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Neoplasm

1. Calcified metastasis occurs in the lungs from following organs: a) b) c) d) e) Stomach Testis Breast Ovary Thyroid

2. Tumors of embryogenic origins are: a) b) c) d) e) Dermoid cyst Nephroblastoma Glioblastoma Reticullar cell sarcoma Retinoblastoma

3. Following tumors produce Osteoblastic metastasis a) b) c) d) e) Breast Bronchus/Lungs Thyroid Prostate Kidney

4. Tumors of the kidney a) b) c) d) e) Hypernephroma Angiomyolipoma Basal cell carcinoma Pseudo mucinous cyst adenoma Wilms tumor

5. Grading of tumors a) b) c) d) e) f) Correlates with neoplasms aggressiveness Is based on size of lesion Is based on the degree of differentiation of tumor cells Refers to the presence/absence of blood borne metastasis Is based on number of mitosis within tumor Spread to regional lymph node

6. Proto oncogene are transformed into oncogene by following mechanism a) b) c) d) e) Deletion Point mutation Gene amplification Mosicism Balanced translocation

7) Tumor marker of Ca prostate a) b) c) d) e) PSA Acid phosphatase LDH Alkaline phosphatase CEA

8) Radiological features of malignant bone tumor a) b) c) d) e) Irregular, indistinct margin Moth eaten bone destruction Uninterrupted periosteal reaction Often with sun ray appearance Geographic bone destruction

9) Characteristics of multiple myeloma a) b) c) d) e) ESR raised Osteolytic lesions are common Hypercalcaemia may be absent S.alkaline phosphatase usually elevated Bence jones proteinuria

10) Premalignant lesion of skin are a) b) c) d) e) Solar keratosis Molluscum fibrisum Radiodermatitis Congenital naevi Basal cell papilloma

11) Angiogenesis in tumor is promoted by following factors a) b) c) d) e) Vascular endothelial growth factor (VEGF) Hypoxia inducible factor Thrombospondin Basic fibroblast growth factor Endostatin

12) Metastasis of malignant tumor in lymph node a) b) c) d) e) is common sarcoma generally follows the route of lymphatic drainage is always present when lymph nodes on more than 1 cm in dm can be detected by FNAC influence staging

13. Dystrophic calcification a) b) c) d) e) f) g) h) i) j) k) l) m) n) o) Occurs in absence of any derangement of calcium metabolism Result in the formation of Psammoma bodies Seen in association with hyperparathyroidism Lead to heterotropic Seen in milk-alkali syndrome Seen in dead tissue Seen in viable tissue Occurs when there is disordered metabolism of calcium Occurs in normal calcium level Occurs when destructive bone lesion Calcium deposition occurs in dying tissue S. calcium level is high Calcium metabolism is normal Initiation & propagation phases are involved Crystalline calcium carbonate is formed

Ans : a) T b) T c) F d) F e) F f) T g) F h) F i) T j) F k) T l) F m) T n)T o) F 14. Common sites of bone metastasis a) b) c) d) e) Pelvis Ribs Below knee Lower end of femur Upper end of humorous

Ans : a) T b) T c) F d) F e) T 15. Functional tumors of ovaries are a) b) c) d) e) Hills cell tumor Dysgerminoma Choriocarcinoma Teratoma Seminoma

Ans : a) T b) T c) T d) T e) F 16. Orbital metastasis commonly occurs from a) b) c) d) e) Bronchus Kidney GI tract Ovaries Pancreas

Ans : a) T b) T c) T d) F e) T

17. Solid ovarian tumors are a) b) c) d) e) Dermoid Struma ovarii Serous cystadenoma Thecoma Granulosa cell tumor

Ans : a) F b) F c) F d) T e) T 18. Teratoma a) b) c) d) e) may originate outside the gonad of the testis are unable to produce HCG can be benign may show extra embryonic differentiation have show peak incidence in 6th decade

Ans : a) T b) F c) T d) T e) F 19. Exfoliative cytology is useful for diagnosis of a) b) c) d) e) Meningioma Bronchial cancer Multiple myeloma Cervical cancer Vesical cancer

Ans : a) F b) T c) F d) T e) T 20. Common anterior mediastinal tumors are a) b) c) d) e) Thymoma Bronchogenic cyst Teratoma Neurogenic tumor Lymphoma

Ans : a) T b) F c) T d) F e) T 21. Intracranial brain tumor in children under 5yrs. Include a) b) c) d) e) Glioblastoma multiformis Optic nerve glioma Brain stem glioma Polycystic osteocytoma Haemangio blastoma

