1.

Brand Name: Rifadin, Rimactane

Generic Name:

rifampicin/rifampin

Drug Classification:

Antibiotic, Antituberculotic (first line)

Mechanism of Action: Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible Mycobacterium tuberculosis organisms. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. Inhibits DNA-dependent RNA polymerase activity in susceptible bacterial cells. Rifampin, a semisynthetic broad-spectrum bactericidal antibiotic, inhibits bacterial RNA synthesis by binding strongly to the beta subunit of DNA-dependent RNA polymerase, preventing attachment of the enzyme to DNA, and thus blocking initiation of RNA transcription Indication: Treatment of Pulmonary TB in conjunction with at least one other effective antituberculotic. Neisseria meningitidis carriers, for asymptomatic carriers to eliminate meningococci from nasopharynx; not for treatment of meningitis. Unlabeled uses: Infections caused by Staphylococcus aureus and Staphylococcus epidermis, usually in combination therapy; gram-negative bacteremia in infancy; Legionella pneumophilia, not responsive to erythromycin; leprosy (in combination with dapsone); prophylaxis of meningitis caused by Haemophilis influenzae. This antibiotic treats only bacterial infections. It will not work for viral infections (e.g., common cold, flu).

Contraindication:

Contraindicated with allergy to any rifamycin, acute hepatic disease, lactation. Use cautiously with pregnancy (teratogenic effects have been reported in preclinical studies; safest antituberculous regimen for use in pregnancy is condidered to be rifampin, isoniazid, and ethambutol).

Side Effects: Less serious side effects may include: tired feeling; or red or orange colored urine, stools, tears, sweat, or saliva. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

Adverse Drug Effects:

CNS: headache, drowsiness, fatigue, dizziness, inability to concentrate, mental confusion, generalized numbness, muscle weakness, visual disturbances. Dermatologic: Rash, pruritus, urticaria, flushing, reddish discoloration of body fluidstears, saliva, urine, sweat, sputum. GI/ Hepatotoxic: heartburn, distress, anorexia, vomiting gas, cramps, diarrhea, hepatitis, pancreatitis, jaundice, liver failure in severe cases- nausea, vomiting, abdominal cramps with or without diarrhea GU: hemoglobinuria, hematuria, renal insufficiency, acute renal failure, menstrual disturbances. Hematologic: eosinophilia, thrombocytopenia, transient leucopenia, hemolytic anemia, decreased Hgb, hemolysis; Blood dyscrasias (sore throat; unusual bleeding or bruising) Other: pain in extremities, osteomalacia, myopathy, fever, flulike symptoms.

Flu-like symptoms - with chills, fever,

headache, arthralgia, and malaise. Rifampin has good penetration into the brain, and this may directly explain some malaise and dysphoria in a minority of users.

Nursing Responsibilities: Administer on an empty stomach, 1 hr before or 2 hr after meals. Administer in a single daily dose. Consult pharmacist for rifamoin suspension for patients unable to swallow capsules. Prepare patient for the reddish-orange coloring of body fluids (urine, sweat, sputum, tears, feces, saliva); soft contact lenses may be permanently stained; advise patients not to wear them during therapy. Warning: arrange for follow-up visits for liver and renal

function tests, CBC, and ophthalmic examinations. Health Teachings Teach client to take drug in a single daily dose. Take on an empty stomach, 1 hr before or 2 hrs after meals. Inform client to take this drug regularly; avoid missing any doses; do not discontinue this drug without consulting the health care provider. Tell client to have periodic medical checkups, including eye examinations and blood test, to evaluate the drug effects. Inform client that he may experience the drugs side effects (especially the red colored secretion) Instruct client to see his physician if he experience fever, chills, muscle and bone pain, excessive tiredness or weakness, loss of appetite, N/V, yellowing of eyes/skin, unusual bleeding or bruising, skin rash or itching. Instruct client to remove contact lenses as they may discolor

Additional infos:

2. Brand Name: Tebrazid (Canada)

Generic Name:

pyrazinamide

Drug Classification:

Antibacterial

Mechanism of Action:

