Every biology student is familiar with DNA - the ladder-like blueprint of life built on a backbone of the sugar deoxyribose. Scientists are now hacking this structure to make entirely new DNA-like molecules built on different sugar skeletons, opening an exciting new world of synthetic genetics. Plus, we find out what happens when music has sex, discover why the X chromosome is more than just a number, and our gene of the month is the unfortunate Ken and Barbie.