NEBULIZED BROCHODILATORS FOR DOGS AND CATS Medication Isoetharine Isoproterenol Aminophylline Dosage 0.5 - 1.

0 ml of 1:3 saline dilution TID 0.5 ml of 1:200 dilution 100 mg Reference Booth DM. Drugs affecting the respiratory system, in King LG (ed): Textbook of Respiratory Disease in Dogs and Cats, p. 229, 2004.

NEBULIZED ANTIBIOTICS FOR DOGS Medication Gentamicin Gentamicin Kanamycin Polymyxin B Colistin Dosage 50 mg / 3 ml 4 - 6 mg / # / 3 - 4 ml NaCl 250 mg / 3 ml 166,666 IU / 3 ml 30 mg / 3 ml Reference Bemis DA. Bordetella and Mycoplasma respiratory infections in dogs and cats, Vet Clin North AM Small Anim Pract 22 (5), p. 1173, 1992 (all 4) Sherding RG. Canine infectious tracheobronchitis, in Brichard SJ, Sherding RG (eds): Saunders Manual of Small Animal Practice, p.103, 2000. McKiernan BC. Tracheobronchitis aerosol therapy (PT-59), Western Veterinary Conference Notes, 2003. (gentamicin 4-6 mg/#)

NEBULIZED DRUGS FOR DOGS AND CATS Medication Dosage Methylprednisolone sodium succinate (anti-inflammatory) Saline 6 - 10 ml for 15-20 min SID-QID ANTIBIOTICS FOR AVIAN NEBULIZATION Medication Amikacin Sulfate Carbenicillin Cefotaxime Erythromycin Gentamicin Piperacillin Tylosin Dosage (in 10 ml saline) 50 mg for 15 min BID 200 mg for 15 min BID 100 mg for 10-30 min BID-QID 100 mg for 15 min TID 50 mg for 15 min TID 100 mg for 10-30 min BID-QID 100 mg for 10-60 min BID Reference Rupley AE, Manual of Avian Practice, p. 336, 1997 Reference Ford RB. Infectious tracheobronchitis, in King LG (ed): Textbook of Respiratory Disease in Dogs and Cats, p. 364, 2004.

ANTIFUNGALS FOR AVIAN NEBULIZATION Medication Amphotericin B Clotrimazole Miconazole Dosage 1 mg/ml saline for 15 min SID-BID for 5-7 days 1% solution for 30-45 min SID for 3 days, off 2 days Dilute in saline for 15-20 min BID Reference Rupley AE, Manual of Avian Practice, p. 505, 1997.

DRUGS IN METERED DOSE INHALERS Medication Dosage BRONCHODILATORS - Beta2 Agonists Albuterol 180-360 ug every 20 min Albuterol 90 ug as needed up to QID Salmeterol 21 ug BID STEROIDS Beclomethasone 200 ug TID-QID Fluticasone 110-220 ug BID ANTICHOLINERGIC AGENTS Ipratropium bromide MAST CELL STABILIZERS Cromolyn Sodium Nedrocromil IVAX GENERIC DRUGS Medication Albuterol sulfate inhalation solution Cromolyn sodium inhalation solution Ipratropium bromide inhalation solution Dosage 2.5 mg/3 ml - oral inhalation only 25 x 3 ml unit dose vials / box 20 mg/2 ml - aqueous solutoin for nebulization 30 x 2 ml unit dose vials / box 0.5 mg/ 2.5 ml unit dose vials / box 25 x 2.5 mlo unit dose vials / box Reference Dowling PM. Using metered dose inhalers in veterinary patients (PT-65), Proc. Western Vet Conf, 2004. (albuterol 180-360 ug, salmeterol) Padrid P. Feline Asthma: Diagnosis and Treatment, Vet clin North Am Small Anim Pract 30(6), p. 1279, 2000. (albuterol 90 ug, fluticasone 220 ug BID Boothe DM. Drugs affecting the respiratory system, in King LG (ed): Textbk of Respiratory Disease in Dogs and Cats, p. 229, 2004. (beclemethasone) Johnson L. Prespectives and controversies in feline bronchial disease. Proc. Atlantic Coast Vet Conf, 2003. (fluticasone 110 ug BID) Dowling PM. Treatment options for feline asthma and canine bronchitis (VET-321), Proc. Western Vet Conf, 2004.

NEBULAIR ULTRASONIC NEBULIZER AND ACCESSORIES

Clinical Signs of Respiratory Disease coughing, wheezing, gagging (wretching), nasal discharge, labored breathing, exercise inteolerance, lethargy (cats - misdiagnosed as hairballs) Feline Asthma 1% of cats in the U.S. (1 million) suffer from this respiratory disease. Infectious Tracheobronchitis, a.k.a. Bordetella (kennel cough) in dogs Bordetella (coughing and contageous) is inside the trachea - must be treated with inhalation therapy for best results Bordetella - bacterial component is what's treated. Chronic Bronchitis Respiratory Therapy - Oral, Systemic, and Aerosol Therapy Advantages of Aerosol Therapy Systemics in blood cannot cross blood-bronchus barrier for treatment inside the airways. More rapid clinical response due to higher drug concentrations in the lower respiratory tract. avoid side effects from steroids and aminoglycoside antibiotics reduced toxicity due to lower doses mobilize respiratory secretions (saline) NebulAir turns aqueous drugs into mist (particles 1-5 microns) with a piezoelectric crystal that vibrates at 2.5 million cylces/second. Nebulizing in rooms or cages will create a large amount of resistant bacteria in the clinic. This method should be last resort. Portable - why bring contageous animals around other animals? Types of nebulizers Compressed air (or oxygen driven) - oldest models Jet-enhanced - a valve system allows for additional air delivery during inspiration Ultrasonic - latest technology, eliminates the need for a compressed air source (allowing portability). NebulAir Small Animal Aerosol Chamber (Spacer) designed for optimal delivery of medication from Metered Dose Ihalers (MDIs) patented design to direct particle flow into the mask can be used with feline mask or canine anesthesia masks

NEBULAIR ULTRASONIC NEBULIZER AND ACCESSORIES

NebulAir Portable Ultrasonic Nebulizer NebulAir Canine Ventilation Circuit NebulAir Feline Mask NebulAir Small Animal Aerosol Chamber (Spacer)

$149 $25 $20 $20

these prices are approximated as of 10/25/04