Market Spotlight: Pharmaceuticals

Solutions for Catalyst and Activated Carbon Removal in Active Pharmaceutical Ingredients Manufacturing

Intense competition. Off-brand pirating. Offshore manufacturers pushing substandard product. Ingredient shortages. Tighter regulations. The stakes have never been higher in the pharmaceuticals market. Meeting these challenges puts added strain on manufacturers to work with tighter budgets and shorter market deadlines.

How does a manufacturer stay ahead of the game and still maintain a quality product reputation? Eaton has answers. We offer a selection of filtration products that deliver consistent, reliable API containment and recovery, while creating opportunities for cost reduction as well.

BECO Integra Disc housing

Maintaining Process QC and Ingredient Control

Eaton combines sales, engineering, manufacturing, customer service, and technical sales support into one focused business objective: Provide customers with optimum filtration solutions.
Active pharmaceutical ingredients (API) are defined by the US Food and Drug Administration as substances used singly or in a mixture to produce a medicinal product. When used in drug production, these substances become the API for that product. Catalysts, bonded to activated carbon as a base material, are used to expedite a reaction process, such as hydrogenation. The increased use of metal catalysts such as palladium, rhodium, and ruthenium requires containment and recovery to meet catalyst residue limits set by the United States Pharmacopoeia (USP) and the European Pharmacopoeia (Ph. Eur.). On a secondary but equally important level catalysts are expensive, making their recovery and reuse a budget consideration as well. Activated carbon is also employed in API manufacturing to remove color, contaminants, and impurities from product via chemical adsorption. If the carbon is used in free-powder form, the residue has to be removed. Both methods require filter solutions able to handle high volumes of solids. Engineering the Better Idea Many filtration options for catalyst and activated carbon removal are adequate. They may, however, not be optimal for your application. Among the challenges are designs that feature economy but increase the risk of filtration bypass. Some are complicated and increase staff workload to maintain. The choice of filter media can also be a concern. Eaton resolves these issues with a family of solutions under the BECO trademark. BECO depth filter sheets are specially manufactured to ensure high particulate holding capacity and safe, consistent retention. Very pure, finely fibrillated cellulose fibers in combination with filtrationactive mineral components, such as diatomaceous earth, form the matrix of the filter media. BECO depth filter sheets are typically used in enclosed and classic plate and frame filters. The new, pure BECOPAD and the high-purity, pharma-grade BECOPAD P are the first and only mineral-free depth filter media produced to date with special, high-purity cellulose. In the BECOPAD range, highpurity celluloses form a unique, superfine filtration structure that does not require inorganic ingredients, lessening the burden of material recovery. BECO filter sheets and BECOPAD depth filters are also used to produce BECODISC stacked disc cartridges where they contribute to superior mechanical and chemical stability. BECODISC stacked disc cartridges enable simple insertion and removal in BECO INTEGRA DISC stacked disc cartridge housings.

BECO Integra Disc Multi-column housing

Smart Choices for Pharmaceutical Applications

BECOPAD and BECOPAD P Unique, mineral-free depth filter media for catalyst and activated carbon removal.
Features Pure cellulose Enhanced chemical and mechanical resistance in the filtration of aggressive solvents No mineral components Benefits Filter aids, such as DE or perlite, no longer needed Higher bursting strength minimizes the risk of bypass Minimum content of extractable ions; Full ashability during combustion

BECODISC Stacked disc cartridge with superior mechanical stability.

Features Pre-pressed design Three-part stainless steel segmented sleeve Extremely high assembly pressure (5000 - 8000N) Cell separator Benefits Consistent performance Extremely stable Exceptional bypass security Cells remain in place, even after steam sterilization

BECO Integra Plate Enclosed plate and frame filter.

Features Enclosed design User-friendly assembly CIP/SIP capability: external gasket (EC/EP) or sealing area (OEP) produces a hermetically enclosed filter packet Complete discharge of the filtration system via special design of lower product channels and riser pipes Low height Exclusive external chamber design Automatic hydraulic pressure regulation Benefits No product loss, no leakage Easy to handle, operate, and clean Enables cleaning and sterilization of filtration system provides for reliable cleaning validation Minimizes risk of product loss, eliminates emissions during opening provides a very dry filter cake Convenient handling: easy, precise depth filter sheet replacement Complete condensate drain No leakage, high safety
BECO Integra Plate

BECO Integra Disc/Sanitary Design Stacked disc cartridge housing design for range of filter areas from 6.35 ft2 (0.59 m2) up to a maximum of 671.67 ft2 (62.4 m2).
Features O-ring mounted in the filter dome, not in the bottom part of the vessel DGRL/ASME approved V-ring quick closure device for 12 and 16 housings Venting unit with diaphragm pressure gauge, membrane valve, and aseptic side glass Sanitary tightening device Multi column design available Benefits Ensures full CIP capability, no dead space, no liquid or impurities remain underneath O-ring after cleaning Easy, fast, and safe handling, no clamp screws Easy to clean, sanitary standard No metal spring in contact with product, no risk of corrosion, easy to clean Extensive variety of filtration areas
BECO Integra Solo

BECO Integra Solo Enclosed single-sheet filter with a filling space designed as a pressure vessel, suitable for inserting a filter medium.
Feature Features Proven, accepted technology Benefit Ideal for large cake volumes

BECODISC ACF 07 Alternative to powdered activated carbon.

Features No contact with powdered activated carbon Carbon impregnated filter media Benefits Expedites cleaning and cleaning validation of vessels, pipes, housings, and accessories Easier and cleaner handling

North America HQ 70 Wood Ave., South, 2nd Floor Iselin, NJ 08830 Toll Free: (800) 656-3344 (North America Only) Voice: (732) 767-4200 China No. 3, Lane 280, Linhong Road Changning District, 200335 Shanghai, P.R. China Voice: +86-21-5200-0099 Singapore 4 Loyang Lane #04-01/02 Singapore 508914 Voice: +65-6825-1668

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For more information, please e-mail us at filtrationinfo@eaton.com Visit us online at eaton.com/filtration for a complete list of Eatons filtration products
2012 Eaton Corporation. All Rights Reserved. All trademarks and registered trademarks are the property of their respective owners. Litho USA.

All information and recommendations appearing in this brochure concerning the use of products described herein are based on tests believed to be reliable. However, it is the users responsibility to determine the suitability for his own use of such products. Since the actual use by others is beyond our control, no guarantee, expressed or implied, is made by Eaton as to the effects of such use or the results to be obtained. Eaton assumes no liability arising out of the use by others of such products. Nor is the information herein to be construed as absolutely complete, since additional information may be necessary or desirable when particular or exceptional conditions or circumstances exist or because of applicable laws or government regulations.

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