GHID DE FARMACOLOGIE PENTRU ASISTENTI MEDICALI st ASISTENTI DE FARMACIE CRIN MARCEAN VLADIMIR-MANTA MIHAILESCU(GID DE FARMACOLOGIE PENTRU ASISTENTI MEDICALI $1 SISTENT! DE FARMACIE Cin Marcesn, Vladimir-Mante Mihilesca Copyright© 201, 2012, 2014 Eatura ALL rol DEGRINMARCEAN De VIADIMIR-MANTA MIMATLESCU [ Desciera CIP aBibliotecif Nalonale Romanist -MARCEAN, CRIN (Ghd de farmacologie petra assent medical aistenti de farmnacie/ (rin Marcean, Viadimie- Manta Mibalesc,~ Bucuret: altura ALL, 2011 ‘bog. ISBN 978.973-571-579-1 [Mihilsc, Vladimir 61500758) J GHID DE FARMACOLOGIE ‘Toate deprle reervateEtuil ALL. pentru asistenti medical gi asstenfi de farmacie ‘Nici parte din acest wolum mu poate cola ‘rk permisonen sexist Elta ALL. ‘Deepurle de divtrbut in stinitate sarin tn exclastitate eit Allright reserved, Te dstetbuton of this book outside Romani, without the writen permission of ALL i strily prohibited ‘Copyright © 201, 2012, 2014 by AL. alturs ALL: Bd. Constrctrior ne. 208 sector 6 cod Q60512~ Bucuret ‘Te:021 4022600 | Fax: 0214022610 eartamentalditcbupie: Tel 021 40226 30;021 4022633 | Comencile: —_comenziallro sora Redactr: De. Blanca Vase ‘ehnoredactre: Livia Stlca Covet: Mihaela Violeta Dumitra Design coperti: Alerandra Nowe |CUVANT INTRODUCTIV A sci un ghd de acces pres mun sib tn nt i vil dell ace persons sno sje cf pg dein se pabolovanal eareserosiogen din outn al test macs eb lade Bincpa desc ae deo fk pts termina. Un stemenes seenari poste Bexapat in let, crrea deme pcre Tam batt Pst at de apie gd nar wet progres in domenl ‘Hine mediamenflt inca as terion apt iil dj ap ftenood rap ao nou gnerabe de en tempetldtiatn no produces ns pe pa Smart, descnpest ok prop le {oer subeny-a deseronele rea aden ncn ple pent “Amconerpa cs hide faroesoge conform carl in got et tw nla posed santa, pnts aie mela general dae eve sen mae tind a dim o rte prt pga L Loctres et strctart pete sens, previnte xsodle nan de ‘avant 1. GID DEFARMACOLOGIE GENERALA 2. GHID DE FARMACOTERAPIE 3. GHID DE FARMACOTOXICOLOGIE Devin ex hil elma vitro een mel asst de {armace am aor un pf nal e~ ane redo atl cet - pe i generale La schimb, a cosieramporant ent aivises perl Tatmec-sntar am dat mal rare devote ia ele programa de laviindat ~ indie de ile contrandetr eor de administrate Stele adverse, cae unto pa atten ei visa blown pe Fea: Det cu sal de a conten eno i a ote nein de bk ale acest die dar meses mee a ps sh sul cent pe ceca ce aie medal sist de fami ol in mans lor inept cu mediante, dec pe formar se vai teoretce nh dar mal pu pia Din aces mot, ecunea GHID DE FARMACOTERAPIE aps caro mare putea volun,(A NANCE, VLADIMIR ARTA MIA In eptrt ca orine eptselr din seu GHID DE. FARMACO- ‘TERAPIE am conierat neal modicar nde pan cade al oxi ‘mantld aemacaog,aoptnd o staan pragma ood node ‘AL A float in eal mare partes aera ices AT (Arata, “hepa Chal Cafeadon Stam) spats de Ora Mondals 2 Sitges ans nomenenorle de meierene df nowt dln ati Evtnd stl enamerces arr deter dase grape de {nedcament, casera relent vsne ord espe sae gamed ‘Soe trap de tote ere (eaves emote eine), Se ecade “SHG, o pecepete ole a ace imens omen se pate fice med ‘adie ocr agen terapete now ape a apo rela pine ea opr struct u Ta plo ale per tote ole (onde cod ‘le sbud®), meicamentle au cpt ee cod lo, fp care aliens ‘Suse rc! subne~ pin splat a end = ds, grup ‘abgrapa rapt dn ue fae pte, pein compara cu subtafele Invade, ex ese agonist antagonist Ton peta ca eta voluma ‘preci eine mest acd sf tn tex a dale [NTC nu fst iat ora cle gop portant Atagem seni ck ic a unele aptle teri reetat dpi cada sti al programe ‘nlc, am Ret index tun mana Indep ete 0 sud {informe desis ok ispands ier (ager, previ) cast ota cre stud Am ct, tle of antici dora neva ce Info itoro, fe ot et seni medial, ssn de armale sab ua prtesoat! ‘Urmiodexenpa anor lc depot din ale a intrdus wap spre pode bilge late In erepetcs anaes sera heterloge, lnmmoglie mane peti vccns cla dae acs pode un rtd omen ctrl de medicament propria ni Ameer de ctu Fate i consei am crest an capt separt despre ogres 9 aco leg de eicomant care fometat blct de stad pena fama Colegiul ptr serviced psa. \ Tcl ce cpt nero cnopnle pce tn mod pei seaeriatadtelor mela st moar ole nate lor medal atria moajlor at nla mean od se [sie de frac x formal fate ator de forma’ tel Inc prin sroctrs coon sb, maa fe ul umbelor catego. (Gade dee dea trode doa ghd de pepti, pst din ‘one «ono prepare ner (ete vorb de roduseantinfcone de ut stone necube- exp 15g de ace ejecta cap. 7) 8 done ‘otek inactvata paced aviteardr ede medico sunita Not important Cale AT, aml din abl ne de smut denise pein ounce denn oink ‘icant NU wtie eort cua cate tte errs ‘complicate detaees spun dn tte prea aos ‘Ere cu cop det ml ot it el iris ‘nme tnlneer loune + ade especieCUPRINS ‘Abreie snob sate een 1S SPCTIUNEA . GHID DEFARMACOLOGIE GENERALA. 1. Nef tod 1.1: Domeni principale ram ale anmesogi nro 12. Caeaten ATC 1.3. Papa forme mace ate eer dima) 24 14 surge onto ptr nedaentt ee 30 15. Farmaco dapat ermal homeopti ne 31 16. reserpine asiterlar defarmacio— 31 17. Nomenltrsmediementlt nn nem ey 18. Grope portant de substan nt farmacoepic it tonelogie eee 2. Farmacocinted generale 3? 2.1, Gite deaminisrare aber mediate 37 22, Disuibua eines medlnmentsle in ogame #0 23, Metiolare leprae medicaments 2.4. Timp de lt never 25. Dorarea median event 5. Ghidde admintareumeicamenion (te sister medal) ‘ML Repl gma 132 Admire mecaiensor dew stem 6 95 Admiitire medcamenlar ew tpi eal) von 2, Administ ttmentaat in nil pale 8 4 Furmacsoge molecular ft faracodipmlermnennseronmns S {i Famacorcepio nnn nen 42 Atal 463. Ttanerl en membrane nee(CUS MAK, VADIR ATA MINAS |, Neurtansmiten (mein eit) engeno TB ‘5 Meet tema nervos eget SNV) "SS nerves simp (otaript) = mena aden 76 132 Seal prsipati~ deni iene BS 38. Siang pang nen “SECTIUNEA A IFA. GHD DE FARMACOTERAPIE.~ 6 Medan aareaa ity (61 Mediated antlers. 6, Peper cu eonime gestive (408) {8 Metleamente penta fection eptle [A 05) — 7. Madiamente petra bol de mats st metabolism. 