Pyrazinamide is a prodrug that stops the growth of Mycobacterium tuberculosis. M. tuberculosis has the enzyme pyrazinamidase which is only active in acidic conditions.[6] Pyrazinamidase converts pyrazinamide to the active form, pyrazinoic acid which accumulates in the bacilli. Pyrazinoic acid was thought to inhibit the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids[7] although this has been discounted.[8] It was also suggested that the accumulation of pyrazinoic acid disrupts membrane potential and interferes with energy production, necessary for survival of M. tuberculosis at an acidic site of infection. Further studies reproduced the results of FAS I inhibition as the putative mechanism first in whole cell assay of replicating M. tuberculosis bacilli which have shown that pyrazinoic acid and its ester inhibit the synthesis of fatty acids.[9] This study was followed by in vitro assay of tuberculous FAS I enzyme that tested the activity with pyrazinamide, pyrazinoic acid and several classes of pyrazinamide analogs. Pyrazinamide and its analogs inhibited the activity of purified FAS I.[10]Mutations of the pyrazinamidase gene (pncA) are responsible for pyrazinamide resistance in M. tuberculosis.

Indication:

Pyrazinamide is used with other medications to treat tuberculosis (TB). It is an antibiotic and works by stopping the growth of bacteria.This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness. Initial treatment of active tuberculosis in adults and selected children when combined with other antituberculosis agents. After treatment failure with other primary drugs in any form of active tuberculosis.

Contraindication:

Pyrazinamide is contraindicated in conditions like Renal diseases, Hepatic disease.

Side Effects:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); a fever; unusual weakness or fatigue; nausea, vomiting, or loss of appetite; yellow skin or eyes; dark urine; difficult or painful urination; worsening gout; a rash; or arthralgia

Adverse Drug Effects:

Dermatologic Acne; photosensitivity. GI Anorexia; nausea; vomiting. Genitourinary Dysuria; interstitial nephritis. Hematologic-Lymphatic Increased serum iron; sideroblastic anemia with erythroid hyperplasia; thrombocytopenia; vacuolation of erythrocytes. Hepatic Hepatotoxicity. Metabolic-Nutritional Porphyria. Musculoskeletal Mild arthralgia, myalgia. Miscellaneous Fever; hypersensitivity reactions, including pruritus, rash, urticaria. Adverse reactions CNS: headache GI: nausea, vomiting, diarrhea, peptic ulcer, abdominal cramps, anorexia GU: dysuria, increased uric acid secretion Hematologic: hemolytic anemia Hepatic: hepatotoxicity Metabolic: hyperuricemia, gout Musculoskeletal: joint pain Skin: urticaria, photosensitivity

Nursing Responsibilities:

Monitor Measure baseline serum uric acid and liver function prior to the onset of therapy and periodically during treatment.

Patient Information/ Teaching Points

Emphasize need to be compliant with regimen and that doses should not be missed. Explain that long-term therapy (6mo to 2yr) will be necessary. Inform diabetic patients that drug may interfere with urine ketone values. Emphasize importance of follow-up examinations to monitor effectiveness of therapy and identify adverse reactions. Instruct patient to report the following symptoms to health care provider: fever; loss of appetite; malaise; nausea and vomiting; darkened urine; yellowish skin or eye discoloration; pain or swelling joints. Advise patient to avoid intake of alcoholic beverages and alcohol-containing products.

Nursing Implications Assessment & Drug Effect

Observe and supervise closely. Patients should receive at least one other effective antituberculosis agent concurrently. Examine patients at regular intervals and question about possible signs of toxicity: Liver enlargement or tenderness, jaundice, fever, anorexia, malaise, impaired vascular integrity (ecchymoses, petechiae, abnormal bleeding). Hepatic reactions appear to occur more frequently in patients receiving high doses. Lab tests: Obtain liver function tests (especially AST, ALT, serum bilirubin) prior to and at 24 wk intervals during therapy. Blood uric acid determinations are advised before, during, and following therapy.

Patient & Family Education

Report to physician onset of difficulty in voiding. Keep fluid intake at 2000 mL/d if possible. Monitor blood glucose (diabetics) for possible loss of glycemic control. Do not breast feed while taking this drug without

consulting physician.

