclear inclusion Pleomorphism with mitosis No portal triad

Normal liver

Intrahepatic CholangioCA
Gross: Liver no cirrhosis Mass with marked desmoplastic or fibrotic response in surrounding tissue Intrahepatic duct dilatation Patho: Glandular pattern Desmoplastic reaction or dense fibrotic tissue Mucinous element in gland

Alcoholic Cirrhosis
Gross: Diffuse nodularity of liver surface Multiple, uniform, small regenerative nodule < 3 mm (micronodular cirrhosis) fibrous band Patho: Multiple regenerative nodules with fibrous septum Cluster of hepatocyte without central veins Irregular thickness of cords cells

Viral Cirrhosis
Gross: Irregular liver surface Regenerative nodules separated by broad bands fibrous Numerous macronodules (> 3 mm)

FNH
Gross: Well circumscribe yellow-tan mass Depressed central stellate fibrous scar Central scar contain large blood vessel Thickened plate characteristic of regeneration parenchyma between septa Patho Focal nodulation Regenerative noudule with fibrous band Radiating septa show foci of lymphocyte & bile duct proliferation

Hepatic Adenoma
Gross: Subcapsular, well circumscribed single mass Yellow-tan color with bile-stained No central scar Patho: Adenoma on Rt. side Well differentiated hepatocytes less abundant & eosinophilic cytoplasm Disorganized cords No normal lobular architecture No portal triad

Hemangioma
Gross: Well-circumscribed masses, red dark color Blood-filled spongy No encapsulated Other liver parenchyma is normal Patho: Mass composed of dilated, RBC-filled, vascular channels line by flat endothelial cell Fibrous stroma No encapsulated

Patho No.1

Patho No.2

Metastatic Liver
Gross: Multiple yellow-tan irregular mass Some area necrosis and hemorrhage Umbilication on surface Patho: depend on primary CA No.1 IDC (breast) metastatic seen on Rt.side Normal liver on Lt.side No.2 Complex glandular nodule surrounded by fibrous tissue
Malignant cell: Pleomorphism, Hyperchromatin, Mitosis

Acute Cholecystitis
Gross: Thickened, edematous GB wall Exudative fibrin covering GB serosa Multifoci of gangrene Patho: Mucosal ulceration Foci of debris & hemorrhage Inflammatory cell (PMN) infiltration

Chronic Cholecystitis
Gross: Gray-white, marked fibrous thickening of GB wall Erythematous and ulcerated some area mucosa due to impaction of large GS Patho: Fibrous thickening of GB wall Mucosal necrosis &ulceration in some areas Chronic inflammatory cell infiltration
Rokitansky-Aschoff sinuses (mucosal epithelium out pouching through muscular layer)

Cholesterolosis of GB
Gross: Geographic yellow mucosal surface (strawberry-like appearance)

Patho: Foamy macrophages in lamina propria of villi tips in mucosa Fibrovascular stroma

Gross No.1

Gross No.2

Adenocarcinoma of GB
Gross: No.1: Fungating mass extends into GB lumen and GB wall Multiple white stone, Thick wall GB No.2: Large black GS in lumen Irregular area of yellow tumor and infiltrating from GB wall directly into adjacent liver Patho: Glandular structures line by atypical columnar cell Pleomorphism, hyperchormatin, mitosis Mucin content in gland Malignant cell invade to muscular layer