M.

Ahsan Ul Haq

Brand No. 01. Genticyn

Generic Name

Company

Name

Category

Dosage Form Cream Inj

Dose

Indications

Adverse Effects

Gentamycin Reckitt &

Benakiser

Antibiotic Aminoglyco -side

3-4 times daily

02.

Amikin

Amikacin

Bristol Myers Squib NOvartis

Antibiotic Aminoglyco side Macrolide

03.

Azomax

Azithromycin

5mg/kg IM/ IV in three divided doses for 7-10 days Children2mg/kg 8hourly Ear/eye Ear:2-4drops 3-4times drops daily Eye:1-2 drops/ 4 hours Inj 100mg Adults: upto 15mg/kg daily 250mg Children: 10mg-15mg/kg 500mg/ daily depending upon the vial indications Adults:500mg once daily Cap for 3 days ( for genital 250mg Susp: per infection 1000mg single dose 5ml, Children: 5-10 ml single 200mg dose daily powder Apply 2 times daily I applicator full at night Adult:600mg-2.7g daily Children: 15-40mg/kg in divided doses Use in adults only; 500mg by slow IV infusion over 60 minutes

Skin ulcer, bur, impetigo, folliculitis, wounds Serious UTIs Eye: topical bacterial infection Serious infections due to amikacin sensitive organisms Upper and lower respiratory tract, skin, soft tissue infection. Otitis media, uncomplicated genital infection due to clamydia species Moderate/ severe acne vulgaris Bacterial vaginosis Serious clindamycin sensitive infections Infections caused by pathogens sensitive to levofloxacin

sensitization ototoxicity nephrotoxicity superinfection

ototoxicity nephrotoxicity

GI upsets, allergy, hepatic necrosis, dizziness, vertigo, renal failure, stevens johnsons syndrome, oedema, anaphylactic shock Dry skin dermatitis, diarrhea or colitis Vaginal irritation GI upsets, diarrhea or colitis Blood disorders GI upsets, Headache, insomnia, pain in muscles and joints

04.

Dalacin

Clindamycin

Pfizer

Antibiotic T:Lotion Lincosamide V-vaginal cream Inj 300mg 600mg Cap 150mg
300mg

05.

Levaquin

Levofloxacin

Barrett Hodgson

Flouroquinl ones

Injection 500mg Tablets 250mg 500mg

Sr. Brand No. 06. Floxy

Generic Name Ofloxacin

Company

Name GSK

Category

Dosage Form

Dose

Indications

Adverse Effects

Quiniolone

IV infusion 200mg/ 100ml Film coated tablets 200mg

Adults:200-400 once daily or twice daily depending upon the infection

UTI, infection of lower respiratory tract, urethral or cervical gonorrhoea, nongonococcal urethritis and cervicitis Urinary tract infections, GIT infections due to Gram organisms. Infections of respiratory tract, skin and soft tissue, otitis media, UTIs.

07.

Negram

Nalidixic Acid

Sanafi Searle

Quiniolone

Caplet 1g Suspension 250mg/5ml Tablets 500mg Cap500mg Inj. 500mg/1g powder in vials Susp. 125mg/250mg powder Inj. 250mg, 750mg, 1.5gm Susp.125mg/5ml Tab. 250mg

Adults:500mg-1gm 4 times daily Children: 50mg/kg daily Adult: 1g daily or 2 gm in two doses Children: under 1 year.15mg/kg 1-6 years, 250mg twice daily, over 6 years, 500mg twice daily
Inj:Adults:750mg-1.5g 3 times daily Children:30-100mg/kg/day in 4 doses Susp/Tab:Adults 250mg500mg twice daily Children: 40-120mg twice daily

GI upset, Hypersensitivity, Skin reactions, convulsions, CNS upsets, transient increase in liver enzymes, disturbed kidney function, blood sugar, INJECTION: pain at injection site, hypotension, thrombophlebitis GI , CNS, and visual disturbances, skin rashes, blood dyscrasia, convulsions, photosensitivity, intracranial hypertension

08.