Ans : a) F b) T c) T d) T e) T

22. Followings are locally malignant a) b) c) d) e) Melanoma Marjulins ulcer Rodent ulcer Cylindroma Osteoclastoma

Ans : a) F b) F c) T d) F e) F 23. Increase in frequency of malignant disease occurs in a) b) c) d) e) Long term immunosuppressive therapy Large bowels Chrons disease Celiac disease Ulcerative colitis Xeroderma pigmentosa

Ans : a) T b) F c) T d) T e) T 24. In renal cell Ca, paraneoplastic syndrome include a) b) c) d) e) HTN Haematuria Pain Hypercalcemia Erythrocytosis

25. Tumors of blood vessels include a) b) c) d) e) Glomous tumor Angiosarcoma Adenoma Kaposis sarcoma SCC

Ans : a) T b) T c) F d) T e) T 26. Precancerous skin lesions are a) b) c) d) e) Keloid Hypertrophid scar Marjolins ulcer Leukoderma Venous ulcer

27. Breast carcinoma a) Occurs only in female b) Alcohole decrease the risk

c) Genetic link may be there d) Lymph node metastasis common e) Local disease Ans : a) F b) F c) T d) T e) F 28. A malignant tumor is characterized by a) b) c) d) e) cellular proliferation formation of mass invasion of surrounding tissue increase no. of typical & atypical mitotic figures metastasis

Ans : a) F b) F c) T d) T e) T 29. Tumor supressor gene associated with human cancers are a) b) c) d) e) NF 1 schwannoma Bcl 2 in pancreatic cancer C mye in colonic carcinoma Rb in retinoblastoma BRACA 1 in breast carcinoma

Ans : a) F b) F c) F d) T e) T 30. Following lesions are precancerous a) b) c) d) e) Conjunctival epithelial melanosis Naevi of conjunctiva Superficial spreading melanoma of young adults Hutchisons freckle Ochronosis

Ans : a) T b) F c) F d) T e) F 31. Predisposing factor for colorectal carcinoma a) b) c) d) e) A prior colorectal cancer High fiber diet Ulcerative colitis Decrease fecal bile salts Selenium deficiency

Ans : a) T b) F c) T d) F e) T 32. Basal cell carcinoma a) is the most common malignant eyelid tumor b) has a peak incidence during 5th & 6th decade c) when laterally situated is as invasive as the medially located tumors

d) of morphea type may present with telangiectasia of surface vessels e) of nodulo ulcerative type bleeds easily following trival trauma Ans : a) T b) T c) F d) T e) T 33. Childhood malignancies include a) b) c) d) e) Leukaemia Retinoblastoma Medulloblastoma Renal cell carcinoma Hepatocellular carcinoma

Ans : a) T b) T c) T d) F e) F 34. Bony metastases are common in malignancies arise from a) b) c) d) e) Thyroid Stomach Prostate Bronchus Brain

Ans : a) T b) F c) T d) T e) F 35. The following tumors are benign a) b) c) d) e) f) g) h) i) Papilloma Seminoma Fibroma Multiple myeloma Neurofibrom Hydatidiform mole Wilms tumor Rhabdomyoma Glomous tumor

Ans : a) T b) F c) T d) F e) T f) T g)F h) T i)T 36. Squamous metaplasia occurs in a) b) c) d) e) Colon Renal pelvis Uterus Prostate Pulmonary alveoli

Ans : a) F b) T c) T d) F e) F 37. Following skin reaction are the sign of internal malignancy

a) b) c) d) e)

Pyoderma gangrenosum Generalized pruritus Dermatomyositis Erythema nodosum Superficial thrombophlebitis

Ans : a) F b) T c) T d) T e) T 38. The following tumor markers are oncofaetal antigens a) b) c) d) e) Human serum ACTH Alpha fetoprotein Bence jones protein HCG CEA

Ans : a) F b) T c) F d) F e) T 39. Hormone producing ovarian tumors are a) b) c) d) e) Theca cell tumor Solid teratoma Dysgerminoma Arrhenoblastoma Dermoid cyst

Ans : a) T b) T c) T d) T e) F 40. Locally malignant tumors a) b) c) d) e) Pleomorphic adenoma Basal cell carcinoma Giant cell tumor Ameloblastoma Papillary carcinoma of thyroid

Ans : a) F b) T c) T d) T e) F 41. Following are malignant tumors a) b) c) d) e) Seminoma Melanoma Pleomorphic adenoma Chondroma Carcinoid tumor

