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Investment Highlights
Capital-efficient business strategy focused on finding diamonds in the rough and leveraging research and development investments by big pharma, venture and institutional investors Strategy intended to provide a diversified and more balanced portfolio of risk/return opportunities. Excellagen Wound Care Management Platform: Initial product has now received FDA 510(k) clearance for U.S. marketing and sales Initial focus on diabetic foot ulcers Other product line extensions currently under consideration Consistent with business strategy, support initial launch, seed the market, then monetize Now preparing for launch. Generx Global Cardiovascular Platform: International cost-efficient Phase 3 / Registration Study now cleared for initiation Study Design: 100 patients with SPECT imaging efficacy endpoint Initial medical focus: Patients in Russia with advanced coronary artery disease who have limited access to costly and rationalized bypass surgery and angioplasty / stent procedures (Russian CVD death rates 5X greater than U.S.; average life expectancy for males 57 years) Preparing to initiate. MedPodium In-House Brand Platform: Portfolio of premium, science-based, easy-to-use conditionspecific nutraceuticals designed to promote personal health and well being for today's active, informed and professional lifestyles Seeking revenue-based strategic acquisitions in the nutraceutical space Preparing for initial retail launch of Nutra-Apps products in selected geographic areas. Acquisition Search: Challenging economic environment continues to generate a steady stream of deal flow CXM remains highly selective focused primarily on late-stage clinical development opportunities and revenue-based businesses. Key Investor Metrics: No outstanding debt, substantial trading liquidity, continuing news flow expected Current capital structure provides for significant economic upside potential as CXM executes business strategy Capital-efficient ATM Shelf Registration in place.
Portfolio Status
Company Acquisition Current Key Product Generx [Ad5FGF-4] Phase 3 Registration Study for International Markets
Collateral Therapeutics
Strategic Sale to
Excellagen Wound Care FDA 510(k) Clearance Preparing for Initial Market Launch
Excellagen
Pressure Ulcers
Venous Ulcers
Pre-Formulated Ready-to-Use. One 0.5 cc Excellagen Syringe will Treat Wounds up to 5cm2 in Size Pre-Filled Single Use Sterile Syringes Refrigerated Storage For Professional Use Only
1 Debride
2 Treat
3 Bandage
4 Offload
www.excellagen.com
Medical Devices:
2011 Cardium Therapeutics, Inc.
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2011 Cardium Therapeutics, Inc.
Professional Use Adjunct to Standard of Care Surgical Debridement Broad Product Use Applications Prep: Ready Use Storage: Refrigeration (2 - 8C) Lower Cost
Professional Use Dermal Engraftment Specific Therapeutic Use Claims for DFUs Only Prep: 24 Step Process (Requiring Documentation) Storage: Frozen (-75C) Higher Cost
Tissue Regeneration
Dermagraft is a Registered Trademark of Advanced BioHealing, a subsidiary of Shire PLC.
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Annual
1.3 Million 14 per patient 7 per patient
9.1 Million
$5 Million $10 Million $20 Million $35 Million $50 Million $70 Million $80 Million
Diabetes Association.
Department of Health and Human Services: Agency for Healthcare Research and Quality. $95.00 per Excellagen Treatment.
3 Assumes
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Formulated collagen gel causes a large and rapid time-dependent effect on tissue growth rates. A single application increases the healing rate of neuropathic DFUs..., and more frequent applications hold promise to significantly improve overall incidence of complete wound closure.