Cefatil

Cephradine

Highnoon

Cephalosporin

Hypersensitivity reactions, GI disturbances.

09.

Kefrox

Cefuroxime

CCL

Cephalosporin

Inj: Respiratory tract and soft tissue infections, meningitis, prophylaxis in surgical procedures, UTI & gonorrhea. Susp/Tab:infections of upper and lower respiratory tract, ENT, skin & soft tissue, UTI, gonorrhea. Severe respiratory, genitourinary tract, bone, joint and abdominal infections, sepsis, meningitis

Hypersensitivity reactions, GIT disturbances, pain at injection site, eosinophilia, neutropenia, leucopenia, transient rise in blood urea and liver enzemes, + coombs test GIT disturbances

10.

Rocephin

Ceftriaxone Sodium

Roche

Cephalosporin

IM inj. 250mg/ 500mg/1.0g IV inj: 250mg/ 500mg/1g/2g(inf)

Adult:250mg-2 g slowly deep IM or IV bolus in 34 minutes or infusion in 30 minutes Children:20-80mg/kg in slow infusion depending upon the indications

Hypersensitivity pneumonia, eosinophilia, leucopenia, thrombocytopenia fever and dyspnea

Sr. Brand No. 11. Cafrom

Generic Name Cefpirome

Company

Name Sonafi/ Aventis

Category

Dosage Form Inj 1g powder in vial

Dose

Indications

Adverse Effects

Cephalosporin

Use in adults only: 1-2 g 12 hourly by IV bolus or IV infusion over 20-30 min

Infections of lower respiratory tract, skin, soft tissue, complicated upper and lower UTIs , neutropenia, bacteremia, septicemia

12.

Maxipime

Cefepime

BMS

Cephalosporin

Inj 500mg/1g

Adults: IV IM inj Or IV infusion 1g 12 hourly

Infections due to susceptible organisms in patients over 12 years of age

GI upsets, raised liver enzymes and creatinine, blood dyscrasias, injection site reactions, taste disturbance, hypersensitivity, rarely superinfection Pseudomembranous colitis, superinfection, neutropenia, injection site reactions, GI upset headache Hepatitis, cholestatic jaundice, erythema multiforme, epidermal necrolysis, dermatitis, in renal impairment dizziness, headache, convulsions, superficial staining of teeth with susp. Phlebitis at inj site GI upsets, Headache, Myalgia, insomnia, elevated ALT & CPK levels GI upsets, CNS disturbances, myalgia, pancreatitis, peripheral neuropathy, anemia, jaundice, hepatitis, rash, alopecia

13.

Augmentin

Coamoxiclav

GSK

Betalactamase inhibitor/ broad spectrum penicillin

Inj 600mg Inj 1.2g Syp 126.25mg Syp 312.5mg Tab375m g 625mg,1g Tablets 10mg 20mg 40mg Tablets 10mg 20mg 40mg

14.

Lipitor

Atorvastatin Pfizer

Statin

Inj Adults: 1-2g iv injection or intermittent infusion 6 hourly Children:30mg/kg 8 hourly Syp is used in children Tab in adults only 375mg thrice or 625mg twice daily Adult:10mg-80mg once daily Not used in children

Infections of the respiratory tract, ENT, UTI , and soft tissue infections

primary hypercholesterolemia heterozygous and homozygous hypercholesterolemia, mixed hyperlipidemia

Hyperlipidemia, Congestive heart disease, to lower LDH:HDL and total cholesterol:HDL ratio by raising HDL, in homozygous familial hypercholesterolemia

15.

