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Pediatrics Notes

Pediatrics Notes contributed by anonymous Immunization Timetable Rules of Thumb for Growth Tanner Stages of Pubertal Development Infant Diet Guide APGAR Scoring Teeth Eruption Developmental Milestones Developmental Delay Primitive Reflexes Fluids & Dehydration Immunization Timetable Birth: Hepatitis B (HBV) 2 Mo: Diphtheria, pertussis, tetanus (DTP), oral poliovirus (OPV), Hib Conjugate (hemophilus influenza, type B), HBV 4 Mo: DTP, OPV, Hib Cong 6 Mo: DTP, Hib Conj, HBV 12 Mo: MMR, PPD 15-18 Mo: Diptheria, tetanus, acellular pertussis (DtaP), OPV, Hib Conj 4-6 Yr: DtaP, OPV, MMR 14-16 Yr: Tetanus-adult dose, diptheria-reduced dose, every 10yrs (Td) For Children behind in immunizations (over 1yr old): If < 7yo: DTP, OPV at first visit and then 2, 4, and 10mo later MMR at first visit if >12-15mo, or when becomes 12-15 mo Hib at first visit if >15mo and < 5yo (if <15mo, Hib conj has a special catch-up schedule) DTaP and MMR at 4-6yo and Td at 14-16yo; repeat Td every 10yrs. If >7yo: Td, OPV, MR at first visit (2nd MMR at any time at least 1 mo after 1st). Td and OPV #2 10mo later Td at 14-16yo; Repeat Td every 10 years. Note: Live virus vaccines (OPV, MMR) are contraindicated in immunocompromised children, in children who have immunocompromised people in their household, and in pregnancy.

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Pediatrics Notes
Rules of Thumb for Growth Weight: Neonates lose 5-10% of birth weight in 1st few days of life Birth weight regained by 7-10d, x2 by 4-5 mo, x3 by 1yo and x4 by 2yo Daily gain is 20-30gm/d for 1st 3-4 mo, 15-20gm/d for rest of 1st yr; 5lbs/yr from 2yo to puberty Avg. weight: 3.5kg at birth, 10kg at 1yo, 20kg at 5yo, 30kg at 10yo Height: Avg. length: 20in at birth, 30in at 1yo, 3ft at 3yo, 40in at 4yr (x2 birth length) Avg. gain: 2-3in/yr from 4yo to puberty Head Circumference (H/C): Avg. H/C at birth 34cm, at 2yo 48cm Avg. gain: 2cm/mo for 1st 3mo (40cm by 3mo), 1cm/mo for next 3mo (43cm by 6mo), 0.5cm/mo for rest of 1st yr (46cm by 1yo); 10cm over rest of life Tanner Stages of Pubertal Development Breast development. Stage B1: prepubertal, elevation of the papilla only. Stage B2: breast buds visible or palpable with enlargement of the areola. Stage B3: further enlargement of the breast and areola with no separation of their contours Stage B4: projection of areola and papilla to form a secondary mound over the rest of the breast. Stage B5: mature breast with projection of papilla only. Male genital development Stage G1: prepubertal. Stage G2: enlargement of testis to more than 2.5 cm, appearance of scrotal reddening, and increase in rugations. Stage G3: increase in length and to a lesser extent breadth of penis with further growth of testis. Stage G4: further increase in size of penis and testes and darkening of scrotal skin. Stages G5 and G6: adult genitalia. Pubic hair growth among boys Stage P1: preadolescent, no pubic hair. Stage P2: sparse growth of slightly pigmented, slightly curved pubic hair mainly at the base of the penis. Stage P3: thicker curlier hair spread laterally. Stage P4: adult-type hair that does not yet spread to medial thighs. Stage P5 adult-type hair spread to medial thighs. Appearance of pubic and labial hair among girls Stage PH1: prepubertal, no pubic hair. Stage PH2: sparse growth of long, straight, or slightly curly minimally pigmented hair, mainly on labia. Stage PH3: considerably darker and coarser hair spreading over mons pubis. Stage PH4: thick adult-type hair that does not yet spread to the medial surface of the thighs. Stage PH5: hair is adult type; distributed in the classic inverse triangle.

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Pediatrics Notes
Females: Thelarche (breast buds) 1st sign of puberty at about 11yo, followed by adrenarche (pubic hair). About 1yr after thelarche at Tanner 3, peak growth spurt occurs. About 6mo after growth spurt at Tanner 4, menarche occurs. Breast development from Tanner 2-5 takes 4yrs on avg. and pubic hair development takes 2.5yrs. Males: Testicular growth at about 11.5yrs is 1st puberty sign, marking Tanner 2. Pubic hair appears next with penile enlargement within 1yr of testicular enlargement. Progression to Tanner 5 over 3yrs, with growth spurt in Tanner 4-5. Infant Diet Guide 1st 4-6mo of life: Breast milk or formula; water (helps with constipation) Supplement with vitamin D (if breast fed), fluoride (if not in water) Premies: multivitamin, Fe, +/- folate and fluoride Require 100-120kcal/kg/d After 4-6mo: Start solids (preferably after 6mo) and decrease breast/bottle feeds to <32oz/d; may need to increase water (higher renal solute load) Start 1 new single ingredient food at a time, new foods only q3-4d. Cereal (rice, oatmeal, barley); Fruit (banana); Vegetables (orange before green); juices (0.5 adult juice, 0.5 water). DO NOT give eggs, citrus, desserts, or whole cows milk (can lead to allergies) Decrease breast/bottle feeds as increase solids. Decrease breast/bottle feeds to <24oz/d when teething and DO NOT leave bottle in crib (milkbottle caries). APGAR Scoring Heart Rate: 0 (absent); 1 (<100/min); 2 (>100/min) Respiratory Effort: 0 (absent); 1 (slow, weak cry); 2 (good, vigorous cry) Muscle Tone: 0 (limp); 1 (some extremity flexion); 2 (arms/legs well flexed) Reflex Irritability: 0 (none); 1 (some motion); 2 (cry, withdrawal) Color: 0 (blue, pale); 1 (blue extremities, pink body); 2 (pink all over) Notes: Insert nasal catheter and observe reflex irritability. APGAR is taken at 1 and 5 min, and again at 10 and 20 min in compromised infant. Record lost points (eg. 1min APGAR=9, -1 for color)

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Pediatrics Notes
Teeth Eruption U: Upper, L: Lower Central Incisors Primary: U 5-7mo, L 6-8mo Permanent: U 7-8yr, L 6-7yr Lateral Incisors Primary: U 8-10mo, L 6-8mo Permanent: U 8-9yr, L 7-8yr Cuspids: Primary: U 16-18mo, L 14-18mo Permanent: U 11-12yr, L 9-10yr First Bicuspids: Permanent: U 10-11yr, L 10-12yr Second Bicuspids: Permanent: U 10-12yr, L 11-13yr 1st Molars: Primary: U 12-16mo, L 10-14mo Permanent: U 6-7yr, L 6-7yr 2nd Molars: Primary: U 22-26mo, L 18-22mo Permanent: U 12-13yr, L 12-13yr 3rd Molars (wisdom): Permanent: U 17-22yr, L 17-22yr Developmental Milestones G: Gross Motor, F: Fine Motor, L: Language, S: Social Age: 1mo G: Raises head from prone F: Tight grasp, follows to midline L: Alerts to sound (startle) S: Regards face Age: 2mo G: Lifts head 45deg from prone; lifts chest F: Follows past mid-line L: Social smile S: Recognizes parent Age: 3mo G: Support on fore arms; steady head control F: Holds hands open at rest, follows 180deg L: Coos, vocalizes S: Reaches for familiar people/objects; anticipates feeds Age: 4-5mo G: Rolls front to back, begins to sit when propped, supports on wrists & shifts weight F: Hands to midline, grasps rattle, touches cube on table L: Orients to voice at 5mo; orients to bell laterally, says ah-goo, razzes S: Enjoys looking at environment

