Semnalizarea transmembranara

Alberts Johnson Lewis Raff Roberts Walter

Molecular Biology of the Cell

Fifth Edition

Chapter 15 Mechanisms of Cell Communication

Copyright Garland Science 2008 3

Relevanta medicala a subiectului

...si dimensiunea culturala

 "Variability is the law of life, and as no two faces are the same, so no two bodies are alike..." Sir William Osler Lingvistica Semiotica
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Operam cu modele conceptuale,

... ilustrate adesea simplist...

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Figure 15-1 Molecular Biology of the Cell ( Garland Science 2008)

Credit: Nicolle Rager, National Science Foundation

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Tipurile de comunicare biochimica

... sunt cel mai bine intelese... Insa exista si semnale electrice, mecanice sau compuse...
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Figure 15-3a Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-3b Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-4 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-4a Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-4b Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-4c Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-4d Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-5a Molecular Biology of the Cell ( Garland Science 2008)

Comunicare cu mesaje preluate de-a gata...

... Seamana cu informatiile preluate din media...

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Figure 15-7 Molecular Biology of the Cell ( Garland Science 2008)

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Despre durata in comunicarea intercelulara

...din nou despre dimensiunea temporala...

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Figure 15-6 Molecular Biology of the Cell ( Garland Science 2008)

Despre consecintele comunicarii

...din nou despre numar si timp...

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Figure 15-8 Molecular Biology of the Cell ( Garland Science 2008)

Remember: Exista mai multe paliere de integrare a cunostintelor

...controlul permanent asupra perspectivei este esential...

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Tipare de modele conceptuale

.....fiecare vede altceva...

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Tipar lingvistic in comunicare

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UNEORI receptorul actioneaza ca o protein-kinaza direct

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Cea mai cunoscuta si raspandita cale

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Mecanismele de raspuns la semnale pot fi foarte complexe si implica un numar foarte mare de molecule in celule Un semnal este orice agent care poate influenta comportamentul unei celule. Semnale externe: intensitatea luminii, directia luminii, temperatura, gravitatia, nutrienti, medicamente etc. Celula interactioneaza cu semnalul printr-un receptor. Cei mai multi receptori sunt legati de membrana plasmatica si sunt in mod uzual proteine. Alte molecule din interiorul celulelor vor provoca schimbarile in comportamentul celulei - raspunsul.
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Concluzii
Comunicarea permite integrarea functionala Moleculele de comunicare pot fi secretate sau exprimate pe suprafata In patologie comunicarea este alterata Unele molecule actioneaza la suprafata altele au receptori intracelulari

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Concluzii II
Transferul de informatie se realizeaza pe cai prestabilite Caile se pot intersecta (noduri de comunicare) Farmacologia semnifica manipularea cailor de semnalizare Literatura legata de comunicarea celulara ampla, in mare masura gratuita
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Diversitatea si specializarea rezultate ale comunicarii

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Modelele pot fi din ce in ce mai complicate

... prin simpla adaugare a unor detalii ...la cea mai raspandita cale de semnalizare
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Figure 210. Diagram illustrating how G proteins switch effectors on and off. (Modified and reprinted, with permission, from Linder M, Gilman AG: G proteins. Sci Am 1992;267:56.)

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Cyclic Nucleotide Metabolism - cAMP

SIGMA-ALDRICH

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AMPciclic- PKA

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Alte cai pot fi ilustrate prin modele si mai complicate

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Receptori cu activitate enzimatica intrinseca

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The Mitogen-activated Protein Kinase (MAPK) Cascades

SIGMA-ALDRICH

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PLC-PKC-Ca2+

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Figure 15-39 Molecular Biology of the Cell ( Garland Science 2008)

Calea Jak-STAT

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The JAK/STAT Signaling Pathway

SIGMA-ALDRICH

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Alte exemple de cai Calea factorului de transcriptie NF-kB

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Alte cai de semnalizare au receptori in interiorul celulei

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Actiunea hormonilor steroizi

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Semnificatia se poate interpreta la nivele de integrare mai inalte decat scara celulara
.....fiecare vede altceva...

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Table 15-1 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-9d Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-10 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-12a Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-12b Molecular Biology of the Cell ( Garland Science 2008)

Semnificatia se poate interpreta la nivele de integrare mai joase decat scara celulara
.....la scara moleculara...

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Figure 15-13 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-14a Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-14b Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-14c Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-14d Molecular Biology of the Cell ( Garland Science 2008)

Semnificatia se poate interpreta la nivele de integrare mai joase decat scara celulara
.....sau la scara unor segmente sau secvente dintr-o cale de semnalizare...

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Figure 15-17 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-16a Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-16b Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-30 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-31 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-32 Molecular Biology of the Cell ( Garland Science 2008)

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Table 15-3 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-51 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-35 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-16c Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-21a Molecular Biology of the Cell ( Garland Science 2008) SCAFOLD

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Figure 15-21b Molecular Biology of the Cell ( Garland Science 2008) ON RECEPTOR

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Figure 15-21c Molecular Biology of the Cell ( Garland Science 2008) INCREASED PHOSPHOPYLATION

Semnificatia se poate interpreta la nivele de integrare mai joase decat scara celulara
.....se pot identifica asemanari si deosebiri intre sistemele de comutare moleculara din diferite cai de semnalizare...

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Figure 15-18 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-18a Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-18b Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-19 Molecular Biology of the Cell ( Garland Science 2008)

Semnificatia se poate interpreta la in functie de TIMP la nivele de integrare la scara celulara

.....corelate cu succesiunea, incidenta sau co-incidenta semnalelor...

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Figure 15-20 Molecular Biology of the Cell ( Garland Science 2008) - COINCIDENCE

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Figure 15-23 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-40 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-29 Molecular Biology of the Cell ( Garland Science 2008)

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Table 15-2 Molecular Biology of the Cell ( Garland Science 2008)

Corelatii cu sistemele de transport

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Figure 15-41a Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-41b Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-44 Molecular Biology of the Cell ( Garland Science 2008) (CaM K II, 12 SUBUNITS)

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Figure 15-45 Molecular Biology of the Cell ( Garland Science 2008) CaM K II

Semnificatia se poate interpreta la in functie de TIMP la nivele de integrare la scara celulara

.....corelate cu succesiunea, incidenta sau co-incidenta semnalelor...

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Corelatii structura-functie

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Figure 15-52 Molecular Biology of the Cell ( Garland Science 2008) TK

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Table 15-4 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-53a Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-54 Molecular Biology of the Cell ( Garland Science 2008)

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Table 15-5 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-60 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-66 Molecular Biology of the Cell ( Garland Science 2008)

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Figure 15-68 Molecular Biology of the Cell ( Garland Science 2008)

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Table 15-6 Molecular Biology of the Cell ( Garland Science 2008)

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