Additional infos:

3. Brand Name: Niazid

Generic Name:

isoniazid

Drug Classification:

Antituberculic

Mechanism of Action:

This medication is used with other medications to treat active tuberculosis (TB) infections or alone to prevent those who have a positive TB test from developing symptoms of TB. Isoniazid belongs to a class of drugs known as antibiotics that are active against tuberculosis. Interferes with lipid and nucleic acid biosynthesis in actively growing tubercle bacilli. Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG.[5] KatG couples the isonicotinic acyl withNADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action

of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of Isoniazid, including nitric oxide,[6] which has also been shown to be important in the action of another antimycobacterial prodrug PA-824.[7] Isoniazid is bactericidal to rapidly-dividing mycobacteria but is bacteriostatic if the mycobacterium is slow-growing.[citation
needed]

Isoniazid inhibits the P450 system.

Indication:

Tuberculosis of all forms Prophylaxis in specific patients who are tuberculin reactors (positive Mantoux test)) or who are considered to be high risk for TB.

Contraindication:

Isoniazid is contraindicated in patients who develop severe hypersensitivity reactions, including drug -induced hepatitis; previous isoniazid-associated hepatic injury; severe adverse reactions to isoniazid such as drug fever, chills, arthritis; and acute liver disease of any etiology. Contraindications Hypersensitivity to drug Acute hepatic disease or previous hepatitis caused by isoniazid therapy

Side Effects:

Side effects

Peripheral neuropathy Nausea and vomitting Thrombocytopenia Local irritation at IM site Epigastric distress Elevated AST

Mao ra ni naa sa uban nga sites

Adverse Drug Effects:

Adverse reactions CNS: peripheral neuropathy, dizziness, memory impairment, slurred speech, psychosis, toxic encephalopathy, seizures EENT: visual disturbances GI: nausea, vomiting GU: gynecomastia Hematologic: eosinophilia, methemoglobinemia, hemolytic anemia, aplastic anemia, agranulocytosis, thrombocytopenia Hepatic: hepatitis Metabolic: pyridoxine deficiency, hyperglycemia, metabolic acidosis Respiratory: dyspnea Other: fever, pellagra, lupuslike syndrome, injection site irritation, hypersensitivity reaction

Nursing Responsibilities:

History: allergy to the drug. Can cause peripheral neuropathy which is manifested by tingling sensation on extremities. It can be prevented through use of supplemental vitamin B6 (pyridoxine). Physical: skin color, lesions, T; orientation, reflexes, peripheral sensirivity, bilaterally grip strength ophthalmologic examination; R, adventitious sounds; liver evaluation; CBC;LFTs renal fxn tests, blood glucose. Give in an empty stomach 1 hr before or 2 after meals; may be given with food if GI UPSET OCCURS. Give in a single daily dose. Reverse parenteral dose for pt unable to take oral meds. Dec. foods containing tyramine or histamine in pt diet. Consult doctor and arrange for daily pyridoxine in diabetic, alcoholic or malnourished pt also for pt that develops peripheral neuritis, and those with HIV. Family health teachings: Take this drug in single daily dose. Take drug on an empty stomach, 1 hour before or 2 hours after meals. If GI distress occurs, may be taken with food. Take this drug regularly, avoid missing doses, do not discontinue without first consulting your health care provider. Do not drink alcohol or drink as little as possible. There is an inc. risk of heap if these two drugs

are combined. Avoid foods containing tyramine, consult a dietitian to obtain a list of foods containing tyramine or histamine. Have periodic medical check-ups, including an eye examination and blood test, to evaluate the drug effects. Report for weakness, fatigue, loss of appetite, n/v, yellowing of skin or eyes, darkening of the urine, numbness or tingling in hands or feet. Additional infos:

4. Brand Name: Myambutol, Servambutol

Generic Name:

ethambutol

Drug Classification:

Antituberculotic

Mechanism of Action:

Ethambutol is bacteriostatic against actively growing TB bacilli, it works by obstructing the formation of cell wall. Mycolic acids attach to the 5-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactanpeptidoglycan complex in the cell wall. It disrupts arabinogalactan synthesis by inhibiting the enzyme arabinosyl transferase. Disruption of the arabinogalactan synthesis inhibits the formation of this complex and leads to increased permeability of the cell wall. Mao ra ni,.

