drug drug interactions

Drug Interactions With Chlorpheniramine Anticholinergic drugs, monoamine oxidase inhibitors, and pramlintide are some of the medications that may cause drug interactions with chlorpheniramine. These interactions could reduce the effectiveness of the medicines or lead to side effects such as drowsiness, dry eyes, or difficulty passing urine. In order to decrease your risk of interactions, tell your healthcare provider about all other medications you are taking. Chlorpheniramine Medication Information Chlorpheniramine Chlorpheniramine Side Effects What Is Chlorpheniramine Used For? Chlorpheniramine Dosage Drug Interactions With Chlorpheniramine Precautions and Warnings With Chlorpheniramine Chlorpheniramine Overdose Chlorpheniramine and Pregnancy Chlorpheniramine and Breastfeeding Chlorpheniramine Interactions: An Overview Chlorpheniramine (an active ingredient in Chlor-Trimeton, Tussionex, and many other medications) can potentially interact with a number of other medicines. Some of the medications that may lead to drug interactions with chlorpheniramine include but are not limited to: Acetylcholinesterase inhibitor medications, such as:

Donepezil (Aricept) Galantamine (Razadyne) Rivastigmine (Exelon) Tacrine (Cognex)

Anticholinergic drugs, such as:

Atropine Belladonna (Donnatal, B&O Supprettes, Bellamine S) Benztropine (Cogentin) Clidinium (Librax) Clozapine (Clozaril) Darifenacin (Enablex) Dicyclomine (Bentyl) Diphenhydramine (Benadryl) Glycopyrrolate (Robinul) Haloperidol (Haldol) Homatropine (Hycodan) Hyoscyamine (Levsin) Ipratropium (Atrovent) Oxybutynin (Ditropan, Ditropan XL, Oxytrol) Solifenacin (VESIcare)

Scopolamine (Transderm Scop) Tiotropium (Spiriva) Tolterodine (Detrol, Detrol LA)

Monoamine oxidase inhibitors (MAOIs), such as:

Isocarboxazid (Marplan) Phenelzine (Nardil) Rasagiline (Azilect) Selegiline (Eldepryl, Emsam, Zelapar) Tranylcypromine (Parnate)

Other products that cause drowsiness, such as:

Alcohol Antipsychotic medications Anxiety medications Most antidepressants Muscle relaxants Narcotic pain relievers Sleep medications Some antihistamines

Phenothiazine medications, such as:

Chlorpromazine (Thorazine) Fluphenazine (Prolixin) Perphenazine (Trilafon) Prochlorperazine (Compazine, Compro) Thioridazine (Mellaril) Trifluoperazine (Stelazine)

Pramlintide (Symlin). Drug Interactions With Chlorpheniramine Article Continues on Next Page > 123Next >> Acetylcholinesterase Inhibitor Medications Taking chlorpheniramine with an acetylcholinesterase inhibitor can make both medications less effective. Your healthcare provider may need to monitor you more closely and adjust your dose of these

medications to prevent interactions from occurring. Check with your healthcare provider before combining these medications. Anticholinergic Drugs Combining an anticholinergic medication with chlorpheniramine (which has anticholinergic effects) can increase your risk of chlorpheniramine side effects, such as dry eyes or difficulty passing urine. Check with your healthcare provider before taking these medications together. Monoamine Oxidase Inhibitors (MAOIs) Taking chlorpheniramine and an MAOI together can prolong and intensify certain side effects of chlorpheniramine (such as drowsiness, dry eyes, or difficulty passing urine). Check with your healthcare provider before combining these medications. Other Medications That Cause Drowsiness Check with your healthcare provider before combining chlorpheniramine with any other medication that also causes drowsiness, as undesirable side effects (such as excessive drowsiness, dizziness, or confusion) may result. Phenothiazines Chlorpheniramine may increase the risk of a dangerous irregular heart rhythm (arrhythmia) due to a phenothiazine medication. In addition, combining chlorpheniramine with a phenothiazine increases the risk of excessive drowsiness. Pramlintide Both pramlintide and anticholinergic medications (including chlorpheniramine) can slow down the movement of food through the digestive tract. Taking them together can increase the risk of constipation or nausea. Talk with your healthcare provider before combining these medications.