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Pediatrics Notes
Age: 6-8mo G: Sits alone, rolls both ways, bears weight F: Reaches with either hand, transfers hand to hand, raking, grasp L: Babbles, laughs; at 7mo, orients to bell diagonally; at 8mo, dada/mama indiscriminately S: Stranger anxiety Age: 9-11mo G: Creeps, crawls, pulls to stand, cruises, pivots when sitting F: Pincer grasp, probes/pokes with forefinger, holds bottle L: Understands no & name, waves bye-bye; at 10mo, dada/mama indiscriminately; at 11mo, one word S: Plays pat-a-cake, peek-a-boo; explores environment Age: 12-14mo G: Walks alone F: Throws objects, lets go of toys, mature pincer grasp, points L: Follows 1-step command with gesture, 2 words; at 14mo, 3 words S: Imitates actions, comes when called Age: 15-17mo G: Crawls upstairs, walks backwards, stoops to recover object F: 2-block tower, scribbles, finds hidden toy, inserts raisin into bottle L: 1-step command without gesture, points to 1-2 body parts, 4-6 words, immature jargoning S: Indicates wants without crying Age: 18-20mo G: Runs, kicks/throws ball, sits in chair, walks upstairs with one hand held F: 3-4 block tower, turns 2-3 pages at a time, spoon feeds self, dumps raisin from bottle L: 7-20 words, mature jargoning S: Copies parents at household tasks, plays with other children Age: 21-23mo G: Goes upstairs, squats in play F: 5-block tower, drinks from cup L: Points to 3 body parts S: Asks to have good and go to toilet Age: 24mo G: Up & downstairs, jumps F: Turns pages one at a time, remove shoes, pants, imitates stroke (writing) L: 50 words, 2-word sentences, uses pronouns, points to 5 body parts, follows 2-step commands S: parallel play, asks questions Age: 30mo G: Jumps with both feet off floor, throws ball overhand F: Unbuttons, holds pencil in adult fashion L: Repeats 2 digits, understands concept of 1 S: Tells 1st & last name when asked, gets self a drink Age: 3yr G: Pedals tricycle, alternates feet going up steps, stands briefly on one foot F: 9-block tower, imitates bridge or 3 cubes, draws a circle L: 3-word sentences; uses plurals, past tense, 250 words, understands concept of 2 S: Group play, shares toys, takes turns; knows full name, age, and sex

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Pediatrics Notes
Age: 4yr G: Hops, skips, rides tricycle, climbs ladder, alternates feet going down stairs F: 10-cube tower, catches ball, can cut & paste, draws cross, person with face, arms, body and legs L: Knows 3-4 colors, counts to 10, says song or poem from memory S: Tells tall tales, dresses with supervision Age: 5yr G: Walks on tiptoes, jumps over obstacle F: Ties shoes, uses a knife to spread, and draws triangle, prints 1st name L: Knows colors, defines 1 word, and identifies coins S: Plays competitive games, abides by rules, sexual curiosity, dresses alone Age: 6yr G: Rides bicycle F: Draws person with 6 body parts L: Knows right from left Age: 8yr F: Draws diamond L: Tells time, reads for pleasure S: Sense of humor, home chores Developmental Delay DQ=Developmental score/Chronological age x 100 If <80 (1 standard deviation) do work-up Most common causes of developmental delay: 1. Mental Retardation 2. Autism 3. Psychosocial 4. Hearing loss 5. Expressive/receptive language disorder 6. Selective mutism

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Pediatrics Notes
Primitive Reflexes Reflex: Duration Palmar (hand) grasp: Birth to 4mo Plantar (foot) grasp: Birth to 9mo Automatic stepping: Birth to 2mo Moro: Birth to 3-6mo (tested by supporting the babys head in supine position, then suddenly dropping it 2-3in while supporting) Head in space: 1-2mo/permanent (hold baby upright in air and tilt slightly to side; observe if it can hold head vertically (reflex present) Asymmetric tonic neck (ATNR): Birth-1mo to 4mo (Turning head to one side causes ipsilateral arm to extend and contralateral arm to flex) Symmetric tonic neck (STNR): 5-6mo to 8mo (Extending the head causes hips and knees to flex, while flexing causes hips and knees to extend) Landau: 3mo to 12-24mo (Hold the trunk in prone position and while in the air, look for arm, leg and head extension) Parachute-downwards: 3-4mo/permanent Parachute-sideways: 6mo/permanent Parachute-forwards: 7-8mo/permanent Parachute-backwards: 9-10mo/permanent (Parachute reflexes are protective to sudden disruptions of balance; leg extension for downwards, arms out for others. The baby must have good head control (around 4mo old) to test.

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Pediatrics Notes
Fluids & Dehydration: Assessment of Hydration Status 1. Parent estimate of intake: fluid type (water, formula, juice, etc) and amount retained 2. Parent estimate of output: urine, stool, vomit, drainage, insensible losses (# of diaper changes now vs. usual, consistency of stool) 3. Physical signs (% Dehydrated) Skin Turgor: good (5%), good/slight tenting (10%), tented (15%) Mucous Membranes: moist (5%), tacky (10%), dry (15%) Eyes: normal (5%), deep set (10%), sunken (15%) Fontanelle: flat (5%), soft (15%), sunken (15%) Mental Status: consolable (5%), irritable (10%), lethargic/coma (15%) Cardiovascular: normal (5%), tachy, normal BP (10%), decreased BP, poor capillary refill (15%) Urine/tears: concentrated urine, poor tear production (5%), oliguria, poor tear production (10%), oliguria/anuria, no tears (15%) Note: dehydration estimated from % wt loss from premorbid state Initial Bolus Give a bolus of isotonic (NS or Lac Ringers) to rapidly re-expand the intravascular volume. Assess response (Urine output, capillary refill, vital signs, mental status, etc). Repeat bolus if necessary. 10cc/kg over 1hr for mild dehydration (5%) 20cc/kg over 1hr for moderate dehydration (10%) 30-50cc/kg over 1hr for severe dehydration/shock (15%) Rehydration - Add fluid deficit to maintenance; give half of total volume in 1st 8hr and the rest over 16hr. - Fluid Deficit (cc) = est. % dehydration x wt. (gm); ignore initial bolus in calculation - Maintenance Fluid - Based on wt: - 100cc/kg (4cc/kg/hr) for each of the 1st 10kg - 50cc/kg (2cc/kg/hr) for each of 2nd 10kg - 20cc/kg (1cc/kg/hr) for each additional kg Based on surface area (wt>10kg): 1500-1800cc/m2/d x surface area (m2) <20kg/m2 = [(3.6 x wt)+9]/100 >20kg/m2 = [(2.5 x wt)+9]/100 Require 3mEq Na/100cc, 2mEq Cl/100cc, 2mEq K/100cc (D51/4NS in small children and D51/2NS in older children with 20mEq KCl after 1st void.) Replace ongoing losses (stool, NG tube, etc) cc for cc. Note: above schema is only a guideline; continually reassess and adjust management to needs.

