In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV! Links for this episode Genome wide association study of severe COVID-19 (NEJM) Major genetic risk factor for severe COVID-19 inherited from Neanderthals (Nature) COVID-19 host genetics initiative (Eur J Hum Gen) Prolonged SARS-CoV-2 shedding in immunocompromised host (J Inf Dis) Krugman on Barrington Declaration (NY Times) Letters read on TWiV 676 Timestamps by Jolene. Thanks! Weekly Science Picks Brianne – Kids Meet a Virologist Kathy –  Harvard glass marine invertebrates 3D online Rich – Chernobyl fungi Vincent – Artologica Listener Pick Justin – Totally Under Control Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv