Aeon Astron Europe B.V.

Publication list
(A). Publications Biocornea

1.

Van Essen T, Lin C, Lai H, Hussain A, Luyten G, Jager M. A biocornea of fish scales First results of a research model. Acta Ophthalmologica, Aug 2011; 89: 0. Doi: 10.1111/j.1755-3768.2011.2376.x
Lin CC, Ritch R, Lin SM, Ni MH, Chang YC, Lu YL, Lai HJ, Lin FH. A new fish scale-derived scaffold for corneal regeneration. Eur Cell Mater 2010; 26: 50-7. (SCI)

2.

ologen 1. Cillino S, Pace F Di, Cillino G, Casuccio A. Biodegradable collagen matrix implant vs mitomycin-C as an adjunct in trabeculectomy: a 24-month, randomized clinical trial. Eye advance online publication, 16 Sept 2011; 1-9. (SCI pre-publish) 2. Sarkisian, SR, Rouse, JM. New Methods and Modifications of Glaucoma Filtration Surgery. International Ophthalmology Clinics. 51(3):95106. 51, Summer 2011. (SCI) 3. Rosentreter A, Schild AM, Dinslage S, Dietlein TS. Biodegradable implant for tissue repair after glaucoma drainage device surgery. Case report. J Glaucoma 2011. (SCI) 4. Jacobs NA, Tendulkar M, Ghosh YK. Modified Trabeculectomy technique called effective, quick, reproducible. Ocular Surgery News US, Sept 25 2011 5. 6. Nathan MR. Evolutions and revolutions in glaucoma surgery. Glaucoma Today; Mar 2011. Rosentreter A, Schild AM, Jordan JF, Krieglstein GK, Dietlein TS. A prospective randomised trial of trabeculectomy using mitomycin C vs an ologen implant in open angle glaucoma. Eye 2010; 24: 1449-57. (SCI) 7. Rosentreter A, Mellein AC, Konen WW, Dietlein TS. Capsule excision and ologenTM implantation for revision after glaucoma drainage device surgery. Graefes Arch Clin Exp Ophthalmol 2010; 248: 1319-24. (SCI) 8. Boey P-Y, Narayanaswamy A, Zheng C, Perera SA, Htoon HM, Tun TA, Seah SK, Wong TT, Aung T. Imaging of blebs after phacotrabeculectomy with Ologen collagen matrix implants. Br J Ophthalmol 2010; Published online on 7 Aug 2010. (SCI)*
Aeon Astron Europe B.V.: Reference list, Version 18, Oct 2011

9.

Costin D, Constantin C, Bucatariu MP, al Mousa A, Moraru AD. Combined mechanism glaucoma asociated with Grave's Ophtalmopathy. Case report. Romanian Neurosurgery 2010; XVII: 364-73.

10. Nilforushan N, Yadgari M, Falavarjani KG, Afshar AE. Evaluation of subconjunctival Oculusgen* implantation as an adjunct to trabeculectomy. Iranian J Ophthalmol 2010; 22: 55-62. 11. Sarkisian SR. A replacement for antimetabolites? ologen is a new product that modulates wound healing in glaucoma surgery. Glaucoma Today 2010; 8: 22-4. 12. Papaconstantinou D, Georgalas I, Karmiris E, Diagourtas A, Koutsandrea C, Ladas I, Apostolopoulos M, Georgopoulos G. Trabeculectomy with ologen versus trabeculectomy for the treatment of glaucoma: a pilot study. Acta Ophthalmol 2010; 88: 80-5. (SCI)* 13. Anguelov B. Trabeculectomy with absorbable suture of the scleral flap and subconjunctival biodegradable collagen matrix implant (ologen TM) in primary open angle glaucoma. ( . 2010; 1: 21-28. ologenTM .)

14. Sojin Hong, Jong Rak Lee, Jin Young Choi, Jaewan Choi, Yeon-Deok Kim. Trabeculectomy With Biodegradable Collagen Material: A Report of Two Cases. ( 2 ) J Korean Ophthalmol Soc, June 2010; 51(6): 912-918 15. Sojin Hong, Jong Rak Lee, Yeon-Deok Kim, Jin Young Choi, Jaewan Choi. Fibrous Encapsulation of Biodegradable Collagen Matrix After Trabeculectomy: A Case Report. J Korean Ophthalmol Soc, April 2010; 51(4): 631-635
16. Rao K, Ahmed I, Blake DA, Ayyala RS. New devices in glaucoma surgery. Expert Rev Ophthalmol 2009; 4: 491-504.# 17. Anguelov B. Phacotrabeculectomy with absorbable suture of the scleral flap and subconjunctival biodegradable collagen matrix implant (ologen TM) in eyes with a cataract and primary open angle glaucoma. ( . ologenTM .) 2009; 6: 17-26.