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In Vitro Research Study Data The Science of Formulated Collagen Topical Gel
Activated Platelet Release of PDGF
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Cardiovascular Angiogenesis
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50,000 doses
$100 Million
$150 Million
$200 Million
100,000 doses
$200 Million
$300 Million
$400 Million
150,000 doses
2011 Cardium Therapeutics, Inc.
$300 Million
$450 Million
$600 Million
200,000 doses
$400 Million
$600 Million
$800 Million
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Collateral Therapeutics
(NASDAQ)
Schering AG
As Strategic Partner with Collateral Therapeutics
1996
1997 - 2005
2005 - Present
Current Status
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GENERX [Ad5FGF-4]
Generx [Ad5FGF-4] represents a new regenerative medicine therapeutic class of DNA-based biologics that is being developed for interventional cardiology that is designed to promote a disease-modifying physiological response which stimulates the growth of microvascular circulation based on the one-time administration, using a standard cardiac catheter, as a treatment for patients with advanced coronary artery disease. Generx is currently being developed for international markets outside the United States as a treatment alternative for patients who may not have access to costly and invasive advanced care revascularization procedures, including coronary artery bypass surgery and angioplasty/stents, or may not be optimal candidates for these procedures.
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Generx [Ad5FGF-4] Proprietary Intracoronary Administration of DNA-Based Cardiovascular Growth Factor Therapeutic
2011 Cardium Therapeutics, Inc.
Non-surgical delivery by intracoronary administration by interventional cardiologist during an angiogram procedure Utilizes standard balloon catheter which can be easily integrated into diagnostic angiogram procedures or with other percutaneous coronary interventions New induced transient ischemia / reperfusion techniques are designed to enhance DNA uptake and expression in the heart 40% administered to right 60% to left coronary circulation coronary circulation and
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SPECT
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One-Time Treatment
DNA-Based Delivery
Angiogenic Response
AGENT-2 - Representative Generx-treated patient: 77% improvement in cardiac perfusion at 8 weeks equivalent to bypass surgery and PCI (angioplasty/stenting) at one year.
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p=0.14
p<0.05* 10e10 vp
n=35
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Parameter
Number of Patients Age Stress defect extent (%) Reduction of reversible defect (%)
206
6611
6810
579
598
1811
1610
208
209
-512
-0.87
-0.86
-46
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Product
Clinical Status
Clinical Endpoint
Currently Inactive
Preparing to Initiate
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Developing new and innovative, cost-effective advanced care for coronary heart disease patients in international markets
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CONFIDENTIAL
Why Generx for India? 64.0 Million Indians are Projected to have Coronary Artery Disease by 2015
Generx [Ad5FGF-4] Coronary Anatomy and Cardiovascular Disease Issues in India1
2011 Cardium Therapeutics, Inc.
Simpler administration and cost effective treatment compared to bypass and stents First non-surgical revascularization therapy Stimulates the growth of microvascular circulation in patients with coronary artery disease Women and patients with more advanced disease demonstrated significant treatment effect based on distal disease New induced transient ischemia techniques may reduce treatment variability in earlier stage patients
Multi-vessel disease
1Source:
Cardiovascular Disease Trends in India Naresh Terhan, Escorts Heart Institute and Research Centre
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Pre-Clinical
Nature Medicine
AGENT-1
Circulation (American Heart Association Journal)
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AGENT-2
Journal of American College of Cardiology
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OFF
ON
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www.medpodium.com
MedPodium is a portfolio of premium, science-based, easy-to-use condition-specific nutraceuticals, metabolics,
2011 Cardium Therapeutics, Inc.
aesthetics, and other products designed to promote personal health and well being based on natural formulations for today's active, informed and professional lifestyles. MedPodium's products address healthy lifestyle interests that are increasingly important in our technology-based society, including millennials (young adults aged 20 to 35) who are leading the information revolution. The MedPodiums products will feature sealed capsules, quality, easy to use pills, and will also include, fast-acting drops and sprays, and transdermal delivery system.
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Nutraceutical Formulation
X
Pharmaceutical Philosophy Millennial Target Market
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Nutra Apps
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Level I
Sugar Caffeine iPod Nutraceuticals Nicotine Alcohol
2011 Cardium Therapeutics, Inc.
Level II
Medicinal Marijuana ADHD (Ritalin) Anxiety (Xanax) Depression (Prozac, Zoloft) Sleep (Lunesta) Relax (Valium) Pain (Vicoden, Oxycontin)
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Stage I
Stage II
2011
2013
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