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Pl*ff.,4qZaWzP-Exarr I - FalI 2002
1

Last4 digitsof SSNI.

markedwithan
Questions "*" countfor34ZonJy 342, xl00= -WL,y"I?At
-TIT-1Ft
markedwithan"x" countfor 142onty
Questions
tn: i4. 't'l a
= Et,.E ,"
x100
el d-
(points)

1. Drug-Ais available
asa disodium
salt.The'qlolecyrld
wftgntofNa2Ais342.0glmole.
1M t-
(4) a". You havea stocksolutioncontainiog Cuot)"\qrh How manyml of srock
solutionwouldbe neededto prepare250ml of a 15.0mg%o.solutionof Na2Afor
subseque:rt
i.v. administration? ryt
) ffiJ

,,s'rl.Quitivi _', r r \. ;;-s *,%,

ro':mF'*'tq _-f,"bxi;"
0.,
'r#
(t'.'o = (l.rxt;3t"q(aaar'*)
W\{Ji = 6()Vlblng

[G;; - . <;*r
,+ "- sotofr,om,,,
tl-/'*
b*. How muchrHt would!.B-needed
to makethe 15mg% solutionabove?
>9 tats*0 +LC;
c*, What is the molar concentrationof the 15 mgTosolution?

^ *k. igliyL
x #ffi*'g'.+,
i?b(dry
r m
(r'' d". A nursei, "oo".*.d aboutgiving this drugto a patienton a very low sodium
diet. How many*rq olNa* arecontainedin 20 ml of the !5 mg%osolution?
) r4-!,r'"
., lo@wroa
*,?s5*lotwqls
x5l@\ nnt^x +**
ffife..F^r*- DxiM{re
'KI
cn*H*eg
N-* \
tr
i i -
l(>
E
r ]
{b
 - z:-

2. Sublimationis theprocessby which a solid is transforrneddirectly to a gas.

(3) a". The sublimationpro5esqisenthalpically
(i) favoredt (iii) can'ttell
gindered;

e (3) c.. The subiimation r,.tbcus oY\ \ti

(i) exotherrnic;

(4) d". I didn't lectureabour

ffi,,,,u
drp.o"esVdetail burI did discussother
such processes.Recalling that thermodynamic statefunctions are path-independent,
write an equation which expressesthe enthalpy of sublimation in terms of enthalpies
whichwerediscussed
in class.
*_:
U SOtid

Af{s,rb= 6e:*byl{5etuci
Extra credit
AtL wot At\+rs t N!\"var
(2) e-. Providean of a sublimation process you could
demonstrate
tonour children.

uHadiazineis an acid with pKu = 5.48. Compute the Ku, write a balancedreaction
co\sponding to thatK' identifyingconjugateacid(s)andconjugatebase(s)with
circld$) and box(es)as donein class.

Pkq-=- tcqK^
D+ w'*B - / i t s l
\ z \ n t i l } ' l
K a. : LHJL-fi J
.-.,ri-"-**"TI;;-
- T
l r n i
I t 1F '
L' -i

}al b*Ephedrineis a basewith pKu= 9.36.Computetle Ku, write a balancedreaction

s) witb
d.qt" $"t"$
ymg conJ conjrlgate
bqx(es) in cl .u{J{

Y2- / YL- \+u,c

' ' I

.\ *f
n {{4-
t \
m
-"J{
1*u'*\ t ol * H " {
I
7)
 r J*c{e{lr-+d
tr
r L. '?i""r
->
U

i l i " '-,
ffiT"'
"t"\r/^-''-il n\*/tr------il ll l"
l
l l
l
/
\
/ it il - \
oA*A,.if, o..i;rN- "/".)---(
I (v* t'
vt v' ' 3 NU
i
cHs - :-lr1-i
(c) G) !, I !f'4:
Li
r"{
CompoundC is caffeine,foundin coffee. dr a,
CompoundT is theobromine,foundin chocolate.
r \
ity? (S- )
t\

fr (5)
' ' b.. Explain your answerabove in 15 words or less. Be certain to cleariy indicate the
U i#rmotecular interaction(s)which justify you.r*r*rr. A
Q-4aa4-S,g t/.* uxJi \,{,g
a+rffiu"*"
)\)'O
T ;I,ffifrft^ee6r-
',1 iif 2 lr;r lt4 7,.-9
VT; = *club; ? 1""*;rS
2- Q) c. Accordingto thvMlerckIndex,the solubilityof caffeinein wateris 19in 46ml at
25" C and 1 g{n 1.5ml at 100"C. Is the solubilityof caffeinehigher at25oC or
1oo"c? l$n aQ.