721 Medcameste uted 8) 372. Medieamente antiabetice (A 10) 73. Media hiplipeniants (C10) vo 7A Vitae em 1.5, Sobran ner [A 12) 7.5 Pods pene nti clined eater 279. Sol em pene ati amen) peel tndovenoaed (B05 BA 17, Antonia ql upimene mente 19 1 Medea singel ‘A Prot eatnenn, {42 Masai athemoreie [B 2B] 83. Antitrmbotie [On {U4 Prods destatede sng [805 AN] 15. Soli macromoleclare rebtinentede plat (pein exande" (B05 AA. 93, Medicamenteantaric [C01 Bn env AB 94 Vasaiatatoarcorpaiene [CO D) enc SD 9.5. Nadas nthipeenie [Coes =r Cscarea medicament sthiperensie dap mec de ace an 10. Media dermatlgil Forme ume se mica de ape Tndermatcoye (toa aed fart) cD 104 Medsament sntinfrose Gee dematclope (ples) [01D 6) nnn NS 102.Cortensteroi dew tpi ca [DW] nm NS 10. Antsepie devinfctante paz pe [DOH] 165 10 Prepare peters lee al pe [D0] wromvvoo— 186 1. Media peal ria eT) 1. Diattie (C03) 12. Antepastee nae [G06 BD]. meen 1 113. Atiissice urine [G04 BC 606 BX} 70 12d sparta gent feminin (tater mong nm 1 121. Medien ntfs de waecalgeclogle (G01 Al e171 122. Apo ode ¢apen tcl, mm 1. Hormonl eral edie contacept 175 1344 Conmaceptve hormone eis [G3 1H. Mormon! penta admits ste. 14, Hormoni hpoes ihipotalait 501] — 142 Corcnuralt de ster [1 €2 wer 143 Harmen oii! (1 05 Alanna 144. Anthormei eden! [103 Bo 143 Hormonl puna: [105 A) 146. Ahhormoni paratoien [205 BA 147, Honmoni pancreatic 04 emer 15. Produ antnecowse de wei. 15.1. Agent ntmrobienl (atic Ff) ee 182. Tabercloste 6A m0 153. Aatifiungie (atime) ora 01544 Antec dw semi 05 ‘Ghd de prep, pare adminserc nor produce sninfeone inet (toa aseor medial) 16 Prous lai flste pent maize. 16. Imanoglbuline wane 0684). 162 Vac [Oho 17 Anineopasc (medicament ancanceraa) 2s 171. Gosate (usaf ete) LO] 28 Mecanimele eer acne le ction — 288 Prince tone atest farmer fmattaologl on ee 172.Ghid de prgitie, pst dminares uno cote ejecta (natn iter ea) 258 173. Masur de precaueis ers carl de chimp 964 Ce 18 nomen nn 18 Ao imunostimalitoel 03] 182 Imnonupese [LO4) ene 19. Medica part ocomtat nn 194. Meda antieumatil von 192 Saban merdaeateperierice (curred set) (903A) 193, Medici eteopororel in alor cask ‘nne derleete [M0], 230 Aneseie pl amalgei 204, Aneseie peal [D1 A. 202. Arete eee [NOE B) 203, Analg oplolde N02 Aj 204 Aralgesceantipeic[NO2B) 205, Pode impr igen [N02 Conon 21. Mezata woo bol pelo mn 2.1. Medina nile (N03) ‘Rega miss de preci cal wataent npn arisen meal. 21.2. Media stiplinoninn (NOM) 213. Media anvertigo N07 Ca = pater 25, Sbstantaniparntare nsestcie. BB. Protonode [OI 232 tiene [P C2). 233. Eaoparetcd (PO) 24, Mella apart expat 241. Expecoane [ROS CA] 242 Mieaiies [R05 CB] ccm 243, Ams 05D) 244 Media tite 25 Alege enn = 252. Antisainie dr ste [05)_— = 2% Mean organo sent enn 261. Neda ofall [S0)— i 282. Media flog S02. - 2, Deanfecanteanteptice 17. Dennett dew elke 272. Deegan nan RL Medina opine 282 Medina vail nor ‘Medians alten mod cuentin grog gene. 36 SECTIUNEA A II-A. GHID DE FARMACOTOXICOLOGHE.. 29-Elcte ale meicamenilor in cs sca ligt nate moazlr 399 28.1. Foc decal medicament curl tla 339 292 Vaccine In sal suena nr \ 293. Mediamentein pends Sapte ‘M.Ren adverse (fete secundar) ale meicamentor in etefia estore wma = 2. Rec adverse pein Hosni 12 Reach advene pin fete tance 33. React adverse prin meen lis 3. Interac icmp medicament. 31 Mediamente alto aoc este containdinh vo 357 312. Mediamente are prin ascere ura modi Me C0 een52. ates oe sn 3 "3 Intnl cu dierent nc medina) on 3 a ae [33 Gh detratamen lorie cate prin ingeare {in gener ofa etre nem 38 2. Drogut pent area nn Si es eal 232Dropricescjne derma rapa Gehl ero8 Aten 33. Drogr cx cine islet espe [Sha ere centile 3B 334, Drogen. —veen =n ane {5 Dilete aedogut ves 0 een ABREVIERI $I SIMBOLURI FOLOSITE IN LUCRARE ADH (Anihrtie ormone ng) = hrm nsec - herman ‘creat de hipoulumus toc! in nds hpofedpostiar,d unde ete ‘Sibert peintrun mec de ecbck, Ae actage stricted zor ae tn bl conto tl ail elector din nih 'ADN = oid de(nibonuclse (DNA ~ een) = ai ale x l= al land fom ister ou aj Ing) loi pl), comput din pumeroare anit de mili, Aces sant lube ecre finite prince (adenin uti) ane prince (ctv tun), penton deloxisbor] aed fosfve. ADN-al exe tril dia ee se ‘eemeas romesam parol gear as mpi crate rar le rgmisneloe 'AINS = anasto neteroiene Din sent ci de mediamente ‘acepereajortes medicament eeu cusp oricte ror: ainsi, didefna,indemetacnbupaen ee ‘Al slumisu dlameat chime meta it ub orm de ru i merase malcamente alert. ‘ALT= lni-aminoateral ~ st esimate delabrator pet fui hepteInhepattel sete ae vlna cece in bec er demu Tarmac. 1 ARN = ci bone (NA ~I el) 2d mace cu molecu iat monster avid componente ssemanitoare ct ADN, da ee cine ‘ou local defpoceoaet ral noe de iin, ARN des fer ‘re protineo din cele, apt program iscsi col pei [AST =asperat-amintalrat tet ensnatic ert pest fn iaheptc le hepatteae valor ml reset in sates deni TGO sas on. ‘ATC (Antonia, Tepes, Chol hen) - clara matic mec dpe in rine acest) enrol, tapeue cic "AL =szivenirelt,cn banceany, uapioug nora MAREE (ceca —set ies fore espe el epi gin dee mediate {CaCl done eats uanun ae -prput meet aa cre meen so pers ba sms ee) ae 8 ane ah in gene “cs do omen china crc eet trad in compan de feces neha de rr ends O9W Cer Fulogie yn sa ‘rh rode S30 ole lr hipero) slide ora de feta 745% lupe ole Rpero), in solange Sr pests ‘Eiaare or (ORS = Ora eatin Sth enh {CY = comeplovice snl ae pode come, tone sigma Sn le es we aml he otha cena WWW =n Wal inne be ogl sa cada ie eet creer ne ECS) wn he= dona nd n compen we pus gy gtr Mek nde Meh ol) = mas eit come ean coer hl apa) wr mde as Pfepanma p ants dt te pip col AC, pn xl sae sup iron il ce Der uj) ANauGteice OmoMDE(ND Aut bats SevenSECTIUNEA I GHID DE FARMACOLOGIE GENERALA 1. NOTIUNI INTRODUCTIVE Deine suexeuicaTIE Malice sitencd » melee caine le distant supra ana unt organ so ster aus nani (Bose es or, ‘porioaele cle injectable Lm x) None pas et mai ly ce cae anes oe ‘Prparateglonze = prepare famaceatce standard cbjaue din plate su sbsane mineral eae septate ca stare (0 singar eet a) ‘Sin dlrte combina se medicament Se presi ea poles ens, ‘omprimats pl; extrac aide nolan lide; ung, ceme spe ‘ol pease hirealoaice a ceria opr ofan cei ine ‘er ltr eine, maclagh (tet ais ara prep ie (ese Tip = ne meen a iit not 11. DOMENTUL §1 PRINCIPALELE RAMURT ALE FARMACOLOGIEL Farmacolgi ten cree cop cx origina medicaments tara log stetira cn, talon sfrtetnoraiem,meeniemel dear tne. eft benefice noc preci moda eile sor in acti Dace. Ea cupnde a alert cre tdi sxte dere sper,ans MARCHA, VLADDUR MANTA MEALS Farmacocneia soc i mje (eet) medicament nog tm, abnb, export ueearea pin membrane, dsb in fee ear ogee, em de cine, btanstormide (metabelian dkeyadarea),precum eliiaure medicament (elem de elisa). Tarmacodinamin set acunes mediamectlr supe ltl ‘stor rane inteacgune lor or cep pei; dtemina exper ‘ena lorlymecnimcle ave saa ane entre snd cle profes do reticent organ, Tarmacoepidemiloia re rept ole tcl de medicament te 2 entindsle medicament, pec fetepoie de olay cae ot ftratecu anual geo teapete. Farmacopenein fe sp de iil re tr eet apa (cecil etde medrese "Paracognoci die xe, propre ie chime 9 prepa ‘are medicament de ogine vegetal elma sr mer. Est ora eco de imports pent indus freer armacopralarcepar) preter foes de prezestarea medieamen- ‘og ste repuie¢ mole depres alr. ‘Farmacolois molecular se cap.de meansmeleatine de mare fee incre acinees agen teapet! famume lanl de orga ele, ‘ceptor gleaale membrana, snaps, ezine, seme metgeesecundare, Seed dlertlor metbelame te Tarmacoterapn ae dropt oie (lara mudeamento in practice tl olarl lee egle nel etmple ecamands terapetice Infante edt despre fies bola, Tarmactoriclogia se onip de real tere (late ecandar ne oct) ale ecamene poem ide imositilemediexinetoase ater Inara! indole se opeedvii. Farmacovglena (ren vec al pin tit) te deni at ‘ates rin ere rate vere fet oie le madiesmenlo nt ine ger canoes, imprean ca miloure de preven sett oe, ‘lfarmacetiea (beg Bopharmaces) se orp de rele in tre propietieilo-dhmle ale neato acitatea lor Bogie. “Treble subliniat ct formele cristalzate sou amor, mkrimes particular. na rexcplentula metodel de abricare sera absorbs, bodspen tae chiar etbozace aetunelr nora. Palofarmacoloia cx damental gen erspentics foe bolle tubustlepstice(maeamentelepsotrpe) Touieologi= isjacare radia rattle cata sngtomtlola Acar tect pment decombutere ae nly aniture) Are Tepiurco medina els erin, 1.2. CLASIFICAREA ATC (Anatomical, Therapeutic, Chemical Classification Sytem) ‘eo lsifeae mute a medicament, cae perm sue tro ‘categorie eer produ lat i sco terapesti on not along ‘ele te crite mena a denunie (anton terse chin). Ce ears liane an est do exprare odie, abit conven ad- ‘nis frustrated pecs [NIVEL aratt up anatomi (paras ster ae sex ese expat oar nl, dpa cum aren “AC provine Gln Alimentary ac and measly) ~ copra mdi ‘eaertl per tte segue ate para diy pec PC ‘cl cae se adresee olor tuber metal de nate. A wt Inds ate dpe de nie vance 'B (del Blood and od foming oan) iacade medicament wise ta oe sge x opeor hematopoietic, eceptnd ctor ulate emopaie maligne U ‘(dels Cardoesuer tom) -copsnde medicines inn ci cali! parece (dela Dermatol) copie medial de pein ante oi, trode panini deus oa 1 (dela Gentosrinary prom and ex hrm) - apne medlameste ptr fine spar uriay sl apartl ental marin fain Cnc penta tratameteaninfeoae lel), pram heron ‘exull pent abel re NU cone madcamete fore Io ater ‘Shemial bollr ca tanner esl Ble ener) 1H (omic hormonal prepartion, edn x hormone nd sles) socop de repartee hormonale eacepind hoon seal [9G in salina Al nt neti for steric) ~ caine chimp nbs a ‘iro, antmiaie,taberelatie, se ne in oe de admits sistem, Cle dewzloal 3 AD #6. ‘L mieoplatie and immunamddtng ent) ~ alae tse nmaosuperele 1M (Gea Musculatelaa tem) - confine nediamentle andreas, alec bal encore ale bllor muscle ‘(Gel Nervous te) nce tte moment ct sarees ‘ex ros cents ero peers never esta. (Antares roduc, ce and replete sane paar sete repinatoar de ntch anezay, Uap RAIANTA MITA 1 (ee Repintory sate) ~inule medic pena txt segmeiele sparta epraoneceptind anode infil oper re ster [> J} At un incase lantistaninete de we item: "Sele Souory organ) copa de adres anlztoull aul (oreprteoflmeloie ce pet analiatorl od (rose blog. ' dels Various) cone adc, agne tet ptr baler, produse dec, produst stonutloge avenge Asan. li (a aaj) conta pet eamenle nope (alg CT, RAN, exe- ne ca luasanee (ogni, enmene ea pei) "X= cupinde prodrespterpis (pe bad de mee, terete ee ‘us ate produse vegetal) prepare homenpate. [NIVEL at enolic ina rap rape peal gon ‘et Tnadligae dou ie empl ‘Roster hepa Nas Anges NIVELULl Lal cod sl pe sop type rms teen pin sdapres unlit Eel tire ea a) ‘AteA~ Texpeb, Bg A Peps NU2- Astemie ete, DMIVELUL al Vea syrup into api rng co ‘sip else Eup Gotten corde ele eee) ‘AGS AA™ Paparaciii ‘BOSAA Prepare ca ferbalent ole, [NODBA~Detna eed tae NIVELUL ¥en cou bea pe subrop chink ioe capi pin doce nents seg Exel ere c) TAG AAGT- Acteseodemcce ‘ 1.3, PREPARATE $I FORME FARMACEUTICE : (tn atenia asistenilor de fermacie) 1.3.1. PENTRU ADMINISTRARE PE CALE ORAL ‘Preprate forme) farmaceutic slide Capua cae dean pverlent seh et cont = un mice sl (one cup, eat in aon peli sa che- un. Capsule enteroseuble (gstroenstent) sunt denne se diava ‘nunain nei nd tel teen tome as acres eiamey {olin stems (de exemple, Beeson) ™ Caps gaint apa mln are conn este ner se sonar ell ein esti. Compra, nae mbt acti ingroup sina orm nl die ml ~ Compra ferescont tablet forvscet uncle crese dias perfctr in pga ie le de dnd de cabo. ~ naj propre ad uo od volui snd us owl da eat in ahtr rae eterovluile set ave eit sa gets Sind decane dla aa initia ~ Fatract meals fepaat obj rn concentraea pi lau anit dune! sou extractive dat-un rods etal au ala avid ons "euler cua conint medi raph de 20% "trac solids extract wet: propa eta i oncentraea wet soli erative afin dint prodar eget ss ania cae ste ule ‘hein ap ama 56% (decxmpa eet aa eed). ~ Granules pata eld mic ert prin friars une bale soldi icarport mah in str ~ Palbere: prepara armaceuie sald fut fin vat yu aspect one egitim xg ube Sil ppc fen tu de i lai dp igh subst ac substan inert (genera ete sinning fscomprimatl = Prepare armacetice chide = Dect sole ate, out pis Gerbere ne abstr med cameos in ap. “Batre id: preprat hid bina pin concetarea nelson eave dst-un produ eet su snimal fare in genera ml east d= ‘espunde lg satay modiamenoas (de exempt exact id de). ol buvabis care contne medina in soit peli foe eft e abe apt (deexep, Skolt, le Dea 00090 ‘Tethers fol bore coining cont eros + cont de manga + gcont de copra) Ati El este scp) lamba apete NU pot {bdminuetejecailo ara pe ee rl = Infne(alianth inspec In facia nai): sae exact sonst jin dn proare rg meni un sant inp cota ‘pa atemperetud ah, aproupe de bere,Macerafe (iain pei Ip farmacianats):prepartobfint prin sinc in poe 4 el eubtane Yeeae saimai n scopal trp pico ache “Fpotane: om medicaments chi, care cons tm medicament sctv delete operat nap cu ada unl corey de sic sop 2%. Sop: fron iki esc aitor de medieamente ae ean congenic Slate de intern (ural), In cae saben ci ese ere ala nap end a eid ar Est solu ae Se reparh dor in ‘omental cpl tamer prin dzalmseamedleamens rat sb va de pers) In ease de spe (eventual fart ris) pecan instruc wr aepeni in cae medicament xe pet sub fom de pate font enon nan cha (cee talus) a pase depune fal ecient Se eomandt gars Gaon inate ce dist Exist aupent cae se pepct arin momeatlincperl taenta ea ‘espendaesmeleamenas (a ul forma e ple) Into natal ‘ate desp = Tinctar: medicament bat pin dz alco» mbstallor sective dito lta ea un poodu him (Se nem, unt de bdo, ear evar ~ Ue: prepart cae cone sia in fom hi eb pone lui (de exemple de psec ana Dy ul de) 1.32, PENTRU ADMINISTRARE PE CALE RECTALA fos = Chnme ca sla xs cu spent (2 exemps Dara Desa — tabu usd cal), Soponoare, ere medicament incorpont in ut de ace fl ln emperstire corp (2 exempl, Paracetamol septa Indometacn Spesioar). 