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Pediatrics Notes
Diarrhea Mechanisms 1. Osmotic: ingestion of poorly absorbable solutes. - Dx: diarrhea ceases when osmolytes are removed from intestine. - Increased stool osmolality (>280 mosm) - eg. intestinal disaccharidase deficiency, monosaccharide malabsorption, cathartics (phos and magnesium salts) 2. Secretory: pathological stimulation of normal Na, K, Cl, HCO3 secretion. - Dx: diarrhea continues with fasting. - Stool is isosmotic to plasma (280 mosm) - eg. toxin producing bacteria (E.coli, V. choerae, staph), hormones (gastrin, histamine, prostaglandins, VIP), drugs (phenophthalein, ricinoleic acid) 3. Malabsorptive: - Inflammatory conditions (Crohn's, Sprue), drugs (Digitalis, colchicine, Abx), digestive enzyme deficiency (pancreatic insufficiency), obstruction 4. Exudative: damage to intestinal mucosa resulting in discharge of mucus, serum proteins, and blood into bowel lumen - egs: infection (amebiasis, shigellosis, staph), inflammation (UC, pseudomembranous colitis), ischemia, drugs(Abx, heavy metal poisoning) 5. Increased intestinal motility Bacterial diarrhea Si & Sxs: Bloody stool Dx: Wright stain of stool for poly's; if <3 months, consider bacteremia Causes 1. Yersinia (pseudo-appendicitis, erythema nodosum) 2. Campylobacter 3. Salmonella (cystitis) 4. Shigella (generalized seizures due to toxin, hi temp, hyponatremia) 5. E. coli Tx: Give Pedialyte; feed through diarrhea; DO NOT give Anti-diarrheals (may cause toxic megacolon and retention of toxins) Causes of Chronic Childhood Diarrhea Neonates Infections: previous infections decrease enterocytes Protein intolerance: causes damage to enterocytes Short bowel syndrome NEC Congenital absorptive defect Congenital disaccharidase defect CF

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Pediatrics Notes
<2 yrs Infections Protein intolerance Giardiasis Celiac disease Sucrase/isomaltase deficiency Irritable bowel syndrome CF >2 yrs Infections IBD Giardia Celiac disease Irritable bowel syndrome CF Meningitis Presentation -Displays meningeal irritation signs by18 mo old if meningitis. -If > 2-3yo meningeal irritation absence (can kiss knees) suggests no meningitis Si/Sxs -Hypo/Hyperthermia -irritability -lethargy -poor feeding -Brudzinski's sign-neck flexion causes hip flexion -Kernig's sign- cannot flex hips with thighs at 90 degrees -bulging fontanelle -rising sun sign (from hydrocephalus) -coma/obtundation

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Pediatrics Notes
Bacterial Meningitis General -Meningoencephalitis with vascular involvement > pure meningitis in kids. -Most common entry into CNS is via bacteremia -3 mo-8 mo age of peak incidence Etiology Neonate <28 days -Foci of infection: gut, bladder, swallowing of vaginal/perineal flora intrapartum or in utero infection -Pathogens: GBS, gram negatives (E.coli, Klebsiella, Pseudomonas), Listeria Infant/Children 3 mo-5yrs -Pathogens=pneumococcus, meningococcus, H. flu -Children >3mo have decreased immunity, low nasopharyngeal IgA -Bacteremia can seed CNS, joints, heart, lungs -Most virulent meningitis but most easily treated Labs(LP) -Glucose <50, protein >50, WBC >10. -Opening pressure >140-180 mm /H2O in BM or in a small crying child. -If bloody tap fluid does not decrease with flow, then has hemorrhagic CNS disease (HSV). -Pus=100 PMN's/ml. -Protein cause turbidity -Yellow csf indicates bilirubin Sequelae of BM -Deafness/hearing loss (mild or total)due to CN VIII swelling; etiology: pneumococcus > meningiococcus>H.flu. (pmh). More H.flu in prevaccine population. -Seizures-tonic clonic sz can be presenting symptom of BM in 20-30% of pts. Leukocytes release cytokines which cause cerebral edema. Focal sz can be seen 3-4 days into MB due to localized dz (brain abscess, subdural effusion, empyema). Focal sz indicate poor prognosis. -Cranial nerve palsies-mostly CN VI, the longest intracranial course -increased ICP -Cerebral Palsy/Mental Retardation -Speech problems -Focal neural loss -Death- 5-10% even with abx (GM 20-25%, Strep 10-15%) -Hydrocephalus- increased CSF production in lateral ventricles. Communicating or noncommunicating. Tx with VP shunt (complications: obstruction with no long term mental sequelae to infection with Staph epidermidis with mental sequelae). Aseptic Meningitis -Pathogens=80% Enteroviruses (Coxsackie, polio, echo), 7-8% Arbovirus -Peaks in summer -CSF- lympocytosis at 6-8 hours -Herpes rarely causes meningitis, usually encephalitis

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Pediatrics Notes
Antibiotics for Meningitis Neonates <28 days Pathogens 1.GBS-Amp and Gent. Many are pen/gent resistant, but amp (cell wall inhibitor) helps. 2. E. coli-Gent 3. Gram (-) (Klebsiella)-Gent 4. Listeria (tumbling gram (+) rod)-Amp Infants 4-8 weeks All pathogens for infants and kids should be considered and treated. Abx=Amp and Cefotaxime Infants >8 weeks Encapsulated pathogens 1. Strep pneumo 2. Hib 3. N. meningitides Abx=Amp (enterococcus and listeria) and Cefotax; rifampin for HIB or N. meningitides to decrease carrier state. Chloramphenicol is no longer used; can cause bone marrow suppression and gray baby syndrome (vascular collapse) in neonates always treat h. Flu or neisseria also with rifampin to decrease carrier state (treat contacts also) If no improvement with abx think -not enough or wrong drugs -new pathogen (secondary infection) -abx not penetrating (ie. Abscess) -viral infection Meningococcus: better prognosis if presenting as meningitis (pt survived seeding) rather than bacteremia; most rapidly fulminant but easiest treated.