Eglocard

Simvastatin

Himont

Statin

10-80 mg daily at once or in 3 divided doses in adults depending upon symptoms

Sr. Brand No. 16. pravachol

Generic Name pravastatin

Company

Name Bristol Myers Squib

Category

Dosage Form Tablets 20mg Injection 500mg/1g powder in vials

Dose

Indications

Adverse Effects

Statin

Use only in adults: 10-40mg once daily at bed time Adult: 500mg-1g I/V over 5min or IV over 15-30 min every 8 hour. Meningitis:2gm every 8 hour Children: over 3months, 1020mg/kg Meningitis:40mg/kg Adult: 1mg 8 hourly/ 2mg 12 hourly Children: 30mg/kg-50mg/kg 8hourly

17.

Meronem

Meropenam ICI

Antibiotic Carbapenem

18.

Azactam

Aztrenoam

Bristol Myers Squib

Monobactam

Injection 500mg/1g powder in vials

CHD, recurrent MI, hypercholesterolemia, coronary artery disease, Pneumonia. UTI, intra-abdominal, gynecological, skin and soft tissue infections. Meningitis, septicemia, febrile neutropenia Pneumonia. UTI, intra-abdominal, gynecological, skin and soft tissue infections. Meningitis, septicemia, febrile neutropenia
Lower respiratory tract, , intra-abdominal, gynecological, skin and soft tissue infections, septicemia, prophylaxis in post-operative patients

Rash, myalgia, headache, non-cardiac chest pain, GI upsets, fatigue Rash, abdominal pain, nausea, diarrhea, candidiasis, pseudomembranous colitis. Skin rashes, diarrhea, vomiting, local reaction at injection site, haematological and hepatobiliary reactions GI upsets, colitis, blood dyscrasias, elevatedliver enzymes, urea and creatine, CNS disturbances, convulsions Infusion related events like anaphylactic shock flushing, nephrotoxicity, ototoxicity, neutropenia, nausea, chills, fever., rashes, eosinophelia, phlebitis

19.

Tienam

Imepenam

MSD

Carbapenem & enzyme inhibitor

IV inj 500mg

Adult:250mg-1g by IV infusion 6-8 hourly 500-7520mg deep IM 12 hourly Children: 15mg/kg body weight 6 hourly Adults: 2g daily in divided doses by slow infusion over 60min Children:44mg/kg daily in divided doses by slow infusion over 60min

20.

Vancomycin Vancomycin

Abbott

Antibiotic
Glycopeptide

Inj 500mg/1g powder in vial

Staphylococcal infection when organisms are resistant to other antibiotics

Sr. No. 21.

Brand
Targosid

Generic Name

Company Name

Category

Dosage Form

Dose Adult:400mg I/V or I/M Children:10-16mg/kg

Indications
Gram + infections, endocarditis, UTI, septicemia, infections of skin and soft tissue, lower respiratory tract, joints and bones Rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, acute gout, juvenile chronic arthritis, periarthritis, tendinitis Chronic hepatitis B, Hepatitis C, AIDSrelated Kaposi-s sarcoma, hairy cell leukemia, renal cell carcinoma, T-cell lymphoma, non-hodgkin lymphoma, malignant melanoma Short term treatment of anxiety and anxiety accompanying depression Urinary outflow obstruction, symptoms associated with benign prostatic hypertrophy, Hypertension

Adverse Effects
Local reaction at inj site, thrombophlebitis, rash, fever, bronchospasm, anaphylaxis, GI upsets, vestibular disorders, mild hearing loss, renal failure, superinfection GI disturbances, skin reactions, oedema, CNS effects, malaise, tinnitus, local irritation, skin discolouration with gel.

Teicoplanin Sonafi/ Aventis pharma

Glycopeptide Injection 200mg 400mg

22.

Feldene

Piroxicam

Pfizer

NSAID Oxicam

23.

