Product Information

S1236 Leucovorin Calcium

Technical Data:
M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 601.58 C21H25CaN7O7.5H2O Unknown 99% at -20 2 years 6035-45-6
N H2N N H H2O O O O N N H H2O H2O H2O H2O H N H O N H OCa++ OO

Novel Life Science Reagents

for Cell Signaling Research

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(chemistry support)

Synonyms: Calcium,

Calcium Folinat

techbio@selleckchem.com
(bio support)

Biological Activity
Human lymphoid cell lines were studied for leucovorin requirements to protect from methotrexate (MTX)-induced growth suppression. Over a 72h continuous exposure leucovorin provided better protection to the cell lines LAZ-007 and RAJI than to the cell lines CCRF-CEM and MOLT-4.[1] Leucovorin is a compound similar to folic acid, which is a necessary vitamin. It has been around and in use for many decades. Leucovorin is a medication frequently used in combination with the chemotherapy drugs fluoruracil and methotrexate. Leucovorin is a chemoprotectant, not a chemotherapy drug, however, it is used in addition to these chemotherapy drugs to enhance anti cancer effects with fluorouracil) or to help prevent or lessen side effects (with methotrexate).[2]

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References
[1] Browman GP et al. Cancer Chemother Pharmacol. 1985;15(2):105-10 [2] http://www.chemocare.com/bio/calcium_leucovorin.asp

Return Policy
Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem.

MSDS & CoA

Please visit www.selleckchem.com to download MSDS and CoA.

Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must

Notes
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 Many products are stable in the short-term at temperatures that differ from that . required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet.

be received from our customer service team. Returns accepted will be subject to a 30% restocking charge.

For all product returns and product replacements,please contact Selleck directly by info@selleckchem.com or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt.

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