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Pediatrics Notes
Pneumonia An inflammation of lung parenchyma Viruses are the most common agents in infants Mycoplasma pneumoniae most common in children Bacterial PNA, bugs isolated from blood: strep pneumo, H. flu, Staph aureus in infants, debilitated pts, and adolescents with widely disseminated disease Predisposition to bacterial pna: aspiration, immunodeficiency, congenital anolamies (TE fistula, cleft palate) abnormal mucus clearance (CF, ciliary dysfunction ie Kartagener's, bronchiectasis), CHF. Pneumococcal pna: only signs may be fever + tachypnea. In adults the classic picture is shaking chills, pleuritic pain, prostration, rusty sputum and high mortality Involvement is characteristically lobar consolidation. Complications include empyema & septicemia. Sicklers are particularly susceptible to overwhelming pneumococcal infections. Tx with penicillins Hemophilus influenza: also lobar pna. Distinguished from pneumococcal pna by more indolent course and inadequate response to penicillin. Abx include amox or amp PO but if PO inadequate may require IV amp. 20% of H. flu is resistant to amox/amp, use Augmentin or IV cephalosporin. Staph pna: most common in first year, usually unilateral, abscess, tissue destruction, overwhelming septicemia. 2 typical features: pneumatocele, rapid progression. Empyema with thick purulent fluid is a hallmark. Tx is chest tube for drainage Mycoplasma pna: #1 cause of adolescent pna (25-35%). Incubation period is 2-3 weeks. Sx of headache, malaise, fever, cough. WBC and diff usually normal, "cold agglutinins" may be + after 1st week of illness. CXR looks worse than the pt. Can be fulminant in SS dz pts. Abx = erythromycin. Assoc with bullous myringitis Chlamydia trachomatis: contracted from birth thru infected vagina, usually presents at 1-2 months with low grade fever, machine gun or "staccato cough". Increased eosinophils on differential. cxr will have diffuse interstitial infiltrate. 50% have proceeding conjunctivitis. Dx by giemsa stain of conjunctival inclusion bodies. Abx with erythromycin.

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Pediatrics Notes
Bordetella pertussis: 2000-4000 cases per year in US. Is an encapsulated gram negative rod, infects ciliated epithelium of upper respiratory tract. Pertussis toxin increases adenylate cyclase, organism also synthesizes and exports adenylate cyclase. Dx with culture on Bordet-gengou medium (high % of blood) ID by agglutination with specific antiserum or by fluorescent Ab staining. Assoc with apnea 3 stages of clinical dz: 1) Catarrhal phase, lasts 2 weeks, coryza with increased mucus and secretions, sx similar to cold 2) Paroxysmal phase: usually lasts 1-2 weeks but up to 4 weeks, consists of paroxysms of hacking cough with copious mucus followed by inspiratory " whoop" air rushes past narrowed glottis. 3) Convalescent phase: can last for months. Abx erythromycin, but does not work well after phase I. If used after phase I, will decrease # of organisms in the throat to prevent spreading. Contraindications to giving pertussis vaccine: previous hx of serious reactions to vaccine (temp >105 or severe swelling at injection site) seizure disorder or other significant neurological disorder Indication for admission: age <4-6 months, resp distress, toxic appearing, dehydration, vomiting if not taking PO's, social factors, immunocompromised patients, esp sickler's, CF patients Indic for d/c home: not hypoxic, good sats on room air, good PO intake, good UOP, negative bcx Viral PNA RSV, parainfluenza, influenza A & B Otitis Media Pathogens 1. Strep pneumo (30%) 2. Hib (22%) 3. Moraxella cararrhalis (7%) 4. Group A Strep (2%) 5. Staph aureus (1%) 6. Sterile (35%) 3 tiers of management 1. Amox or amp (amp is QID, causes more GI upset, is not absorbed as well as amox) 2. Pediazole (erythromycin EES + sulfisoxazole) /Bactrim (trimethoprim + sulfamethoxazole) 3. Augmentin-useful against beta-lactamase producing H. flu 4. Ceclor- 2nd gen cephalosporin, can cause serum sickness Wait 48 hours then usually increase from tier 1 to tier 3. Mastoiditis -90% have OM too Pathogens=Group A Strep, Pneumococcus, Staph, H. flu Try Cefotaxime +/- Oxacillin (staph coverage)

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Pediatrics Notes
Neoplastic disorders -Leukemia is the most common onc dz of childhood -CNS tumors-most common solid tumor in kids --Medulloblastoma-Midline cerebellar lesion causes gait/balance deficits. Highly malignant, tends to metastasize throughout CNS. Likely to cause obstruction of 4th ventricle and cause noncommunicating hydro and icreased ICP due to location and rapid growth --Astrocytoma-usually in cortex and cerebellum, causes fine motor deficits, usually slow growing, most common brain tumor in children Hodgkin's Disease -Lymphonas are third in frequency of childhood tumors -Accounts for 40% of new cases of childhood lymphona -usually presents with enlarged NONTENDER cervical node -Dx by biopsy -Reed-Sternberg cells are NOT pathognomonic -4 types=nodular sclerosing, mixed cellularity, lymphocytic predominace, lymphocyte depleted -Staging Stage 1-one lymph node or one extralymphatic organ involved Stage 2-more extensive dz on 1 side of diaphragm Stage 3-both sides of diaphragm Stage 4-diffuse widespread dz with extralymphatic sites "A"- no systemic symptoms "B"- systemic symptoms (fever, night sweats, wt loss of >10% normal body wt in 6 mo) Neuroblastoma -embryonal tumor of neural crest origin -most common in the first years of life -50% of pts are <age 2 -tumor usually in adrenal gland -also frequent in thoracic and cervical sympathetic ganglia -70% secrete catecholamines -catecholamine metabolites VMA, HVA, TM are diagnostic markers Wilms -Nephroblastoma -Most common abdominal neoplasm in children -associated with sporadic aniridia, hemihypertrophy and GU malformations Bone tumors -skeletal malignancies are 4th in frequency in adolescents -uncommon in younger kids -Osteosarcoma-frequently seen in adolescent growth spurt, usually distal femur, proximal tibia, or proximal humerus -Ewing sarcoma-usually age 10-20, can present with pain, swelling, occasionally fever. Radiation is primary therapy.

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Pediatrics Notes
Pediatric Emergencies Fever in the neonate (8 weeks)=ROS Fever=temp > 100.4 or 38 C Labs= CBC c diff, BCX, UA, UCX, CSF protein, glucose, cell count, CX If pt rules out then dx is viral syndrome. 6-7% of neonatal swu's are positive. Of these, 3-4 look sick, 2-3 have an identifiable source of infection and 1-2 would have been missed. The 1-2 that would have been missed is the reason we are so aggressive . Symptoms to look for: changes in mental status, changes in feeding, hypthermia (esp in immediate neonatal period) Fever + SS disease = ROS Sicklers can be functionally asplenic as early as 6 months (when fetal hgb drops) see Howell Jolly bodies (nuclear remnants normally removed by spleen) in blood smear. Asplenics are susceptible to encapsulated organisms (h.flu, meningococcus, pneumococcus) Sicklers with influenza, viral syndromes have 500 times the risk of pneumococcal infection so CX's and ABX are necessary 3 clinical scenarios: 1)"sick" at any age gets admitted for iv abx 2) well appearing and < 4yrs admitted for abx and cx's 3) well appearing and >4 yrs may be treated as an outpt with po ampicillin and blood cx's SS dz + positive CXR = r/o chest crisis A positive CXR in a sickler may be ateletasis, infiltrate or pulmonary infarction In children the cxr appearance will lag weeks behind clinical improvement Chest Crisis: pulmonary infection causes hypoxemia and acidosis which makes RBC's sickle and leads to vasoocclusion which leads to more hypoxemia and acidosis (viscious cycle) This creates an environment for pulmonary infection to thrive TX: fluids and O2 to prevent sickling, PRBC if needed, abx (cefotax or cefurox for encapsulated bugs)