Uniferon

Interferon 2b

Getz

Singlesubtype recombinant

Cap Dispersi ble tablets FDDF tablets Gel Inj. 3MIU/ 5MIU, powder in vials

Adult:20-40mg daily Children: 5mg- 15 mg daily Apply gel 3-4 times daily on affected area 3-20MIU subcutaneously depending on the disorder

Influenza like symptoms, GI and CNS effects, anxiety, convulsions, hyperglycemia, suicidal ideation.

24.

Xanax

Alprazolam Pfizer/ Pharmacia

Benzodiazepine

Tablets 0.25mg 0.5mg 1.0mg Tablets 2mg 4mg

Use only in adults: elderly250mcg 2-3 times daily, others 250-500mcg three times daily, maximum 3mg(6tablets) Use in adults only: initially 1mg daily to 4mg daily

Insomnia, restlessness, headache, dizziness, tremors, blurred vision, GI upsets, stroke, asthenia Headache fatigue, vertigo, dizziness, postural hypertension, lassitude, peripheral oedema.

25.

Cardura

Doxasine

Pfizer

Selective 1 blocker

Sr. No. 26.

Brand Norvasc

Generic Name Amlodipine

Company

Name Pfizer

Category Calcium antagonist

Dosage Form Tablet 5mg 10mg Tablets 1mg 2mg 5mg

Dose Use in adults only initial dose 5mg increase upto 10mg daily

Indications Hypertension myocardial ischemia associated with stable or vasospastic angina Symptomatic treatment of urinary obstruction caused by benign prosthetic hypertrophy. Mild to moderate hypertension Severe respiratory virual bronchiolitis in infants and children, for treating hepatitis C in combination with other drugs. Chronic hepatitis B, Hepatitis C, AIDSrelated Kaposi-s sarcoma, hairy cell leukemia, renal cell carcinoma, T-cell lymphoma, non-hodgkin lymphoma, malignant melanoma
Tuberculosis

Adverse Effects Headache nausea fatigue edema dizziness muscle cramps myalgia pruritis hyperglycemiadry mouth Syncope with initial dose, dizziness, postural hypertension, lassitude, peripheral oedema.

27.

Hytrin

Terazosine

Abbott

Selective 1 blocker

28.

Ribazole Ribavirin

Getz

Antivirus: AnticytoMegalovirus agent

29.

Roferon A

Interferon 2a

Roche

Singlesubtyperecombinant

Cap.100/ 200/400 mg Syp:50m g/100mg per 5ml Tab.500/ 600mg Inj3MIU/ 4.5MIU/ 9MIU/ 18MIU

Use only in adults Urinary obstruction :initially 1mg at night increase upto 10 mg /day Hypertension: 1mg at night increase upto 2-10mg /day Hepatitis c. Adults: over 18 y, with weight under65kg, 400mg twice daily, body weight 6585kg, 400 in morning and 600 in evening, weight over 80kg, 600mg twice. Children.15-20mg/kg in 3 divided doses for 5-7 days 2.5-36 MIU subcutaneous daily for different indications.

Haemolytic anaemia , GIT upsets weight loss, cough, dizziness, aggression, headache, thyroid disorders, hyperurecemia Influenza like symptoms, GI and CNS effects, anxiety, convulsions, hyperglycemia, suicidal ideation.

30.

Isozide

Isoniazid

Nabi Qasim

Isonicotinic acid

Syp

Infants/children: 10-20mg/kg Adults:5-10mg/kg

Peripheral neuropathy, nausea, vomiting, epigastric distress, elevated SGOT, SGPT, SGOPT, fever , skin eruption.

Sr. No. 31.

Brand Rempacin

Generic Name Rifampicin

Company Name Reco

Category Rifamycin

Dosage Form Capsules 150mg 450mg

Dose 150-600mg daily

Indications Tuberculosis

Adverse Effects Nausea vomiting elevated SGOT, SGPT, SGOPT, fever, skin eruption

32.