1.35, PENTRU ADMINISTRARE INJECTABILK (clo parenteral) fone: ~ Soli aponse trie n einai: In one de sabstana et coojauth uncles sdninistest x, allem, alle, alte pe ater a (de exml,istline cu ace pid). De notte, pretest nam Sunt nec vce pl iets gtr, deoarcs seas Sunt astcable Art alte ese erat print-un crcl tl bo Tel (ea dee se rape) tp cop unr fe ete desta un pase de 3 ‘im danetr local unde tebe pict pollen moment per le {ig Facn teanparinantan compartir peo a earl a ‘Sheri ese serps ep en ter ecomparimer near {Greco neeamenn salam spar sal rn psp ‘crn pa done nn gigs nc,= Solujuetouse stereo fle injectable: sunt pee nama Ln erp, enbarbtlBl). 7 Soli tere perfaie nace PVC a In Macane del uot slope atone ipertone (Aen, sll hiperone taba ante int de amine) de electra de con, de aminoacid bamiog umes. ~ Facoane cu plbere dolla care ualiares se ee extenpors ne (i moment wish). Vlabaten slit devine nit din no ‘peut foi econ de pstare der, ind prec n prowpet ~ Pena c sola apone tere, Sent donne ta form eau ca sc lnvirf nde canctssecsr penta nar se stable manerting © ‘ou acest ania pare aad oe eet ijecaen ee pode rin apres unu buon (de exemple prem) 1.34, PENTRU ADMINISTRARE TOPICA (ur extern) IV AFECTIUNE (CUTANATE eat entonle pepe ~ Crema: prepara seal comnta pisme pate 10% bint prin mulslonares usa rs cer ume cv pt elec sn dirie Ingredient, wat in cosmo mec penta une pes ue me cease (de exempl,Clotrinana cre 1) ~ Brule! prepare! hi ince ext spose eesti fi tebe "Gels repr! semicon pe sk de ste clade wnifarm i peat avid oouecare catia Sofie prin presptars pnd deo Folie de col if (Ge exemph, Narfen Ge) ™ Linen prepare bid su semisolid ca ope anpede saa lips eos penta fc a dere sl nee (exemple alec . ™ Past frm de unguet are comin espe spd propor sare (in geen eeu ce pln 25% put ~ Pabere pels prepa ld ia diac sie omogen (de exe ln pide te). * Sarpealc fee medics in pate ne (pele). = Unguents prepa firmace emia in ee seta at xe corporat in-air moe temperais corp (nein Jano. pcerin sau deemed rim Ext ange ioe (ure contin =p) angen: ob (a pimes op) 1.45 PVTRU INHALARE IV SCOP TERAPEUTIC LOCAL SAU st mt flo Bova mana presse (ray, MDE = mtd de ner in sal rn contador bea 2 cere sane Sueno bua secre ae Gedonete dpe, sen. Soli petra sera (ep Palmoryme~ fle cu sae ‘halatorie, dd. ta mucoviscldon ) me "bt en ge = Datel note gn a presente general inher (de exempla, Narcotan*), = lt PEVTRU ADMINISTRARE TOPICA (all IVTRANAZAL se ~ Aerool zai: ena a Bsconne presi xp, Oya ae. re sp, Oly ~ Glas uae: sant sstere cll semicon, dat are al Inca fara peat repent total. = Solu marae deux extern: ef nei zl (pte x pipet (Geena Ring, 1.3.7, PENTRU ADMINISTRARE TOPICA AURIGULARA (el) (nae ~ Soli otc cu decongestonante analgesic, antieptice su antibi- oie: (Seep, alga’: otk contain Ioan Uda) 1.38, PENTRU ADMINISTRARE LOCALA OCULARA sss: ~ Solu oftaimice stele ali petra insta ocr (Se capi Uni’ oinodeflonci. ~ Uguenteoftalmic, care sunt de el i concentra mi mi act ‘tect (de exempl, Zvire guest ofall, confind ecco). 1.39, PENTRU ADMINISTRARE LOCALA INTRAVAGINALA se fo ~ Comprimatevaginal (de xem, Clara = Ovalevaglnal (le xemp, gy, ~ Sou pentr splits vain (2 xempl, Micona Boob) ~ Crema vaginal (2 eer Lome),1.4, MASURI SLECHIVALENTE FOLOSITE PENTRU ‘MEDICAMENTE “oa 1.1 Ms leben tae in farmacograti Pe bare at mips apne y= eae ag = Tg mers OD ise eae [se ea igs pe [ester 38 i etarpibae lene bss i poe td i i | " ists a a Sea hae) ee) -Ta Tats et mn iaigisuaiaeyoat-1g [ewe kde ta [apa spe Isat Seager Ikgresgmnceioes| gon re gous [mer gst sats nie omy sya fasossth alge eet Pee aiaitema eb eer ‘ia Bi aia ge cf [sree psazal coms on [srr aaa pa a ‘sm ae aaa ee una ease in [sme tne =o 1.5. FARMACOLOGIA ALOPATA § FARMACOLOGIA HOMEOPATA, aumacolgia alopti peach dels principal de bat un medicament fcce tba prodoch espe ogi por an eft inves det Cel pe cae earn bal inpotia cre et recomandat Alot te ea mal spl mands tepals fe obit pert hc Malian presen anise madi eset sarin famace log slopt coped prdase marl (aie vegetal anal a lh pote pode nt nga ‘armacologia homeogti pect des prinpal py amume un e- iment ence uebuse prods apr ngnism sniton aco eet (cele etuete eno impotria cir ste comand Sine scar =celecare sat semaine vind alte cena). omeopals tlizen dept mar pene perro mediate tae x tease din pte orgsnisme animale, prodase miner chine wate a Aa progres ep zeal sa cots Act dite fan ed diate iosetve (ap aol gern, plbere de aoe Als de ese sac nel prodaehamenpte edt inatiameheameatle (de ‘rempl, Oscilcoccinum": pods angrgal prea ib ford de ble ‘are as ede et ease bel). Ta er lc vor ld ‘bare pune meliamenthemeople 1.6, PRESCRIPTIA MEDICALA (in atentiaasitentlr de farmacie) \ _Prescripi dil (rta poate canine peprte medial indai- le foul finale repartea cror compost ee sana narra ope) sas frmale agate, caoeepate de mode pin sais mn ator |. substan to form amacope comin, ‘Presripin medal su Somat de ref ete camer pe baa crue ‘aemacineiereari medicament, Ea cade aligns motel im oven ‘superscripts format dn: ~ seta rete unde gues insta mele (aint medic n- vids polls, ceatral de disoonieptaaent, pal) de ude te ~ re revit fn frmlara dee nde ae ompletents anele ‘penamele pues, ss~ ange spc pei unde ese oat niall boa sna in tpl de connie mums fd obser in wade digo: 4. ume pecin propia le pat lt 1 unr pearson = prime 6 aes pesca in rt ao ral eft ee, “Time: melenestl preps eae: 1 Mepis etedetna poco in rma tb se pit metcnestl pets pace admins exempt Ms = Tie ttn ntl vac en si, Aca nd ‘ies necern coal onl ogi ated clr soe Stecancstor cre ele pepe, vate, Sete, cea 0 mace errs pte aot amine pce, cl podtor ‘sl (ormle fen) abi na est nce tcf cpnde nda ie esas cr ‘wi ft endear Pes acuta perl nile DS (ela tre sper, nn aid ~ snes) Ba tebe ede te pound ace pesmi dent clea ue Inc bk Tire pone ume ntocms 2 een dat preseriert ete ‘Lint semare peated ps tampa aii store desndes orem "NU pea one ecard tence ees nate aiork amine palais, repre csi mineral eine {gue aims sient alpen mje e- ‘Shimer amicus sate pee pot etre ace m0 ‘Otc ell In mod ibs presnaes eel prs mei aun exemple for magia net in ora oss Visuals \ on aa ice svt Gauri) 1V Sle 25 mg (1 100) Mice ft re i nla ca he 1412 gs ter oe a 117. NOMENCLATURA MEDICAMENTELOR (rice medicament et prerenat pe pai sub desire uk comercnl snucit pe stbolue™ epee mar) "(rade mar) care sn ec Pec ete mii reap rh de cet denice esas epee prospect plane de ecland artnet Dedesbtensaliiteulesapert §idenamiea comand internal (DCI care, cep sear medicament Ingo categorie ine delat pert derenem ramroaedesinoine sb care eal spre exempl: Pace” (atin). Cosiares med amentlor afc, de le, dp DCL. Din eet te eat ch a ep Siac prorat este cunostres medicament pins