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Pediatrics Notes
Fever + painful limp = r/o septic arthritis Fever with a painful hip = r/o septic hip Most likely dx is toxic synovitis (aka transient synovitis, an inflammatory response 7-10 days post URI. Tx'd with antiinflammatories) Septic hips must be ruled out because it can lead to necrosis of the femoral head Hip joint tap done by ortho in the OR Mnemonic for ddx of painful limp: STARTS HOTT Septic arthritis Toxic transient synovitis Acute rheumatic fever Rheumatoid arthritis Trauma Sickle cell dz Henoch Schonlein Purpura Osteomyelitis TB Tumor Other causes: Legg-Calve-Perthes (idiopathic avascular necrosis) Slipped capital femoral epiphysis (head of femur falls posterior and inferior off femur, usually seen in overweight pubertal boys) Fever + Seizure = r/o meningitis Labs: CSF protein, glucose, cell ct, gram stain and cx Be aware of cushings triad from increased ICP: hypertension, bradycardia and variable respirations Fever + Petechiae = ros in adults think mening in children think H. flu type B tx with 3rd gen cephalosporin

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Pediatrics Notes
Cyanosis of newborn (dusky) ---really blue lips--polycythemia sepsis/infxs metabolic/hypoglycemic pulm stenosis cardiac lesion neuro - lose stim to breathe *check vitals, O2 sat, ABG on RA and O2, EKG and CXR, consider PG (for tiny babies)then echo last Tet of fallot-- if pulm atresia, need PG to keep open ductus arteriosus (blue tet) Tricuspid atresia-- need EKG to show all vent large except RV, dec pulm bloodflow, gen VSD Truncus arteriosus-- AV cushion defect so always VSD, pulm blood flow sounds cont murmur in blue baby, echo find pulm art off trunk, tx will close VSD and remove pulm art so trunk will be Aorta Transpositoion of great arteries--2 circuits in parallel, no shunting and ductal dependent; CXR ball on string= parallel great vessels c cardiomegaly, gen male and big baby, need surgical swap of vessels Total anomalous venous return-- may get obstructed vein thru organs (below diaphragm) and lead to pulm edema, tachypnea and *small heart with big Right heart

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Pediatrics Notes
Hyperbilirubinemia Indirect ddx--hemolytic anemias, Gilbert's, Crigler-Najjar Hemolysis=spherocytosis, pyruvate kinase or G6PD deficiency, hemoglobinopathies (sickle cell, thalassemia) Gilbert=UDP glucuronosyl transferase defect. Jaundice with mild illnesses, fasting, physical stress Crigler-Najjar=type 1 is complete absence of UDP glucuonosyl transferase, type 2 limited activity so phenobarbital will reduce bili but will not have any effect in type 2. Direct hyperbili ddx *Viral--Hepatitis, EBV, CMV, HSV *Metabolic--Wilson's, Alpha-1-antitrypsin deficiency, CF *Biliary Tract d/o--Cholelithiasis, Cholecystitis, Choledochal cyst, Sclerosing cholangitis *Autoimmune Liver Disease--Type 1 (anti-smooth muscle Ab), Type 2 (anti-liver-kidney-microsomal Ab) *Heptotoxins--Acetaminophen, anticonvulsants, anesthetics, antituberculous agents, chemotherapeutic agents, antibiotics, OCP. Others include Etoh, insecticides, organophosphates *Vascular causes--Budd-Chiari, veno-occlusive disease Hepatitis A-high AST, ALT and conjugated bili Wilson's disease-AR d/o of copper metabolism results in accumulation in the liver, CNS, kidney, cornea and other organs. CNS manifestations may present with or without hepatic sx. Kayserfleischer rings (golden brown discoloration in the sone of the descemet membrane of the cornea is virtually always present when neuro or psych sx develop. Can have coombs-negative hemolytic anemia due to oxidative injury to rbc by excess copper. W/U for indirect: CBC, retic, smear, haptoglobin, direct and indirect coombs, hemoglobin electrophoresis, red cell enzyme assay, test for spherocytosis W/U for direct hyperbili: LFT's, coags, albumin, glucose, cholesterol, ammonia, abdominal U/S, Hepatitis panel, Ceruloplasmin/24 hr urine copper, ANA, ASMA, anti-liver-kidney-microsomal Ab, serum alpha-i-antitrypsin level and phenotype, liver biopsy **the most sensitive test for synthetic liver function is the PT** worrisome signs *onset of hepatic encephalopathy *Vit K resistant prolongation of PT *Cerebral edema *Bili >18 *Rising serum bili with decreasing ALT/AST *Rising serum creatinine *Hypoglycemia *Sepsis *Ascites *pH < 7.3 in acetaminophen overdose

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Pediatrics Notes
Cystic Fibrosis Mutation on chromosome 17, autosomal recessive Most common lethal genetic mutation among caucasians, carrier rate 5% Disorder of exocrine gland function that results in abnl mucus production Characterized by: -Recurrent pulmonary infections --Infants usually with staph --Children with pseudomonas Any child with a second episode of pna should have a sweat chloride Malabsorption from pancreatic exocrine insufficiency FTT Increased electrolyte conc in sweat Meconium ileus Endocrine insufficiency (DM) Cor pulmonale Clubbing Nasal polyps Infertility Hepatic and biliary cirrhosis Bleeding from decreased vitamin K absorption and decreased coag production from liver cirrhosis Pneumothorax: mucous plugging causes ball valve phenom with air trapping rectal prolapse

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Peds Rotations _ NORMAL LITTLE BUGGER STUFF 1. Sleep a. When is a baby going to sleep all night? 6 months 1) total sleep =14 hrs 2) longest sleep period 10-11 hrs 3) # of naps = 2 4) no longer need to be fed @ night b. Sleep position? Back to Sleep prevents SIDS Feeding a. Dont give solid food until > 4 mo (need good head support) Crying: a. Colic 1) Periods of unexplained crying and irritability 2) 10-20% of children 3) Rule of 3s a) 3 hours of crying (@ same time of day; usu afternoon or evening) b) 3 days a week c) begins in 1st 3 weeks of life d) improves by 3 mo of age b. Normal crying 1) @ 2 wk 1 _ hrs / d 2) @ 6 wk 2 _ hrs / d 3) @ 8 wk PEAKS 4) @ 12 wk 1 hr / d c. Differentials 1) Idiopathic 2) Colic 3) Heat / cold 4) Lying position 5) Illness a) Surgical abdomen b) Infections (OM, UTI, Meningitis) c) GI (constipation, gas, GERD, intussesception) d) Trauma / Abuse e) Testicular torsion Temper Tantrums a. Ignore them b. Separate from situation or other children Short stature a. Constitutional short stature 1) NOT A DISEASE! Normal variation 2) Characteristics: a) Fhx of delayed puberty b) Delayed dentition in pt c) Delayed bone age c normal growth rate d) Most will have catch-up growth nl final height 3) W/u: a) Plot on growth curve b) Look @ parents c) Bone age study b. Familial short stature 1) Height below nl on growth chart 2) Bone age accurate Development

Questions _ PROTECTING THE LITTLE BUGGERS 7.

from Chris H

2. 3.

