Haloperidol

Pronunciation: ha-loe-PER-i-dole Trade Drug: Haldol Trade Drug: Novo-Peridol

haloperidol decanoate Trade Drug: Haldol Decanoate Trade Drug: Haloperidol LA haloperidol lactate Trade Drug: Haldol Trade Drug: Haldol Concentrate
Indications and Dosages Psychotic disorders

Adults and children older than age 12: Dosage varies for each patient. Initially, 0.5 to 5 mg P.O. b.i.d. or t.i.d. Or, 2 to 5 mg I.M. lactate every 4 to 8 hours, although hourly administration may be needed until control is obtained. Maximum, 100 mg P.O. daily. Children ages 3 to 12 who weigh 15 to 40 kg (33 to 88 lb): Initially, 0.5 mg P.O. daily divided b.i.d. or t.i.d. May increase dose by 0.5 mg at 5- to 7-day intervals, depending on therapeutic response and patient tolerance. Maintenance dose, 0.05 mg/kg to 0.15 mg/kg P.O. daily given in two or three divided doses. Severely disturbed children may need higher doses.
Chronic psychosis requiring prolonged therapy

Adults: 50 to 100 mg I.M. decanoate every 4 weeks.

Nonpsychotic behavior disorders

Children ages 3 to 12: 0.05 to 0.075 mg/kg P.O. daily, in two or three divided doses. Maximum, 6 mg daily.
Tourette syndrome

Adults: 0.5 to 5 mg P.O. b.i.d., t.i.d., or as needed. Children ages 3 to 12: 0.05 to 0.075 mg/kg P.O. daily, in two or three divided doses. Elderly patients: 0.5 to 2 mg P.O. b.i.d. or t.i.d.; increase gradually, as needed. Adjust-a-dose: For debilitated patients, initially, 0.5 to 2 mg P.O. b.i.d. or t.i.d.; increase gradually, as needed.
Delirium

Adults: 1 to 2 mg I.V. lactate every 2 to 4 hours. Severely agitated patients may require higher doses. Elderly patients: 0.25 to 0.5 mg I.V. every 4 hours.
Adverse Reactions CNS: severe extrapyramidal reactions CV: anorexia ECG changes, n/v, blurred vision, hypertension, GI, dry mouth, constipation, diarrhea,dyspepsia,tachycardia,hypotension, tardivedysyskinesia,,neuroleptic,malignant,syndrome,seizures,sedation,drowsiness,lethargy headache,insomnia,confusion,vertigo,GU,urine retention,menstrual irregularities priapism,Hematologicleukopenia,leukocytosis,Hepaticjaundice,Skin rash,other skin reactions

diaphoresis.
Interactions Drug-drug Anticholinergics

Effect: May increase anticholinergic effects and glaucoma. Action: Use together cautiously.

Azole antifungals, buspirone, macrolides

Effect: May increase haloperidol level. Action: Monitor patient for increased adverse reactions; haloperidol dose may need to be adjusted.
Carbamazepine

Effect: May decrease haloperidol level. Action: Monitor patient.

CNS depressants

Effect: May increase CNS depression. Action: Use together cautiously.

Lithium

Effect: May cause lethargy and confusion after high doses. Action: Monitor patient.
Methyldopa

Effect: May cause dementia. Action: Monitor patient closely.

Rifampin

Effect: May decrease haloperidol level. Action: Monitor patient for clinical effect.
Drug-lifestyle Alcohol use

Effect: May increase CNS depression. Action: Discourage use together.