2/ Q) d. Is caffeineanelectroly,"o6ilI**i}\ Circleone.
\__-___j-l

8' (8) e. What is theaqueoussolubilityof caffeineat 65oC? Expressyour answerin units

\r of "g/ml". Hint: thisis an easyZ-partproblemwhich we discussed
in class.You
cando it andyou don't needany additionalinformation.
rl u rS\-
1
-- AA+
\ r r{+ -r\
\-x,J* tz_)

-- 10,Odt =
,K,d" &
n^o{^" I
olYH;
trt
I

/ Xcs"c\-- l o , C 2I t \
'^\-iil*.t-
r (: \
i33sL ',qZL ,/)
)v't
t t ? '
, ' n
/ft
\"ftnll= Q " O l b q :r

:-Ill\uun^a - '16e+
= :-,d(fi
t - -
t _-\
i l
-a J" X
EG'*,r , -^b,,
fi,f b\ u
.'t/ 1 t'l
{rF
\ X = . \ b 3l l n n i
!
 -q-
F. You areaskedto prepare250 nrl of an isotonicsolutioncontaining0.87obarbitalNa
V (drug-B) and1,57oPhenobarbitalNa (drug-P)

L (6 a. How manygramsof B, P, andNaCl wouldyou use?

U
|I ,/' Compund IvIW E ^r;'"
barbitalNa 2M.2 0.29 0.I7
phenobarbiral
Na 2Y.2 0.24 0.I4
NaCi 58.5 i.00 0.58
dexkose 198.2 0.16 0.093

-
n Q a' J Aez<\'^ '
X a=')''n".'-Q^= 9n " 2n 5c { P fl o' d- *; l' $
"-.'
too fYt- ^ rr,24.nr
=ilt't Nac{ '5f1 N" t-t
e\ )n( )t*xL , = x :
,6[u.l
{.; )

5
Vn^4* 2$b*n',r{"
?g)
1oO
," = "11 NoC ,'*,
e) &

(4) b. How manygramsof dextrosecouldbe usedin piaceof theNaCl?

-t)1No.o x^ )3W^w* = t'3\-, da-v*v"Eds
o tfu"'' 1

(2) c. Whatis thefregzingpo!4!-o_f

m*.+f;ffir#=ntlzzi
in part(a)?
lhe solutionprepared
'

uk (v^L fora"prof
(2points "u"'*
sionar
es -
t "so' ?ff[.flfls'61"#i]''ffi ],
a
i l

l0 €t #*r:#ssl,
L;;{gie.
E r i<l
I X
t \ )
 r l

,2!W a. Writeanequation
whichdefinest,*, Vtro L

-) (3) b.' Which modeof intermolecuiarinteractionrequirestheshortest

intermol€et*lar
distancein orderto bSsffrctive?
)
4bcnding
(3) c*' As two neutralmoleculesapproacheachotler, whichmodeof intermolecular
) intera*ionir lle{,fiu*rt
t lecfron h?,fic \ nl*rodrCg
d"' Which mode(s)of intennolecularinteractioncanorientone
moleculewith respecrro
20' another?
4- Incfnos*<xh* i rn{--<,rqcfioy_lg
l-.1.. J ,
i- 1t t oltr; BonS rv.q
a. &ry a 'icolligative
property",15wordsor lesg.o#'t giveexamples.

)(3)8'
[-cuI I i 1or+'vt ]>t ol)-er+1 d e1:t )d5
o.,rd n0t-\1/ts,
on *V\&fiuw-lg4ro{ SdL{k,po"y+icjg-r
I
\9 p< & solrrle ,
I
Q) b. 0.97oNacl and2voboricacidhavethesamefreezingpoint
Do ttreyalso
I ff
the same LT7? (circleone)
I (fii fitt (ii) no; (iii) car'rteu
\-/
,{, c. Do a.9voNacl and.2vo boric acidhavethe sameart
LDI r-..-\
tQ,J..; (ii) no; (iii) can'rteil
ATu?. (circle
\vuvtw one)
vuel

(3)
. t'
d. Are 0-9voNacl and2voboic acidisotonic?(circle one)

(3|)
I e.
(i) yes; (ii) no; (61*,tt,etl
\_,,/
F\0,9vo Nacl andZvoboricacidiso-osmotic?(circreone)
. )
rL- (\r) yfs; /f,., \
(ii) no; (iii) can'rrell

I
-t
I
n \/

tq I
 b-
9. You areaskedto formulatea 5 mgVosolutionof drug-Xin an oil/wateremulsion
consistingof 2 partsoil and8 partswater. The ko7*for dug-X is 23.7.