Vaccines a. Contraindications & Precautions 1) Contraindic to Live: Allergy, ImmSupp, Uterine Preg 2) Contraindic to Inactiv: ALlergy, Encephalitis) 3) Precaution to either: Illness b. ImmComp pts: 1) NO - OPV, VZV 2) OK DPT, MMR? c. Pertussis contraindications: Previous vaccine T>103 F, adverse rxn, collapse synd, encephalopathy after 1st 7 days, seizure 1) zIf fever < 103 DaPT Abuse a. Si/Sx of Shaken Baby Syndrome: 1) retinal hemorrhage 2) subdural hematoma 3) burns: donut butt, stocking & gloves, cigs b. Ecchymosis DDx 1) Over buttocks a) Henoch-Schonlein purpura (Anaphylactoid purpura) (i) Peaks in winter months (ii) May follow viral / bacterial infection Safety a. Carseat 1) Face back of car (since infant head control is weak & head is large for body) 2) 1 yo or > 20 lbs Face forward 3) 4 yo or 40 lbs Booster seat 4) 6 yo Booster seat 5) 8 yo legally dont need booster seat

8.

9.

4.

5.

6.

10. Poisoning a. Most common lethal ingestion 1) Fe (#1 cause of OD death) 2) TCA 3) Cardiac meds b. Ipecac 1) Use with large pills 2) DO NOT use with a) Corrosive substance, hydrocarbon b) Pinpt pupils c) Comatose pt d) Absent BS e) Shock f) _ ICP g) _ BP h) CNS depressants i) TCA since it induces _ LOC in 20 min 3) May be used @ home w/in 1 hour of ingestion 4) Causes emesis in 20 min 5) 30% of toxin remain in gut even if given w/in _ hr of ingestion 6) Dose a) 6 mo 5 mL b) 1 y 15 mL c) > 1 y 30 mL c. Gastric Lavage d. Activated charcoal 1) 1 gm per kg 2) does not work for Fe, Lithium, CN, etoh, acids and alkali e. Radiopaque substances on KUB CHIPPED 1) Chloral hydrate, Ca++ carbonate 2) Heavy metals

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Peds Rotations 3) Iron 4) Phenothiazines 5) Play-doh, KCl 6) Enteric coated pills 7) Dental amalgam Metabolic Acidosis MUDPILES 1) Methanol, CO, Metformin 2) Uremia 3) DKA 4) Paraldehyde, Phenformin 5) Isoniazid, Iron 6) Lactate, Lithium 7) Ethylene glycol, ethanol 8) Salicylates, starvation, seizures

Questions

from Chris H

_ NEONATOLOGY QUESTIONS 13. Respiratory Distress Syndrome a. Aka hyaline membrane dz b. Pathophys: 1) Surfactant deficiency _ lung compliance 2) Diffuse atelectasis with V/Q mismatch c. Popln: > 70% of 28-30w gest neonates have RDS d. Si/Sx: Tachypnea, retractions, nasal flaring, grunting (_FRC), cyanosis e. DDx: 1) TTN 2) Pneumonia 3) Aspiration syndromes (mec, blood, amniotic fluid) 4) BPD 5) Atelectasis 6) PTX, pneumoperitoneum, pneumopericardium, p eumomediastinum 7) TE Fistula 8) Laryngomalacia 9) Vascular ring 10) Tracheomalacia 14. Fetal EtOH Syndrome a. Binge drinking in mom b. Sx 1) FTT 2) Smaller than avg 3) _: _ IQ (63), ADD 4) HEENT: microcephaly, short nose, smooth philtrum, thinsmooth upper lip 5) Small nails 15. Teratogens a. Aminopterin craniofacial, limb b. Phenytoin facial (small nose, upper lip bowed, strabismus) , dysplastic nails Phenny-looking cupid c roaming eyes c. Warfarin bony defects, hypoplastic nasal bridge Broken bones/bridges in war d. Accutane craniofacial (triangular facies), heart defects e. Methyl mercury microcephaly, deafness, blindness, _ IQ ToMMy, the deaf, dumb, blind boy f. Trimethadione craniofacial, growth retardation 16. Downs Syndrome a. Epid: 1) 1/700 2) 2/3 of moms <35 yo; _ risk with moms > 35 yo b. Si/Sx: 1) HEENT: Hypertelorism, brushfield spots, epicanthal folds, protruding tongue, no neck, 2) Abd: umbilical hernias, 3) Ext:: simian crease, wide spacing b/w first and second toes 4) Congenital hypothyroidism 5) Atlantoaxial instability 6) _ risk for URI, obsesity, alzheimers!, AML 7) 1/3 have heart probs: a) Endocardial cushion defects!: ASD 1/6, VSD 1/10 b) PDA 1/50 c) Tetralogy of Fallot 1/100 17. Turners Syndrome a. 45 XO b. 1/8000

f.

_ ABNORMAL LITTLE BUGGER STUFF 11. Encopresis / Enuresis a. Encopresis 1) Fecal incontinence or soiling of formed or semi-formed stool in underwear by a child > 4 yo 2) No urge to defecate; lose sensation of having to poop a) Chronic constipation rectal wall stretched / vault enlarges experience signific anorectal pain (i) defecate small amt of stool to obtain relief dirty when awake / clean when asleep OR (ii) involuntary leakage of liquid stool around hard stool mass 3) Tx a) Mineral oil b) No behavior mod or psychotherapy needed b. Enuresis 1) Ages a) Start potty training by 2 yo b) Most are continent of urine in daytime by 3-4 yo c) 10-15% @ 6 yo d) 5% @ 16 yo e) 3 % @ 12 yo 2) DDx: UTI, DM, DI, Pyelo, glomerulonephritis a) Delayed maturation (unable to sense bladder) 3) Workup: UA, UCx 4) Treatment: NOT recommended before 6 yo a) Imipramine TCA via anti-Musc actns b) DDAVP

12. Psych a. Ano;rexia 1) 1-5% of teen girls 2) Very skinny 3) Si / Sx a) Perfectionist behavior b) Low self-esteem c) H/o being mildly overweight b. Autism 1) No / diff communic by 18 mo 2) Uncuddly 3) Delayed or absent smiling 4) Hrs of solitary smiling 5) Ritualistic / repetitive routines

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Peds Rotations c. Sx: 1) Short, webbed neck 2) Puffy hands & feet 3) Wide spaced nipples 4) Gonadal dysgenesis 5) Multiple pigmented nevi 6) Spatial, perceptual difficulties probs with math Assoc sx: 1) Coarct of aorta 2) Horseshoe kidney

Questions 1) 2) e.

from Chris H Immunized S. pneumo (peaks @ 4 yo; tx: E-mycin, PCN, cephalosporin, vanco), S. aureus Not imm H. flu, type B (Tx: Amox / Augmentin)

d.

18. Marfans Syndrome a. AD b. Fibrillin gene disorder c. Dissection of aorta f.

Mycoplasma pneumonia 1) Walking atypical pneumonia 2) W/u: a) Cold agglutinins b) Complement fixation test c) Sputum culture (2-3 w) fried eggs d) Mycoplasma DNA probe 3) Tx: a) Self-limited b) E-mycin, TCN (dont give if < 7 y) Chlamydia pneumonitis (not a TORCH bug) 1) Afebrile pneumonia usu seen in infants b/w 4-12 w 2) Tachypnea, cough, apnea + conjunctivitis, rales, wheezing 3) Staccato cough 4) Tx: Erythromycin / azithro RSV 1) Bronchiolitis in < 2 yo 2) Si/sx: a) Temperature instability b) Respiratory distress, Apnea c) Nasal discharge d) Poor feeding 3) Tx: a) Symptomatic relief b) O2 prn c) Aerosol ribavirin only if severe (controversial cuz of sefx) d) _-agonist aerosols e) Palivizumab??