noninaat tb cae spe pe ais cpr crt a oe pe pm ioc DCT al ‘urn parame, debi comercial cu sibel de exempl, Lineal (Organi), Se pone observa, ck demi comer sn ester foarte sopsive peat compo aun sau modu de sinister ‘melicament Esemple:Aminoven sai desmnoac pers amiisrare ‘he Asmofugs sole olf ansinaich; Ant compeime de cabo fm de alice fee de neuralare a cts cell gstie;Conrae seid valpo ndeat in epllepie (Qrevine cre de conv epg) Intra exudes pert adminicrare i Resa: comprinte pe bind de naproen, date abl veumatnale; Heino eampeimate ‘uhdminiee (emi): tag sole mace nota medi anges ‘ib Tse? sp atu: Tusincomprimaeantanive; Vermigl: pension vermis (hein) ee 1.8, GRUPE IMPORTANTE DE SUBSTANTE INTALNITE IN FARMACOTERAPIE $1 IN TOXICOLOGIE 184 atcaLorzit Alessi sunt state nganice de gine vga 9 struct com ple react bac contin in leu aml dea foarte ee ‘Bacodinami Indo mi arn done mar toe, Eth ae prod ‘nee. Emumerim ali cel a dent. Ateopna slid lt din mirigank (Aap lado) ae pln- te slince, ate acne anclinege pusinpatilie), lca ma Colaura nee act ge ii onoarinar vind pei eet ‘mri Indore mar ete excita l SNC. ~ Chinidina sled din scour ror chink (Cnchona oii exe un ome el chine fost in earlgie ca antneee antennae ieesaetnmeemnteerice tas oes pee Soe eee eter err ern tociecnaecamiacnanetrar reese eet rear acaic nara oa ed eau cane armicenetor ramen Pepe gher ae are Spaced econ rage Bioee Ceeicmoteearteen Samet siccienansprats ee i acetilcoline! la pla Srinath acer iat =e Seta oer ee abana onan opeieceree rent je tent enchant reer reer ee Cea emai ee ee seaerer rae ttn eee epee racers sees ras renee Teena ‘paternic Folost ca dro de cite toxicomsni: produce dependent (morltio- co aoe seer gua oar ear aire mong ornate esata ate mee meee meetin Paster Tae mecgiaeatee ames me fi ~ Nicotine pricy eal di ttn (atau tabu). Crees dependent ema mar devine oie, vind eee praise espea temo neuronal dn sited nero een (fete pnglplepic). Papaveria, alld din opis dar pepart site ae scant a0- past find remot al muscu need gasoline lt a Sind de olonltai oll! intestinal bare, lor are ~ Pilocarpng, alld din arb Papas brand ete sober celine (psinpatconimet) inden afaloge ca ttn = ‘lampsacom pene eae mis (jones pup Pe cale peal ‘Se wa caida toxic co stop ~ Scoplamina (hon), slid midi in wel lane solnace, cleanliness (prasinptaiie) anime apa SNC ‘cones ca depinant moar sett Se se, prepart mln a ‘msfcamentl Soba zat a ata lear ier sire. ~ Stcnin, av veel, dol din Syeor max voile tn ect pene stuns et otiant tant In dove mic NU se ose in pret in erpestic, -Tubocurarny, alld vet arte ok proves plants Chon- aden tomertci, ee ean paraznt a mca site en ‘loare setlsine (ate ste neurtranentorala plac tre eal seurmascl), Detail sunt nent x aja in area peer, ensue une reel mca complte (na! dct below onectt n sapot vse ar, ae ar mrp pia pra ‘irri, 1.82. 61100z121 {icc snt subsartede crigine oil cae cds prin it ‘in out componest:o component loft nuns mal me monn pute dm gS ae a ‘macolnani, cu un poten eat Cela pic rep rope lei ga un sant oa din depo (Distal purpura Preznt find ct mira aia. a stacserapla oder flne digo- inl extras la dee nes (Digan) care, ato popisior ‘ale tniedace one nde in ines cardc tn nee aa a ‘uli (> Caps MEDICATIA APARATULUT CARDIOVASCULAR 1.83 FLAvoNoIDe LAvINE) Fino repre opr de abn cede ppmen g- Sent penn epson sce rele hacia ce oa {3 invnd in compo sor models rane Dineen rp Fare bof (tami) evince io nine ne1.4 PRCTINELE etm rene mi i lt re ee ra nan dnl pssst in ind ent ‘eS pote repre all elon ce). Avg pope ‘Sine prn e mano in tenpetic oii ine. 1.4.5, SAPONINELE ‘Siponinlsentsubsanc e xg volt careasinleszalorocom- poof cen overdo) ons meg hon cu tocar Fel Pipi compu ster din membrane a opti tion ‘edt find osama peste cd val in slo oath el corps Frade fe oer dinitrate, EiGjone tot 9 expstorasa pe ale nj decane berlin torte Se aloes pone slr unde sspens eos resus es deergep, FARMACOCINETICA GENERALA 2.1. CAILE DE ADMINISTRARE $1 ABSORBTIA. MEDICAMENTELOR 2.41 Adminstraea pe cle oa “disatraen pcs orl (er 0 = po) execs ma ferent -Absrbfa medamantlr ae Joe elites sje special in ‘one superior unl Ea ee fret de diva sa upendares {evicantls a ap Absorb poste imino de reser lente ‘ashor medion acompatie ye spar are, Sod geste pin ‘seh nestalasant unl medesmente:ecaltlpeiclin (pea line} lreting, nina. Die set mot se comand admire anor t u Concer init peach ‘eta Seeneleamente ptomacl plc spina or nan eso (esi ‘Vamplcinh, Damp, soba tate penta mace pais (ed cats pede, defo oate elt entinaatoare wet Alene» AINS) [> Aatnfamatonremestecoiene fn cep. 19} amines ‘media Guph me pe stomsel pln, Une medicament ane nt rene {he sub form de ape etre (gasrorestat) ae eer - ‘ete atv nana oi, rnd arte smc (Ge xp Bicol). ‘Tarts cape patrons sunt rate medicament cae el c= eer eunuch! ital (Se exe, Budesoal). ‘ale ol denies contandet incr de visser gtlger operas stare decom 2.2, Adinisteaes bing ‘Adminate sublingual (6) ze avant ck sg nts et nea cule oclind primal pss (Wee) ri fet. Se lot ents Dine meat cae st acponee pee sec Dinan pte [popu de colicin ils patu acne eornarodtaoas [> ‘cottoare coronene nap. 9) 2113, Admintrare rectal “Admins etal (po eto =p) tien tt excuse = cae (modesto et pnts uelemedcamentcare treble [3 cfnees in dsianteupntonreantermiecuamlnoeeren (praca ‘nal nce AINS ndometacn, dfs) NU e laces etalk {ncaa dierent anorectal exeptnd mdlemenele end ‘Sie deadninerae losin retool ulcer emorag. 2.14, Adminstrares prin injec stbewtanate ‘Adnstece pin bj subeteate (ee) ete ost pence media mene hideslebe nant lector pre cera iz ih clei Jel im mii, deoree gi engin et rata pack neti ‘eat coset In blew sodroamde emorage, douse dc a Formaves de hemaoume locale 2.4.5 Adninsenea rin jc intramnscuare ‘Adinstaen pin cl treme (mete even ull, Pe cao ales nod in onan sla dros, medicanenle pose supe Alef, dma Lm incoet ed expec ten condor de spied apart de aces fgoane sx necrie tefl mused! Cle im ete comraidat In bole inde Iba deonce dtr formaes de heatpue inact 2.16, Administrares pein inject intravenose () sea pein peta endorenoae(PEV) "Adminsrare pin nj nirrenas (xe) su pin perf endovenoase (©) te nat nat pena abo in slo spon. Pesce cles lnrode in orpnismmedeamente cares itn per rt cle nee sreincanue de gn sole hpertone up are preib) sule "ule prodsle de sage plaonl Arete sun acfune imei con ‘all dvdr node posible wet edn in period presi Tide ti i PEV), co agurees un cnt constants pe units de tp. Uszares sparta competent de saiie ional jennie (ip Infsomt injectnat sir sete pei tee mare sin- pe Mediementde cr goin amiaaina, stein) seadmistead Se dlomtein sla none tn PE, an tm foe estes mostaraea (Geminie connate bln ster tera induces 2 