Aeon Astron Europe B.V.: Reference list, Version 18, Oct 2011

18. Anguelov B. Trabeculectomy with absorbable suture of the scleral flap and subconjunctival biodegradable collagen matrix implant (ologen TM) in refractory glaucoma. ( . ologenTM .) 2009; 5: 23-30. 19. Aptel F, Dumas S, Denis P. Ultrasound biomicroscopy and optical coherence tomography imaging of filtering blebs after deep sclerectomy with new collagen implant. Eur J Ophthalmol 2009; 19: 223-30. (SCI)* 20. Dietlein TS, Jordan J, Lueke C, Krieglstein GK. Modern concepts in antiglaucomatous implant surgery. Graefes Arch Clin Exp Ophthalmol 2008; 246: 1653-64. (SCI) 21. Zelefsky JR, Hsu W-C, Ritch R. Biodegradable collagen matrix implant for trabeculectomy. Expert Rev Ophthalmol 2008; 3: 613-7. 22. Kohlhaas M. Postoperative Risks in Previously Operated Eyes are Lowered. Trabeculectomy With mitomycin C and ologenTM Implant. (Postoperative Risiken bei voroperierten Augen werden gesenkt. Trabekulektomie mit Mitomycin C und ologenimplantat.) Ophthalmologische Nachrichten, Oct. 2008. 23. Hsu W-C, Ritch R, Krupin T, Chen HS-L. Tissue bioengineering for surgical bleb defects: an animal study. Graefes Arch Clin Exp Ophthalmol 2008; 246: 709-17. (SCI) 24. Tope A, Mermoud A, Shaarawy TM. Glaucoma 2007. Ophthalmology Times Europe 2007; 3: 33-9. 25. Ritch R. Using bioengineered collagen matrix during trabeculectomy. Biodegradable polymer implants show promise for improving the function of filtering blebs. Glaucoma Today 2007; 5: 14-5.
Footnotes: * OculusGenTM used in the study is the prototype brand name and has been renamed into ologen Collagen Matrix in July 2007 with enhanced biocompatibility, longer biodegradation time in accordance with the wound healing process, and more pressure sustainability and resistance to humidity. ologen Collagen Matrix has also improved for better performance and efficacy in terms of IOP control and overall surgical outcomes, which can be shown in the preliminary meta-analysis based on the SCI publications available to date. The meta-analysis publications will be reviewed and published some time in the future.

# In this review, all the references cited under Oculusgen collagen implant (references no. 42-46) were originally referred to ologen Collagen Matrix (please refer to our publication list: (B). 47, (B). Aeon Astron Europe B.V.: Reference list, Version 18, Oct 2011

19, (A). 3, (B). 15, and (A). 5, respectively). The authors of this review and the publisher of the journal have been asked to issue an erratum in order not to misleading the readers. For the information of ologen Collagen Matrix, please see the publication list above.

(B). Scientific program (available upon request) 1. The 2011 World Glaucoma Congress (WGC); Jun 29 Jul 2, 2011, Paris, France. J. Lin. Can MMC be replaced: Collagen matrix for eye tissue repair. R 341. Introduction of ologen Collagen Matrix. S. Cillino. Can MMC be replaced: Collagen matrix for eye tissue repair. R 341. Biodegradable collagen matrix implant vs. mitomycin-C as an adjuvant in trabeculectomy: A two-year randomized clinical trial. J. Lai. Can MMC be replaced: Collagen matrix for eye tissue repair. R 341. Trabeculectomy with ologen and MMC. P. Sathyan. Can MMC be replaced: Collagen matrix for eye tissue repair. R 341. Trab with ologen : The practical tips for the better outcome and the Indian experience. 2. The 10th Congress of BDO; 13-16 October, 2011, Riviera Varna, Bulgaria (, )

Daskalov C, Baraharska Y, Kostalevska C, Kuneva I. (.,

., ., ..) Surgical remedy on glaucoma: ologen vs Ahmed valve. ( : Ologen Ahmed.); symposium glaucoma I, 14 Oct 2011.