_ RESPIRATORY ILLNESSES 19. LUNG INFECTIONS a. VIRAL (most are viral) insidious onset 1) Pneumonia RSV, parainfluenza, adeno, influenza Bronchiolitis RSV 2) Asthma 3) Sinusitis 4) Croup parainfluenza, RSV (<3 yo) 5) Otitis media a) Often followed in 1-2 w by effusion and no erythema 6) Pharyngitis b. BACTERIAL acute onset 1) <3 mo: GBS, Chlamydia, S. aureus, G- orgs * S. aureus in < 3 mo fever, abd dist, resp distress, toxic, unilateral invlvmt 2) 3 mo5 y: S pneumo, H influenza, M catarrhalis, S aureus, GAS 3) > 5 y: Mycoplasma pneumo (>12), Chlamydia pneumo 20. PNEUMONIA revisited a. Terminology Pneumonia: lung inflamm + consolidatn of alveolar spaces Pneumonitis: lung inflamm consolidation Lobar : localized to 1+ lobes that are consolidated Bronchopneumonia: lung inflamm centered in bronchioles; mucopurulent exudates, patchy consolidation, multiple lobes Interstitial: inflamm of interstitium (alv walls, sacs, ducts, bronchioles); viral or chronic b. Bugs 1) Neonate & 4-16 w a) V: RSV, CMV, Herpes virus, entero, flu, parainfluenza b) B: GBS, S aureus, H. flu, s pneumo, C trach (afeb) 2) < 5y a) V: RSV, adeno, influ b) B: S. pneumo, H. flu, GAS, S aureus 3) > 5 y a) V: influ, VZB b) B: M pneumo, C pneumo, Legionella, S pneumo c. Sx: Tachypnea, cough, malaise, pleuritic chest pain, retractions 1) Viral _ fever , streaky infiltrates, WBC normal 2) Bact - _ F/C, dyspnea, lung consolidation c _ breath sounds; X-R: lobar consolidation, pleural effusion; _ WBC Based on CXR lobar consolidation & pleural effusion g.

21. PERTUSSIS, aka whooping cough a. _ risk in < 5 yo; 50% in <6 mo b. sx: 1) paroxysmal cough post-tussive vomiting 2) facial petechiae, redness, venous engorgement, cyanosis c. Tx 1) E-mycin / azithro admit 2) warm mist O2 3) suction 4) parenteral fluids 22. OTITIS MEDIA a. Suppurative infxn of middle ear b. 6 mo 2 yo c. Bugs: 1) S. pneumo 2) H. flu, non-type 3) M. catarrhalis d. Sx: 1) Fever 2) Irritable, pulling ear 3) 4-7 d after nasopharyngitis 4) N/V 5) Diarrhea e. PEx: bulging, immobile, erythematous, loss of landmarks f. Tx: amoxicillin, or augmentin, or bactrim g. If 3 wks later still have effusion Tx: decongestant; dont put back on ABx!!!

d.

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Peds Rotations h.

Questions a. b. > 5 yo Sx: 1) Wheeze 2) Dyspnea, tachypnea 3) Cough: persistent, night, exercise-induced 4) Post-tussive emesis 5) CP Tx: 1) Acute short-acting steroids 2) . 3) Cromolyn sodium

from Chris H

Complication: ORBITAL CELLULITIS 1) Si/sx: a) _ fever b) orbital pain, c) _ vision, limited EOM d) proptosis 2) Periorbital cellulitis sx: a) < 2 yo b) fever c) lid swelling d) toxic 3) w/u: a) CT of orbit b) BCs c) ESR d) CBC 4) Tx: a) Broad-spec parenteral abx (oxacillin and/or ceftriaxone) x 3-4 w minimum b) Drain infected sinus or orbital abscess if complicated

c.

_ SYSTEMIC stuff aka no idea where else to put it 27. Fever a. < 6 mo r/o sepsis! b. W/u: full septic w/u no matter dx 1) Blood: CBC, BCx 2) Urine: UA, UCx, UGS 3) CSF: LP 4) Resp: CXR 28. ROSEOLA / HHV 6 a. 6 mo 4 yo b. Fall, spring c. Si/Sx: 3-5 d of high fever in nl child fever breaks rash for 1-2 d on neck & trunk d. Fever before rash! (DDx: Mr. HE measles, roseola, hand-ftmouth, ery???) e. Tx: symptomatic relief, antipyretics 29. MEASLES a. Si/Sx: 1) fever, HA, malaise 2) sore throat, cough, coryza, conjunctivitis, 3) LAD 4) pink maculopapular exanthem (face trunk extremities) 5) photophobia 6) KOPLIK SPOTS (opposite lower molars) b. Tx: Supportive, VITA, Tylenol c. Prev: MMR 30. Lymphadenopathy a. Staph / strep: tx augmentin; no I&D b. ImmComp; HIV 31. Meningococcemia EMERGENCY! a. N. meningitides b. < 1 yo c. Si/sx: 1) Petechiae, purpuric rash on lower extremities, buttocks 2) _ BP / Septic shock from endotoxin 3) DIC 4) Oliguria, renal failure 5) Coma d. Fulminant meningococcemia 1) Aka Waterhouse-Freidrichson Syndrome 2) Bilateral hemorrhagic adrenals e. DDx: 1) Generalized vasculitis 2) Septicemia due to another org 3) HSP 4) RMSF 5) Atypical measles

23. SINUSITIS a. Bugs 1) S. pneumo 2) H. flu, non-type 3) M. catarrhalis b. Si/Sx: 1) Persistent mucopurulent rhinorrhea 2) BAD BREATH! 3) Cough @ night 4) Nasal stuffiness 5) HA 6) Facial swelling, TTP c. Tx: 1) Amox / Augmentin 2) Drainage prn complicated sinusitis 24. SORE THROAT a. Group A, _-hemolytic strep 1) Scarlet fever: rash 24-48 h after pharyngitis 2) Tx: PCN b. EBV 1) Si/sx: a) pharyngitis (enlarged tonsils, exudates), b) exanthem (pharyngeal petechiae) c) fever d) LAD @ posterior cervical e) Splenomegaly (50%) f) Eyelid edema, maculopapular rash, urticarial rash 2) Dont treat with AMPICILLIN!!! 80-100% get rash 3) Tx: bed rest 25. ALLERGIC RHINITIS / CONJUNCTIVITIS a. 5-10% of kids b. Type I allergic response c. Sx: 1) sneezing, nasal congestion, rhinorrhea, 2) itchy nose, eyes, soft palate 3) allergic shiners lower eyelids dark 2 venous stasis d. FHx: asthma or atopic dermatitis e. Tx: Envt control f. Antihistamines (H1 antags) g. DO NOT use decongestants rebound edema 26. ASTHMA

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Peds Rotations f. Tx: Give penicillin G IV immediately