Pulmobutol

Ethambutol

Amson

Ethambutol

Tablets 400mg

Tuberculosis

Anorexia, nausea vomiting abdominal distress, fever, malasia, headache, dizziness, elevated serum uric acid, optic neuritis

33.

PZA-CIBA

Pyrazinamide

Novartis

Nicotinic acid derivative

Syrup Tablets 500mg

Adult:2030mg/kg/day Children: not recommended

Tuberculosis in conjunction with other drugs

Hepatitis

34.

Dilantin

Phenytoin

ParkeDavis/ Pfizer

Hydantoins

Susp.

Adult: 100mg 2-4 times maxm. 600mg Below6years: 20-30mg/day

Epilepsy Migraine Trigeminal neuralgia

Gastric distress, sleeplessness, allergic reactions, gingival hypertension, blood dyscrasias, skin rashes.

35.

Epilim

Sodium valporate

Sanofi/ Searle

Carboxylic acid derivative

Liquid Tablets

All forms of Adult:600mg daily upto 2.5g epilepsy daily Child:20mg/kg -40mg/kg daily

Weight gain, hair loss, oedema, pancreatitis, hepatic failure, thrombocytopenia, neurological effects

Sr. No. 36.

Brand Gabatin

Generic Name Gabapentin

Company Name Zaka Health Care

Category Gabaanalogue

Dosage Form Capsules 100mg 300mg 400mg

Dose Adult:300800mg/day Children:1035mg/kg/day

Indications Adjunctive treatment for partial seizures. Neuropathic pain

Adverse Effects Dizziness Ataxia Fatigue Anxiety confusion Hypertension Vertigo Arthralgia purpurea Congestive heart failure, edema, leukopenia, leukocytosis, eosinophilia, headache, fatigue, blurred vision
myopathy. Osteoporosis. Peptic ulcer Impaired wound healing Convulsions convulsions anorexia, nausea, vomiting, and diarrhea. headache, weakness, dizziness, Gynecomastia

37.

Lexopine

Carbamazepine Highnooon Iminostilbine

Tab. 200mg

800-1200mg daily

38.

Deltacortril Prednisolone

Pfizer

Glucocorticoid Tab. 5mg

Calculated for individual patient on the basis of the disease and the patient Adult:0.175mg/day

Generalized tonic clonic and partial seizures in epilepsy Trigeminal neuralgia Prophylaxis of manic depressive psychosis Collagen and allergic conditions requiring systemic corticosteroid therapy

39.

Lanoxin

Digoxin

GSK

Cardiac glycoside

Tab. Inj.

Heart Failure Atrial Fibrillation

40.

Dobutamed Dobutamine

Mediceena

Beta-agonist

Injection 250mg/5ml

Dilute with 500ml intravenous solution and administer at low rate

Cardiac inotropic agent, short term treatment of cardiac decompensation due to depressed contractability resulting from cardiac surgery or organic heart disease

Palpitation Increased heart rate blood pressure Hypotension

Sr. No. 41.

Brand Dopamine

Generic Name Dopamine

Company Name Abbott

Category Beta-1-agonist

Dosage Form Injections 200mg/5ml 800mg/10ml

Dose Dilute with normal saline(250500ml)or other intravenous solutions and infused at a low rate

Indications Adjunct in the treatment of shock (e.g. MI, open heart surgery, renal failure, cardiac decompensation, etc.) which persists after adequate fluid volume replacement. Treatment of hypertension; nephropathy in type 2 diabetic patients; reduce risk of stroke in patients with hypertension and left ventricular hypertrophy.

Adverse Effects Headache Anxiety Nausea Dyspnea Ventricular arrhythmia

anginal pain

42.

Normopress

lasartan

CCL pharma

Angiotensin II antagonist

Tablets 25mg 50mg

Adults:initial50 mg/day Maintenance dose 100mg/day Children:0.71.4mg/kg/day

orthostatic hypotension fatigue dizziness Cellulitis Diarrhea UTI Anemia Hypoglycemia