Indication:

Ethambutol eliminates certain bacteria that cause tuberculosis (TB). It is used with other medicines to treat tuberculosis and to prevent you from giving the infection to others. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Wala na koy laing makit.an.

Contraindication:

Ethambutol hydrochloride is contraindicated in patients who are known to be hypersensitive to this drug. It is also contraindicated in patients with known optic neuritis unless clinical judgemnet determines that it may be used. Ethambutol hydrochloride is contraindicated in patients who are unable to appreciate and report visual side ettects or changes in vision (eg, young children, unconscious patients). Ethambutol hydrochloride is contraindicated in patients who are known to be hypersensitive to this drug. Renal impairment, old age and optic neuritis are relative contraindications (PDR, 1989).

Side Effects:

loss of appetite upset stomach vomiting numbness and tingling in the hands or fee optic neuritisblurring of vision

Ethambutol side effects. - blurred vision; - inability to see the colors red and green; - itching; - loss of appetite; - numbness and tingling in the hands or feet; - skin rash; - sudden changes in vision; - upset stomach; - vomiting;

Adverse Drug Effects:

Serious Reactions

anaphylaxis hypersensitivity syndrome erythema multiforme thrombocytopenia neutropenia leukopenia optic neuritis blindness, irreversible peripheral neuropathy pulmonary infiltrates hepatotoxicity, incl. fatal

Nursing Responsibilities:

Assess patient for infection (appearance of wounds, sputum, VS, urine and stool and WBC.) at beginning and during therapy. Obtain specimens before initiating therapy. Take drug as indicated. Not to be given to children 6 years below due to optic neuritis Provide supplemental vitamin A. if not contraindicated

Perform visual acuity and color discrimination test before and during therapy Ensure that any changes in vision dont result from an underlying condition Obtain AST and ALT levels before therapy,

and monitor these levels every 3 to 4 weeks In patients with impaired renal function, base dosage on drug level.

Always give drug with other antituberculotics to prevent development of resistant organisms Monitor uric acid level; observe patients signs and symptoms of gout.

Additional infos:

5. Brand Name: Zovirax

Generic Name:

acyclovir

Drug Classification:

Antiviral

Mechanism of Action:

Mechanism of action Aciclovir differs from previous nucleoside analogues in containing only a partial nucleoside structure: the sugar ring is replaced with an open-chain structure. It is selectively converted into acyclo-guanosine monophosphate (acyclo-GMP) by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation than cellular thymidine kinase. Subsequently, the monophosphate form is further phosphorylated into the active triphosphate form, acycloguanosine triphosphate (acyclo-GTP), by cellular kinases. Acyclo-GTP is a very potent inhibitor of viral DNA polymerase; it has approximately 100 times greater affinity for viral than cellular polymerase. As a substrate, acyclo-GTP is incorporated into viral DNA, resulting in chain termination. Although acyclovir resembles a nucleotide, it has no 3' end. Therefore, after its incorporation into a growing DNA strand, no further nucleotides can be added to this strand. It has also been shown that viral enzymes cannot remove acyclo-GTP from the chain, which results in inhibition of further activity of DNA polymerase. Acyclo-GTP is fairly rapidly metabolised within the cell, possibly by cellular phosphatases. In sum, aciclovir can be considered a prodrug: it is administered in an inactive (or less active) form and is metabolised into a more active species after administration.

Indication:

Initial and recurrent mucosal and cutaneous HSV 1 and 2 and varicella zoster infections in immunocompromised patients Severe initial and recurrent genital herpes infections in selected patients Herpes simplex encephalitis in patients > 6 mo Acute treatment of herpes zoster (shingles) and chickenpox Ointment: Initial HSV genital infections; limited mucocutaneous HSV infections in immunocompromised patients Cream: Recurrent herpes labialis (cold sores) in patients > 12 yr Unlabeled uses: Cytomegalovirus and HSV infection following transplant, herpes simplex infections, varicella pneumonia, disseminated primary eczema herpeticum Contraindicated with allergy to acyclovir, seizures, CHF, renal disease, lactation. Use cautiously with pregnancy.