Ans : a) T b) T c) F d) F e) T 42. Metastatic calcification occurs in following organ

a) b) c) d) e) f) g) h)

Stomach Lungs Cornea Blood vessels Kidney Atheroma Wall of IVC Old tubercular lesion

Ans : a) T b) T c) F d) T e) T f) F g) F h) F 43. S. Tumor markers are a) b) c) d) e) f) g) h) i) Alpha fetoprotien ALT PSA CM MB CEA Prolactin CA 125 Acid phosphatase C reactive protein

Ans : a) T b) F c) T d) F e) T f) T g) T h) T i) F 44. Predisposing factors for gastric carcinoma include a) b) c) d) e) Pernicious anemia Blood group A Gastric polyp Hypercalcaemia Alcohole consumption

Ans : a) T b) T c) T d) F e) T 45. Specific tumor markers of hepatoblastoma a) b) c) d) e) Gamma GTT Alpha fetoprotein CEA (carcino embryonic antigen) Alpha-1 antitrypsin level CA 19-9

Ans : a) F b) T c) F d) F e) F 46. Metaplasia is charecterized by a) an increase in the no. & size of the cell b) variation in size & shape of the cells

c) an increase in the nucleo-cytoplasmic ratio of cells d) cloudy swelling of cells e) an acute inflammatory reaction Ans : a) F b) T c) F d) F e) F 47. Premalignant condition of the skin are a) b) c) d) e) Eczematous dermatitis Lupus vulgaris Solar keratosis Melanoma Marjolins ulcer

Ans : a) F b) F c) T d) F e) F 48. Metaplasia is a) b) c) d) e) an irreversible chage commonly occurs in GIT caused by vit-A defficiency an undesirable change in most circumstances found in Barretts oesophagus

Ans : a) F b) F c) T d) T e) T 49. Metastatic calcification a) b) c) d) e) is associated with hypercalcaemia can occur in renal failure is encountered in areas of necrosis is almost inevitable in atheroma principally affects the gastric mucosa

Ans : a) T b) T c) F d) F e) T 50. Carcinoma in situ has the following characteristic a) b) c) d) e) Basal membrane intact Carcinoma goes upto the superficial layer Frequently invade into lymphatics It is solely a benign neoplasm Reversible by medical treatment

Ans : a) T b) T c) F d) F e) F 51. Exfoliative cytology is useful for the diagnosis of a) Ca of urinary bladder b) Ca of gall bladder +s46, 55

c) d) e) f) g) h) i) j) k)

Bronchial Ca Endometrial Ca Thyroid Ca Meningioma Multiple myeloma Cervical cancer Vesical cancer Stomach Salivary gland

Ans : a) T b) T c) T d) F e) F f) F g) F h) T i) T j) T k) ? 52. The embryonic tumor of infancy include a) b) c) d) e) Neuroblastoma Osteogenic sarcoma Medulloblastoma Cholangio-carcinoma Nephroblastoma

Ans : a) T b) F c) T d) F e) T 53. Displastic epithelium a) b) c) d) e) Invariably become neoplastic Charectristicly shows lack of polarity May shows nuclear pleomorphism May occurs in metaplastic epithelium In the cervix may be detected by a smear

Ans : a) F b) F c) F d) T e) T 54. Following tumors may produce hormones a) b) c) d) e) Choriocarcinoma Bronchial carcinoma Fibroma of ovary Islets cell tumor of pancreas Chromophobe pituitary adenoma s45

Ans : a) T b) T c) F d) T e) T ii) 55. Alpha- feto protein is found in increase amount a) Primary carcinoma of liver/HCC b) Colorectal carcinoma c) Pancreatic carcinoma s44

d) Seminoma of testis e) Hepatic adenoma f) breast Ans : a) T b) F c) T d) T e) T f) F s47

56. Following tumors may secrete hormones a) b) c) d) e) Carcinoid tumors Choriocarcinoma Benign teratoma of ovary Monodermal teratoma of the ovary Seminoma

Ans : a) T b) T c) F d) T e) T 57. Metaplasia, the transformation of 1 fully differentiated tissue into another, occurs in s48 a) b) c) d) e) Connective tissue elements The GIT CNS Billiary system The urothelium

Ans : a) T b) T c) F d) T e) T 58. Staging of tumor depends on a) b) c) d) e) extend of tumor size of tumor differentiation of tumor nodal metastasis no. of mitosis s49

Ans : a) T b) T c) F d) T e) F 59.