spenlc« solilrwkoase (pt proce embobe grisaat), cepbe fin levees espa dense PEV (ntalipis potund") (> Sous rus penta noe parecer endonenoss inca.) 2417, Adastearea pl aha ‘Astras rn nl een ane eer (aca ‘ne pcasesalinacrosl) [> Aneel eneraltnesp 2) 9ntratamen- tulusor fit plo Ip stl boa sundae bronhodatatare ‘benadrenergce (albu, fot) gucocorot ilar (becomet- 1220 dprepianal (Cap. 26 MEDIGATIA APARATULUT RESPIRATOR, 2.18, Adnminstrare prin abr catanatt ‘Adminsraree pi bore cna ptr edcameat ew stele ce fnlosta pune tant: wnguent fpr cu ogc ashi ain, 2.19, Adminhtrarea ope (pentru actiun loa) ‘Administares topic (petrentionlocl) pepe ctl petr t= meron pr de urpuete, sltiuspenay payin nsec Into dermatalopes Exit nt gunguens apolar car rms le a san (e exempl, Nurofen” gel ~ care conn baprfen ~ 9 Fast” fe cae conn etnprofn = Imparvadurerdormuralare na acu) 2.1.10, Adansrarea ope intraazal ‘Adnistraren topic inranaral se fected prin ita ese pre rte oe avind elt anime, ecogestonant sun anal. Ee Inde In teen cburuce nek important Pentru medleaesteni,nsconn naa ete wt sen canal aoetie (bomen nite ‘eccipoiar, ADH), pi sles or par. 21.11 Adnsrarea ope cat ‘Adnan topic bel else i dele forme de seats pene medicamene cu efet loa pin stu (te peferaie e ‘She bdjonnren cor! bcos ar putea aes eet tant) lain ‘ome low cu Cea aan In mat oase lero nero "ein neh ping perder 2.1.12 Adminstrare tpl caart |dminierae tpt oar login ofalnoloie sab om col ol pet desist sete ci de sini) 2.1.13. Adore ntaeca() =adminstrarnintrareiian () ess eaeeve reeret doar tora edie, deparece ile ta inte mide! pind arden nerve sialon inode (deeb sine (ede esate ave. Afefe, en ers al me ‘ca st aborere cals ntraraiins! Pt node gum apestece ‘pec dente rablnestere(Bupracaina", Maree Spal drcortzon ‘eta bidrocorizon hemsuciat canis aabinanié aval aua in St ‘pect da suman SE 22. DISTRIBUTIA $1 CINETICA -MEDICAMENTELOR IN ORGANISM Distesates medeamena fn oransm prcrge pat tape: teamportalin singe ane ents 2 tae prope = Saaeninfete \ (tt ce sant seit in organism, madicamentele sung in celia sangvint, unde o parte cir lege depron plate In eel ada ‘stil or us peta important re bldsponiblistes crepe "proce dn atten drut care slung ln sage Formula de ‘ala pers n medinment ee concn emt dp adminis oi edayenls® ~~ cesta ep edminor alin cel demas a ep ee vexce {hax i vlan uct de de ps cseet oma Uo at parsmatrfarte nfarmacoeinetl ee peak ( if ‘in dis enle,rominit in onl nee ob frm penser tinge concen part der sled «coca mame) Ene ‘ident tings pen lay foarte rap n adnate cv ‘ein admins tm. gsc ma len nadine al fmt Jeti adminsuares pressor cu cere naa rela in sing, medicamentle patra spl In mod sent In eine np int Un se depoiee loft (epee In feet flys) tea dete orane (et, ne), rg owl eh Be ‘ogc (LCR, lial srs, a anume sobs prac pot troes bse hematoencelali,pitund in astemnlnevorceal Anes futur mediaestlarse desert dps lpres de amcor spe fic eantaren menbranlr else [> Cop FARMACOLOGIE MOLE- CCULARA SFARMACODINAMIE) 2.3. MBTABOLIZAREA $1 EPURAREA ‘MEDICAMENTELOR facearea stil woul medicament fn eg produce prin dot ‘Prin metablizare, proces pin came eden te m0 sien tnactvas Roll pnp revioe act atu, deviate ‘sor loam” (in sao epic dn hepateeaeate severe s fin rece sees mecnis a fence), Un agent medinmetog Seton sepa ensielor dn organ ladles ibn Stn indacoare (cu fet ue asp ensele) sunt - peste alle foots fenton, carbamazepine nese tole oor ‘medicament micyrtnds eats, A tne oo eft de nar a indir all metaolaaermedieementlr ee nr yin, ‘sted cal escuela ect, ‘Un rol debit de important In metabolaes medicament evi e tocromalal PaSD, tt ca smboll CYP. Acta repre spere de eum care sctonn prin ranter de econ neal ‘etl substan Beco rnt ain de un compos organ soracate MAREN, VLADIMIE:ANTA MIMAILISCU trae cite eal cate tn lures coromall P40. Ensim ‘ot notte ect pre cu (repreentind perf) nae se ada (hun punde del terran aii apt ole museca nse a salon urmait deen minarindicind gona speek. Aliment sat Iredale cre fr nto aupn ener dn cern 450 {erie din sera cant cu al redcament care sant metabolite prin eornele YP Eeempe peu de grep inhind C¥PS A¢ cree dpondiate dip ot (mediement annem acjonind ca leant sletv al canallor ale ose (mediunentaneroia lzat n tamentl neti ex HI) it eile CYP din et cee concer seh pepo an ‘hrc anemia (anita stenue de gener «nae tenzoiscpne cpl! (medicament rokinete neat nef ga tocol le emideprene, carvan, tecoomal taconaa anbele sot ings) and feist saps enameor CYP hepa, mes ences sec a aera snp ui de spare» uncr ‘uur eardorarcdare “Tell 21. Medleamene cre cons sata penta enzo din sperumlla CYP (ms [iment ex earner ine [CrPIAT [Aetna pret ead aren Op soins Gan eve ona eum let icant acceso) mariah dicen asp) [crc [Be ne a eta ops pam (etc ln ‘kone te) be len pyr sid bend art 2) . [GvPUCIa— [Diner (race george | tee pnt et snr cansstraps prossno ian tama pa cics Premera. propenoll ean adrenepe § ces nn TA gine [EHPaDS |e oe oar nc) Ron Toe ‘nectar [Sa [mn ger cn a aa Gr etirdseee ee es sone sen degen Ae exemple pv guna vat de medicament aupa cro acvone ‘enue din ermal 450 Tala 2, ‘Prin excel renal, vb nance edenance-al ace soatn- fe Glearanceal plasma e defn c fndvoluml de plasm eprat ‘scx subs aunts dein (+ un mln ge cael dup oma Vier deduces edema FEV Ceca a na Canam = ‘praca complet «wal medicament dn orpanem mac exci r- sal eet stata heptel de metabolism + eae "ea prin rane (isin). 24, TIMPUL DEINJUMATATIE, ‘pele cnt ost eee 1 Contain: iat te iat oxieut a(CUNMARCEN, VADINIRAANTA MIILESCU ~ sinpal de nue leat de faa de dtp (4 car expen rc ecest peta ca subst tanga jae concent pa mati ator ear nest. Ee un ip malapid ~ unl de jamaica fe de pure, 9) cae exeit da sat neces per ca medicarenl lang sunita concentra pla ‘sce rr eiminr pe ert linia ind ele renal). tun tp eu valareral lent Second chpuce une ube ate eta peste 98% esi oproape compe) upto prion ep oral are det {pal etnjnae. Formal cael mall de jute tn general eal de tee ‘Gave pamaie * 25. DOZAREA MEDICAMENTELOR Prin don leg cate de substan care provoac un anu fet farmacalop a tol se evident tables dander consi una dine problems fundanente al fmcoteraiel oseslapel tract erie de fence In minus edu faa rape ar supradaiiept ves conerite ‘em de pve pn ntxes ele Downes uti medicament wares taport ca vinta ett corporal (exact, ex pra orp), alen faint ta, ste funcfonls sich graviates alan trate so de eveaiin carseat aces, puns peacoat ‘tevenule el adverse apirte carl amen Lunde mein tment admins, cum rf metosens, medina seep, pn, se onerous lvl sere (concentra pera ese) penn exit cettainen ‘eet doit once ‘Sables dozer in cus ual atament repre stb ¢remponae- tinea medi cura Ta ore azure, pate sgt, dose