Contraindication:

Acyclovir is contraindicated in lactation, hypersensitivity, severe renal impairment, hypoxia and in neurological diseases.

Side Effects:

diarrhea, nausea, and a general ill feeling.

Adverse Drug Effects:

Systemic administration CNS: Headache, vertigo, depression, tremors, encephalopathic changes Dermatologic: Inflammation or phlebitis at injection sites, rash, hair loss GI: Nausea, vomiting, diarrhea, anorexia GU: Crystalluria with rapid IV administration, hematuria Topical administration Dermatologic: Transient burning at site of application General: Anaphylaxis, angioedema, fever, headache, pain, peripheral edema. Nervous: Aggressive behavior, agitation, ataxia, coma, confusion, decreased consciousness, delirium, dizziness, dysarthria, encephalopathy, hallucinations,paresthesia, psychosis, seizure, somnolence, tremors. These symptoms may be marked, particularly in older adults or in patients with renal impairment (seePRECAUTIONS). Digestive: Diarrhea, gastrointestinal distress, nausea. Hematologic and Lymphatic:Anemia, leukocytoclastic

vasculitis, leukopenia,lymphadenopathy, thrombocytopenia. Hepatobiliary Tract and Pancreas: Elevated liver function tests, hepatitis,hyperbilirubinemia, jaundice. Musculoskeletal: Myalgia. Skin:Alopecia, erythema multiforme, photosensitive rash, pruritus, rash,Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria. Special Senses: Visual abnormalities Urogenital: Renal failure, renal pain (may be associated with renal failure), elevated blood urea nitrogen, elevated creatinine, hematuria Nursing Responsibilities: Assessment History: Allergy to acyclovir, seizures, CHF, renal disease, lactation, pregnancy Physical: Skin color, lesions; orientation; BP, P, auscultation, perfusion, edema; R, adventitious sounds; urinary output; BUN, creatinine clearance Interventions Systemic administration Ensure that the patient is well hydrated. Topical administration Start treatment as soon as possible after onset of signs and symptoms. Wear a rubber glove or finger cot when applying drug. Teaching points Systemic administration Complete the full course of oral therapy, and do not exceed the prescribed dose. Oral acyclovir is not a cure for your disease but should make you feel better. Avoid sexual intercourse while visible lesions are present. These side effects may occur: Nausea, vomiting, loss of appetite, diarrhea; headache, dizziness. Report difficulty urinating, rash, increased severity or frequency of recurrences. Topical administration Wear rubber gloves or finger cots when applying the drug to prevent autoinoculation of other sites and transmission to others. This drug does not cure the disease; application during symptom-free periods will not prevent recurrences. Avoid sexual intercourse while visible lesions are present. This drug may cause burning, stinging, itching, rash; notify your physician if these are pronounced.

Additional infos:

6. Brand Name: Diflucan

Generic Name:

fluconazole

Drug Classification:

Antifungal

Mechanism of Action:

Therapeutic actions Binds to sterols in the fungal cell membrane, changing membrane permeability; fungicidal or fungistatic depending on concentration and organism.

Indication:

Treatment of oropharyngeal, esophageal, vaginal, and systemic candidiasis Treatment of cryptococcal meningitis Prophylaxis of candidiasis in bone marrow transplants Contraindicated with hypersensitivity to fluconazole, lactation. Use cautiously with renal impairment.

Contraindication:

Side Effects:

Vomiting, headaches, and dizziness are among the most commonly reportedside effects of fluconazole.

Adverse Drug Effects: Adverse drug reactions associated with fluconazole therapy include:[4]

Infrequent (0.11% of patients): anorexia, fatigue,

constipation

Rare (<0.1% of

patients): oliguria, hypokalaemia, paraesthesia, seizures, alopecia, Stevens-Johnson syndrome, thrombocytopenia, other blood dyscrasias, serious hepatotoxicity including hepatic failure,anaphylactic/anaphylactoid reactions

Very rare: prolonged QT interval, torsades de pointes

Nursing Responsibilities:

