An Industrial Visit to the Malladi Drugs and Pharmaceuticals, Ranipet

As an integral part of the Biotechnology programme, all the students of III year, SVCE visited the Malladi drugs and Pharmaceuticals, Ranipet on ______________. This visit provided us an insight on how the company works and their areas of research and development. The company has five manufacturing units in India and one in the USA. In fact, it is the only facility in the United States of America for manufacturing Pseudoephedrine HCl. The manufacturing units, which are ISO 9001:2000, cGMP compliant, audited by the USFDA, EDQM, TGA and other big Pharma Majors; establish a benchmark for other manufacturing units in the Industry. The company has validation capabilities across the Product Development Cycle equipped with dedicated QA and QC teams thus ensuring that the manufacturing units are completely safe for the environment and for their workers. The units have Zero effluent discharge and an impeccable safety record. The reaction conditions range from -70C to +230C and the company also has expertise in Fermentation-based products. Having received prestigious Acharya P C Ray Award for indigenous technology development for the indigenous process we developed to manufacture Ephedrine, the company also has global patents on New Chemical Entities. Some of the therapeutic products that are produced by the company include: Androgens (testosterone), esterogen (estradiol benzoate) and progestogen (allyl estrenol). Some of the active pharmaceutical ingredients produced by the company include: Therapeutic segment Cough & Cold Anti- parkinsons Anti-asthmatic CNS Anti-inflammatory Active Pharmaceutical Ingredient Ephedrine and salts Selegiline HCl Budesonide Lorazepum Fluticasone propionate

Research and Development has played a big role in Malladi's success. The companys R&D centre has been recognised by Anna University and the Department of Science and Technology, Government of India. The research team is staffed with Scientists and Doctors in Organic Chemistry, Analytical Chemistry, Pharmacology, Microbiology and Biotechnology. The areas of focus with respect to biotechnology are: Fermentation

Enzyme Technology in-house capabilities from strain screening to Pre-clinical studies for bio-pharmaceuticals Bio-analytical Service, Media and Yield Optimization, Process Scaleup and Fermentation Bio-Process Development

The chief chemical reactions that involved in the production include acylation, benzoylation, nitration, esterification, tosylation and methylation. The companys effective effluent treatment plant is involved in converting the residues into fertilizer for the neighbouring lands. In conclusion, the industrial visit to the Malladi drugs contributed to the better understanding of the industry-related concepts. It provided us a better understanding of drug discovery and development processes in pharmaceutical industry.