Composition Eritromisin stearat HPMC Starch 1500 Magnesium stearat Avicell Metil Paraben PVAP PEG Aqua coat

function active substance Binder Desintegran Lubricant Diluent Preservatif Coating agent Plaztizer Solvent

account/tablets 347.5 mg 15 mg 5 mg 1,25 mg 130.25 mg 1 mg 1,35 mg 3 mg 10.65 mg

account/Batch 0.3475 g 150 mg 50 mg 12.5 mg 1302.5 mg 10 mg 13.5 mg 30 mg 106.5 mg

MANUFACTURE OF TABLET CORE . Milling of drugs (erythromycin) and excipients (diluent : avicel, binder : HPMC) 2. Mixing of milled powders 3. Compression into large, hard tablets called slugs 4. Screening of slugs 5. Mixing with lubricant (mg. stearat) and disintegrating agent (starch 1500) 6. Tablet compression MANUFACTURE OF TABLET COATED The tablets (or granules) are placed within the coating apparatus and agitated. 2. The coating solution is sprayed on to the surface of the tablets. 3. Warm air is passed over the tablets to facilitate removal of the solvent from the adsorbed layer of coating solution on the surface of the tablets. 4. When the solvent has evaporated, the tablets will be coated with the solid component of the original coating solution Alas an penggunaan sediann Ph stability of erythromycin ranged 6-8. so erythromycin should be made in the enteric tablet dosage form. (AHFS: 1361) Enteric coatings are those which remain intact in the stomach (and exhibit low permeabllity to gastric fluids). but break down readily once the dosage form reaches the small intestine. The prime uses of such coatings are, To maintain the activity of drugs that are unstable when exposed to the gastric milieu, To minimize either nausea or bleeding that occurs with those drugs that irritate the gastric mucosa ( tablets vol. 3 ) . Mg. Stearat : material to glidan and lubricants that are not soluble in water, which is more effective as a lubricant and is used in small concentrations. can reduce the friction on the tablet and the hydrophobic nature, which would prevent the tablet

attached to the punch. and the degree of subtlety either to increase the flow of other materials 2. Starch 1500 : Extensive application usage, has moisture content between 4.5-7.0 and have a free flow and good 3. Avicel 102 : widespread use, has a violent nature, the fragility and the flow is good, has a faster wicking rate for water and more stable and effective use . Metil paraben : The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds. Antimicrobial activity increases as the chain length of the alkyl moiety is increased, but aqueous solubility decreases . Hydroxypropylmethylcellulose (HPMC) soluble in various organic solvents or cosolvent systems, as well as water. L-HPC is a low molecular weight, crosslinked It functions not only as a tablet binder but also a tablet disintegrant., it is not soluble in water. It has tremendous swelling capability which accounts for its disintegration property. L-HPC may be used in both. 1. PVAP : soluble in water, quickly dissolving coating. PH does not dissolve in the stomach but dissolves rapidly in the PH in the small intestine, resulting in a powerful film, kompartibel . PEG 400 : modify the physical properties of polymers to reduce the fragility of the film, is a water soluble plazticizer, improve the effectiveness of increasing tablet, and to avoid the outbreak of the coating film when compressed into tablets . Aqua coat (30% pseudolateks atil cellulose and distilled water), has advantages of high solid content (ie greater ability to overlay) and a lower viscosity, allowing the use of less water.