psec se vet dup prospect tablet pin unl farmed lela giana «1 dors medicaments tebule pect urmitoardenofsni: ~ ete recomandab deva mini erpeti sic dove cen ml mich prin ears efatal bent Ia ae flo eps ui oped (pre deoseie de dena mast erapeatc, eae fd aro econ toxic expan a sest se: ~ dozl po formate petra 24 dor (dns ni) ndcinde-semo- sa dept (nclonae) pe ze Be ot 6 nla pnts 0 rd admis (Joa ou) ends se dec sv repre “ ue, Mur dona foment in alate pet tenga cs pole Input pe ae ape rie, rita de adminsre dies ort ean meant a chip cel medieunen carl ani cre erapetce Hee tt de neon de meer a unl nivel sere eet Ulett, nei severe admins a intervie de cite tel, ca ma go, I ct se sau chiar opt ore. Fests mediate adnate old pe (Gov, nite de peer a), ale har Inner de ‘pts (oldani: ~ lnurele medicament cre etrtamentincspe cao do sa mare ‘sigur concentra seats piel eee avorae fa scar ip. ‘Acta est dora de tac sa dora de lar fl perte dian vores onao isons dex ~ nace meicmens,c contin Is amine urmitoare se tlle urtont cu odor al mic dar ae sigue ieee neces ‘te dona de intretineres ~ penta erie substan care prune in xpi, eo canta mic ‘ima cie proves eft tice seme fas # oral -dova teh “Anu cn inp in pel cle via In cet en i mein eines a format ote de date beaut (Di,) ere cde You imal de experi atte cu es (100%) dona ltl dle Ds) ‘ar cide unitate din animal deepen oe (09)3. GHID DE ADMINISTRARE A MEDICAMENTELOR (in atentia asistentilor medicali) Denny suexpLicaytt “Ansar nls io odcee itavenone In np scart uel secede, “nde eraara bac anamea vnc (hice ater pe material tin de comport normal ng vehicle de ental ttc: ches stops rapment dest adpes, gent deta medal, fragment de pce, agent de rumors lave de pars bul eat, bl deine, “Emploi = pep frmacese sli pti ade care ade I te gman Inmon eempertra corp, permind shee subtaet Ace pin ple plas), 3.1. REGULI GENERALE : ~ Iain feos medicament sevr ci cx see stich. fermenal ecapzare respect nsptor (rfid fare NU ebute ares). "Nico medicament NU aaa dat terol de expe srs peambal sua pe het acon, te dept ~Mediamentle vor fue in abl egal. NU ee permis wl. ‘tea ur abana seri pede inte meinen orf psate conf instructor dep a ‘jen din propel insofar Deck ma aunt specie anu cod eacite depute, medcmense vor inte ancien cu temper ‘nee de 16.200, ceare de rl de lar alipost de ale slate denmeneal. 4 Anume medcamene sects prvi ie bs temperature de + 48°C i NUin congo): ili imunogiobllo acu serre Hpermune, produce henge, Aca hat se melons de he pe smal aun prospec apr In Giger cu mediante NU se Sopot tet mere se ere sbsene chic dena ace igi find on ff Prous soe din gier eed nites adit inet [ntemperaura corp ste x deste ners mia vei lament temperur set de caret sce Inject tun pote ‘rodoceneroch inodus x patededanao rise vento! ~ Fant hea produse (sunt pine!) ae ble oct in oagetor mame cl are ce Conse au ab orm ghee pops ‘angels (PC) clprecptt de bling stnemotled A Deeg lr Sefice rp. imei nits aint ii ene a peat ‘corp Oda decongat,un asemenea pode NU mos poste ecg, (ete ear de eatin aru, acute cs) namie cpt seni anal pec. steiner injec let “Seva respect csc acon detlr (exit mameroas mid- camente—in special anos ~ case pat npr ue doe 25 oh ecu goede de administra actor. ~ Init administra su fect tataments,pecrans cae ane east sri sew ap eran. Pate ase eva core de dk su confundste medcaentor dn parteablaavlt se recomend st medi pe cle ors ends ‘ec assents medic 3.2. ADMINISTRAREA MEDICAMENTELOR DEUZSISTEMIC Insccasth eerie ine maticamente cae stones isl spre mor organ ste apart a nip negli, neat de. {al peunde sant inde. 4124 CALEA ORALA ~ Aczat cae upoat ti eblnvi cmd ca con xe bit de det, VS nero gt se cae ff a mod a emer ~ Medians sisirea cage soc lng i= peste spn). Cc ce ut deep et nao fea! peator cs pp °~ tchidel cups dearest po ames cu ete can dep, | ‘Tbe 3:1. Cie de administra a medicamentlor ces inp lope doe prospec isto u coon asemees anes Se pm an ter In nin ot NU seer nodae medeament hide Int-9 pore de [eae [Sate eae (rine, decree red pat ch te incite! estan [omg ues Cate mednl tu conaat rss prepare penta aer- etry emma sa deradarea substan ei Renae Suspense dimen epus Din acest rt Saon oo leona van A). onl (antvete) eect (cae are aise atta), Tote angen ue tices ch unin funda dese cojancvae ape marines plcaplon utr ‘or tampoane confine pele din compres tie ax ane bgt ‘nl dest ela oerremfstedn chip deepipce 34, ADMINISTRAREA TRATAMENTULULIN UNITATILE SPITALICESTI In pj dete de adn «medicaments, pot exists wale onc des un pala al sa hie inte sce so itl dar rar pal deca imine ars mele se adits in conosco ‘Prescrpidnpgin deste fl de oberg Tceath pind, medicament sunt numer f melons cu demu sate comercial ub are se vex Infirm psa). NU st wee LCi (dec poate alter npn) in sesprin prin ve seta {fin comnt Alu de medicament un sinatra de recente, fain deans ¢daz penta 24 deo urate de menoaren del nr rere. mal evento peice ont emp Bahra pram rt gmmocc) ef detane, ‘Sneed pate sa {ign ce ins nme, 2 Rate nt 0 dura Sed 1a utc cong 0 tev conpin ep, ‘Cision ey cee ep Sapo 1 Cavite x puter es rc dn ‘inte te ok ra ceeoc oleic ee |. redo nt Supe den ppt Dan itr sided pra 5 ll been de ‘Neate de ep dant S454 ‘ned te epee pri "Pri de ese dS 4 oh red 8s [Eu Domr el corte rash 0a pasa dec mln ‘gerne pa. 5 Reenin compre ge came po igs fitleens adele ‘Smo ct an 250. asa SR oli peer Lite son: 1 es (mp nce pe Spe ere ue st nee, fk avi meet curt saa medi de gd intern medleamenta presen fico un atl avind arn ern toae san snd oor de penta armani ie 4, FARMACOLOGIE MOLECULARA $1 FARMACODINAMIE DeFINp stexeLicaTHE Corp sa = gop de mace newo oma in earn tua bak misfertiorcererale (el despa in tng) edd pect slat pe ‘ecjme dao aleane deme cu subst cen: hao fol ‘sparta in rere mot extepramiale (iti utente) “potamas= lc regan dn net itn parte entero ven- twill ste alta al ml uc! nero oral dn oad ca Fancy imporsante: ast eee comple compare tenant ‘eoonena tresses snail pend seca! de amas ih (ental sti) contoleut dures (pa boron anh tact ‘eon poz posers) umerease Res vee metabo neg chiral hidrsecote, respi cul inervine a ne ‘vuln prodiceren sr para erst exo fa), Tocusnige bel neg’) = grape de nero inkl x pigment siuati ls bats pedncullr cecal, Are rl in motlies egies (ig ctr Test de pers (ai alps) > Cap 28 ~ MEDICATIA ANTIALERG: Shap = leita te neuron Bato leg decomigtat (single ‘ona ealztspis intermedi! neurtaneitosor (= mee ch i, los = mash de stant ena stot aaa endear cereale (os in deni una i saga), format din mal mle rp de earn ee ‘i Ai fa snap neuron di speaep ote cle septs. 4.1, FARMACORECEPTORIL ‘Un mare muri de medicament scones in egeiem rin interedl ‘or enum eeperi armacoreepor supa ctors pote fet agp (esimlaea aces sa antago (inhib ci). 