3.

The 2010 World Ophthalmology Congress (WOC); June 5-9, 2010, Berlin, Germany. Kohlhaas M. Can MMC be replaced: ologen for eye tissue repair. H9. 500 experiences with ologen collagen matrix in trabeculectomy. Ni J. Can MMC be replaced: ologen for eye tissue repair. H9. Introduction of ologen Campos EC. Can MMC be replaced: ologen for eye tissue repair. H9. Use of ologen collagen matrix in strabismus surgery

4.

The 5th International Congress on Glaucoma Surgery (ICGS); November 11-13, 2010, New Delhi, India. Rao BS. Plenary Session 1-Trabeculectomy: The state of the art. PL1.5: Improving success of trabeculectomy.

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Sharmila R. Plenary session 6-Wound Healing: The eye under control. PL6.5: Trabeculectomy with subconjunctival biodegradable implant (ologen) for the treatment of glaucoma. Singh K. Plenary session 6-Wound Healing: The eye under control. PL6.7: Collagen implant in trabeculectomy: our experience. Kusumesh R. Plenary session 6-Wound Healing: The eye under control. PL6.8: Outcome of trabeculectomy with combined use of subconjunctival collagen implant and mitomycin c. Aung T. Plenary Session 9-New Surgical Options: Looking ahead. PL9.6: ologen implants for Pharcotrabeculectomy. Ariga M, Crowston J. Instruction Course 10 (basic)-Wound healing: Practical considerations.

(C). Conference papers and presentations (2008-present) Biocornea 1. Lin CC, Ritch R, Lin SM, Ni MH, Chang YC, Lin FH. Biocornea: A New Fish Scale-derived Scaffold for Corneal Regeneration. The 25th APAO-AAO Joint Congress; September 16-20, 2010, Beijing, China. 2. 3. Lin CC, Ritch R, Lin SM, Ni MH, Chang YC, Lai HJ, Lin FH. The ARVO 2010 Annual Meeting; May 2-6, 2010, Fort Lauderdale, USA. van Essen TH, Lin CC, Lai HJ, Hussain AK, Luyten GPM, Jager MJ. A biocornea of fish scale- evaluation of a research model. PNO 4088, Association for Research in Vision and Ophthalmology annual meeting; May 1 5, 2011, Fort Lauderdale, USA. ologen 1. Maragatham K. ologen implant in primary trabeculectomy. Hall D. 59th Annual Conference of the Tamil Nadu Ophthalmic Association. Aug 05 Aug-07 2011, Tamil Nadu, India. 2. Alagatta SD, Sasi Kumar R, Rao D, Shetty B. Safety and efficacy of ologenTM implant and adjunctive mitomycin C in trabeculectomy in Asian Indian eyes with advanced glaucoma. P567, The 2011 World Glaucoma Congress (WGC); Jun 29 Jul 2, 2011, Paris, France. 3. Shihadeh W, Alwattar B. The outcome of trabeculectomu using a collagen matrix implant (ologen). P569, The 2011 World Glaucoma Congress (WGC); Jun 29 Jul 2, 2011, Paris, France. 4. Chen HS, Hsu W. Three-year Follow-up of Trabeculectomy with Biodegradable 3D Porous Collagen-Glycosaminoglycan Scaffold for