Questions 1) 2)

from Chris H Air/barium enema to diagnose/reduce (works in 75%) Surgical resection if severe

_ CV 32. Murmurs a. PDA: continuous, harsh, machine-like b. Transposition: NO murmur or SEM (@ ULSB) c. VSD: holosystolic murmur d. ASD: systolic ejection

36. ROTAVIRUS a. Winter mos b. Sx: 1) Vomiting 3-4 d 2) Diarrhea 7-10 d 3) Dehydration c. W/u: rotazyme testing d. Tx; supportive fluids/lytes 37. APPY a. <16 yo b. DDx: ectopic pregnancy, ov cyst, ov torsion, PID c. Sx: 1) Periumbilical dull crampy pain x 1-2 d moves to McBurneys pt/RLQ 2) Fever 3) Voluntary guarding (invol of perfd) d. Tx: cut the sucker out. 38. SALMONELLA TYPHI a. Rose spots on abd b. Mimics appy c. Tx: 1) Only for _ risk pts 2) Cipro (if > 12) or ceftriaxone 39. DIARRHEA a. Acute GastroEnteritis: supportive tx b. Giardia 1) Sx: Anorexia, nausea, glatulence, abd dist, wt loss 2) Tx: quinacrine, metro

_ NEURO 33. SEIZURES (see sz sheet)

_ MSk 34. LIMP a. DDx 1) Septic arthritis a) Surgical emergency! or bone/articular surfaces destroyed permanently b) Si/sx: (i) Pain, involuntary guarding, muscle spasms, (ii) visible erythema, (iii) toxic, febrile, (iv) _ appetite c) Bugs (i) Gonococcal ceftriaxone (ii) Staph/strep (child) ox/nafcillin 2) Toxic synovitis a) 3-10 yo, male b) Si/sx: (i) pain in hip (ii) limited ROM (iii) _ intensity vs septic arthritis (iv) low fever c) tx: bed rest, crutches d) IF < 5 yo pain, limited ROM, usu @ hip jt; no constitutional sx! SCFE

_ SKIN 40. Erythema multiforme a. Looks like??? b. Resolves in 1-3 wks some hyperpigmentation 41. Atopic dermatitis / Eczema a. Tx: 1) Advice a) Avoid soap, detergents, chemicals b) Wear loose fitting clothes c) Cut nails so cant scratch d) Limited bathing, ewww 2) Use lubricants 3) Topical steroids 42. Impetigo a. Looks like 1) small fluid filled vesicles that rupture easily 2) Honey colored thick crust 3) Weeping lesions b. Tx: 1) 1st gen ceph cephalexin 2) erythromycin 43. Cellulitis a. Looks like 1) Painful, erythematous, indurated infxn

3)

_ GI 35. INTUSSUSCEPTION a. 6-18 mo old b. Lymphoid hyperplasia with telescoping of proximal seg into distal c. RF: CF, HSP d. DDx: colic, perf, Hirschsprung, necrotic bowel e. Si/sx: 1) ACUTE onset of colicky pain c knees drawn up 2) Crying, irritability, lethargy 3) vomiting 4) fever 5) currant jelly stool 6) sausage-shaped mass in upper abd f. Tx:

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Peds Rotations 2) Regional LAD Tx: PCN

Questions

from Chris H h) Myocarditis SUBACUTE (11-21 d) a) Arthritis b) Skin desquamation @ jcn of nail and fingertips 3) CONVALESCENT (>21d) a) Coronary artery aneurysms (20-25%) b) Arthritis c) Thrombocytosis d) MI, CP DDx: measles, scarlet fever, SSSS, TSS, RMSF W/u: 1) CBC _ WBC, mild anemia 2) Plt _ 3) ESR _ 4) UA: sterile pyuria, proteinuria 5) EKG prolonged PR, QT 6) Echo: coronary aneurysms Tx: 1) _ dose of aspirin 2) IV gamma-globulin (_ risk of aneurysm formation) 3) NOOOOOO corticosteroids! 2)

b.

_ GU / Renal 44. STD a. Gonorrhea M sx 1) 2-14 d incubation 2) mild discomfort in urethra, dysuria 3) d/c: purulent, yellow-green 4) _ freq, _ urgency b. Chlamydia M sx 1) 7-28 d incubation 2) acute onset 3) mild dysuria 4) d/c: clear to mucopurulent c. Tx: 1) Ceftriaxone x 1 shot 2) Doxycycline x 7 d bid 45. HEMATURIA / PROTEINURIA (see Dr. Anands lecture) a. Post Strep GN b. Nephrotic Syndrome 1) What is it? a) Proteinuria b) Hypoalbuminemia c) Edema d) Hyperlipidemia 2) Si/Sx: a) H/o URI b) Edema (i) Puffy eyes (ii) Ascites (iii) Pleural effusion (iv) Scrotal/labial edema c) No fever 3) W/u: a) Urine dipstick b) Blood chemistry c) R/o PSGN ASO??? d) R/o SLE SLE 4) Tx: a) corticosteroids b) if no response renal bx

d. e.

f.

47. Henoch-Schonlein purpura (Anaphylactoid purpura) a. Epid: 1) #1 vasculitis in children 2) Peaks in winter months 3) May follow non-specific viral / bacterial URI 4) 4-10 yo b. DDx: thrombocytopenia, vasculitis, ARF, SLE, meningococcemia, acute/chronic GN c. Si/Sx 1) GI pain: Cramping, intermittent, vomiting, bloody diarrhea 2) Periarticular pain, tender c mvmt / arthritis (ankle, hand, knee) 3) Purpura a) Palpable non-thrombocytopenic purpura, circular b) Appears over buttocks, lower extremities 4) scrotal, scalp swelling 2 edema 5) Renal: Glomerulonephritis with asymptomatic hematuria d. Tx 1) Supportive 2) PO Corticosteroids 48. Anemia a. Fe Deficiency 1) Etiol a) _ intake of whole cows milk inadequate Fe Intake b) small amts of GI blood loss c) menstruating adolescent 2) Epid: 24 mo most common 3) W/u a) _ serum Fe b) _ serum binding protein / TIBC c) _ ferritin d) _ marrow iron e) _ marrow sideroblasts 4) tx: 4-6 mg/kg/d of Fe div TID b. Pb poisoning 1) Etiol: inhibit heme synth 2) Smear: hypochromic, microcytic anemia, basophilic stippling 3) Tx: chelation therapy with DMSA

_ ALLERGY RHEUMATOLOGY IMMUNOLOGY HEMATOLOGY 46. KAWASAKIS DISEASE a. Etiology: unknown b. Popln: 5 yo, M>F c. Si/sx: 1) ACUTE (10 d) a) Conjunctivitis b) Fever > 5 d c) Rash d) Puffy hands and soles e) Change in oral mucosa puffy, hard, cracked lips f) Cervical LAD g) Aseptic meningitis

_ MISC WARD STUFF 49. FEN

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Peds Rotations a. Maintenance IV 1) 100-50-20 mL/kg/d, or 4-2-1 mL/kg/ 2) electrolytes a) Na 4 meq/kg/d (i) 0.9 NS 154 meq Na (ii) _ NS 77 meq Na b) K 2 meq/kg/d c) Cl 50-200 mg/kg/d

Questions

from Chris H

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