drug alcohol or food intrctn

Chlorpheniramine and Alcohol (Ethanol) Moderate Drug Interaction GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and impairment of judgment, thinking, and psychomotor skills. MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Contra Indication
Chlorpheniramine (Maleate) is contraindicated in conditions like Hypersensitivity.

drug disease intrctn chlorpheniramine Alcoholism

Chronic alcohol abusers may be at increased risk of hepatotoxicity.Severe liver injury, including cases of acute

liver failure resulting in liver transplant and death, has been reported in patients

chlorpheniramine Liver Disease

Severe Potential Hazard, High plausibility.it is primarily metabolized in the liver to inactive forms. However, small quantities are converted by minor pathways to metabolites that can cause hepatotoxicity or methemoglobinemia.

chlorpheniramine Anticholinergic Effects

Therapy with antihistamines should be administered cautiously, if at all, in patients with preexisting conditions that are likely to be exacerbated by anticholinergic activity, such as urinary retention or obstruction; angle-closure glaucoma, untreated intraocular hypertension, or uncontrolled primary openangle glaucoma; and gastrointestinal obstructive disorders.

chlorpheniramine Cardiovascular Disease

may cause adverse cardiovascular effects, particularly when used in high dosages and/or in susceptible patients. In cardiac tissues, these agents may produce positive chronotropic and inotropic effects via stimulation of beta-1 adrenergic receptors. Cardiac output, oxygen consumption, and the work of the h eart may be increased

Chlorpheniramine Renal/Liver Disease Patients with renal and/or liver disease may be at greater risk for adverse effects from antihistamines due to drug and metabolite accumulation. Therapy with antihistamines should be administered cautiously in such patients.

Dosage form
dosage form is a mixture of active drug component and nondrug component.depending on the type of admistration it is of several types.they are liquid dosage form,solid dosage form and semisolid dosage forms Oral Chlorpheniramine Dosage for Adults
Depending on the particular product, a typical chlorpheniramine dose for adults is 4 mg every 4 to 6 hours (not to exceed 24 mg per day) for immediate-release products or 8 to 12 mg every 8 to 12 hours (not to exceed 24 mg in 24 hours) for various extended-release products. Keep in mind that these are general guidelines and specific medications may have different directions. Be sure to follow the directions for your particular product.

Oral Chlorpheniramine Dosage for Children

In general, chlorpheniramine can be dosed by age or by weight for children. Based on weight, a standard recommended dose is 0.35 mg per kg per day (0.16 mg per pound per day), divided into smaller doses given every four to six hours. Based on age, the recommended chlorpheniramine dose is as follows:

Age 2 to 6 -- 1 mg every 4 to 6 hours, not to exceed 6 mg in 24 hours Age 6 to 12 -- 2 mg every 4 to 6 hours, not to exceed 12 mg in 24 hours Age 12 and older -- usual adult dosing.

Chlorpheniramine (Maleate) 's dosage details are as follows: Dose Single Dose Frequency Route Instructions

Adult Dosage ( >12 years. )

10.000 mg 4.000 mg 10 (10) 4 (4) 24 hourly 6 hourly IV,IM,SC PO Max. 24 mg daily

Paedriatic Dosage ( 20 Kg. )

0.375 mg/kg 0.375 mg/kg 0.150 mg/kg 0.375 mg/kg 7.5 (7.5) 7.5 (7.5) 3 (3) 7.5 (7.5) 24 hourly 24 hourly 8 hourly 24 hourly Intra Muscular Intra Venous Oral Subcutaneous -

Neonatal Dosage ( 3 Kg. )

0.100 mg/kg 0.3 (0.3) 8 hourly oral

Formula C16H19ClN2
3-(4-chlorophenyl)-N,N-dimethyl3-pyridin-2-yl-propan-1-amine

Chlorpheniramine -- Teratogenic Agent: Introduction

Chlorpheniramine -- Teratogenic Agent: There is evidence to indicate that exposure to Chlorpheniramine (an antihistamine medication) during pregnancy may have a teratogenic effect on the fetus. A teratogen is a substance that can cause birth defects. The likelihood and severity of defects may be affected by the level of exposure and the stage of pregnancy that the exposure occurred at. Synonyms

Chloropheniramine

Chlorophenylpyridamin Chlorophenylpyridamine Chloroprophenpyridamine Chlorphenamine Chlorpheniramine Maleate Chlorprophenpyridamine Clorfeniramina Dexchlorpheniramine Dexchlorpheniramine Maleate