DRUG STUDY Freq.

/ Route/ Dosage 20mg / cap PO, od Mechanism of Action Inhibits the action of acid pump and binds to hydrogenpotassium adenosine triphosphatase at secretory surface of gaxtric parietal cells to block formation of gastric acid Nursing Responsibilities 1. Dosage adjustments arent needed for patients with renal/hepatic impairment 2. Omeprazole increases its own bioavailability with repeated doses. Drug is labile in gastric acid; less drug is lost to hydrolysis because drug increases gastric pH. 3. Alert: Dont confuse Prilosec with prozas, Prilocaine, or Prinivil. 4. Serum gastrin levels rise in most patients during the first 2 weeks of therapy

Drug Name Omeprazole (omepron)

Indication > symptomatic gastroesophageal reflux disease (GERD) without esophageal lesions > erosive esophagitis and accompanying symptoms caused by GERD > maintenance of healing erosive esophagitis > pathologic hypersecretory conditions (such as Zollinger Ellison syndrome) > duodenal ulcer (short-term treatment) > helicobacter pylori infection and duodenal ulcer disease, to eradicate H. pylori with clarithomycin (dual therapy) > short-term treatment of active benign gastric ulcer

Contraindication Contraindicated in patients hypersensitive to drugs and its components

Adverse Effects > CNS : headache, dizziness, asthenia > GI: diarrhea, abdominal pain, nausea, vomiting, constipation, flatulence > Musculoskeletal: back pain > Respi: cough, upper respiratory tract infection >Skin: rash

DRUG STUDY Drug Name Clindamycin (Dalacin C) Freq. / Route/ Dosage 300mg / cap , PO , q6H Mechanism of Action Inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosome. Indication > infections caused by sensitive staphylococci , streptococci, pneumococci, bacteroids ,fusobacterium, and clostrisium perfringens, and other sensitive aerobic and anaerobic organisms > pelvic inflammatory disease Contraindication Contraindicated in patients hypersensitive to drug and lincomycin Adverse Effects > CV: thrombophlebitis > GI: nausea, vomiting, abdominal pain, diarrhea, pseudomembranous colitis. > Hematologic: transient leucopenia, eosinophilia, thrombocytopenia > Hepatic: jaundice > Skin: maculopapular rash, urticaria > Other: anaphylaxis Nursing Responsibilities 1. Use cautiously in neonates or patients with renal or hepatic disease, asthma, history of GI disease, or significant allergies. 2. Drug doesnt penetrate blood-brain barrier 3. Obtain specimen for culture and sensitivity tests before giving first dose. Therapy may begin pending results. 4. Dont refrigerate reconstituted oral solution because it will thicken. Drug is stable for 2 weeks at room temperature. 5. Monitor renal, hepatic, and hematopoietic functions during prolonged therapy. 6. Observe patient for signs and symptoms of superinfections.

7. Alert: Dont give opiods antidiarrheals to treat drug-induced diarrhea; they may prolong and worsen diarrhea.

DRUG STUDY Drug Name Ibuprofen (Alaxan) Freq. / Route/ Dosage 200mg / tablet tid Mechanism of Action Produces inflammatory, analgesic and antipyretic effects possibly by inhibiting prostaglandin synthesis. Indication > Rheumatoid arthritis, osteoarthritis, arthritis > mild to moderate pain, dysmenorrhea > fever > juvenile arthritis Contraindication Contraindicated in patients hypersensitive to drugs and in those with angioedema, syndrome of nasal polyps or bronchospastic reaction to aspirin or other NSAIDs Adverse Effects > CNS: headache, dizziness, nervousness, aseptic meningitis > CV: peripheral edema, fluid retention, edema > EENT: tinnitus > GI: epigastric distress, nausea, occult blood loss, peptic ulceration, diarrhea, constipation, dyspepsia, flatulence, heartburn, decreased appetite. > GU: acute renal failure, azotemia, cystitis, hematuria > Hematologic: prolonged bleeding time, anemia, neutropenia, pancytopenia, thrombocytopenia, aplastic anemia, leucopenia, agranulocytosis > Metabolic: hypoglycemia, Nursing Responsibilities 1.Use cautiously in patients with GI disorders, history of peptic ulcer disease, hepatic or renal disease, cardiac decompensation, hypertension or known intrinsic coagulation defects 2. Dont use drug in pregnant women. 3.3. Check renal and hepatic function periodically in patients on longterm therapy. Stop drug if abnormalities occur and notify prescriber. 4. Because of their antipyretic and anti-inflammatory actions, NSAIDs may mask signs and symptoms of infection. 5.It may take 1-2 weeks before full anti-inflammatory

hyperkalemia > Respiratory: bronchospasm > Skin: pruritis, rash, urticaria, Stevens-Johnson syndrome

effects occur 6.Alert: Dont confuse Trendar with Trandate 7.Blurred / diminished vision and changes in color vision have occurred.