1)A young adult with albinism is found to be at increased risk for skin cancer.

Which of the following is the precursor of melanin? A. B. C. D. Tryptophan Tyrosine Arginine Glycine

The correct answer is B 2) A chronic alcoholic develops severe memory loss with marked confabulation. Deficiency of which of the following vitamins would be most likely to contribute to the neurologic damage underlying these symptoms? A. B. C. D. Folic acid Niacin Riboflavin Thiamine

The correct answer is D 3) Dietary intake of which of the following amino acids can substitute for a portion of the daily requirement of niacin? A. B. C. D. Alanine Asparagine Methionine Tryptophan

The correct answer is D

4) Which of the following amino acids is most responsible for the buffering capacity of hemoglobin and other proteins? A. B. C. D. Arginine Aspartic acid Glutamic acid Histidine

The correct answer is D. 5). The structural proteins are involved in maintaining the shape of a cell or in the formation of matrices in the body. The shape of these proteins is: A. Globular B. Fibrous C. Stretch of beads D. Planar Answer B. Fibrous 6). Which one of the following can be a homologous substitution for isoleucine in a protein sequence? A. Methionine B. Aspartic acid C. Valine D. Arginine Answer C. Valine

7) Proteins are linear polymers of amino acids. They fold into compact structures. Sometimes, these folded structures associate to form homo or hetero-dimers. Which one of the following refers to this associated form? A. Denatured state B. Molecular aggregation C. Precipitation D. Quaternary structure Answer D. Quaternary structure 8). The sigma subunit of prokaryotic RNA Polymerase: A. Binds the antibiotic Rifampicin B -amanitin

C. Specifically recognizes the promoter site D. Is part of the core enzyme Answer C Specifically recognizes the promoter site 9) Alpha helix and Beta pleated sheet are examples of: A. Primary structure B. Secondary structure C. Tertiary structure D. Quaternary structure Correct answer : B. Secondary structure 10) In which of the following conditions the level of creatinine kinase 1 increases ? A. Myocardial ischemia B. Brain Ischemia C. Kidney damage

D. Electrical cardioversion Correct answer : B. Brain Ischemia

11)A person on a fat free carbohydrate rich diet continues to grow obese. Which of the following lipoproteins is likely to be elevated in his blood? A. Chylomicrons B. VLDL C. LDL D. HDL Correct answer : B. VLDL

12)Which of the following group of proteins assist in the folding of other proteins? A. Proteases B. Proteosomes C. Templates D. Chaperones Correct answer : D. Chaperones 13)An enzyme that makes a double stranded DNA copy from a single stranded RNA template molecule is known as: A. DNA polymerase B. RNA polymerase C. Reverse transcriptase D. Phosphokinase Correct answer : C. Reverse transcriptase

14)A segment of a eukaryotic gene that is not represented in the mature messenger RNA is known as: A. Intron B. Exon

C. Plasmid D. TATA box Correct answer : A. Intron 15)Shine Dalgarno sequence in bacterial mRNA is near: A. AUG codon B. UAA codon C. UAG codon D. UGA codon Correct answer : A. AUG codon 16) Both Vitamin K and C are involved in: A. The synthesis of clotting factors B. Post translational modifications C. Antioxidant mechanisms D. The microsomal hydroxylation reactions Correct answer : B. Post translational modifications

17)The predominant isozyme of LDH in cardiac muscle is: A. LD-1 B. LD-2 C. LD-3 D. LD-5 Correct answer : A. LD-1

18)Fluoride, used in the collection of blood samples for glucose estimation, inhibits the enzyme: A. Glucokinase B. Hexokinase C. Enolase D. Glucose-6-phosphatase

Correct answer : C. Enolase

19)Enzymes that move a molecular group from one molecule to another are known as: A. Ligases B. Oxidoreductases C. Transferases D. Dipeptidases Correct answer : C. Transferases 20)The amino acid residue having an imino side chain is: A. Lysine B. Histidine C. Tyrosine D. Proline Correct answer : D. Proline

