Summary of the January 5, 2016 issue, including articles on opioid prescribing after nonfatal overdose, skin lesions associated with anti-tumor necrosis factor therapy, sudden cardiac arrest, HBV reactivation in solid tumors, and hypothyroidism; an ACP best practice advice paper on the use of generic medications; and commentaries on community health in New Orleans after Hurricane Katrina, as well as the recent Institute of Medicine report "Improving Diagnosis in Health Care."