Aeon Astron Europe B.V.: Reference list, Version 18, Oct 2011

Treatment of Refractory Glaucoma. P634, The 2011 World Glaucoma Congress (WGC); Jun 29 Jul 2, 2011, Paris, France. 5. Kee MJ, Ho YJ, Changwon K. Clinical experience of mytomycin-C soaked collagen matrix implant in trabeculectomy. P636, The 2011 World Glaucoma Congress (WGC); Jun 29 Jul 2, 2011, Paris, France. 6. Wiyogo WA. Trabeculectomy using biodegradable collagen matrix implant in chronic primary glaucoma patients. P644, The 2011 World Glaucoma Congress (WGC); Jun 29 Jul 2, 2011, Paris, France. 7. Ali SI. Study of the safety and effectiveness between ologen TM collagen matrix implant and mytomycin-C in standard glaucoma filtration surgery. P648, The 2011 World Glaucoma Congress (WGC); Jun 29 Jul 2, 2011, Paris, France. 8. 9. Rosentreter A, Schild AM, Gaki S, Mellein AC, Dietlein TS. The ARVO 2011 Annual Meeting; May 1-5, 2011, Fort Lauderdale, USA. Rouse JM, Sarkisian SR. Trabeculectomy Using Collagen Matrix Implant: A retrospective Review on 1-Year Data. AGS, 21st Annual Meeting; March 3-6, 2011, Dana Point, California, USA. 10. Rao BS. Ologen as an adjunct in refractory glaucoma surgery. The 25th APAO-AAO Joint Congress; September 16-20, 2010, Beijing, China. 11. Tzvetkova B, Anguelov B. The 9th Congress of the EGS; September 12-17, 2010, Madrid, Spain. 12. Jin Ho Y, Chul Min K, Changwon K. The 9th Congress of the EGS; September 12-17, 2010, Madrid, Spain. 13. Rosentreter A, Mellein AC, Konen WW, Dietlein TS. P-TU-066 Capsule Exzision and ologen Implantation for Revision After Glaucoma Drainage Device Surgery. WOC 2010; June 5-9, Berlin, Germany. 14. Rosentreter A, Schild AM, Jordan JF, Krieglstein GK, Dietlein TS. A Prospective Randomized Trial of Trabeculectomy Using Mitomycin C vs. an Ologen Implant in Open Angle Glaucoma. The ARVO 2010 Annual Meeting; May 2-6, 2010, Fort Lauderdale, USA. 15. Htoon HM, Boey P-Y, Narayanaswamy A, Zheng C, Perera SA, Wong TT, Aung T. Imagining of Blebs After Phacotrabeculectomy With Ologen Collagen Matrix Implants. The ARVO 2010 Annual Meeting; May 2-6, 2010, Fort Lauderdale, USA. 16. Chen HSL, Hsu WC. Trabeculectomy With Biodegradable Porous Collagen-Glycosaminoglycan Matrix Implant for Treatment of Refractory Glaucoma. AAO-PAAO Joint Meeting; Oct 24-27, 2009, San Francisco, USA.
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17. Ogle J, Lim BA. 12.8.5 Surgical Treatment: Filtering surgery: Other. WGC 2009; July 8-11, 2009, Boston, USA. 18. Sumantri W. 12.8.10 Surgical Treatment: Filtering surgery: woundhealing antifibrosis. WGC 2009; July 8-11, 2009, Boston, USA. 19. Narayanaswamy KA, Seah SK, Perera SA, Wong TT, Hoh ST, Aung T. 12.14.3 Surgical Treatment: Combined cataract extraction and glaucoma surgery: Phacoemulsification. WGC 2009; July 8-11, 2009, Boston, USA. 20. Chen HS-L, Hsu W-C. 12.8.2 Surgical Treatment: Filtering surgery: With tube implant or other drainage devices. WGC 2009; July 8-11, 2009, Boston, USA. 21. Chen H. EH2-352 Trabeculectomy With Biodegradable 3D Porous Collagen-Glycosaminoglycan Indonesia. 22. Prihatningtias R, Sadasih W, Rahmi F. EN1-039 The Comparison Between ologen Collagen Matrix Implant & Mitomycin-C in the Glaucoma Filtration Surgery. The 24th APAO-AAO Joint Congress; May 16-19, 2009, Bali, Indonesia. 23. Sadasih W. EN1-043 The Comparison Between ologen Collagen Matrix Implant & Mitomycin-C in the Glaucoma Filtration Surgery. The 24th APAO-AAO Joint Congress; May 16-19, 2009, Bali, Indonesia. 24. Ali I, Butt N. EN2-027 Study of the Safety and Effectiveness Between Collagen Matrix Implant and Mitomycin-C in Standard Glaucoma Filtration Surgery. The 24th APAO-AAO Joint Congress; May 16-19, 2009, Bali, Indonesia. 25. Shihadeh W A. Efficay and Safety of Utilizing a Biodegradable Collagen Matrix Implant in Trabeculectomy. MEACO; March 26-30, 2009, Manama, Bahrain. 26. Wu Q, Du X, Song B. SP058 Trabeculectomy With ologen Collagen Matrix Implant: the Treatment Outcomes After Six Month of Follow-up. The 5th Congress of SEAGIG; September 25-27, 2008, Seoul, Korea. 27. Singh K, Khurana C. SF017 Bleb Characteristics of Subconjunctival Collagen Implant in Trabeculectomy Compared With Mitomycin Blebs. The 5th Congress of SEAGIG; September 25-27, 2008, Seoul, Korea. 28. Kohlhaas M. DO.16.04 Trabeculectomy With Mitomycin C and ologen. The 106th DOG Congress; September 18-21, 2008, Berlin, Germany. 29. Ozcan AA, Dulger E, Simsek F. Ex-PRESS R-50 Miniature Glaucoma Implant Insertion Under the Sclera Combined With Mitomycin C and
Aeon Astron Europe B.V.: Reference list, Version 18, Oct 2011