21)Vitamin B12 acts as co-enzyme to which one of the following enzymes? A. Isocitrate dehydrogenase B. Homocysteine methyl transferase C. Glycogen synthase D. G-6-P dehydrogenase Correct answer : B. Homocysteine methyl transferase 22)During replication of DNA, which one of the following enzymes polymerizes the Okazaki fragments? A. DNA Polymerase I B. DNA Polymerase II C. DNA Polymerase III D. RNA Polymerase I Correct answer : C. DNA Polymerase III

23)Which type of RNA has the highest percentage of modified base? A. mRNA B. tRNA C. rRNA D. snRNA Correct answer : B. tRNA 24)A nucleic acid was analyzed and found to contain 32% adenine, 18% guanine, 17% cytosine and 33% thymine. The nucleic acid must be: a) Single-stranded RNA b) Single-stranded DNA. c) Doublestranded RNA d) Double stranded DNA Correct answer : d) Double stranded DNA 25) All take place in mitochondria except a) Fatty acid oxidation b) EMP pathway c) Electron transport chain d) Citric acid cycle Correct answer : b) EMP pathway 26)Glycolysis occurs in a) Cytosol b) Mitochondria c) Nucleus d) Lysosome Correct answer : a) Cytosol 27)Active form of vitamin D is a) Cholecalciferol b) 24, 25 (OH)2 vit-D

c) 1, 25 (OH)2 vit-D d) 25-OH vit-D Correct answer : c) 1, 25 (OH)2 vit-D 28)All of the following are essential aminoacids except a) Methionine b) Lysine c) Alanine d) Leucine Correct answer : c) Alanine 29)First substrate of Krebs cycle is a) Pyruvate b) Glycine c) HCl d) Lipoprotein Correct answer : a) Pyruvate 30)The amino acid producing ammonia in kidney is a) Glutamine b) Alanine c) Methionine d) Glycine Correct answer : a) Glutamine

31)Dinitrophenol causes: A. Inhibition of ATP synthase B. Inhibition of electron transport C. Uncoupling of oxidation and phosphorylation D. Accumulation of ATP Correct answer : C. Uncoupling of oxidation and phosphorylation

32)Protein that precipitates on heating to 45 C and redissolves on boiling is: A. Bence Jones Protein B. Gamma globulin C. Albumin D. Myosin Correct answer : Bence Jones Protein 33) An infant diagnosed with phenylketonuria would be expected to be deficient in which of the following nonessential amino acids, assuming that it is not obtained from dietary sources?

A. B. C. D.

Asparagine Cysteine Glutamine Tyrosine

The correct answer is D 34) Which of the following pairs of enzymes is required for the process of gluconeogenesis?

A. B. C. D.

Fructose-1,6-bisphosphatase and pyruvate carboxylase Glucose-6-phosphatase and phosphofructokinase-1 Glucose-6-phosphatase and pyruvate dehydrogenase Phosphoenolpyruvate carboxykinase and glucokinase

The correct answer is A.(PFK-2 AND KEY ENZYME)

35). The general formula of monosaccharides is (A) CnH2nOn (B) C2nH2On (C) CnH2O2n (D) CnH2nO2n Ans-a 36) pentose sugar is (A) Dihydroxyacetone (B) Ribulose (C) Erythrose (D) Glucose Ans-b 37)Isomers differing as a result of variations in configuration of the OH and H on carbon atoms 2, 3 and 4 of glucose are known as (A) Epimers (B) Anomers (C) Optical isomers (D) Steroisomers Ans-a( C4 EPIMER GLUCOSE-GLACTOSE)( C2 EPIMER GLUCOSE-MANNOSE) 38). Cane sugar is known as (A) Galactose (B) Sucrose (C) Fructose (D) Maltose ANS- B 39). The constituent unit of inulin is (A) Glucose (B) Fructose (C) Mannose (D) Galactose Ans-b(HOMOPOLYSACHRIDE) GFR ESTIMATION 40). The glycosaminoglycan which does not

