CURRICULUM VITAE HULIAN YIN, M.S. MD. Email: hy12e3296@westpost.

net Home Phone: 513-861-0236 Cellular Phone: 513-673C0851 Citizenship: US Citizen EDUCATION 1989-1991 Visiting Scientist, Medical University of Nanjing, Jiangsu, China 1983-1986 M.S, Biology, University of Suzhou Medical College, Jiangsu, China 1978-1983 M.D, Suzhou Medical College, Jiangsu, China EMPLOYMENT 11/08- present Research Assistant IV Department of Anesthesia Childrens Hospital Medical Center, Cincinnati, OH 45239 08/07- 11/08 Senior Research Assistant Department of Pharmacology & Cell Biophysics University of Cincinnati, Cincinnati, OH 45267-0056 07/03- 07/07 Senior Research Assistant Department of Environment Health University of Cincinnati, Cincinnati, OH 45267-0056 02/99-07/03 Research Fellow Division of Human Genetics Childrens Hospital Medical Center, Cincinnati, OH 45220 07/98-01/99 Research Associate Department of Anatomical Sciences & Neurobiology School of Medicine, University of Louisville, Louisville, KY 40202 01/98-06/98 Visiting Scientist Department of Ophthalmology & Visual Sciences School of Medicine, University of Louisville, Louisville, KY 40202 12/93-12/97 Associate Professor Department of Immunology Medical School of Sun Yat-sen University, Guangzhou, China 10/87-12/93 Assistant Professor, Department of Immunology Medical School of Sun Yat-sen University, Guangzhou, China RESEARCH SKILLS Molecular Biology Purification of DNA and RNA from cells or tissues PCR genotyping and RT-PCR and real time-PCR Non-radioactive labeling of DNA and RNA probes and Hybridization methods Cloning and Subcloning Protein expression in eukaryotic cells and purification Tissue culture Primary tissue culture (Heart, Brain, Lung, Liver, stem cells.)

Cell line culture Protein techniques Western Blotting, TLC and HPLC In vitro translation and immunoprecipitation Immunochemistry, ELISA Heart mitochondrial isolation and enzyme activity assay Pathology Confocal image microscopy Fixing and embedding tissue and tissue sectioning, staining Mice and Rat handling and surgery Basic computer skills Microsoft Word Microsoft Power Point Microsoft Excel Adobe Photoshop AWARDS AND HONORS 1998 Certificate for Meritorious Work Department of Ophthalmology, University of Louisville 1996 University Award for Advanced Scientific Research Progress, Medical School of Sun Yat-sen University, Guangzhou, China 1995 Award for Extraordinary Achievements in Scientific Progress Second Prize for Study of Prevention of Cataracts (Certification No. 95200206). National Health Ministry China 1995 Award for Extraordinary Achievements of Scientific Progress, First Prize for Study of Prevention of Cataracts (Certification No. 95-1-206) Medical School of Sun Yat-sen University, Guangzhou, China. 1994 Award for Achievements in Scientific Progress, Second Prize for Study of development of visual function in normal infants and c hildren. Medical School of Sun Yat-sen University, Guangzhou, China. PUBLICATIONS A. ORIGINAL PAPERS AND REPORTS 1. Tichelaar JW, Yan Y, Tan Q, Wang Y, Estensen RD, Young MR, Colburn NH, Yin H , Goodin C, Anderson MW, You M. A dominant-negative c-jun mutant inhibits lung c arcinogenesis in mice.Cancer Prev Res (Phila). 2010 Sep;3(9):1148-56. Epub 2010 Aug 17. 2. Tichelaar JW, Wesselkamper SC, Chowdhury S, Yin H, Berclaz PY, Sartor MA, Le ikauf GD, Whitsett JA. Duration-dependent cytoprotective versus inflammatory ef fects of lung epithelial fibroblast growth factor-7 expression. Exp Lung Res. 20 07 Oct-Nov;33(8-9):385-417. 3. Qi X, Kondoh K, Yin H, Wang M, Ponce E, Sun Y, and Grabowski G.A. Ex vivo lo calization of the mouse saposin C activation region for acid beta-glucosidase. M ol Genet Met. 2002; 76:189-200. 4. Xie J, Yin H, and Zhang Z. ERKs protein expression in normal developmental a nd deprived visual cortex in rats detected with immunohistochemical analysis. Ch in J Neuroanat.2002; 18(1):8-12

