Executive Editor Michael Roy speaks with Roscoe O. Brady, Jr., M.D., Ph.D., and Mark A. Halko, Ph.D., about their research on identifying and treating a network of connectivity in the brain corresponding to negative symptom severity in schizophrenia. The difference between positive and negative symptoms in psychosis, and why the symptoms are important [2:39] Identifying the treating the underlying circuitry of negative symptoms in the brain [6:25] Discussion of the results of the study [10:20] Symptom severity and the link between the prefrontal cortex and cerebellum [12:27] Aspects of the study that are relevant for researchers, clinicians, and other mental health professionals [20:40] What's next in this line of research and clinical care [25:40] Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Stitcher, or wherever you listen to it. The podcast is now on Spotify. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. Also visit the online edition of this month’s Journal to watch a video of Deputy Editor Daniel S. Pine, M.D., present highlights from the issue. Follow the Journal on Twitter. E-mail us at ajp@psych.org