6CA MANCHA, VLADINUR UAT MINAS Receptor st mcrmolcle petee carp ep in od pif an nite ubtane fermi comple sve loge Autucol honben ms (peruse medicament exerts retenes pis nerd ceo espa ‘Se mums farmacoreceporl octet cape peimete oh ateac- towne cameicmetle Manion ore ge ep TS eceporkadeeeric sunt nivl terminal serose sn te panda mules cu ordain Se dees deus cer " ecttr , psgenglonr au postop cae vf a muh ‘tea slr angie; smal lor produce aceon 1 acttr a prsnail cror smaire deter seen Sc (idenondelints = Yecepor radeenergc sunt stro molec situ terminrea Sno inpstic spn le mes ~ rt ae substan = ope ‘link Se desrbexe dot eter *rectptr loca opin ia moc simular lor are eft ‘E coogeeecablih ioc tte pox) atonal ‘crc (ono po) de acceler ral ere (cone trop post) In pls au eit nhtvoraapra most intestine prota = esplor issih etl a bonlorsoulare lr pro- ‘tee bono bronhiodistaf. np relat vase pris simleat gdlina mol = receptor colinepe cut localial pe membracelenewolor pare sip dn iri npn ispand ators cu acecld. Seip In douk caer: receptor maccarini (ot x M0) or sia determin bre ‘Sead mare areas es seen tensa arterial, cones ‘masealr neste consi (pas) bro cere sere {ior ia abarle bron, . * recep icotnl (no cuN) cro stlareprodge iar Iipertenane ae, pllpoe, lie ceetrenprstinu Ines. cl i cpa mac sit send pod ewe ald oe din eset pte ana mast) ‘mle sin ot nna cl rote dei leo ‘Seat sto a eeplor cotzoi fin tops clr lag acocorict si ior snes de proineesiatice de protic eee satin Instr rind wn alin fee terpeuicaecortcoseoar: receptor dial sn stun ocd: medicament dale i xr acfonea pin aren dant recep vied ele pout dn pet de vdere tno, nt pbatmato fect nee dn punt de vedere ‘nat ft dromotep: ~ receptor dopaminergic un ree tn soap ners de i ell vbr ena di inten round la stnlaen ca dopa (ad {inet rma di DOPA = adrenalin) prin excrete tort se produce vasodistaje n inchcucetres deta rina ltren ‘aso coronarine rere dbtall oe decontacpe animes sun proline, Prope ces eee: sun wit incomes {octl nape el cardoges ~ recepior pectic pete eltopoetin (coral de cee ito ‘estat in dye hemstpaic, condiponeak actives see pen prolifera 9 leer lormeor nee erobltce ia eto (ems) mare, ~ receptor histamine st atc apne Neti Se deetbse out catego ~ rcpt cor smal delays tre apr, r= ‘ge esa ater contaia yr nee tena pos rom Crnbloconstii). Acs enomenes ints ot © ‘av nent focal anal sunt inate arbor bone a ‘i cine de asin bron: Modi alr ebaness pe lcs ascestr repr recptrt My stan In cod gaily cio excite prac © hiperecreitdt n store, Media antici modern se bsee pe substan cae loceer receptor din coasts ~ receptor ivllnl lp pera clr vores pun era nine nel ande cet ve aetion pin meboliaea cdl Jn belt tp 2 oaanheodepende lo pot acta darren abo sib fst expat igual slim ‘ie ipo sunt lose ataentl sees ip de ibe sara, scree rela erporor nin capacitor foto; ~ receptor de eaotiene rant sta none intervie. seed stn bron roductnd cota msc needa anor bo his cresnd pemebats cpr eo tranandhesde chide mobic lescocte cae nies cal mscoara Tatami tae bre nt ‘ill dele medicament antag seetrler penta ee tees “ receptol speci pentru occ, a i mimes (mjc we tn condone sctvintn cone! pete dela contro aero; ~ receptor opal (movin) sunt pean! im neon in annie mata le SNC (alam steal be stella) iid lect sorting deren produ endogen’ cues prope endoringeeine)‘CRIN Wa ncoaN, ABI MANTA MALES ~ recor petra prosaglandinesnt ml male lr Penta poe tapaninee est receptor ola cu PD. Petu prostaglandin exis ‘eeprom se i cosa gastroduodens 1 Fenra potglndaee Faun rector not PR tia masse rors in motcltre ern femervie Pet prostacicind exp ‘on nota stan macs asc. 42, AUTACOIZIE Dine substan pode in mod Slo de etre utr un ol fan nal civ eine astaceso, ce conet ot rin intermodal receptor. ‘Aisa = conser harmon! lol, dar care NU sunt seri lanl ndoriog cided ese sont reprezena eis urnatoure obsta 1 HISTAMINA, amin bogens et ere de granule bazfe din ge de mcs pet, masons src ude cll evens Ex ac- ‘ness pin ermal unr rcpt sellin elect lp: “Teton spe eeptsiortip H,hitamina eco eile de ‘perenaiiate med (wae alice de ip = ree anaflactie). ae pot forte tense ance: keen are ena (nk a tara de yo eral ‘ace prin vada rtenlelr enone avenue pases ple: 5 pais de ural deme peririe eu sobre (deme Snponeraic) eer ign, in rere pesoeaiicap- Tae ins de tranedare de ei plasmas a ppl etre: ise pce proek(conrbi aca de sim boo) ‘rn bronhocenstiea prods de conetura masa ate 3 Trochllor mi ; = sjiocind saps ceptors pH, din coat serpoc ist ‘rin decane osc gue pats in ad otc! pops 2 Gece hrs ido oie fro lap era ate fond aupe rector ip expo pesagp itn ‘era fection a ell noe termina sting din ‘tema ero ena. local or cesta eepol un fle asap tapes tn str legen lune gate noi degescte Cu un ermen gee ‘ie eeoene Morale tint deena c antihistamine. xi dos catego ‘side snthitemince: ~anthistamince dew semi, cae scones pin boss recep torr 1 vind cet ater Dine aces fe parte da eae Yin cleakina (egy, cloenoxami,dorfeiremina, drops mina (Nin), prometcna(Romergn). I genera I nd: loratdina (Ccie’)cetihise Cy", lemeetana Xp") (> ‘Anthsmince de sitemic In cxp. 23}. rmacoterapce suns utara eee; rine lbs des edema engine ‘otc Gulch; beak srl enomenele alge rose dfn eins a de contact cu nele ple, ~enthisaminieleataclde scones pin ocr expo in ‘uence and elect anaes ein edi (Hate), ‘unidine Gane, matin (Quanta), skating Ci) (> Antistaiice cap. 6 nde accep le acest ‘ler pec seu duodenal: enfin de et pve emailer “este supine n ele terval heuer apt ‘ere edeaeatons produce de meas INS. ‘ BRADIKININA afc ke Kinng, forme sub cine ei en- ime, alien a plan n une stu Ete an andlor tern ‘re permease eapler, produce cotactis macula ated, boa bosons stmaleas receptor der. Aenea ea ca mediator s0- nb erie de perenne contra mec de dedngare are de stm rong, ‘ SEROTONINA (S-Aidrnisiptamion = 5-417) ete o end togens event jet animale vegetal, precuniaunele ein Areata Ae neureransmiitor a olla poducees oma» who proce cogine {let In proces de wrsoelar, ne fini nator seine ‘n fuel hormonale legals, podace conta sl muse tar nee, vatoconsc(trandnd HTA),iibaren sori xc. ‘Acjoneat pin intermedi uno ceptor pci (iu. Asap bul ius ae lect de stmsae perils itt acl obdonale ‘clare; supa opuatullcdowscalr ae x fect ble ips ‘mere apratlrspzatr determin bronhoconaie ype In ava rolin mecnismal och al ste depreae nhbon espit ‘eseotoni fd flan eat afcgan [9 Medeaentatdeeesie in ‘ip. 22). Malaerolis produces viru de cast eta mice. Cul caret stopad aces fect fd ondansetron (cre locos receptor tertonnerge, 2 SISTEMULRENINA-ANGIOTENSINA,Anpotesiogenl esto g- opraeak frat tn eat eet natn asa Sb fans reel (cori secret de paral tsps inch, agitnssogeal °