contain uronic acid is (A) Hyaluronic acid (B) keratan sulphate (C) Chondroitin sulphate (D) Dermatan sulphate Ans-b 41). Lactate formed in muscles can be utilised through (A) Rapoport-Luebeling cycle (B) Glucose-alanine cycle (C) Coris cycle (D) Citric acid cycle Ans-c 42)NAcetylglucosamnine is present in (A) Hyaluronic acid (B) Chondroitin sulphate (C) Heparin (D) All of these Ans d 43)McArdles disease is due to the deficiency of (A) Glucose-6-phosphatase (B) Phosphofructokinase (C) Liver phosphorylase (D) muscle phosphorylase Ans=d(GLYCOGEN STORAGE DISEASE) 44)During starvation, ketone bodies are used as a fuel by (A) Erythrocytes (B) Brain

(C) Liver (D) All of these Ans b FIRST 2 WEEK- GLUCOSE AFTER 3 WEEK- KETONE BODIES FATTY ACID 45)The optically inactive amino acid is (A) Glycine (B) Serine (C) Threonine (D) Valine Ans- a COOH NH2-C-H H 46)Sulphur containing amino acid is (A) Methionine (B) Leucine (C) Valine (D) Asparagine Ans-a (Methionine AND CYSTEINE) 47). Sakaguchis reaction is specific for (A) Tyrosine (B) Proline (C) Arginine (D) Cysteine Ans-c (BASIC ) GUANIDINIUM GROUP 48)The protein present in hair is (A) Keratin (B) Elastin (C) Myosin (D) Tropocollagen Ans-a 49)Fibrous proteins have axial ratio

(A) Less than 10 (B) Less than 10 and generally not greater than 34 (C) Generally 10 (D) Greater than 10

Ans-d 50)Denaturation of proteins results in (A) Disruption of primary structure (B) Breakdown of peptide bonds (C) Destruction of hydrogen bonds (D) Irreversible changes in the molecule Ans-c 1 PEPTIDE / 2- HYDROGEN /3-HYDROPHOBIC,ELECTROSTATIC,VANDER WALL /4=2+3 510A lipoprotein inversely related to the incidence of coronary artherosclerosis is (A) VLDL (B) IDL (C) LDL (D) HDL And d (DEPOSIT CHOLESTEROL) , LDL (REMOVE CHOLESTEROL),VLDL (DEPOSIT TG IN PHERIPHERAL TISSUE) 52)The main site of urea synthesis in mammals is (A) Liver (B) Skin (C) Intestine (D) Kidney Ans-a 53)The amino acids involved in the synthesis of creatine are

(A) Arginine, glycine, active methionine (B) Arginine, alanine, glycine (C) Glycine, lysine, methionine (D) Arginine, lysine, methionine Ans-a ANHYDRIDE- CREATININE RENAL FUNCTION 54)The minimum number of polypeptide chains in an immunoglobulin is (A) Two (B) Four (C) Five (D) Six Ans-4 (2 LIGHT /2 HEAVY CHAIN) 55)Kwashiorkor occurs when the diet is severely deficient in (A) Iron (B) Calories (C) Proteins (D) Essential fatty acids Ans-c 56)Essential fatty acid: (A) Linoleic acid (B) Linolenic acid (C) Arachidonic acid (D) All these Ans-d 57)The cholesterol molecule is (A) Benzene derivative (B) Quinoline derivative (C) Steroid (D) Straight chain acid Ans c 58)Gauchers disease is due to deficiency of

the enzyme: (A) Sphingomyelinase (B) Glucocerebrosidase (C) Galactocerbrosidase (D) -Galactosidase Ans-b COMPLEX LIPID PHOSHOLIPID AND GLYCOLIPID