5. Li Z, Qian Y, Zhang Z, Zhang M, and Yin H. Primary report for investigation of changes in the expressions for PKCa, and PKCb isozymes in visual cortex of de prived rat. Chin Anat Res. 2002; 24(2):141-144 6. Zhang Z, Yin H. Detection of EP1and FP receptor mRNA in the iris-ciliary bod y using in situ hybridization. Chin Med J. 2002; 115(8):1226-1229. 7. Li Z, Xie J, Qian Y, Zhang Z, and Yin H. Investigation of gene expression of N-methyl-D-aspartate (NMDA) receptors in visual cortex of cat. Chin Anat Res. 2 002; 24:40-43. 8. Xie J, Zhang Z, and Yin H. Investigation of transcripts of ERK mRNAs in deve lopmental visual cortex of rats. Chin J Neuroanat. 2001; 17:309-314 9. Mukhopadhyay P, Bian L, Yin H, Bhattacherjee P, and Paterson C. Localization of EP (1) and FP receptors in human ocular tissues by in situ hybridization. In vest Ophthalmol Vis Sci. 2001; 42: 424-428. 10. Cai J, * Yin H,* Wu R, Modderman G, Chen Y, Jensen J, Hui C, and Qiu M.(* T hese authors contribute equally) Evidence for the differential regulation of Nkx -6.1 expression in the ventral spinal cord and foregut by Shh-dependent and Cind ependent mechanisms. Genesis.2000; 27:6-11. 11. Cai J, Yin H, Guo H, Li G, Zhang Y, Chen Y, and Qiu M. Expression and regul ation of the chicken Nkx-6.2 home box gene suggest its possible involvement in t he ventral neural patterning and cell fate specification. Dev Dyn. 1999; 216:459 -468. 12. Zhang Z, Xie j, Tang X, Li S, and Yin H. Distribution of intracellular regu lated kinase-1 and C2 mRNA in kitten visual cortex. Chin J Neuroanat. 1999; 15: 110-114. 13. Zhang Z, Yin H, Zeng J, Chen B, and Li S. Clinical results of acrysoft fold able intraocular lens implantation in china. Asia-Pacific J Ophthalmol. 1999; 11 : 2-6. 14. Zhang Z, Zeng J, Yin H, Borchman D, and Paterson C. Membrane lipid-a-crysta lline interaction and membrane Ca2+-ATPase activities. 1999; Curr Eye Res. 18: 56-61. 15. Yin H, Xie J, Tang T, Zhao G, Li S, and Zhang Z. Distributions of five NMDA receptor subunit mRNAs in cat visual cortex. Chin J Immunol. 1998; 14: 131-135. 16. Yin H, Xie J, Tang T, Zhao G, Li S, and Zhang Z. Alteration of NMDA recepto r five subunit mRNA expression in visual cortex of light deprived kitten. Chin J Immunol. 1998; 14: 152-156. 17. Yin H, Zhang Z, Lin Y, and Li S. The utilization and preparation of NMDAR1 gene in cat visual cortex. Chin J Immunol. 1997; 13:60-62. 18. Yin H, Zhang Z, Yang S, and Li S. RT-PCR amplification of NMDAR1 gene of vi sual cortex in kitten. Chin J Immunol. 1997; 13: 71-73. 19. Yin H, Shen Y, Han X, Zhou X, and Ding G. Differential diagnosis on breast mass in child bearing women caused by tumor and filariasis. Chin J Zoonoses. 199 6; 12: 53-55. 20. Zhang Y, Wang B, and Yin H. The cloning and sequencing of cDNA encoding hum an hIL-10 gene. J Cell Mol Immunol. 1996; 12:17-20. 21. Zhang Y, Wang B, Yang B, and Yin H. RT-PCR amplification of human IL-10gene . Acad J SUMS. 1996; 17: 316-318 22. Yin H, Zhang Z, and Yang S. Soluble interleukin 2 receptor detected in aque ous humor in diabetic cataract. Chin J Immunol. 1995; 11: 637-639. 23. Yin H, Shen Y. Study on the combined diagnosis of breast filarial granulom a. Chin J Zoonoses. 1994; 102: 70-72. 24. Yin H, Shen Y. Serological diagnosis in patients with lymphatic filariasis. Chin J Immunol. 1994; 10: 93-95. 25. Yin H, Wang H, and Shen Y. Comparison of dot-ELISA with standard-ELISA for detection of antibodies in patients with lymphatic filariasis. Acad Med J Yanzho u. 1993; 5: 9-12. 26. Yin H, Wang H, and Shen Y. Detection of circulating filarial antigens using antibodies against adult worm with dot-ELISA. Chin J Zoonoses.1993; 9:24-25. 27. Shen J, Yin H, and Du L. A serological survey of toxoplasma infection in pr