Scaffold

for

Treatment

of

Refractory

Glaucoma. The 24th APAO-AAO Joint Congress; May 16-19, 2009, Bali,

OculusGen**

Application.

The XXVI

Annual

Congress

of

ESCRS;

September 13-17, 2008, Berlin, Germany. 30. Shihadeh W. Efficacy and Safety of Utilizing A Biodegradable Collagen Matrix Implant in Trabeculectomy. The XXVI Annual Congress of ESCRS; September 13-17, 2008, Berlin, Germany. 31. Yuan F, Li L, Chen X, Wang Scaffold L. for Biodegradable Treatment of 3D-Porous Refractory Collagen-Glycosaminoglycan

Glaucoma. WOC 2008; June 28-July 2, 2008, Hong Kong. 32. Lim BA, Ogle J. GC-D1-166 The Use of Biodegradable Collagen Implant in Trabeculectomy. WOC 2008; June 28-July 2, 2008, Hong Kong. 33. Grewal SPS, Grewal D, Jain R, Brar GS. GC-D1-188 Adjunct Use of Biodegradable Porous Collagen-Glycosaminoglycan With Trabeculectomy Implant for in Phacoemulsification 2008, Hong Kong. 34. Kaljurand K. GC-D3-133 Ologen Collagen Matrix Implant in Glaucoma Filtration Surgery. WOC 2008; June 28-July 2, 2008, Hong Kong. 35. Ali SI, Butt NH. Study of the Safety and Effectiveness Between ologen Collagen Matrix Implant and Mitomycin-C in Standard Glaucoma Filtration Surgery. WOC 2008; June 28-July 2, 2008, Hong Kong. 36. Jansari P, Porwal M, Hindocha C. Trabeculectomy With Subconjunctival Biodegradable Implant. WOC 2008; June 28-July 2, 2008, Hong Kong. 37. Grewal SPS, Jain R, Grewal D, Brar GS. Safety and Efficacy of OculusGen** Biodegradable Collagen Matrix Implant in Phacotrabeculectomy Surgery. The 2008 ASCRS-ASOA Symposium and Congress; April 4-9, 2008, Chicago, USA. Combined Surgical

Management of Primary Open Angle Glaucoma. WOC 2008; June 28-July 2,

Footnotes: * Before year 2008, there are 26 ologen posters or presentations presented in the international Conferences. ** OculusGenTM Collagen Matrix has been renamed into ologen Collagen Matrix in July 2007. The implants used in this study are OculusGenTM Collagen Matrix. The material constituents and the physical properties of OculusGenTM Collagen Matrix has been improved and upgraded for better performance and efficacy. This becomes ologen Collagen Matrix. Furthermore, when ologen Collagen Matrix is applied in trabeculectomy, loose suture on the sclera flap is strongly recommended.

Aeon Astron Europe B.V.: Reference list, Version 18, Oct 2011

Abbreviations: AAO, American Academy of Ophthalmology; APAO, Asia-Pacific Academy of Ophthalmology; ARVO, Association for Research in Vision and Ophthalmology; ASCRS, American Society of Cataract and Refractive Surgery; ASOA, American Society of Ophthalmic Administrators; DOG, Deutsche Ophthalmologische Gesellschaft; EGS, European Glaucoma Society; ESCRS, European Society of Cataract and Refractive Surgeons; ICGS, International Congress on Glaucoma Surgery; MEACO, Middle East African Council of Ophthalmology; SEAGIG, South East Asia Gluacoma Interest Group; SOE, European Society of Ophthalmology; WGC, World Glaucoma Congress; WOC, World Ophthalmology Congress.

Aeon Astron Europe B.V.: Reference list, Version 18, Oct 2011