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Match Document Document Title Score 1 US20110081362 TREATMENT OF CANCER Described herein are methods based, in part, on the discovery of genes or gene products that can be 101 down-modulated to inhibit the growth and survival of a cell, such as a cancer cell. In one... 2 7498333 Enantiomers of selected fused heterocyclics and uses thereof This invention relates to novel compounds having the structural formula (I) and to their 69 pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or... 3 7199107 Antisense modulation of kinesin-like 1 expression Antisense compounds, compositions and methods are provided for modulating the expression of 59 kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,... 4 7163927 Antisense modulation of kinesin-like 1 expression Antisense compounds, compositions and methods are provided for modulating the expression of 59 kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,... 5 7902240 Substituted pyrazole and triazole compounds as KSP inhibitors Disclosed are new substituted pyrazole and triazole 58 compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with... 6 7662581 Eg5 co-crystals This invention provides methods of identifying an Eg5 binding ligand. The ligand is identified by 58 using the atomic coordinates of an Eg5 crystal to generate a three dimensional structure. The three... 7 7820646 Cyclized derivatives as Eg-5 inhibitors The present invention relates to new substituted imidazole compounds have the following Formula 54 (I) and to the pharmaceutically acceptable salts, esters, or prodrugs thereof, to compositions of the... 8 7718628 Antisense modulation of kinesin-like 1 expression 51 Antisense compounds, compositions and methods are provided for modulating the expression of

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kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,... ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT The present invention relates to a method of treating cancer by pretreatment with anti-mitotic agents followed by at least one aurora kinase inhibitor. Extensive illustrations are provided for the... Compositions and methods for inhibiting expression of Eg5 gene The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Eg5 gene (Eg5 gene), comprising an antisense strand having a nucleotide sequence which is... Mannich Base N-Oxide Drugs Disclosed are Mannich base N-oxides of drugs containing acidic NH groups. Pharmaceutical compositions comprising a therapeutically effective amount of Mannich base N-oxides, or a N-oxide... Mitotic kinesin inhibitor A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R1... Tetrahydroquinolines Disclosed are compounds of formula (I), wherein W, R, R1, R2, R3, R4, R5, R6, and R7 have the meanings indicated in claim 1. Said compounds can be used for the treatment of tumors, among other things. Enantiomers of Selected Fused Pyrimidones and Uses in the Treatment and Prevention of Cancer This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or... Mitotic kinesin binding site The present invention is directed to the identification, characterization and threedimensional structure of a novel ligand binding site of KSP. Binding of ligands to the novel binding site result...

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US20100285001 Method and Compositions Related to Synergistic Responses to Oncogenic Mutations Disclosed are compositions and methods related to new targets for cancer treatment. US20070249636 Selected Fused Heterocyclics and Uses Thereof This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or... US20060041128 Selected fused heterocyclics and uses thereof This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or... US20060063751 Novel fused heterocycles and uses thereof This invention relates to novel compounds having the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification and to their pharmaceutical compositions and to... US20060041129 Enantiomers of selected fused heterocyclics and uses thereof This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or... US20020165240 Method of treating proliferative diseases using Eg5 inhibitors The invention provides a method for treating a condition via modulation of the Eg5 protein activity comprising administering to a mammalian species in need of such treatment an effective amount of... US20080153854 NOVEL FUSED HETEROCYCLES AND USES THEREOF This invention relates to novel compounds having the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification and to their pharmaceutical compositions and to... US20090099210 ENANTIOMERS OF SELECTED FUSED HETEROCYCLICS AND USES THEREOF This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or...