(7) a. Whatis thecoXcentration

of drug-X in theaqueousphaseof the emulsion? |
i{' Kq-= # = }e.1 Co: t?,\i ^Mt
= fo V'+ C'e\w
Co= P"tCw &U'. = fol" t flr"V*;
Sry(, lOfine= 231c'ilPY/v:('t
+€ ilu';
lO : eznlaJ*,'
5r.nq,]o
ic*
ry'% = 5*'L*cu,
1.40wq"lo
L-+_-'
= ft-<)
\,/
(e z el T(fiD'l"D

@! Howmuchdrug-Xis cootained
\; e':?3r31e
in theoil phaseof 1 ouncedffrg'Uffirsffi**'
l) (1 ounce
=zg.itrt)

-=S{fml
;ir'Jia {jop*'*") - , t"t"lJ l0 "
- A\^/ I"ttv
":--"---**-T:**"*\.- ^ F A.^-^ ^Ya*?

'qFlS- .n43}
'353t}
h6
.'.?3I:*& ?
-*itg
bDJ-- [9'"64-
*W hez i-Z+rry7r.
-
(4) c'. The aqueoussolubilityof drug-Xis 0.02M. Wnutis a roughestimateof its (
solubilityin oil? \
-iL ^r*. - {.o{q)
JF a,..,"g\,. u, A r^*il"iicr^a1p_ ,4fuirrt
t'u' V^fr.U^g,.\s.4LLt-- gtA LLnr.aj.ol LA,ox-,t{q
u^q-o'o?t*,,i'f '
K>*t 2^9.+
a 2

Shl
90r29+ (o"oL$= UH
(2) d'. Extra credit: why is your answerto part c just a rough estimate?(5 words or ress)
t Y ) -+::t**i-*
(L- ;
,|
b

I
a- I
) A^e$S -0lt U/\r*o( Ary$*xx$*efo
/ ) &t tu'qL o,L?AL.,r.rq
wfur,.H,f*a-
 -7-
(4) 10' rffhat is the solubilityof compoundABz giventhatits Kro$ a.2
x*1p-10?
NB, =r ,A'i Pi: i knu:Ln{Ls'l'
(o*D (o*a4
g ar'b'o={y)f ex)z
€

0 9,? u,lr':= ?xt

_ t2\ ./

)\ \,aottttoffi X = 3o1
'a$r\''f1
. / / \
\ \

J
I
I
physicianorders10ml of a 5 mgvoDC1.solutionto be administeredto a
pital patientby i.v. infusionoverapproximately2 hours. DC1 is a sparingly
solubleC1-saltwith \o = 4.2 x 10-7 andmolecularweight3l2.Sg/mole.The
nursenotesthatthepafiLntisalready'".Euio!ffilytesupplementbyi'v.
infusionandnotesthat,by coincidence,therejust happenstobe 2-00rnt of
electrolytesolutionleft in thei.v. bagandthattheinfusionpumpis setat 100

% ml/h. Sheis just aboutto mix the 10ml of DC1 with the200 ml of electrolvte
whensherecallsthepossibilitythatthe drugmix precipitatein thei.v. bug.
Hopingto avoidstartinga secondinfusion,shecallsthl pha:rracistto usliif
mixing would be oK. The total Cl'concentratiooin theplain electrolyte
solutionis 0.1M.

would anyDC1 precipitate?If so,how much? show ealculationswhich

supportyour answer.
':S;i-fd".:+ x ji*bt
loowrl
''
lr--- lomnn6 gtZ.'g<r = '!,(,'\ rr
Y N.,?ru

uTio> 1 ' ,G t q v lr D
l-
c n r o o t- H s * ( o . l n 4 ) - t ,saltcz
C\ ro*'.{ '= :ggegg:,

* 1f:$T "$1rQ =
xr""q{,oqben1)=1p^rD?jtffi,
9.ev-ril= {x) r};:q
/ \'/ {o
_^,:{,*l-]];v'--
i
tfrSee
ffiffiD) le
,{: q 4\;_,:i_-j{*#***Sione}a*e,tcr