M1 AML without maturation Blasts have a high nuclear to cytoplasmic ratio and generally lack granules Immature but

t more than 3% are peroxidase (+)

M3- Acute Promyelocytic Leukemia Majority of cells are hyper granular promyelocytes Majority of the patients are aged 35-40 Translocation (8;21) Heavily granulated promyelocyte circulating in the peripheral blood of a patient with APL. A suggestion of the nuclear contour can be discerned against the granular background. Cells appear as dark or overstained due to the granules

M2- AML with maturation Faint granules can be appreciated under high power. Full range of myeloid maturation through granulocytes. Auer rods present in most cases; Definitive characteristic is presence of translocation (8;21)

M4- Acute Myelomonocytic Leukemia

Aberrancy can be noted in both the myeloid and monoctyic forms. Blast and promonocytes make up less than 20% of the cells in the bone marrow. In the peripheral blood there is a leukocytosis present composed mostly of granulocytes, myeloid precursors, and monocytes.

M6- Acute Erythroleukemia

Here is a dysplastic red cell precursor with coarse basophilic stippling. This example is from a case of erythroleukemia.
M5- Acute Monocytic Leukemia

--In M5a, monoblasts and promonocytes dominate. There is also the presence of vacuoles which are phagocytic.

M7- Acute Megakaryocytic Leukemia Blasts of Megakaryocytic lineage predominate. Myelofibrosis or increases in bone marrow reticulin is seen in most cases. --In M5b, monocytes predominate in peripheral blood.

Megakaryocytic clustering is shown. The megakaryocytes are of variable size and show dysplastic nuclear changes. This finding was noted in a patient with a diagnosis primary myelofibrosis.

Source:

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