egnancy C A detection of toxoplasma antibodies in umbilical cord blood from norm al and abnormal infants. Acad Med J Benbu. 1984; 9: 248-250. B. BOOK CHAPTERS 1. H Yin. Chapter 8. T-Cell maturation in thymus, Chapter 9. B-cell Activation a nd Antibody Production. In Current Cellular and Molecular Immunology, edited by Xue Yuan Lin. Science Publishing Inc., Beijing, 1999. 2. H Yin. Chapter 17. Parasitic infection and allergy, Chapter 22. Parasitic inf ection and 3. H Yin. pneumonic diseases, Chapter 32. Parasitic Infection and Breast Disease s, Parasites and 4. H Yin. Clinical Medicine. 2nd edition, edited by Yi Ping Sheng. Peoples Healt h Publishing Inc. Beijing, 1999. 5. H Yin. Chapter 9. Infectious diseases mediated by acari insects, Chapter 11. Infectious 6. H Yin. Diseases mediated by insects. In Infectious Diseases Mediated by Insec ts, edited by Zhao Yue Xu. Ningxia Peoples Publishing Inc. Ningxia, 1989. C. ABSTRACT AND PRESENTATIONS 1. J Cai, H Yin, M Agrawal and M Qiu. Expression and regulation of the NKX.6.2 ( GTX) homebox gene in the developing neural tube, Society Neurosci. 25,1999. (Soc iety for Neuroscience 29th Annual Meeting, October 23-28, Miami Beach, Florida.) 2. H Yin, L Bian, P Mukhopadhyay, P Bhattacherjee and CA Paterson. Localization of EP1 and FP receptor mRNAs in human ocular tissues. Invest Ophthalmol Visual S ci. 1999;40(4):S502 (The Association for Research in Vision and Ophthalmology (A RVO) Annual Meeting, May 9-14, Fort Lauderdale, Florida, 1999.) 3. S Li, H Yin, J Xie, X Tang and Z Zhang. Preliminary report of alteration of N MDA receptor five subunit mRNA expression in visual cortex of light deprived kit ten. Invest Ophthalmol Visual Sci. 1999; 40(4):S645. (Annual Meeting, May 9-14, Fort Lauderdale, Florida, 1999.) 4. J Xie, H Yin, X Tang, S Li, and Z Zhang. Layer distributions of five NMDA rec eptor subunit mRNAs in kitten visual cortex using in situ hybridization. Invest Ophthalmol Visual Sci. 1999; 40(4): S 646. (Annual Meeting, May 9-14, Fort Laude rdale, Florida, 1999) 5. K Ding, H Yin, R Gao, X Tang, J Xie, S Li, and Z Zhang. Distribution of extra cellularly regulated kinase-1 and C2 mRNA in kitten visual cortex. Invest Ophtha lmol Visual Sci. 1999; 40(4):S646. (Annual Meeting, May 9-14, Fort Lauderdale, F lorida, 1999.) 6. H Yin, S Li, Z Zhang and N Cooper. NMDAR1 expression in kitten visual cortex. Invest Ophthalmol Visual Sci. 1998; 39(4): S325 (the Association for Research i n Vision and Ophthalmology (ARVO) Annual Meeting, May 10-15, Fort Lauderdale, Fl orida, 1998.) 7. P Mukhopadhyay, L Bian, H Yin, P. Bhattacherjee and C.A. Paterson. mRNA in si tu hybridization of EP1 and EP2 receptors in human ocular tissues. AOPT (Associatio n for Ocular Pharmacology & Therapeutics) Oct 15, 1998. 8. Z Zhang, H Yin, Z Huang and S Li. Soluble interleukin 2 receptor detected in aqueous humor in patients with diabetic cataracts. Invest Ophthalmol Visual Sci. 1997; 38 (4): S528. (The Association for Research in Vision and Ophthalmology A nnual Meeting, May 9-14, Fort Lauderdale, Florid