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US20070287703 Fused Pyrimidones Useful in the Treatment and the Prevention of Cancer Compounds which possess Eg5 inhibitory activity and are useful for their anti-cell-proliferation (such as anti-cancer) activity and thus in methods of treatment of the human or animal body are... US20060270689 Novel Fused Heterocycles and Uses Thereof This invention relates to novel compounds having the formula (I) (a chemical formula should be inserted hereplease see paper copy enclosed herewith) m=0, 1, 2 n=0, 1 (I) wherein R1, R2, R3, R4,... 6900214 Cyano-substituted dihydropyrimidine compounds and their use to treat diseases The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer agents.... US20100087508 Compositions and Methods for Inhibiting Expression of Eg5 and VEGF Genes This invention relates to compositions containing double-stranded ribonucleic acid (dsRNA) in a SNALP formulation, and methods of using the compositions to inhibit the expression of the Eg5 and... US20030008888 Novel cyano-substituted dihydropyrimidine compounds and their use to treat diseases The present invention provides compounds of formula I 1 and pharmaceutically acceptable salts thereof. The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer... 7022850 Bicyclicpyrimidones and their use to treat diseases The present invention is directed to dihydropyrimidones having formula I or II and methods of using them to induce mitotic arrest, thereby making them useful as anti-cancer agents and other... 6809102 Cyano-substituted dihydropyrimidine compounds and their use to treat diseases The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof.The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer agents.... US20070281899 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 GENE The invention relates to a double-stranded

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ribonucleic acid (dsRNA) for inhibiting the expression of the Eg5 gene (Eg5 gene), comprising an antisense strand having a nucleotide sequence which is... Cyano-substituted dihydropyrimidine compounds and their use to treat diseases The present invention provides compounds of formula I 1 and pharmaceutically acceptable salts thereof. The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer... COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 GENE The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Eg5 gene (Eg5 gene), comprising an antisense strand having a nucleotide sequence which is... Pyrrolotriazinone compounds and their use to treat diseases The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof useful for inducing mitotic arrest thereby making them useful as anti-cancer agents and other... Pyrrolotriazinone compounds and their use to teat diseases The present invention provides compounds of formula I 1 and pharmaceutically acceptable salts thereof useful for inducing mitotic arrest thereby making them useful as anti-cancer agents and other... LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES This invention relates to compositions containing double-stranded ribonucleic acid (dsRNA) in a lipid formulation, and methods of using the compositions to inhibit the expression of the Human... Bicyclicpyrimidones and their use to treat diseases The present invention is directed to dihydropyrimidones having formula I or II and methods of using them to induce mitotic arrest, thereby making them useful as anti-cancer agents and other... Methods for the preparation of pyrrolotriazine compounds A method for preparing a compound having the

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formula: including the steps of:(a) cyclizing a compound of formula II: to form a compound of formula I: (b) deprotecting the nitrogen atom of the... Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors A process is provided for the process for preparing a pyrrolotriazine aniline p38 kinase inhibitor such as amide II by the direct aminolysis of the ester I wherein ester I is reacted with a strong... CENTROSOME-ASSAY The present invention provides a centrosome assay for the identification of preferably, Eg5 inhibitors. Novel Dihydropyrimidine Derivatives And Their Use As Anti-Cancer Agents The invention concerns molecules of formula (I), drugs containing same and their use as anti-cancer agents. Antisense modulation of kinesin-like 1 expression Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,... ANTISENSE MODULATION OF KINESINLIKE 1 EXPRESSION Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,... ANTISENSE MODULATION OF KINESINLIKE 1 EXPRESSION Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,... Kinesin inhibitors The present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions... Antisense modulation of kinesin-like 1 expression Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise

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antisense compounds, particularly antisense oligonucleotides,... Kinesin inhibitors The present invention provides for compounds, compositions, methods and systems for inhibiting 10 cell growth. More specifically, the present invention provides for methods, compounds and compositions... METHOD AND COMPOSITIONS FOR INHIBITION OF DOUBLE STRANDED DNA VIRUSES A method of inhibiting double-stranded DNA virus 10 infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of an inhibitor selected from the... CYCLIZED DERIVATIVES AS EG-5 INHIBITORS The present invention relates to new substituted 7 imidazole compounds have the following Formula (I) and to the pharmaceutically acceptable salts, esters, or prodrugs thereof, to compositions of the... MITOTIC KINESIN INHIBITORS The present invention relates to compounds that are useful for treating cellular proliferative diseases, 7 for treating disorders mediated, at least in part, by KSP, and for inhibiting KSP. The...