GLCEROPHOSPHOLIPID AND SPINGOPHOSOLIPID /////N GLYCOSPINGOLIPID AND A GLYCOSPINGOLIPID CEREBROSIDE

59)An important finding in Neimann-Pick disease is (A) Leukopenia (B) Cardiac enlargement (C) Corneal opacity (D) Hepatosplenomegaly Ans-d 60)Richner-Hanhart syndrome is due to defect in (A) Tyrosine transaminase (B) Phenylalanine hydroxylase (C) Hepatic tyrosine transaminase (D) Fumarylacetoacetate hydrolase Ans-a 61)An inborn error, maple syrup urine disease is due to deficiency of the enzyme: (A) Isovaleryl-CoAhydrogenase (B) Phenylalnine hydroxylase (C) Adenosyl transferase

(D) -Ketoacid decarboxylase Ans-d deficient decarboxylation of branched chain 62)Ochronosis is an important finding of (A) Tyrosinemia (B) Tyrosinosis (C) Alkaptonuria (D) Richner Hanhart syndrome Ans-c tyrosine metabolism .(deposition of alkapton bodies in bone_ 63)A characteristic feature of Kwashiorkar is (A) Fatty liver (B) Emaciation (C) Low insulin lever (D) Occurrence in less than 1 year infant Ans-a 64 B-Oxidation of fatty acids requires all the following coenzymes except (A) CoA (B) FAD (C) NAD (D) NADP Ans-d 65)All the following statements about ketone bodies are true except (A) Their synthesis increases in diabetes mellitus (B) They are synthesized in mitchondria (C) They can deplete the alkali reserve (D) They can be oxidized in the liver Ans-d

66-Galactosidase is deficient in (A) Fabrys disease (B) Krabbes disease (C) Gauchers disease (D) Metachromatic leukodystrophy Ans b glucocerebroside- gaucher disease. COMPLEX LIPID PHOSHOLIPID AND GLYCOLIPID

GLCEROPHOSPHOLIPID AND SPINGOPHOSOLIPID /////N GLYCOSPINGOLIPID AND A GLYCOSPINGOLIPID CEREBROSIDE

67)Saponification: (A) Hydrolysis of fats by alkali (B) Hydrolysis of glycerol by liposes (C) Esterification (D) Reduction Ans a (amount of KOH required to soapnify the fatty acid in one gram of fat.) 68)Iodine number denotes (A) Degree of unsaturation (B) Saponification number (C) Acid number (D) Acetyl number Ans-a (number of gram of iodine absorbed by 100 gram of fat) 69 B-Oxidation of odd-carbon fatty acid chain produces (A) Succinyl CoA (B) Propionyl CoA (C) Acetyl CoA (D) Malonyl CoA

Ans-b ( even acetyl Co A) 70)The rate limiting step cholesterol biosynthesis is (A) Squalene synthetase (B) Mevalonate kinase (C) HMG CoA synthetase (D) HMG CoA reductase Ans-d / rate limiting in ketogenesis (HMG CoA synthetase) 71)Bile is produced by (A) Liver (B) Gall-bladder (C) Pancreas (D) Intestine Ans a

72)One manifestation of vitamin A deficiency is (A) Painful joints (B) Night blindness (C) Loss of hair (D) Thickening of long bones Ans-b 73)Vitamin synthesized by bacterial in the intestine is (A) A (B) C (C) D (D) K Ans-k / k1- phylloquinone (plant)/ k2- menaquinone (bacteria)/k3 menadione )(synthetic) 74)Both Wernickes disease and beriberi can

be reversed by administrating (A) Retinol (B) Thiamin (C) Pyridoxine (D) Vitamin B12 Ans- b 75)Riboflavin deficiency causes (A) Cheilosis (B) Loss of weight (C) Mental deterioration (D) Dermatitis Ans-a