Assessment History: Hypersensitivity to fluconazole, renal impairment, lactation, pregnancy Physical: Skin color, lesions; T; injection site; orientation, reflexes, affect; bowel sounds; renal function tests; CBC and differential; culture of area involved Interventions Culture infection prior to therapy; begin treatment before lab results are returned. Decrease dosage in cases of renal failure. Infuse IV only; not intended for IM or SC use. Do not add supplement medication to fluconazole. Administer through sterile equipment at a maximum rate of 200 mg/hr given as a continuous infusion. Monitor renal function tests weekly, discontinue or decrease dosage of drug at any sign of increased renal toxicity. Teaching points Drug may be given orally or intravenously as needed. The drug will need to be taken for the full course and may need to be taken long term. Use hygiene measures to prevent reinfection or spread of infection. Arrange for frequent follow-up while you are using this drug. Be sure to keep all appointments, including those for blood tests. These side effects may occur: Nausea, vomiting, diarrhea (eat frequent small meals); headache

(analgesics may be ordered). Report rash, changes in stool or urine color, difficulty breathing, increased tears or salivation.

Additional infos:

7. Brand Name: Trikacide (CAN)

Generic Name:

metronidazole

Drug Classification:

Antibiotic; Antibacterial; Amebicide; Antiprotozoal

Mechanism of Action:

Therapeutic actions Bactericidal: Inhibits DNA synthesis in specific (obligate) anaerobes, causing cell death; antiprotozoaltrichomonacidal, amebicidal: Biochemical mechanism of action is not known Acute infection with susceptible anaerobic bacteria Acute intestinal amebiasis Amebic liver abscess Trichomoniasis (acute and partners of patients with acute infection) Preoperative, intraoperative, postoperative prophylaxis for patients undergoing colorectal surgery Topical application: Treatment of inflammatory papules, pustules, and erythema of rosacea Unlabeled uses: Prophylaxis for patients undergoing gynecologic, abdominal surgery; hepatic encephalopathy; Crohn's disease; antibiotic

Indication:

associated pseudomembranous colitis; treatment ofGardnerella vaginalis, giardiasis (use recommended by the CDC)

Contraindication:

Contraindicated with hypersensitivity to metronidazole; pregnancy (do not use for trichomoniasis in first trimester). Use cautiously with CNS diseases, hepatic disease, candidiasis (moniliasis), blood dyscrasias, lactation.

Side Effects:

Potential side effects seen with metronidazole include diarrhea or constipation, dizziness, and nausea.

Adverse Drug Effects:

Adverse effects CNS: Headache, dizziness, ataxia, vertigo, incoordination, insomnia, seizures, peripheral neuropathy, fatigue GI: Unpleasant metallic taste, anorexia, nausea, vomiting, diarrhea, GI upset, cramps GU: Dysuria, incontinence, darkening of the urine Local: Thrombophlebitis (IV); redness, burning, dryness, and skin irritation (topical) Other: Severe, disulfiram-like interaction with alcohol, candidiasis (superinfection) Assessment History: CNS or hepatic disease; candidiasis (moniliasis); blood dyscrasias; pregnancy; lactation Physical: Reflexes, affect; skin lesions, color (with topical application); abdominal exam, liver palpation; urinalysis, CBC, liver function tests Interventions Avoid use unless necessary. Metronidazole is carcinogenic in some rodents. Administer oral doses with food. Apply topically (MetroGel, MetroCream) after cleansing the area. Advise patient that cosmetics may be used over the area after application. Reduce dosage in hepatic disease. Teaching points Take full course of drug therapy; take the drug with food if GI upset occurs. Do not drink alcohol (beverages or preparations containing alcohol, cough syrups); severe reactions may occur. Your urine may appear dark; this is expected. Refrain from sexual intercourse unless partner wears a condom during treatment for trichomoniasis. Apply the topical preparation by cleansing the area

Nursing Responsibilities:

and then rubbing a thin film into the affected area. Avoid contact with the eyes. Cosmetics may be applied to the area after application. These side effects may occur: Dry mouth with strange metallic taste (use frequent mouth care, suck sugarless candy); nausea, vomiting, diarrhea (eat frequent small meals). Report severe GI upset, dizziness, unusual fatigue or weakness, fever, chills.

Additional infos: