Modifiable Risk Factors *Age *Sex *Race *Heredity Atherothrombotic Disease lipid deposition formation of plaque narrowing of lumen

of blood vessel turbulent blood flow alteration in flow velocities intimal disruption or plaque rupture activation of clotting cascade activated platelets adhere to plaque surface fibrin clot

Partially Modifiable Risk Factors *Hypertension *Cardiac Impairments *Blood Lipid Abnormalities *Diabetes Mellitus Embolic Disease dislodged thrombi travel in the bloodstream Small vessel disease microaretromata or elevated BP occlusion of criface in the penetrating arteric endothelial injury

Modifiable Risk Factors *Smoking *Fat and Salt Intake *Obesity *Sedentary Lifestyle HPN chronic elevation of blood vessel Amyloid angiopathy deposition of beta amyloid sheets in the tunica media of blood vessel wall rigid, fragile and weak blood vessel

degeneration of formation of tunica media Chacot-Bauchad smooth muscle aneurysm in lipohyalinotic smooth muscle vessels is replaced with collagenous fibers unelastic blood vessel narrowing of lumen

Occlusion Hypoperfusion

rupture

increased ICP

pain, dizziness

Compression of the different lobes of The brain systemic HPON reduces cerebral perfusion pressure Small arteries interruption of blood supply to the brain alteration in the functioning Constrict in of the different lobes activation of attempt to ischemia auto regulatory maintain distal tissue hypoperfusion FRONTAL LOBE: dysfunction in system pressure membrane the motor control of voluntary movements (e.g. speech) and hypoxia control of a variety of emotional expressions PARIETAL LOBE: dysfunction in the general senses of the body Tissue ischemia TEMPORAL LOBE: dysfunction in hearing and memory, disequilibrium OCCIPITAL LOBE: visual abnormalities Cell Death